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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Acc ID: CHEBI:28368
Term: novobiocin
Definition: A coumarin-derived antibiotic obtained from Streptomyces niveus.
Chemical ID: MESH:D009675
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2multiple interactionsEXP 6480464CTD[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium

PMID:19853032
Abcg2decreases activityISORGD:13526156480464CTDNovobiocin results in decreased activity of ABCG2 protein

PMID:32305507
Abcg2multiple interactionsISORGD:13526156480464CTDNovobiocin inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCG2 protein] Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone] Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone] Novobiocin inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow] Novobiocin inhibits the reaction [Methoxsalen results in decreased activity of ABCG2 protein]

PMID:29079042 PMID:32305507
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