![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Rpn1 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Rpn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of RPN1 mRNA | CTD | PMID:36331819 | Rpn1 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Rpn1 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of RPN1 mRNA | CTD | PMID:22206623 | Rpn1 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Rpn1 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of RPN1 mRNA | CTD | PMID:17555576 | Rpn1 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Rpn1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPN1 mRNA | CTD | PMID:17942748 | Rpn1 | Rat | 17beta-estradiol | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of RPN1 mRNA | CTD | PMID:19167446 | Rpn1 | Rat | 17beta-estradiol | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of RPN1 mRNA | CTD | PMID:20823114 | Rpn1 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Rpn1 (Mus musculus) | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether affects the expression of RPN1 mRNA | CTD | PMID:30294300 | Rpn1 | Rat | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | 2,3',4,4',5-pentachlorobiphenyl results in increased expression of RPN1 mRNA | CTD | PMID:31388691 | Rpn1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Rpn1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPN1 mRNA | CTD | PMID:17942748 | Rpn1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RPN1 mRNA | CTD | PMID:34747641 | Rpn1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Rpn1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RPN1 mRNA | CTD | PMID:21570461 | Rpn1 | Rat | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of RPN1 mRNA | CTD | PMID:21346803 | Rpn1 | Rat | 2,6-dimethoxyphenol | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [pyrogallol 1,3-dimethyl ether co-treated with Furaldehyde] results in increased expression of and affects the localization more ... | CTD | PMID:38598786 | Rpn1 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of RPN1 mRNA | CTD | PMID:21346803 | Rpn1 | Rat | 2-bromohexadecanoic acid | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | 2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ... | CTD | PMID:38195004 | Rpn1 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Rpn1 | Rat | 3H-1,2-dithiole-3-thione | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | 1,2-dithiol-3-thione results in increased expression of RPN1 mRNA | CTD | PMID:22959925 | Rpn1 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of RPN1 protein | CTD | PMID:34186270 | Rpn1 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... | CTD | PMID:36041667 | Rpn1 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of RPN1 mRNA | CTD | PMID:28973697 | Rpn1 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of RPN1 mRNA | CTD | PMID:30047161 | Rpn1 | Rat | acetylsalicylic acid | decreases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Aspirin results in decreased expression of RPN1 mRNA | CTD | PMID:15928584 | Rpn1 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of RPN1 mRNA | CTD | PMID:28959563 | Rpn1 | Rat | actinomycin D | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of RPN1 protein | CTD | PMID:38460933 | Rpn1 | Rat | Aflatoxin B2 alpha | decreases methylation | ISO | RPN1 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of RPN1 exon | CTD | PMID:30157460 | Rpn1 | Rat | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of RPN1 mRNA | CTD | PMID:30047161 | Rpn1 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of RPN1 mRNA | CTD | PMID:16483693 | Rpn1 | Rat | benzo[a]pyrene | increases methylation | ISO | RPN1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of RPN1 3' UTR | CTD | PMID:27901495 | Rpn1 | Rat | beta-lapachone | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of RPN1 mRNA | CTD | PMID:38218311 | Rpn1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RPN1 mRNA | CTD | PMID:25181051 | Rpn1 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... | CTD | PMID:36041667 | Rpn1 | Rat | bisphenol A | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of RPN1 protein | CTD | PMID:34186270 | Rpn1 | Rat | bisphenol A | affects expression | ISO | RPN1 (Homo sapiens) | 6480464 | bisphenol A affects the expression of RPN1 mRNA | CTD | PMID:30903817 | Rpn1 | Rat | bisphenol AF | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | bisphenol AF results in increased expression of RPN1 protein | CTD | PMID:34186270 | Rpn1 | Rat | Bisphenol B | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of RPN1 protein | CTD | PMID:34186270 | Rpn1 | Rat | bisphenol F | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Rpn1 | Rat | bisphenol F | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of RPN1 protein | CTD | PMID:34186270 | Rpn1 | Rat | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... | CTD | PMID:36041667 | Rpn1 | Rat | bucladesine | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of RPN1 mRNA | CTD | PMID:20823114 | Rpn1 | Rat | buspirone | decreases expression | EXP | | 6480464 | Buspirone results in decreased expression of RPN1 mRNA | CTD | PMID:24136188 | Rpn1 | Rat | cadmium atom | increases oxidation | ISO | Rpn1 (Mus musculus) | 6480464 | Cadmium results in increased oxidation of RPN1 protein | CTD | PMID:24077948 | Rpn1 | Rat | cadmium atom | multiple interactions | ISO | Rpn1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RPN1 more ... | CTD | PMID:37325564 | Rpn1 | Rat | cadmium atom | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | 2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ... | CTD | PMID:38195004 | Rpn1 | Rat | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of RPN1 mRNA | CTD | PMID:33453195 | Rpn1 | Rat | cadmium dichloride | multiple interactions | ISO | Rpn1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RPN1 more ... | CTD | PMID:37325564 | Rpn1 | Rat | cadmium dichloride | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | 2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ... | CTD | PMID:38195004 | Rpn1 | Rat | caffeine | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Caffeine results in increased expression of RPN1 protein | CTD | PMID:31195006 | Rpn1 | Rat | caffeine | decreases phosphorylation | ISO | RPN1 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of RPN1 protein | CTD | PMID:35688186 | Rpn1 | Rat | carbon nanotube | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of RPN1 mRNA; Nanotubes, Carbon results in increased more ... | CTD | PMID:25554681|PMID:25620056 | Rpn1 | Rat | carbon nanotube | affects expression | ISO | Rpn1 (Mus musculus) | 6480464 | Nanotubes, Carbon affects the expression of RPN1 protein | CTD | PMID:21135415 | Rpn1 | Rat | chromium(6+) | affects expression | ISO | Rpn1 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of RPN1 mRNA | CTD | PMID:28472532 | Rpn1 | Rat | clofibrate | decreases expression | ISO | Rpn1 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of RPN1 mRNA | CTD | PMID:17585979 | Rpn1 | Rat | coumestrol | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of RPN1 mRNA | CTD | PMID:19167446 | Rpn1 | Rat | cyclosporin A | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | Cyclosporine results in increased expression of RPN1 mRNA | CTD | PMID:25270620 | Rpn1 | Rat | cyclosporin A | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of RPN1 mRNA | CTD | PMID:20106945|PMID:25562108 | Rpn1 | Rat | dexamethasone | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Rpn1 | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of RPN1 mRNA | CTD | PMID:17379624|PMID:21266533 | Rpn1 | Rat | doxorubicin | decreases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of RPN1 mRNA | CTD | PMID:29803840 | Rpn1 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of RPN1 mRNA | CTD | PMID:29391264 | Rpn1 | Rat | folic acid | decreases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of RPN1 mRNA | CTD | PMID:21867686 | Rpn1 | Rat | folpet | decreases expression | ISO | Rpn1 (Mus musculus) | 6480464 | folpet results in decreased expression of RPN1 mRNA | CTD | PMID:31558096 | Rpn1 | Rat | FR900359 | increases phosphorylation | ISO | RPN1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of RPN1 protein | CTD | PMID:37730182 | Rpn1 | Rat | furfural | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [pyrogallol 1,3-dimethyl ether co-treated with Furaldehyde] results in increased expression of and affects the localization more ... | CTD | PMID:38598786 | Rpn1 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of RPN1 mRNA | CTD | PMID:22061828 | Rpn1 | Rat | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of RPN1 mRNA | CTD | PMID:24136188 | Rpn1 | Rat | indometacin | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Rpn1 | Rat | isoniazide | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Isoniazid results in increased expression of RPN1 protein | CTD | PMID:40015660 | Rpn1 | Rat | isoprenaline | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | Isoproterenol results in increased expression of RPN1 mRNA | CTD | PMID:21823215 | Rpn1 | Rat | ivermectin | decreases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of RPN1 protein | CTD | PMID:32959892 | Rpn1 | Rat | lead diacetate | decreases expression | ISO | Rpn1 (Mus musculus) | 6480464 | lead acetate results in decreased expression of RPN1 mRNA | CTD | PMID:21829687 | Rpn1 | Rat | medroxyprogesterone acetate | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of RPN1 mRNA | CTD | PMID:20823114 | Rpn1 | Rat | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of RPN1 mRNA | CTD | PMID:30467583 | Rpn1 | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of RPN1 mRNA | CTD | PMID:30047161 | Rpn1 | Rat | miconazole | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | Miconazole results in increased expression of RPN1 mRNA | CTD | PMID:27462272 | Rpn1 | Rat | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of RPN1 mRNA | CTD | PMID:24136188 | Rpn1 | Rat | nitrates | multiple interactions | ISO | Rpn1 (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of RPN1 more ... | CTD | PMID:35964746 | Rpn1 | Rat | Nutlin-3 | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of RPN1 protein | CTD | PMID:38460933 | Rpn1 | Rat | ozone | decreases expression | EXP | | 6480464 | Ozone results in decreased expression of RPN1 protein | CTD | PMID:33146391 | Rpn1 | Rat | ozone | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of RPN1 mRNA | CTD | PMID:35430440 | Rpn1 | Rat | paracetamol | affects expression | ISO | Rpn1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of RPN1 mRNA | CTD | PMID:17562736 | Rpn1 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of RPN1 mRNA | CTD | PMID:33387578 | Rpn1 | Rat | paracetamol | multiple interactions | ISO | Rpn1 (Mus musculus) | 6480464 | PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of RPN1 mRNA] | CTD | PMID:29246445 | Rpn1 | Rat | paracetamol | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | Acetaminophen results in increased expression of RPN1 mRNA | CTD | PMID:29246445 | Rpn1 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Rpn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of RPN1 mRNA; [perfluorooctane sulfonic more ... | CTD | PMID:36331819 | Rpn1 | Rat | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of RPN1 mRNA | CTD | PMID:30047161 | Rpn1 | Rat | pirinixic acid | decreases expression | ISO | Rpn1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of RPN1 mRNA | CTD | PMID:23811191 | Rpn1 | Rat | resveratrol | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of RPN1 mRNA | CTD | PMID:23557933 | Rpn1 | Rat | sodium chloride | multiple interactions | ISO | RPN1 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of more ... | CTD | PMID:38598786 | Rpn1 | Rat | sodium dichromate | decreases expression | ISO | Rpn1 (Mus musculus) | 6480464 | sodium bichromate results in decreased expression of RPN1 mRNA | CTD | PMID:31558096 | Rpn1 | Rat | sodium fluoride | decreases expression | ISO | Rpn1 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of RPN1 protein | CTD | PMID:27548804|PMID:28918527 | Rpn1 | Rat | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of RPN1 mRNA | CTD | PMID:30047161 | Rpn1 | Rat | tacrolimus hydrate | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | Tacrolimus results in increased expression of RPN1 mRNA | CTD | PMID:25270620 | Rpn1 | Rat | tetrachloromethane | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of RPN1 mRNA | CTD | PMID:27339419|PMID:31919559 | Rpn1 | Rat | thapsigargin | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Thapsigargin results in increased expression of RPN1 mRNA | CTD | PMID:22378314 | Rpn1 | Rat | thapsigargin | increases expression | EXP | | 6480464 | Thapsigargin results in increased expression of RPN1 protein | CTD | PMID:35544339 | Rpn1 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of RPN1 mRNA | CTD | PMID:34492290 | Rpn1 | Rat | titanium dioxide | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of RPN1 mRNA | CTD | PMID:23557971 | Rpn1 | Rat | titanium dioxide | increases methylation | ISO | Rpn1 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of RPN1 gene | CTD | PMID:35295148 | Rpn1 | Rat | titanium dioxide | decreases expression | ISO | RPN1 (Homo sapiens) | 6480464 | titanium dioxide results in decreased expression of RPN1 protein | CTD | PMID:30910687 | Rpn1 | Rat | triphenyl phosphate | affects expression | ISO | RPN1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of RPN1 mRNA | CTD | PMID:37042841 | Rpn1 | Rat | triptonide | increases expression | ISO | Rpn1 (Mus musculus) | 6480464 | triptonide results in increased expression of RPN1 mRNA | CTD | PMID:33045310 | Rpn1 | Rat | tunicamycin | increases expression | ISO | RPN1 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of RPN1 mRNA | CTD | PMID:22378314|PMID:29453283 | |