Abcg2 (ATP binding cassette subfamily G member 2) - Rat Genome Database

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Gene: Abcg2 (ATP binding cassette subfamily G member 2) Rattus norvegicus
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Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
RGD ID: 631345
Description: Enables several functions, including cytoskeletal protein binding activity; efflux transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cellular response to lipid; embryonic process involved in female pregnancy; and renal urate salt excretion. Located in external side of apical plasma membrane and nucleus. Biomarker of diabetes mellitus; secondary hyperparathyroidism; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; erlotinib pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP binding cassette subfamily G member 2 (Junior blood group); ATP-binding cassette protein G2; ATP-binding cassette sub-family G member 2; ATP-binding cassette, sub-family G (WHITE), member 2; ATP-binding cassette, subfamily G (WHITE), member 2; Bcrp; BCRP1; breast cancer resistance protein 1 homolog; broad substrate specificity ATP-binding cassette transporter ABCG2; urate exporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Abcg2em1Sage  
Genetic Models: SD-Abcb1aem1Sage Abcg2em1Sage SD-Abcg2em1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2487,676,241 - 87,802,757 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl487,745,319 - 87,802,409 (+)Ensembl
Rnor_6.0488,765,441 - 88,890,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl488,832,178 - 88,890,621 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04153,587,206 - 153,712,481 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4487,502,584 - 87,560,017 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1487,747,008 - 87,804,442 (+)NCBI
Celera482,507,731 - 82,564,802 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-Hydroxypyrene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2',5'-Dihydroxychalcone  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-methylcholanthrene  (ISO)
4'-epidoxorubicin  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylumbelliferone  (ISO)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azaorotic acid  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxypsoralen  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6alpha-methylprednisolone  (ISO)
7-Hydroxymethotrexate  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
abacavir  (ISO)
actinomycin D  (ISO)
acyclovir  (ISO)
aflatoxin B1  (EXP,ISO)
albendazole S-oxide  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
anandamide  (ISO)
androst-4-ene-3,17-dione  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
Azaspiracid  (ISO)
azathioprine  (EXP)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoylhypaconine  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bis-4-nitrophenyl phosphate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carboplatin  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP,ISO)
cimetidine  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
corticosterone  (ISO)
crizotinib  (ISO)
curcumin  (ISO)
cyazofamid  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dabrafenib  (ISO)
daidzein  (ISO)
Danofloxacin  (ISO)
dantrolene  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
depsipeptide  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (ISO)
diethyl phthalate  (EXP)
Diferuloylputrescine  (EXP)
digoxin  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
E3040  (ISO)
endosulfan  (EXP,ISO)
erlotinib hydrochloride  (ISO)
estriol  (ISO)
estrone  (ISO)
estrone 3-sulfate  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
everolimus  (ISO)
flavone  (ISO)
flavones  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
glutathione  (ISO)
glyburide  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
haloperidol  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
Hypaconitine  (ISO)
hypoxanthine  (ISO)
indole-3-methanol  (ISO)
indoxyl sulfate  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
ketoconazole  (EXP)
kynurenic acid  (ISO)
L-methionine  (EXP,ISO)
lapatinib  (ISO)
lead diacetate  (EXP)
ledipasvir  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lucifer yellow dye  (ISO)
lupeol  (ISO)
luteolin  (ISO)
LY294002  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
Mesaconitine  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylmercury chloride  (EXP,ISO)
metiram  (ISO)
mifepristone  (ISO)
milbemycin  (ISO)
mitoxantrone  (ISO)
Mitragynine  (ISO)
MK 571  (ISO)
mometasone furoate  (ISO)
morphine  (EXP)
N-benzoylglycine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (EXP)
naproxen  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
nicotine  (ISO)
nilotinib  (ISO)
nimesulide  (ISO)
nitrofen  (EXP)
nitrofurantoin  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
novobiocin  (EXP,ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oltipraz  (ISO)
omeprazole  (ISO)
oroxylin A  (ISO)
oxaliplatin  (EXP)
oxfendazole  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paliperidone palmitate  (ISO)
panobinostat  (ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pheophorbide a  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
porphyrins  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prazosin  (ISO)
probenecid  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
pterostilbene  (ISO)
quercetin  (EXP,ISO)
quetiapine fumarate  (ISO)
reserpine  (ISO)
resmethrin  (ISO)
resveratrol  (ISO)
rhodamine 123  (ISO)
rifampicin  (ISO)
risperidone  (ISO)
rosuvastatin calcium  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium hydrogencarbonate  (EXP)
Soman  (EXP)
stilben-4-ol  (ISO)
streptozocin  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
sulpiride  (ISO)
sunitinib  (EXP,ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
taurocholic acid  (ISO)
taxane  (ISO)
tectochrysin  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
toluene  (EXP)
topotecan  (EXP,ISO)
trans-piceid  (ISO)
triamcinolone  (ISO)
triamterene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venetoclax  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
warfarin  (ISO)
WIN 55212-2  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2. null
2. Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen. Adachi Y, etal., Mol Pharmacol. 2005 Mar;67(3):923-8. Epub 2004 Dec 14.
3. Gene specific epigenetic regulation of hepatic folate transport system is responsible for perturbed cellular folate status during aging and exogenous modulation. Ahmad Najar R, etal., Mol Nutr Food Res. 2016 Jun;60(6):1501-13. doi: 10.1002/mnfr.201500991. Epub 2016 Apr 21.
4. Association of genotypes and haplotypes of multi-drug transporter genes ABCB1 and ABCG2 with clinical response to imatinib mesylate in chronic myeloid leukemia patients. Au A, etal., Biomed Pharmacother. 2014 Apr;68(3):343-9. doi: 10.1016/j.biopha.2014.01.009. Epub 2014 Feb 7.
5. Coexpression of Multiple ABC-Transporters is Strongly Associated with Treatment Response in Childhood Acute Myeloid Leukemia. Bartholomae S, etal., Pediatr Blood Cancer. 2016 Feb;63(2):242-7. doi: 10.1002/pbc.25785. Epub 2015 Oct 29.
6. A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk. Campa D, etal., Int J Cancer. 2012 Aug 15;131(4):803-12. doi: 10.1002/ijc.26436. Epub 2011 Nov 28.
7. Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia. Campbell PK, etal., Leuk Res. 2011 Oct;35(10):1321-9. doi: 10.1016/j.leukres.2011.05.004.
8. ABC transporter function and regulation at the blood-spinal cord barrier. Campos CR, etal., J Cereb Blood Flow Metab. 2012 Aug;32(8):1559-66. doi: 10.1038/jcbfm.2012.47. Epub 2012 Apr 4.
9. Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum. Collins JF, etal., Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G964-71. Epub 2005 Jan 6.
10. Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat. Cygalova L, etal., Toxicol Lett. 2008 May 30;178(3):176-80. Epub 2008 Mar 21.
11. High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients. Delord M, etal., Oncotarget. 2013 Oct;4(10):1582-91.
12. Synergistic interaction of ABCB1 and ABCG2 polymorphisms predicts the prevalence of toxic encephalopathy during anticancer chemotherapy. Erdilyi DJ, etal., Pharmacogenomics J. 2008 Oct;8(5):321-7.
13. Expression of the breast cancer resistance protein in breast cancer. Faneyte IF, etal., Clin Cancer Res. 2002 Apr;8(4):1068-74.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier. Halwachs S, etal., Mol Pharmacol. 2011 Oct;80(4):621-9. doi: 10.1124/mol.111.072421. Epub 2011 Jul 7.
16. Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s). Hori S, etal., J Neurochem 2004 Aug;90(3):526-36.
17. Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA. Hori S, etal., J Neurochem. 2005 Apr;93(1):63-71. doi: 10.1111/j.1471-4159.2004.02994.x.
18. Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. Hosomi A, etal., PLoS One. 2012;7(2):e30456. doi: 10.1371/journal.pone.0030456. Epub 2012 Feb 10.
19. Decreased urinary secretion of belotecan in folic acid-induced acute renal failure rats due to down-regulation of Oat1 and Bcrp. Jin QR, etal., Xenobiotica. 2009 Oct;39(10):711-21.
20. Association of the BCRP C421A polymorphism with nonpapillary renal cell carcinoma. Korenaga Y, etal., Int J Cancer. 2005 Nov 10;117(3):431-4.
21. Impaired expression and function of breast cancer resistance protein (Bcrp) in brain cortex of streptozocin-induced diabetic rats. Liu YC, etal., Biochem Pharmacol. 2007 Dec 15;74(12):1766-72. Epub 2007 Aug 21.
22. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Narang VS, etal., Am J Physiol Cell Physiol. 2008 Aug;295(2):C440-50. Epub 2008 Jun 4.
25. Estrogen receptor alpha induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells. Oda K, etal., J Pharm Sci. 2013 Sep;102(9):3364-72. doi: 10.1002/jps.23549. Epub 2013 Apr 16.
26. Post-transcriptional regulation of breast cancer resistance protein after intestinal ischemia-reperfusion. Ogura J, etal., Biol Pharm Bull. 2008 May;31(5):1032-5.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Effect of endotoxin on the expression of placental drug transporters and glyburide disposition in pregnant rats. Petrovic V, etal., Drug Metab Dispos. 2008 Sep;36(9):1944-50. Epub 2008 May 27.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis. Qian X, etal., Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E757-69. doi: 10.1152/ajpendo.00645.2012. Epub 2013 Feb 12.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
37. Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability. Rong Z, etal., Life Sci. 2013 Feb 27;92(3):245-51. doi: 10.1016/j.lfs.2012.12.010. Epub 2013 Jan 16.
38. Concurrent effects of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp genetic polymorphisms with risk of cancer, clinical output, and response to treatment with imatinib mesylate in patients with chronic myeloid leukemia. Salimizand H, etal., Tumour Biol. 2016 Jan;37(1):791-8. doi: 10.1007/s13277-015-3874-4. Epub 2015 Aug 7.
39. Expression of the BCRP gene (ABCG2/MXR/ABCP) in childhood acute lymphoblastic leukaemia. Sauerbrey A, etal., Br J Haematol. 2002 Jul;118(1):147-50.
40. Hepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1. Shimano K, etal., Am J Pathol 2003 Jul;163(1):3-9.
41. Expression and transport activity of breast cancer resistance protein (Bcrp/Abcg2) in dually perfused rat placenta and HRP-1 cell line. Staud F, etal., J Pharmacol Exp Ther. 2006 Oct;319(1):53-62. Epub 2006 Jun 29.
42. BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. Steinbach D, etal., Leukemia. 2002 Aug;16(8):1443-7.
43. Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism. Sugimoto R, etal., Kidney Int. 2017 Mar;91(3):658-670. doi: 10.1016/j.kint.2016.09.041. Epub 2016 Dec 15.
44. Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: frequent expression and possible correlation with shorter disease-free survival. Suvannasankha A, etal., Br J Haematol. 2004 Nov;127(4):392-8.
45. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
46. ABCG2 expression, function, and promoter methylation in human multiple myeloma. Turner JG, etal., Blood. 2006 Dec 1;108(12):3881-9. Epub 2006 Aug 17.
47. Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat. Uno S, etal., Biopharm Drug Dispos. 2009 Jan;30(1):49-54.
48. Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats. van Vliet EA, etal., Epilepsia. 2005 Oct;46(10):1569-80.
49. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Woodward OM, etal., Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10338-42. doi: 10.1073/pnas.0901249106. Epub 2009 Jun 8.
50. Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes. Xu D, etal., Acta Pharmacol Sin. 2014 Sep;35(9):1215-25. doi: 10.1038/aps.2014.39. Epub 2014 Aug 25.
51. Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model. Yang C, etal., Oncotarget. 2015 Sep 29;6(29):27714-24. doi: 10.18632/oncotarget.4663.
52. Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation. Yousif S, etal., J Neurochem. 2012 Nov;123(4):491-503. doi: 10.1111/j.1471-4159.2012.07890.x. Epub 2012 Sep 3.
53. Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion. Yue W, etal., Mol Pharm. 2009 Jan-Feb;6(1):134-43.
54. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. Zamek-Gliszczynski MJ, etal., Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18.
Additional References at PubMed
PMID:9861027   PMID:12429862   PMID:12477932   PMID:12958161   PMID:16244436   PMID:16870176   PMID:17098188   PMID:17145775   PMID:17380269   PMID:17437964   PMID:17635990   PMID:17669244  
PMID:18378562   PMID:18834626   PMID:18841445   PMID:19503597   PMID:19541926   PMID:20053405   PMID:20216549   PMID:20399185   PMID:20460386   PMID:21075088   PMID:21106720   PMID:21775706  
PMID:21803024   PMID:22393122   PMID:22869929   PMID:22998451   PMID:23306951   PMID:23584883   PMID:24342797   PMID:25539457   PMID:25868844   PMID:26119820   PMID:26252052   PMID:26364927  
PMID:26467765   PMID:26727197   PMID:27180978   PMID:27616577   PMID:28554189   PMID:28577929   PMID:28623970   PMID:29610494   PMID:30405239   PMID:31983315   PMID:33558655   PMID:33790363  
PMID:34255797   PMID:35345975  


Genomics

Comparative Map Data
Abcg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2487,676,241 - 87,802,757 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl487,745,319 - 87,802,409 (+)Ensembl
Rnor_6.0488,765,441 - 88,890,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl488,832,178 - 88,890,621 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04153,587,206 - 153,712,481 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4487,502,584 - 87,560,017 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1487,747,008 - 87,804,442 (+)NCBI
Celera482,507,731 - 82,564,802 (+)NCBICelera
Cytogenetic Map4q24NCBI
ABCG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38488,090,264 - 88,231,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl488,090,150 - 88,231,628 (-)EnsemblGRCh38hg38GRCh38
GRCh37489,011,416 - 89,152,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,230,440 - 89,299,035 (-)NCBINCBI36hg18NCBI36
Build 34489,370,018 - 89,436,901NCBI
Celera486,303,350 - 86,371,627 (-)NCBI
Cytogenetic Map4q22.1NCBI
HuRef484,757,887 - 84,903,974 (-)NCBIHuRef
CHM1_1488,988,243 - 89,128,985 (-)NCBICHM1_1
T2T-CHM13v2.0491,416,761 - 91,562,592 (-)NCBI
Abcg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39658,561,476 - 58,669,436 (+)NCBIGRCm39mm39
GRCm39 Ensembl658,561,508 - 58,672,661 (+)Ensembl
GRCm38658,584,491 - 58,692,451 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl658,584,523 - 58,695,676 (+)EnsemblGRCm38mm10GRCm38
MGSCv37658,546,666 - 58,642,445 (+)NCBIGRCm37mm9NCBIm37
MGSCv36658,526,250 - 58,622,029 (+)NCBImm8
Celera660,752,972 - 60,848,739 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.82NCBI
Abcg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495547412,365,903 - 12,408,715 (+)NCBIChiLan1.0ChiLan1.0
ABCG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1491,101,321 - 91,170,418 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl491,101,321 - 91,170,157 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0480,379,108 - 80,446,641 (-)NCBIMhudiblu_PPA_v0panPan3
ABCG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,443,778 - 11,517,674 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,443,780 - 11,517,674 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3230,372,283 - 30,510,869 (+)NCBI
ROS_Cfam_1.03211,496,580 - 11,635,323 (-)NCBI
ROS_Cfam_1.0 Ensembl3211,496,586 - 11,573,345 (-)Ensembl
UMICH_Zoey_3.13211,580,165 - 11,719,079 (-)NCBI
UNSW_CanFamBas_1.03211,406,011 - 11,544,317 (-)NCBI
UU_Cfam_GSD_1.03228,508,945 - 28,549,001 (+)NCBI
UU_Cfam_GSD_1.03228,373,259 - 28,501,671 (+)NCBI
ABCG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8130,889,684 - 130,945,393 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18130,853,414 - 130,945,388 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,193,291 - 140,228,765 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,458,110 - 36,599,753 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603715,206,025 - 15,348,744 (-)NCBIVero_WHO_p1.0

Position Markers
AI428558  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,802,161 - 87,802,259 (+)MAPPERmRatBN7.2
Rnor_6.0488,890,021 - 88,890,118NCBIRnor6.0
Rnor_5.04153,711,881 - 153,711,978UniSTSRnor5.0
RGSC_v3.4487,559,770 - 87,559,867UniSTSRGSC3.4
Celera482,564,555 - 82,564,652UniSTS
Cytogenetic Map4q24UniSTS
RH130231  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,802,540 - 87,802,720 (+)MAPPERmRatBN7.2
Rnor_6.0488,890,400 - 88,890,579NCBIRnor6.0
Rnor_5.04153,712,260 - 153,712,439UniSTSRnor5.0
RGSC_v3.4487,560,149 - 87,560,328UniSTSRGSC3.4
Celera482,564,934 - 82,565,113UniSTS
RH 3.4 Map4541.5UniSTS
Cytogenetic Map4q24UniSTS
RH143656  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,795,997 - 87,796,107 (+)MAPPERmRatBN7.2
Rnor_6.0488,883,857 - 88,883,966NCBIRnor6.0
Rnor_5.04153,705,717 - 153,705,826UniSTSRnor5.0
RGSC_v3.4487,553,606 - 87,553,715UniSTSRGSC3.4
Celera482,558,391 - 82,558,500UniSTS
RH 3.4 Map4541.5UniSTS
Cytogenetic Map4q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)457114432102114432Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478885890102684881Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48342841995853334Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat


Genetic Models
This gene Abcg2 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:64
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000009546
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 33 33 2 33 14 29 10
Low 36 24 8 17 8 6 6 60 6 31 11 6
Below cutoff 3 2 5 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_181381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB094089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB105817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY089996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY089997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY089998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY274118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009546   ⟹   ENSRNOP00000009546
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl487,745,319 - 87,802,409 (+)Ensembl
Rnor_6.0 Ensembl488,834,066 - 88,890,268 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088983   ⟹   ENSRNOP00000075138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl488,832,178 - 88,890,621 (+)Ensembl
RefSeq Acc Id: NM_181381   ⟹   NP_852046
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2487,745,319 - 87,802,409 (+)NCBI
Rnor_6.0488,834,066 - 88,890,268 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
RGSC_v3.4487,502,584 - 87,560,017 (+)RGD
Celera482,507,731 - 82,564,802 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236573   ⟹   XP_006236635
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2487,748,089 - 87,802,757 (+)NCBI
Rnor_6.0488,837,278 - 88,890,209 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236576   ⟹   XP_006236638
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2487,676,241 - 87,802,757 (+)NCBI
Rnor_6.0488,765,441 - 88,890,209 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592620   ⟹   XP_017448109
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2487,755,294 - 87,802,757 (+)NCBI
Rnor_6.0488,843,594 - 88,890,209 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107562   ⟹   XP_038963490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2487,688,949 - 87,802,757 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_852046   ⟸   NM_181381
- UniProtKB: Q80W57 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236638   ⟸   XM_006236576
- Peptide Label: isoform X1
- UniProtKB: Q80W57 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236635   ⟸   XM_006236573
- Peptide Label: isoform X1
- UniProtKB: Q80W57 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448109   ⟸   XM_017592620
- Peptide Label: isoform X1
- UniProtKB: Q80W57 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009546   ⟸   ENSRNOT00000009546
RefSeq Acc Id: ENSRNOP00000075138   ⟸   ENSRNOT00000088983
RefSeq Acc Id: XP_038963490   ⟸   XM_039107562
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80W57-F1-model_v2 AlphaFold Q80W57 1-657 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693086
Promoter ID:EPDNEW_R3611
Type:multiple initiation site
Name:Abcg2_1
Description:ATP binding cassette subfamily G member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0488,834,048 - 88,834,108EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631345 AgrOrtholog
BioCyc Gene G2FUF-44660 BioCyc
Ensembl Genes ENSRNOG00000007041 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000009546 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009546 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC_2_trans UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABCG2 UniProtKB/Swiss-Prot
  ABCG_dom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:312382 UniProtKB/Swiss-Prot
NCBI Gene 312382 ENTREZGENE
PANTHER PTHR48041:SF92 UniProtKB/Swiss-Prot
Pfam ABC2_membrane UniProtKB/Swiss-Prot
  ABC2_membrane_7 UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PharmGKB ABCG2 RGD
PhenoGen Abcg2 PhenoGen
PROSITE ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt ABCG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q80ST1 UniProtKB/Swiss-Prot
  Q80UR3 UniProtKB/Swiss-Prot
  Q80XF3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-16 Abcg2  ATP-binding cassette, subfamily G (WHITE), member 2  Abcg2  ATP-binding cassette, sub-family G (WHITE), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Slc1a7  ATP-binding cassette, sub-family G (WHITE), member 2  Abcg2  ATP-binding cassette protein G2  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED