Grm7 (glutamate metabotropic receptor 7) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Grm7 (glutamate metabotropic receptor 7) Rattus norvegicus
Analyze
Symbol: Grm7
Name: glutamate metabotropic receptor 7
RGD ID: 619857
Description: Enables several functions, including PDZ domain binding activity; calmodulin binding activity; and glutamate binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; negative regulation of glutamate secretion; and negative regulation of neuron apoptotic process. Located in several cellular components, including dendritic shaft; postsynaptic membrane; and rough endoplasmic reticulum. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone membrane. Orthologous to human GRM7 (glutamate metabotropic receptor 7); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutamate receptor, metabotropic 7; metabotropic glutamate receptor 7; metabotropic glutamate receptor mGluR7; metabotropic glutamate receptor subtype 7b; mGluR7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Grm7em2Mcwi  
Genetic Models: SS-Grm7em2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24143,730,862 - 144,613,230 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4143,731,259 - 144,612,344 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4149,120,940 - 150,010,094 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04144,901,718 - 145,790,918 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04143,529,922 - 144,417,702 (+)NCBIRnor_WKY
Rnor_6.04142,452,616 - 143,368,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4142,780,987 - 143,367,578 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04205,768,625 - 206,090,308 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04206,230,927 - 206,680,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44146,952,340 - 147,270,225 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14146,889,004 - 147,035,543 (-)NCBI
Celera4132,321,261 - 133,197,545 (+)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies. Bradley SR, etal., J Neurosci. 1996 Mar 15;16(6):2044-56.
2. Compartmental localization of a metabotropic glutamate receptor (mGluR7): two different active sites at a retinal synapse. Brandstatter JH, etal., J Neurosci. 1996 Aug 1;16(15):4749-56.
3. Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. Croci C, etal., J Biol Chem. 2003 Dec 12;278(50):50682-90. Epub 2003 Sep 30.
4. Enrichment of mGluR7a in the presynaptic active zones of GABAergic and non-GABAergic terminals on interneurons in the rat somatosensory cortex. Dalezios Y, etal., Cereb Cortex 2002 Sep;12(9):961-74.
5. PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. Dev KK, etal., J Neurosci. 2000 Oct 1;20(19):7252-7.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus. Gillard SE, etal., J Comp Neurol 2003 Jun 30;461(3):317-32.
8. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. Hirbec H, etal., J Biol Chem. 2002 May 3;277(18):15221-4. Epub 2002 Mar 12.
9. Immunolocalization of metabotropic glutamate receptor 7 in the rat olfactory bulb. Kinzie JM, etal., J Comp Neurol. 1997 Sep 1;385(3):372-84.
10. Constitutive endocytosis of the metabotropic glutamate receptor mGluR7 is clathrin-independent. Lavezzari G and Roche KW, Neuropharmacology. 2007 Jan;52(1):100-7. Epub 2006 Aug 7.
11. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference to the presence in glutamatergic ganglion neurons. Li JL, etal., Neurosci Lett. 1996 Feb 2;204(1-2):9-12.
12. The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals. Millan C, etal., J Biol Chem 2002 Apr 19;277(16):14092-101.
13. Co-expression of metabotropic glutamate receptor 7 and N-type Ca(2+) channels in single cerebrocortical nerve terminals of adult rats. Millan C, etal., J Biol Chem. 2003 Jun 27;278(26):23955-62. Epub 2003 Apr 11.
14. Expression, purification, crystallization and preliminary X-ray analysis of the ligand-binding domain of metabotropic glutamate receptor 7. Muto T, etal., Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jul 1;63(Pt 7):627-30. Epub 2007 Jun 29.
15. Ca2+-dependent binding of calcium-binding protein 1 to presynaptic group III metabotropic glutamate receptors and blockage by phosphorylation of the receptors. Nakajima Y Biochem Biophys Res Commun. 2011 Sep 9;412(4):602-5. doi: 10.1016/j.bbrc.2011.08.006. Epub 2011 Aug 10.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. Okamoto N, etal., J Biol Chem 1994 Jan 14;269(2):1231-6.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors. Saugstad JA, etal., Mol Pharmacol 1994 Mar;45(3):367-72.
23. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. Shigemoto R, etal., J Neurosci. 1997 Oct 1;17(19):7503-22.
24. High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus. Somogyi P, etal., Eur J Neurosci. 2003 Jun;17(12):2503-20.
25. Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Sorensen SD, etal., Mol Pharmacol. 2002 Jun;61(6):1303-12.
26. Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis. Wang WY, etal., Neuroscience. 2016 Jan 28;313:199-212. doi: 10.1016/j.neuroscience.2015.11.038. Epub 2015 Nov 24.
Additional References at PubMed
PMID:9144652   PMID:9473604   PMID:9630572   PMID:9875342   PMID:9920659   PMID:10488094   PMID:11122333   PMID:11584003   PMID:11698585   PMID:11943148   PMID:11953448   PMID:12065412  
PMID:12814372   PMID:14622100   PMID:15313036   PMID:15494036   PMID:16204199   PMID:16775145   PMID:16987251   PMID:17167337   PMID:18599484   PMID:19047183   PMID:19154087   PMID:19374778  
PMID:20375012   PMID:21288202   PMID:22287544   PMID:22479593   PMID:22617702   PMID:22781839   PMID:23085525   PMID:23382219   PMID:23612982   PMID:24399715   PMID:25881041   PMID:27296637  
PMID:27488423   PMID:29505788   PMID:31627896   PMID:33500274  


Genomics

Comparative Map Data
Grm7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24143,730,862 - 144,613,230 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4143,731,259 - 144,612,344 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4149,120,940 - 150,010,094 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04144,901,718 - 145,790,918 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04143,529,922 - 144,417,702 (+)NCBIRnor_WKY
Rnor_6.04142,452,616 - 143,368,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4142,780,987 - 143,367,578 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04205,768,625 - 206,090,308 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04206,230,927 - 206,680,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44146,952,340 - 147,270,225 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14146,889,004 - 147,035,543 (-)NCBI
Celera4132,321,261 - 133,197,545 (+)NCBICelera
Cytogenetic Map4q41NCBI
GRM7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3836,861,115 - 7,741,533 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl36,770,001 - 7,741,533 (+)EnsemblGRCh38hg38GRCh38
GRCh3736,902,802 - 7,783,220 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3636,877,927 - 7,758,217 (+)NCBINCBI36Build 36hg18NCBI36
Celera36,840,354 - 7,720,749 (+)NCBICelera
Cytogenetic Map3p26.1NCBI
HuRef36,836,943 - 7,718,334 (+)NCBIHuRef
CHM1_136,853,465 - 7,733,719 (+)NCBICHM1_1
T2T-CHM13v2.036,851,699 - 7,732,437 (+)NCBIT2T-CHM13v2.0
Grm7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396110,622,304 - 111,544,191 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6110,622,542 - 111,544,191 (+)EnsemblGRCm39 Ensembl
GRCm386110,645,349 - 111,567,230 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6110,645,581 - 111,567,230 (+)EnsemblGRCm38mm10GRCm38
MGSCv376110,595,592 - 111,517,224 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366110,611,375 - 111,533,007 (+)NCBIMGSCv36mm8
Celera6112,489,164 - 113,410,129 (+)NCBICelera
Cytogenetic Map6E3NCBI
Grm7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554215,724,797 - 6,542,475 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554215,723,662 - 6,542,557 (-)NCBIChiLan1.0ChiLan1.0
GRM7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.136,907,165 - 7,934,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl36,907,180 - 7,933,536 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v036,811,005 - 7,691,344 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GRM7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12010,230,568 - 11,058,693 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2010,230,557 - 11,058,703 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2010,264,476 - 11,098,444 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02010,260,908 - 11,089,193 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2010,261,498 - 11,089,124 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1209,981,742 - 10,808,873 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02010,328,873 - 11,156,987 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02010,300,259 - 11,134,699 (-)NCBIUU_Cfam_GSD_1.0
Grm7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494212,994,552 - 13,751,982 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366025,110,995 - 5,488,555 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366025,111,406 - 5,488,506 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1363,318,171 - 64,203,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11363,318,002 - 64,203,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21370,580,925 - 71,026,770 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRM7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12242,901,451 - 43,779,815 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041122,794,490 - 123,682,715 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grm7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477318,089,300 - 19,109,716 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477318,088,942 - 19,110,838 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grm7
5436 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir34arno-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18704095

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:111
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000056570
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat

Markers in Region
D4Got234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24144,208,084 - 144,208,275 (+)MAPPERmRatBN7.2
Rnor_6.04142,957,340 - 142,957,530NCBIRnor6.0
Rnor_5.04206,270,616 - 206,270,806UniSTSRnor5.0
RGSC_v3.44146,613,244 - 146,613,434UniSTSRGSC3.4
Celera4132,792,861 - 132,793,051UniSTS
Cytogenetic Map4q42UniSTS
RH144597  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24144,525,486 - 144,525,662 (+)MAPPERmRatBN7.2
Rnor_6.04143,281,069 - 143,281,244NCBIRnor6.0
Rnor_5.04206,593,740 - 206,593,915UniSTSRnor5.0
RGSC_v3.44147,181,968 - 147,182,143UniSTSRGSC3.4
Celera4133,112,650 - 133,112,825UniSTS
RH 3.4 Map4950.8UniSTS
Cytogenetic Map4q42UniSTS


Genetic Models
This gene Grm7 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 42
Low 10 2 2 22 14 17
Below cutoff 2 11 10 8 2 8 5 5 2 9 16 6 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056570   ⟹   ENSRNOP00000053411
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4143,731,259 - 144,612,344 (+)Ensembl
Rnor_6.0 Ensembl4142,780,987 - 143,367,578 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000056996   ⟹   ENSRNOP00000053829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4143,731,259 - 144,551,904 (+)Ensembl
RefSeq Acc Id: NM_031040   ⟹   NP_112302
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24143,730,862 - 144,612,344 (+)NCBI
Rnor_6.04142,452,616 - 143,367,578 (+)NCBI
Rnor_5.04205,768,625 - 206,090,308 (+)NCBI
Rnor_5.04206,230,927 - 206,680,107 (+)NCBI
RGSC_v3.44146,952,340 - 147,270,225 (+)RGD
Celera4132,321,261 - 133,197,545 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108422   ⟹   XP_038964350
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24143,730,899 - 144,612,326 (+)NCBI
RefSeq Acc Id: XM_039108423   ⟹   XP_038964351
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24143,730,899 - 144,551,956 (+)NCBI
RefSeq Acc Id: XM_039108424   ⟹   XP_038964352
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24143,730,898 - 144,613,230 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_112302   ⟸   NM_031040
- Peptide Label: precursor
- UniProtKB: P35400 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000053411   ⟸   ENSRNOT00000056570
RefSeq Acc Id: XP_038964352   ⟸   XM_039108424
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038964350   ⟸   XM_039108422
- Peptide Label: isoform X1
- UniProtKB: F1LWV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964351   ⟸   XM_039108423
- Peptide Label: isoform X1
- UniProtKB: F1LWV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000053829   ⟸   ENSRNOT00000056996
Protein Domains
G_PROTEIN_RECEP_F3_4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35400-F1-model_v2 AlphaFold P35400 1-915 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619857 AgrOrtholog
BioCyc Gene G2FUF-43431 BioCyc
Ensembl Genes ENSRNOG00000005662 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000053411 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000053829 ENTREZGENE
  ENSRNOP00000053829.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056570 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000056996 ENTREZGENE
  ENSRNOT00000056996.5 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81672 UniProtKB/Swiss-Prot
NCBI Gene 81672 ENTREZGENE
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCD3G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grm7 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPC7R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LWV8 ENTREZGENE, UniProtKB/TrEMBL
  F1LZS5_RAT UniProtKB/TrEMBL
  GRM7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Grm7  glutamate receptor, metabotropic 7    metabotropic glutamate receptor mGluR7  Name updated 1299863 APPROVED
2002-08-07 Grm7  metabotropic glutamate receptor mGluR7      Symbol and Name status set to provisional 70820 PROVISIONAL