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Gene: Htra2 (HtrA serine peptidase 2) Rattus norvegicus
Symbol: Htra2
Name: HtrA serine peptidase 2
RGD ID: 1308906
Description: Exhibits serine-type peptidase activity. Involved in several processes, including ceramide metabolic process; pentacyclic triterpenoid metabolic process; and response to herbicide. Localizes to cytosol and mitochondrion. Used to study transient cerebral ischemia. Biomarker of asphyxia neonatorum; cryptorchidism; middle cerebral artery infarction; and status epilepticus. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2); PARTICIPATES IN intrinsic apoptotic pathway; Parkinson's disease pathway; INTERACTS WITH bisphenol A; clofibric acid; cobalt dichloride.
Type: protein-coding
Also known as: high temperature requirement protein A2; LOC297376; protease, serine, 25; Prss25; serine protease HTRA2, mitochondrial
Homo sapiens (human) : HTRA2 (HtrA serine peptidase 2)  HGNC  Alliance
Mus musculus (house mouse) : Htra2 (HtrA serine peptidase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htra2 (HtrA serine peptidase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HTRA2 (HtrA serine peptidase 2)
Canis lupus familiaris (dog) : HTRA2 (HtrA serine peptidase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htra2 (HtrA serine peptidase 2)
Sus scrofa (pig) : HTRA2 (HtrA serine peptidase 2)
Chlorocebus sabaeus (African green monkey) : HTRA2 (HtrA serine peptidase 2)
Heterocephalus glaber (naked mole-rat) : Htra2 (HtrA serine peptidase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04113,883,671 - 113,886,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,883,670 - 113,886,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,568,771 - 178,571,933 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,262,206 - 117,265,368 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14117,506,685 - 117,509,829 (-)NCBI
Celera4104,551,592 - 104,554,754 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Htra2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308906
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.