Thnsl2 (threonine synthase-like 2) - Rat Genome Database

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Gene: Thnsl2 (threonine synthase-like 2) Rattus norvegicus
Analyze
Symbol: Thnsl2
Name: threonine synthase-like 2
RGD ID: 1309144
Description: Predicted to enable pyridoxal phosphate binding activity and serine binding activity. Predicted to be involved in 2-oxobutyrate biosynthetic process; dephosphorylation; and serine family amino acid catabolic process. Orthologous to human THNSL2 (threonine synthase like 2); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC297332; MGC95104; RGD1309144; similar to Hypothetical protein MGC59076; threonine synthase-like 2 (bacterial); threonine synthase-like 2 (S. cerevisiae); Tsh2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84104,671,305 - 104,691,084 (-)NCBIGRCr8
mRatBN7.24103,112,974 - 103,132,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4103,112,963 - 103,132,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,503,548 - 108,522,443 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04104,278,636 - 104,297,531 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04102,882,869 - 102,901,912 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0498,976,559 - 98,997,187 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,976,550 - 98,995,590 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,753,102 - 163,773,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,329,517 - 104,348,465 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14104,573,999 - 104,592,946 (-)NCBI
Celera492,288,587 - 92,307,161 (-)NCBICelera
Cytogenetic Map4q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
glafenine  (EXP)
inulin  (ISO)
ketamine  (EXP)
L-ethionine  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
omeprazole  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:17034760  


Genomics

Comparative Map Data
Thnsl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84104,671,305 - 104,691,084 (-)NCBIGRCr8
mRatBN7.24103,112,974 - 103,132,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4103,112,963 - 103,132,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,503,548 - 108,522,443 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04104,278,636 - 104,297,531 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04102,882,869 - 102,901,912 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0498,976,559 - 98,997,187 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,976,550 - 98,995,590 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,753,102 - 163,773,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,329,517 - 104,348,465 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14104,573,999 - 104,592,946 (-)NCBI
Celera492,288,587 - 92,307,161 (-)NCBICelera
Cytogenetic Map4q32NCBI
THNSL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38288,170,346 - 88,186,627 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl288,170,295 - 88,186,636 (+)EnsemblGRCh38hg38GRCh38
GRCh37288,469,865 - 88,486,146 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36288,250,950 - 88,267,261 (+)NCBINCBI36Build 36hg18NCBI36
Celera288,299,987 - 88,316,198 (-)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef287,392,048 - 87,408,933 (+)NCBIHuRef
CHM1_1288,399,093 - 88,415,447 (+)NCBICHM1_1
T2T-CHM13v2.0288,181,454 - 88,198,653 (+)NCBIT2T-CHM13v2.0
Thnsl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39671,105,150 - 71,121,364 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl671,105,150 - 71,121,423 (-)EnsemblGRCm39 Ensembl
GRCm38671,128,166 - 71,144,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl671,128,166 - 71,144,439 (-)EnsemblGRCm38mm10GRCm38
MGSCv37671,078,392 - 71,094,370 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36671,057,977 - 71,073,955 (-)NCBIMGSCv36mm8
Celera673,207,460 - 73,223,442 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.14NCBI
Thnsl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955424526,602 - 543,603 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955424526,967 - 543,603 (-)NCBIChiLan1.0ChiLan1.0
THNSL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21239,116,409 - 39,132,720 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A39,119,175 - 39,135,471 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A87,303,022 - 87,319,494 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A89,212,380 - 89,228,452 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A89,212,442 - 89,228,446 (+)Ensemblpanpan1.1panPan2
THNSL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11738,196,605 - 38,212,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1738,191,494 - 38,212,809 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,881,890 - 37,898,136 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01738,929,611 - 38,945,863 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1738,929,613 - 38,945,961 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11738,095,938 - 38,111,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01738,132,346 - 38,148,608 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01738,480,076 - 38,496,366 (-)NCBIUU_Cfam_GSD_1.0
Thnsl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629280,158,694 - 80,173,737 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936712681,133 - 699,792 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936712684,711 - 699,714 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THNSL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl357,799,026 - 57,823,440 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1357,800,976 - 57,821,296 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2360,654,264 - 60,669,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
THNSL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11418,603,376 - 18,619,711 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1418,600,437 - 18,619,762 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660801,156,644 - 1,172,977 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thnsl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474916,213,785 - 16,226,700 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474916,198,423 - 16,229,952 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thnsl2
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000008698
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)488656681103194984Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
8662350Eae35Experimental allergic encephalomyelitis QTL 356.2blood tumor necrosis factor amount (VT:0008552)inflammatory exudate tumor necrosis factor level (CMO:0001435)4100834579103761084Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat

Markers in Region
RH130845  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24103,113,095 - 103,113,300 (+)MAPPERmRatBN7.2
Rnor_6.0498,976,681 - 98,976,885NCBIRnor6.0
Rnor_5.04163,753,224 - 163,753,428UniSTSRnor5.0
RGSC_v3.44104,329,639 - 104,329,843UniSTSRGSC3.4
Celera492,288,709 - 92,288,913UniSTS
RH 3.4 Map4646.2UniSTS
Cytogenetic Map4q32UniSTS
RH144071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24103,131,482 - 103,131,622 (+)MAPPERmRatBN7.2
Rnor_6.0498,995,008 - 98,995,147NCBIRnor6.0
Rnor_5.04163,771,149 - 163,771,288UniSTSRnor5.0
RGSC_v3.44104,347,929 - 104,348,068UniSTSRGSC3.4
Celera492,306,627 - 92,306,766UniSTS
RH 3.4 Map4645.9UniSTS
Cytogenetic Map4q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 9 30 22 22 1 29 32 8
Low 2 34 27 19 19 19 8 10 74 6 9 3 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000008698   ⟹   ENSRNOP00000008698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4103,112,963 - 103,132,017 (-)Ensembl
Rnor_6.0 Ensembl498,976,550 - 98,995,590 (-)Ensembl
RefSeq Acc Id: NM_001009658   ⟹   NP_001009658
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,671,305 - 104,690,346 (-)NCBI
mRatBN7.24103,112,974 - 103,132,017 (-)NCBI
Rnor_6.0498,976,559 - 98,995,543 (-)NCBI
Rnor_5.04163,753,102 - 163,773,190 (-)NCBI
RGSC_v3.44104,329,517 - 104,348,465 (-)RGD
Celera492,288,587 - 92,307,161 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107309   ⟹   XP_038963237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,671,305 - 104,691,084 (-)NCBI
mRatBN7.24103,112,974 - 103,132,122 (-)NCBI
RefSeq Acc Id: XM_039107312   ⟹   XP_038963240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,671,305 - 104,691,084 (-)NCBI
mRatBN7.24103,112,974 - 103,132,122 (-)NCBI
RefSeq Acc Id: XM_063285774   ⟹   XP_063141844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,671,305 - 104,691,084 (-)NCBI
RefSeq Acc Id: NP_001009658   ⟸   NM_001009658
- UniProtKB: Q5M7T9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008698   ⟸   ENSRNOT00000008698
RefSeq Acc Id: XP_038963240   ⟸   XM_039107312
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038963237   ⟸   XM_039107309
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q4L2 (UniProtKB/TrEMBL),   A6IA65 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141844   ⟸   XM_063285774
- Peptide Label: isoform X3
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7T9-F1-model_v2 AlphaFold Q5M7T9 1-485 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693108
Promoter ID:EPDNEW_R3633
Type:single initiation site
Name:Thnsl2_1
Description:threonine synthase-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0498,995,555 - 98,995,615EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309144 AgrOrtholog
BioCyc Gene G2FUF-44193 BioCyc
Ensembl Genes ENSRNOG00000006508 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008698.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1380.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127050 IMAGE-MGC_LOAD
InterPro PLP-dep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thr_synth_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thr_synth_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thr_synthase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypto_synt_PLP_dependent UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:297332 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95104 IMAGE-MGC_LOAD
NCBI Gene 297332 ENTREZGENE
PANTHER THREONINE SYNTHASE FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THREONINE SYNTHASE-LIKE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PALP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thr_synth_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Thnsl2 PhenoGen
RatGTEx ENSRNOG00000006508 RatGTEx
Superfamily-SCOP SSF53686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q4L2 ENTREZGENE, UniProtKB/TrEMBL
  A6IA65 ENTREZGENE, UniProtKB/TrEMBL
  Q5M7T9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-01 Thnsl2  threonine synthase-like 2  Thnsl2  threonine synthase-like 2 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Thnsl2  threonine synthase-like 2 (S. cerevisiae)  Thnsl2  threonine synthase-like 2 (bacterial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Thnsl2  threonine synthase-like 2 (bacterial)  RGD1309144  similar to Hypothetical protein MGC59076  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1309144  similar to Hypothetical protein MGC59076  RGD1309144_predicted  similar to Hypothetical protein MGC59076 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309144_predicted  similar to Hypothetical protein MGC59076 (predicted)  LOC297332_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC297332_predicted  similar to Hypothetical protein MGC59076 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL