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Gene: Aplf (aprataxin and PNKP like factor) Rattus norvegicus
Symbol: Aplf
Name: aprataxin and PNKP like factor
Description: Predicted to have DNA-(apurinic or apyrimidinic site) endonuclease activity; nuclease activity; and nucleotide binding activity. Predicted to be involved in DNA metabolic process and regulation of DNA metabolic process. Predicted to localize to the nucleoplasm and site of double-strand break. Orthologous to human APLF (aprataxin and PNKP like factor); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; histone modification pathway; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aprataxin and PNK-like factor; LOC500247; RGD1565557; similar to RIKEN cDNA 2010301N04
Homo sapiens (human) : APLF (aprataxin and PNKP like factor)  HGNC  Alliance
Mus musculus (house mouse) : Aplf (aprataxin and PNKP like factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aplf (aprataxin and PNKP like factor)
Pan paniscus (bonobo/pygmy chimpanzee) : APLF (aprataxin and PNKP like factor)
Canis lupus familiaris (dog) : APLF (aprataxin and PNKP like factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aplf (aprataxin and PNKP like factor)
Sus scrofa (pig) : APLF (aprataxin and PNKP like factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04119,514,822 - 119,568,764 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04184,767,521 - 184,809,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04184,816,979 - 184,819,739 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,796,926 - 121,849,410 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4109,037,717 - 109,083,976 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Aplf
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1565557
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.