RGD Reference Report - Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat.

Authors: Uno, S  Uraki, M  Ito, A  Shinozaki, Y  Yamada, A  Kawase, A  Iwaki, M 
Citation: Uno S, etal., Biopharm Drug Dispos. 2009 Jan;30(1):49-54.
RGD ID: 2315573
Pubmed: PMID:19152228   (View Abstract at PubMed)
DOI: DOI:10.1002/bdd.639   (Journal Full-text)

In this study, a real-time reverse transcription-polymerase chain reaction was used to determine the effects of adjuvant-induced arthritis (AA) on the amounts of mRNA of 12 types of rat ATP-binding cassette (ABC) and solute carrier (SLC) transporters in the liver and small intestine, 7 (D7) and 21 days (D21) after the injection of adjuvant. There were no significant differences in mRNA levels of ABC and SLC transporters between the livers of AA and control rats on D7, except in the case of Mdr1a. However, levels of Mdr1a, Mrp2 and Oatp SLC transporters were significantly lower in AA than in the control livers on D21. In contrast, the mRNA levels of several ABC and SLC transporters, especially Mrp2, Bcrp, LAT2 and Oatp1a5, were significantly lower in the small intestines of AA rats compared with the controls on D7, though there were no significant differences by D21. The time-dependent alterations in mRNA levels of the pregnane X receptor, but not the constitutive androstane receptor, in the liver and intestine were similar to the changes in mRNA levels of most transporters examined. The present study showed that AA was associated with reduced mRNA expression of several ABC and SLC transporters in the liver and small intestine, but that the time courses of the effects of AA on mRNA expression differed between the liver and small intestine. These results raise the possibility of a functional change of the transporters of liver and intestine in AA rats.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ABCB1HumanExperimental Arthritis  ISOAbcb1a (Rattus norvegicus)mRNA:altered expression:liverRGD 
ABCG2HumanExperimental Arthritis  ISOAbcg2 (Rattus norvegicus)mRNA:decreased expression:small intestineRGD 
Abcb1aRatExperimental Arthritis  IEP mRNA:altered expression:liverRGD 
Abcb1aMouseExperimental Arthritis  ISOAbcb1a (Rattus norvegicus)mRNA:altered expression:liverRGD 
Abcg2RatExperimental Arthritis  IEP mRNA:decreased expression:small intestineRGD 
Abcg2MouseExperimental Arthritis  ISOAbcg2 (Rattus norvegicus)mRNA:decreased expression:small intestineRGD 

Objects Annotated

Genes (Rattus norvegicus)
Abcb1a  (ATP binding cassette subfamily B member 1A)
Abcg2  (ATP binding cassette subfamily G member 2)

Genes (Mus musculus)
Abcb1a  (ATP-binding cassette, sub-family B member 1A)
Abcg2  (ATP binding cassette subfamily G member 2 (Junior blood group))

Genes (Homo sapiens)
ABCB1  (ATP binding cassette subfamily B member 1)
ABCG2  (ATP binding cassette subfamily G member 2 (JR blood group))


Additional Information