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Gene: Abcg2 (ATP binding cassette subfamily G member 2) Rattus norvegicus
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Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Description: Exhibits amide transmembrane transporter activity; cytoskeletal protein binding activity; and protein dimerization activity. Involved in several processes, including aging; cellular response to lipid; and embryonic process involved in female pregnancy. Localizes to the apical plasma membrane and nucleus. Biomarker of diabetes mellitus; secondary hyperparathyroidism; and status epilepticus. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; erlotinib pharmacodynamics pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP binding cassette subfamily G member 2 (Junior blood group); ATP-binding cassette protein G2; ATP-binding cassette sub-family G member 2; ATP-binding cassette, sub-family G (WHITE), member 2; ATP-binding cassette, subfamily G (WHITE), member 2; Bcrp; BCRP1; breast cancer resistance protein 1 homolog; urate exporter
Orthologs:
Allele / Splice: Abcg2em1Sage  
Genetic Models: SD-Abcb1aem1Sage Abcg2em1Sage SD-Abcg2em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0488,765,441 - 88,890,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04153,587,206 - 153,712,481 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4487,502,584 - 87,560,017 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1487,747,008 - 87,804,442 (+)NCBI
Celera482,507,731 - 82,564,802 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Abcg2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631345
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2019-05-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.