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Gene: Aplf (aprataxin and PNKP like factor) Rattus norvegicus
Symbol: Aplf
Name: aprataxin and PNKP like factor
RGD ID: 1565557
Description: Predicted to have DNA-(apurinic or apyrimidinic site) endonuclease activity; nuclease activity; and nucleotide binding activity. Predicted to be involved in DNA repair and regulation of DNA metabolic process. Predicted to localize to nucleoplasm and site of double-strand break. Orthologous to human APLF (aprataxin and PNKP like factor); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; histone modification pathway; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aprataxin and PNK-like factor; LOC500247; RGD1565557; similar to RIKEN cDNA 2010301N04
Homo sapiens (human) : APLF (aprataxin and PNKP like factor)  HGNC  Alliance
Mus musculus (house mouse) : Aplf (aprataxin and PNKP like factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aplf (aprataxin and PNKP like factor)
Pan paniscus (bonobo/pygmy chimpanzee) : APLF (aprataxin and PNKP like factor)
Canis lupus familiaris (dog) : APLF (aprataxin and PNKP like factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aplf (aprataxin and PNKP like factor)
Sus scrofa (pig) : APLF (aprataxin and PNKP like factor)
Chlorocebus sabaeus (African green monkey) : APLF (aprataxin and PNKP like factor)
Heterocephalus glaber (naked mole-rat) : Aplf (aprataxin and PNKP like factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04119,514,822 - 119,568,764 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4119,514,840 - 119,568,736 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04184,816,979 - 184,819,739 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04184,767,521 - 184,809,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,796,926 - 121,849,410 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4109,037,717 - 109,083,976 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Aplf
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1565557
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.