Abcg2 (ATP binding cassette subfamily G member 2) - Rat Genome Database

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Gene: Abcg2 (ATP binding cassette subfamily G member 2) Rattus norvegicus
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Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
RGD ID: 631345
Description: Exhibits several functions, including cytoskeletal protein binding activity; efflux transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cellular response to lipid; embryonic process involved in female pregnancy; and urate salt excretion. Localizes to external side of apical plasma membrane and nucleus. Biomarker of diabetes mellitus; secondary hyperparathyroidism; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; erlotinib pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP binding cassette subfamily G member 2 (Junior blood group); ATP-binding cassette protein G2; ATP-binding cassette sub-family G member 2; ATP-binding cassette, sub-family G (WHITE), member 2; ATP-binding cassette, subfamily G (WHITE), member 2; Bcrp; BCRP1; breast cancer resistance protein 1 homolog; broad substrate specificity ATP-binding cassette transporter ABCG2; urate exporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Abcg2em1Sage  
Genetic Models: SD-Abcb1aem1Sage Abcg2em1Sage SD-Abcg2em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2487,676,241 - 87,802,757 (+)NCBI
Rnor_6.0 Ensembl488,832,178 - 88,890,621 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0488,765,441 - 88,890,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04153,587,206 - 153,712,481 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4487,502,584 - 87,560,017 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1487,747,008 - 87,804,442 (+)NCBI
Celera482,507,731 - 82,564,802 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-Hydroxypyrene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2',5'-Dihydroxychalcone  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-methylcholanthrene  (ISO)
4'-epidoxorubicin  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylumbelliferone  (ISO)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxypsoralen  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6alpha-methylprednisolone  (ISO)
7-Hydroxymethotrexate  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
abacavir  (ISO)
actinomycin D  (ISO)
acyclovir  (ISO)
aflatoxin B1  (EXP,ISO)
albendazole S-oxide  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
anandamide  (ISO)
androst-4-ene-3,17-dione  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
Azaspiracid  (ISO)
azathioprine  (EXP)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoylhypaconine  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bis-4-nitrophenyl phosphate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carboplatin  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP,ISO)
cimetidine  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
corticosterone  (ISO)
crizotinib  (ISO)
curcumin  (ISO)
cyazofamid  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
dantrolene  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
depsipeptide  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (ISO)
diethyl phthalate  (EXP)
digoxin  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
E3040  (ISO)
endosulfan  (EXP,ISO)
erlotinib hydrochloride  (ISO)
estriol  (ISO)
estrone  (ISO)
estrone 3-sulfate  (ISO)
ethanol  (ISO)
etoposide  (ISO)
everolimus  (ISO)
flavone  (ISO)
flavones  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
glutathione  (ISO)
glyburide  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
haloperidol  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
Hypaconitine  (ISO)
indole-3-methanol  (ISO)
indoxyl sulfate  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
ketoconazole  (EXP)
kynurenic acid  (ISO)
L-methionine  (EXP,ISO)
lapatinib  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lucifer yellow dye  (ISO)
lupeol  (ISO)
luteolin  (ISO)
LY294002  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
Mesaconitine  (ISO)
methamphetamine  (EXP)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylmercury chloride  (EXP,ISO)
mifepristone  (ISO)
milbemycin  (ISO)
mitoxantrone  (ISO)
Mitragynine  (ISO)
MK 571  (ISO)
mometasone furoate  (ISO)
morphine  (EXP)
N-benzoylglycine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (EXP)
naproxen  (ISO)
nelfinavir  (ISO)
nicotine  (ISO)
nilotinib  (ISO)
nimesulide  (ISO)
nitrofurantoin  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
novobiocin  (EXP,ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oltipraz  (ISO)
omeprazole  (ISO)
oroxylin A  (ISO)
oxaliplatin  (EXP)
oxfendazole  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paliperidone palmitate  (ISO)
panobinostat  (ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pheophorbide a  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prazosin  (ISO)
probenecid  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
pterostilbene  (ISO)
quercetin  (EXP,ISO)
quetiapine fumarate  (ISO)
reserpine  (ISO)
resmethrin  (ISO)
resveratrol  (ISO)
rhodamine 123  (ISO)
rifampicin  (ISO)
risperidone  (ISO)
rosuvastatin calcium  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium hydrogencarbonate  (EXP)
Soman  (EXP)
stilben-4-ol  (ISO)
streptozocin  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
sulpiride  (ISO)
sunitinib  (EXP,ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
taxane  (ISO)
tectochrysin  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP,ISO)
trans-piceid  (ISO)
triamcinolone  (ISO)
triamterene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
warfarin  (ISO)
WIN 55212-2  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. null
2. Adachi Y, etal., Mol Pharmacol. 2005 Mar;67(3):923-8. Epub 2004 Dec 14.
3. Ahmad Najar R, etal., Mol Nutr Food Res. 2016 Jun;60(6):1501-13. doi: 10.1002/mnfr.201500991. Epub 2016 Apr 21.
4. Au A, etal., Biomed Pharmacother. 2014 Apr;68(3):343-9. doi: 10.1016/j.biopha.2014.01.009. Epub 2014 Feb 7.
5. Bartholomae S, etal., Pediatr Blood Cancer. 2016 Feb;63(2):242-7. doi: 10.1002/pbc.25785. Epub 2015 Oct 29.
6. Campa D, etal., Int J Cancer. 2012 Aug 15;131(4):803-12. doi: 10.1002/ijc.26436. Epub 2011 Nov 28.
7. Campbell PK, etal., Leuk Res. 2011 Oct;35(10):1321-9. doi: 10.1016/j.leukres.2011.05.004.
8. Campos CR, etal., J Cereb Blood Flow Metab. 2012 Aug;32(8):1559-66. doi: 10.1038/jcbfm.2012.47. Epub 2012 Apr 4.
9. Collins JF, etal., Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G964-71. Epub 2005 Jan 6.
10. Cygalova L, etal., Toxicol Lett. 2008 May 30;178(3):176-80. Epub 2008 Mar 21.
11. Delord M, etal., Oncotarget. 2013 Oct;4(10):1582-91.
12. Erdilyi DJ, etal., Pharmacogenomics J. 2008 Oct;8(5):321-7.
13. Faneyte IF, etal., Clin Cancer Res. 2002 Apr;8(4):1068-74.
14. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Halwachs S, etal., Mol Pharmacol. 2011 Oct;80(4):621-9. doi: 10.1124/mol.111.072421. Epub 2011 Jul 7.
16. Hori S, etal., J Neurochem 2004 Aug;90(3):526-36.
17. Hori S, etal., J Neurochem. 2005 Apr;93(1):63-71. doi: 10.1111/j.1471-4159.2004.02994.x.
18. Hosomi A, etal., PLoS One. 2012;7(2):e30456. doi: 10.1371/journal.pone.0030456. Epub 2012 Feb 10.
19. Jin QR, etal., Xenobiotica. 2009 Oct;39(10):711-21.
20. Korenaga Y, etal., Int J Cancer. 2005 Nov 10;117(3):431-4.
21. Liu YC, etal., Biochem Pharmacol. 2007 Dec 15;74(12):1766-72. Epub 2007 Aug 21.
22. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
23. MGD data from the GO Consortium
24. Narang VS, etal., Am J Physiol Cell Physiol. 2008 Aug;295(2):C440-50. Epub 2008 Jun 4.
25. Oda K, etal., J Pharm Sci. 2013 Sep;102(9):3364-72. doi: 10.1002/jps.23549. Epub 2013 Apr 16.
26. Ogura J, etal., Biol Pharm Bull. 2008 May;31(5):1032-5.
27. OMIM Disease Annotation Pipeline
28. Petrovic V, etal., Drug Metab Dispos. 2008 Sep;36(9):1944-50. Epub 2008 May 27.
29. Pipeline to import KEGG annotations from KEGG into RGD
30. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. Pipeline to import SMPDB annotations from SMPDB into RGD
32. Qian X, etal., Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E757-69. doi: 10.1152/ajpendo.00645.2012. Epub 2013 Feb 12.
33. RGD automated data pipeline
34. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. RGD automated import pipeline for gene-chemical interactions
36. Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
37. Rong Z, etal., Life Sci. 2013 Feb 27;92(3):245-51. doi: 10.1016/j.lfs.2012.12.010. Epub 2013 Jan 16.
38. Salimizand H, etal., Tumour Biol. 2016 Jan;37(1):791-8. doi: 10.1007/s13277-015-3874-4. Epub 2015 Aug 7.
39. Sauerbrey A, etal., Br J Haematol. 2002 Jul;118(1):147-50.
40. Shimano K, etal., Am J Pathol 2003 Jul;163(1):3-9.
41. Staud F, etal., J Pharmacol Exp Ther. 2006 Oct;319(1):53-62. Epub 2006 Jun 29.
42. Steinbach D, etal., Leukemia. 2002 Aug;16(8):1443-7.
43. Sugimoto R, etal., Kidney Int. 2017 Mar;91(3):658-670. doi: 10.1016/j.kint.2016.09.041. Epub 2016 Dec 15.
44. Suvannasankha A, etal., Br J Haematol. 2004 Nov;127(4):392-8.
45. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
46. Turner JG, etal., Blood. 2006 Dec 1;108(12):3881-9. Epub 2006 Aug 17.
47. Uno S, etal., Biopharm Drug Dispos. 2009 Jan;30(1):49-54.
48. van Vliet EA, etal., Epilepsia. 2005 Oct;46(10):1569-80.
49. Woodward OM, etal., Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10338-42. doi: 10.1073/pnas.0901249106. Epub 2009 Jun 8.
50. Xu D, etal., Acta Pharmacol Sin. 2014 Sep;35(9):1215-25. doi: 10.1038/aps.2014.39. Epub 2014 Aug 25.
51. Yang C, etal., Oncotarget. 2015 Sep 29;6(29):27714-24. doi: 10.18632/oncotarget.4663.
52. Yousif S, etal., J Neurochem. 2012 Nov;123(4):491-503. doi: 10.1111/j.1471-4159.2012.07890.x. Epub 2012 Sep 3.
53. Yue W, etal., Mol Pharm. 2009 Jan-Feb;6(1):134-43.
Additional References at PubMed
PMID:9861027   PMID:12429862   PMID:12477932   PMID:12958161   PMID:16244436   PMID:16870176   PMID:17098188   PMID:17145775   PMID:17380269   PMID:17437964   PMID:17635990   PMID:17669244  
PMID:18378562   PMID:18834626   PMID:18841445   PMID:19503597   PMID:19541926   PMID:20053405   PMID:20216549   PMID:20399185   PMID:20460386   PMID:21075088   PMID:21106720   PMID:21775706  
PMID:21803024   PMID:22393122   PMID:22711747   PMID:22869929   PMID:22998451   PMID:23306951   PMID:23584883   PMID:24342797   PMID:25539457   PMID:25868844   PMID:26119820   PMID:26252052  
PMID:26364927   PMID:26467765   PMID:26727197   PMID:27180978   PMID:27616577   PMID:28554189   PMID:28577929   PMID:28623970   PMID:29610494   PMID:30405239   PMID:31983315  


Genomics

Comparative Map Data
Abcg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2487,676,241 - 87,802,757 (+)NCBI
Rnor_6.0 Ensembl488,832,178 - 88,890,621 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0488,765,441 - 88,890,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04153,587,206 - 153,712,481 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4487,502,584 - 87,560,017 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1487,747,008 - 87,804,442 (+)NCBI
Celera482,507,731 - 82,564,802 (+)NCBICelera
Cytogenetic Map4q24NCBI
ABCG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl488,090,150 - 88,231,628 (-)EnsemblGRCh38hg38GRCh38
GRCh38488,090,264 - 88,231,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37489,011,416 - 89,152,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,230,440 - 89,299,035 (-)NCBINCBI36hg18NCBI36
Build 34489,370,018 - 89,436,901NCBI
Celera486,303,350 - 86,371,627 (-)NCBI
Cytogenetic Map4q22.1NCBI
HuRef484,757,887 - 84,903,974 (-)NCBIHuRef
CHM1_1488,988,243 - 89,128,985 (-)NCBICHM1_1
Abcg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39658,561,476 - 58,669,436 (+)NCBIGRCm39mm39
GRCm39 Ensembl658,561,508 - 58,672,661 (+)Ensembl
GRCm38658,584,491 - 58,692,451 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl658,584,523 - 58,695,676 (+)EnsemblGRCm38mm10GRCm38
MGSCv37658,546,666 - 58,642,445 (+)NCBIGRCm37mm9NCBIm37
MGSCv36658,526,250 - 58,622,029 (+)NCBImm8
Celera660,752,972 - 60,848,739 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.82NCBI
Abcg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495547412,365,903 - 12,408,715 (+)NCBIChiLan1.0ChiLan1.0
ABCG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1491,101,321 - 91,170,418 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl491,101,321 - 91,170,157 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0480,379,108 - 80,446,641 (-)NCBIMhudiblu_PPA_v0panPan3
ABCG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,443,778 - 11,517,674 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,443,780 - 11,517,674 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3230,372,283 - 30,510,869 (+)NCBI
ROS_Cfam_1.03211,496,580 - 11,635,323 (-)NCBI
UMICH_Zoey_3.13211,580,165 - 11,719,079 (-)NCBI
UNSW_CanFamBas_1.03211,406,011 - 11,544,317 (-)NCBI
UU_Cfam_GSD_1.03228,373,259 - 28,501,671 (+)NCBI
UU_Cfam_GSD_1.03228,508,945 - 28,549,001 (+)NCBI
ABCG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8130,775,472 - 130,998,660 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18130,853,414 - 130,945,388 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,193,291 - 140,228,765 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCG2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,458,110 - 36,599,753 (-)NCBI
Vero_WHO_p1.0NW_02366603715,206,025 - 15,348,744 (-)NCBI

Position Markers
AI428558  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,802,161 - 87,802,259 (+)MAPPER
Rnor_6.0488,890,021 - 88,890,118NCBIRnor6.0
Rnor_5.04153,711,881 - 153,711,978UniSTSRnor5.0
RGSC_v3.4487,559,770 - 87,559,867UniSTSRGSC3.4
Celera482,564,555 - 82,564,652UniSTS
Cytogenetic Map4q24UniSTS
RH130231  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,802,540 - 87,802,720 (+)MAPPER
Rnor_6.0488,890,400 - 88,890,579NCBIRnor6.0
Rnor_5.04153,712,260 - 153,712,439UniSTSRnor5.0
RGSC_v3.4487,560,149 - 87,560,328UniSTSRGSC3.4
Celera482,564,934 - 82,565,113UniSTS
RH 3.4 Map4541.5UniSTS
Cytogenetic Map4q24UniSTS
RH143656  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,795,997 - 87,796,107 (+)MAPPER
Rnor_6.0488,883,857 - 88,883,966NCBIRnor6.0
Rnor_5.04153,705,717 - 153,705,826UniSTSRnor5.0
RGSC_v3.4487,553,606 - 87,553,715UniSTSRGSC3.4
Celera482,558,391 - 82,558,500UniSTS
RH 3.4 Map4541.5UniSTS
Cytogenetic Map4q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)4734240492484039Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)429549895112807890Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43427793299067150Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)436615599145611886Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)437703272115372927Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)443414605155469929Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)443414792146942075Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)443414792146942075Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)446898276145611886Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)449906054145611886Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)455324953148360954Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)455375865125671711Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45579156492484312Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)456092756101092756Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)456092756101092756Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45710107792990863Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458166424103166424Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)458640017154427984Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)46043912799066957Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)460439127113416139Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)461038901127777403Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)461708341113100992Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)461975371106975371Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)462947687125671711Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)463537179157286626Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)463938412108938412Rat
2312569Pur19Proteinuria QTL 193.40.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46598924397759057Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470773471132455556Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)471476518116476518Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)471476518116476518Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473786419132455556Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)475258970120258970Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)475258970120258970Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)476567036121567036Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)477307388116916073Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)477307388116916073Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)479555067124555067Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)479557856116916073Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47956245198542106Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481874073119546974Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)481959983152055009Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48447525797479149Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)484475257178931073Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)485794049129615056Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486312589146942261Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486312589147702403Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486438317168047091Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486532519131532519Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487136446132136446Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487136446132136446Rat


Genetic Models
This gene Abcg2 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:64
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000009546
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 33 33 2 33 14 29 10
Low 36 24 8 17 8 6 6 60 6 31 11 6
Below cutoff 3 2 5 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_181381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB094089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB105817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY089996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY089997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY089998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY274118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009546   ⟹   ENSRNOP00000009546
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl488,834,066 - 88,890,268 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088983   ⟹   ENSRNOP00000075138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl488,832,178 - 88,890,621 (+)Ensembl
RefSeq Acc Id: NM_181381   ⟹   NP_852046
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2487,745,319 - 87,802,409 (+)NCBI
Rnor_6.0488,834,066 - 88,890,268 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
RGSC_v3.4487,502,584 - 87,560,017 (+)RGD
Celera482,507,731 - 82,564,802 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236572   ⟹   XP_006236634
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0488,832,296 - 88,890,209 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236573   ⟹   XP_006236635
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2487,748,089 - 87,802,757 (+)NCBI
Rnor_6.0488,837,278 - 88,890,209 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236574   ⟹   XP_006236636
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0488,833,236 - 88,890,209 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236576   ⟹   XP_006236638
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2487,676,241 - 87,802,757 (+)NCBI
Rnor_6.0488,765,441 - 88,890,209 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762961   ⟹   XP_008761183
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0488,839,917 - 88,890,209 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592620   ⟹   XP_017448109
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2487,755,294 - 87,802,757 (+)NCBI
Rnor_6.0488,843,594 - 88,890,209 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107562   ⟹   XP_038963490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2487,688,949 - 87,802,757 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_852046   ⟸   NM_181381
- UniProtKB: Q80W57 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236638   ⟸   XM_006236576
- Peptide Label: isoform X1
- UniProtKB: Q80W57 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236634   ⟸   XM_006236572
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006236636   ⟸   XM_006236574
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006236635   ⟸   XM_006236573
- Peptide Label: isoform X1
- UniProtKB: Q80W57 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008761183   ⟸   XM_008762961
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448109   ⟸   XM_017592620
- Peptide Label: isoform X1
- UniProtKB: Q80W57 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009546   ⟸   ENSRNOT00000009546
RefSeq Acc Id: ENSRNOP00000075138   ⟸   ENSRNOT00000088983
RefSeq Acc Id: XP_038963490   ⟸   XM_039107562
- Peptide Label: isoform X1
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693086
Promoter ID:EPDNEW_R3611
Type:multiple initiation site
Name:Abcg2_1
Description:ATP binding cassette subfamily G member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0488,834,048 - 88,834,108EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631345 AgrOrtholog
Ensembl Genes ENSRNOG00000007041 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000009546 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000075138 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009546 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000088983 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC_2_trans UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABCG2 UniProtKB/Swiss-Prot
  ABCG_dom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:312382 UniProtKB/Swiss-Prot
NCBI Gene 312382 ENTREZGENE
PANTHER PTHR48041:SF92 UniProtKB/Swiss-Prot
Pfam ABC2_membrane UniProtKB/Swiss-Prot
  ABC2_membrane_7 UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PharmGKB ABCG2 RGD
PhenoGen Abcg2 PhenoGen
PROSITE ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt ABCG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q80ST1 UniProtKB/Swiss-Prot
  Q80UR3 UniProtKB/Swiss-Prot
  Q80XF3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-16 Abcg2  ATP-binding cassette, subfamily G (WHITE), member 2  Abcg2  ATP-binding cassette, sub-family G (WHITE), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Slc1a7  ATP-binding cassette, sub-family G (WHITE), member 2  Abcg2  ATP-binding cassette protein G2  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED