Mat2a (methionine adenosyltransferase 2A) - Rat Genome Database

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Gene: Mat2a (methionine adenosyltransferase 2A) Rattus norvegicus
Analyze
Symbol: Mat2a
Name: methionine adenosyltransferase 2A
RGD ID: 619985
Description: Enables ATP binding activity; amino acid binding activity; and methionine adenosyltransferase activity. Involved in several processes, including S-adenosylmethionine biosynthetic process; circadian rhythm; and response to cAMP. Predicted to be part of methionine adenosyltransferase complex. Predicted to be active in cytosol. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MAT2A (methionine adenosyltransferase 2A); PARTICIPATES IN choline metabolic pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adoMet synthase 2; adoMet synthetase 2; MAT 2; MAT-II; methionine adenosyltransferase 2; methionine adenosyltransferase II, alpha; non-hepatic-type S-adenosylmethionine synthetase; S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthetase isoform type-2; Sams2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,048,043 - 106,053,612 (-)NCBIGRCr8
mRatBN7.24104,489,877 - 104,495,447 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,488,466 - 104,495,493 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4109,869,381 - 109,874,948 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,644,494 - 105,650,061 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,257,643 - 104,263,213 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,297,478 - 100,303,047 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,296,075 - 100,303,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,067,990 - 165,073,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,739,943 - 105,745,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14105,984,423 - 105,989,953 (-)NCBI
Celera493,642,240 - 93,647,807 (-)NCBICelera
Cytogenetic Map4q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (ISO)
5-formyltetrahydrofolic acid  (ISO)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercitrin  (ISO)
quinomethionate  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
WIN 55212-2  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development. Chen YW, etal., J Immunol Res. 2021 Jun 24;2021:5510869. doi: 10.1155/2021/5510869. eCollection 2021.
2. S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver. Garcia-Trevijano ER, etal., FASEB J 2000 Dec;14(15):2511-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
6. Molecular cloning and nucleotide sequence of cDNA encoding the rat kidney S-adenosylmethionine synthetase. Horikawa S, etal., J Biol Chem 1990 Aug 15;265(23):13683-6.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression. Kim JS, etal., J Biol Chem. 2005 Jan 7;280(1):677-84. Epub 2004 Oct 25.
9. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
10. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Lu SC, etal., Am J Physiol Gastrointest Liver Physiol. 2000 Jul;279(1):G178-85.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain. Ngai YF, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R613-22. doi: 10.1152/ajpregu.00075.2015. Epub 2015 Jul 15.
14. Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation. Paneda C, etal., Hepatology 2002 Jun;35(6):1381-91.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:7665609   PMID:9461287   PMID:10644686   PMID:12023972   PMID:17317269   PMID:17485851   PMID:20102719   PMID:20439489   PMID:22271545   PMID:22318685   PMID:25075345   PMID:25416956  
PMID:27548429   PMID:33179842   PMID:34284075   PMID:36555116  


Genomics

Comparative Map Data
Mat2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,048,043 - 106,053,612 (-)NCBIGRCr8
mRatBN7.24104,489,877 - 104,495,447 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,488,466 - 104,495,493 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4109,869,381 - 109,874,948 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,644,494 - 105,650,061 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,257,643 - 104,263,213 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,297,478 - 100,303,047 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,296,075 - 100,303,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,067,990 - 165,073,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,739,943 - 105,745,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14105,984,423 - 105,989,953 (-)NCBI
Celera493,642,240 - 93,647,807 (-)NCBICelera
Cytogenetic Map4q32NCBI
MAT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,539,168 - 85,545,281 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,539,168 - 85,545,281 (+)EnsemblGRCh38hg38GRCh38
GRCh37285,766,291 - 85,772,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,619,799 - 85,625,914 (+)NCBINCBI36Build 36hg18NCBI36
Build 34285,677,945 - 85,684,059NCBI
Celera285,594,476 - 85,600,591 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,662,610 - 85,669,745 (+)NCBIHuRef
CHM1_1285,695,908 - 85,702,210 (+)NCBICHM1_1
T2T-CHM13v2.0285,541,227 - 85,547,340 (+)NCBIT2T-CHM13v2.0
Mat2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,409,779 - 72,416,539 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,409,782 - 72,416,541 (-)EnsemblGRCm39 Ensembl
GRCm38672,432,796 - 72,439,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,432,799 - 72,439,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,382,793 - 72,389,552 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,362,308 - 72,369,067 (-)NCBIMGSCv36mm8
Celera674,527,849 - 74,534,608 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
Mat2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,953,623 - 1,961,164 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554241,953,623 - 1,961,164 (-)NCBIChiLan1.0ChiLan1.0
MAT2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,837,386 - 40,847,214 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,840,148 - 40,849,976 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,589,301 - 85,595,437 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A87,140,504 - 87,148,322 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,141,857 - 87,148,322 (+)Ensemblpanpan1.1panPan2
MAT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,525,635 - 39,532,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,525,626 - 39,532,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,197,011 - 39,203,887 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01740,272,327 - 40,279,204 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,272,327 - 40,279,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,401,948 - 39,408,822 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,473,851 - 39,480,724 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,873,693 - 39,880,568 (-)NCBIUU_Cfam_GSD_1.0
Mat2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,141,369 - 79,147,930 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,709,716 - 1,717,499 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,710,513 - 1,717,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAT2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,218,688 - 59,225,249 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1359,220,203 - 59,225,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,132,444 - 62,137,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAT2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,609,533 - 21,615,822 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,611,040 - 21,615,615 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604590,847,836 - 90,855,647 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mat2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,596,381 - 17,603,867 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,596,381 - 17,603,804 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mat2a
35 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000018170
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4103194805112478794Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat

Markers in Region
BE097659  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24104,495,693 - 104,495,846 (+)MAPPERmRatBN7.2
Rnor_6.04100,303,294 - 100,303,446NCBIRnor6.0
Rnor_5.04165,073,806 - 165,073,958UniSTSRnor5.0
RGSC_v3.44105,745,719 - 105,745,871UniSTSRGSC3.4
Celera493,648,054 - 93,648,206UniSTS
RH 3.4 Map4630.67UniSTS
Cytogenetic Map4q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000018170   ⟹   ENSRNOP00000018170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,490,387 - 104,495,493 (-)Ensembl
Rnor_6.0 Ensembl4100,297,478 - 100,303,047 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084782   ⟹   ENSRNOP00000072361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,488,474 - 104,495,480 (-)Ensembl
Rnor_6.0 Ensembl4100,296,075 - 100,303,080 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098451   ⟹   ENSRNOP00000094572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,488,471 - 104,495,493 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101797   ⟹   ENSRNOP00000085794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,488,474 - 104,495,480 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106271   ⟹   ENSRNOP00000088414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,488,466 - 104,495,493 (-)Ensembl
RefSeq Acc Id: NM_134351   ⟹   NP_599178
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,048,043 - 106,053,612 (-)NCBI
mRatBN7.24104,489,877 - 104,495,447 (-)NCBI
Rnor_6.04100,297,478 - 100,303,047 (-)NCBI
Rnor_5.04165,067,990 - 165,073,559 (-)NCBI
RGSC_v3.44105,739,943 - 105,745,472 (-)RGD
Celera493,642,240 - 93,647,807 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_599178 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42106 (Get FASTA)   NCBI Sequence Viewer  
  AAH62394 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018170.6
  ENSRNOP00000072361.1
  ENSRNOP00000085794.1
  ENSRNOP00000088414.1
  ENSRNOP00000094572
  ENSRNOP00000094572.1
GenBank Protein P18298 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_599178   ⟸   NM_134351
- UniProtKB: P18298 (UniProtKB/Swiss-Prot),   A0A8I6ALA1 (UniProtKB/TrEMBL),   A6IAC2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018170   ⟸   ENSRNOT00000018170
Ensembl Acc Id: ENSRNOP00000072361   ⟸   ENSRNOT00000084782
Ensembl Acc Id: ENSRNOP00000088414   ⟸   ENSRNOT00000106271
Ensembl Acc Id: ENSRNOP00000085794   ⟸   ENSRNOT00000101797
Ensembl Acc Id: ENSRNOP00000094572   ⟸   ENSRNOT00000098451
Protein Domains
S-adenosylmethionine synthetase C-terminal   S-adenosylmethionine synthetase central   S-adenosylmethionine synthetase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18298-F1-model_v2 AlphaFold P18298 1-395 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693137
Promoter ID:EPDNEW_R3653
Type:single initiation site
Name:Mat2a_1
Description:methionine adenosyltransferase 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04100,303,093 - 100,303,153EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619985 AgrOrtholog
BioCyc Gene G2FUF-44146 BioCyc
BioCyc Pathway METHIONINE-DEG1-PWY [L-methionine degradation I (to L-homocysteine)] BioCyc
  PWY-5041 [S-adenosyl-L-methionine salvage II] BioCyc
BioCyc Pathway Image METHIONINE-DEG1-PWY BioCyc
  PWY-5041 BioCyc
Ensembl Genes ENSRNOG00000013520 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018170.6 UniProtKB/TrEMBL
  ENSRNOT00000084782.2 UniProtKB/TrEMBL
  ENSRNOT00000098451 ENTREZGENE
  ENSRNOT00000098451.1 UniProtKB/TrEMBL
  ENSRNOT00000101797.1 UniProtKB/TrEMBL
  ENSRNOT00000106271.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5622019 IMAGE-MGC_LOAD
InterPro ADOMET_SYNTHASE_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synthetase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synthetase_sfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171347 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72314 IMAGE-MGC_LOAD
NCBI Gene 171347 ENTREZGENE
PANTHER PTHR11964 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam S-AdoMet_synt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mat2a PhenoGen
PIRSF MAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADOMET_SYNTHASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADOMET_SYNTHASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013520 RatGTEx
Superfamily-SCOP SSF55973 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A2G3_RAT UniProtKB/TrEMBL
  A0A8I6A819_RAT UniProtKB/TrEMBL
  A0A8I6ALA1 ENTREZGENE, UniProtKB/TrEMBL
  A6IAC2 ENTREZGENE, UniProtKB/TrEMBL
  F1LRB8_RAT UniProtKB/TrEMBL
  METK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P688_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 Mat2a  methionine adenosyltransferase 2A  Mat2a  methionine adenosyltransferase II, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Mat2a  methionine adenosyltransferase II, alpha      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Mat2a  methionine adenosyltransferase II, alpha      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in proliferating liver 727376
gene_expression expression is decreased 1.4 fold in SHR compared with WKY rats 1357414
gene_process important for liver cell proliferation 727376