ABCB1 (ATP binding cassette subfamily B member 1) - Rat Genome Database

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Gene: ABCB1 (ATP binding cassette subfamily B member 1) Homo sapiens
Symbol: ABCB1
Name: ATP binding cassette subfamily B member 1
RGD ID: 730823
Description: Exhibits several functions, including ATP binding activity; ATPase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; lipid translocation; and regulation of anion transport. Localizes to apical plasma membrane; cell surface; and nucleoplasm. Implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Biomarker of several diseases, including familial temporal lobe epilepsy 3; human immunodeficiency virus infectious disease; kidney cancer (multiple); nasal type extranodal NK/T-cell lymphoma; and ovarian cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC20; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, subfamily B, member 1; ATP-dependent translocase ABCB1; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; MGC163296; multidrug resistance protein 1; P glycoprotein; p-170; P-glycoprotein 1; P-GP; PGY1; phospholipid transporter ABCB1
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl787,503,017 - 87,713,323 (-)EnsemblGRCh38hg38GRCh38
GRCh38787,503,017 - 87,713,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37787,132,333 - 87,342,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,970,884 - 87,180,500 (-)NCBINCBI36hg18NCBI36
Build 34786,777,598 - 86,987,215NCBI
Celera781,837,832 - 82,047,176 (-)NCBI
Cytogenetic Map7q21.12NCBI
HuRef781,744,182 - 81,952,578 (-)NCBIHuRef
CHM1_1787,063,281 - 87,272,756 (-)NCBICHM1_1
CRA_TCAGchr7v2786,464,691 - 86,673,953 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (IAGP)
acute lymphoblastic leukemia  (EXP,IAGP)
adrenocortical carcinoma  (EXP)
allergic rhinitis  (IAGP)
Alzheimer's disease  (ISO)
Anthracycline-induced Cardiotoxicity  (IAGP)
asthma  (IEP)
Behcet's disease  (IAGP)
Breast Neoplasms  (EXP,IAGP)
cannabis abuse  (EXP)
carcinoma  (EXP)
cardiomyopathy  (ISO)
Chemical and Drug Induced Liver Injury  (EXP,IAGP,ISO)
Chronic Hepatitis C  (IAGP)
chronic myeloid leukemia  (IAGP)
colorectal adenocarcinoma  (IAGP)
Colorectal Neoplasms  (EXP)
congenital heart disease  (EXP)
Critical Illness  (IAGP)
Crohn's disease  (IAGP)
Cronkhite-Canada syndrome  (ISO)
cryoglobulinemia  (IAGP)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (EXP)
disease of cellular proliferation  (EXP)
disease of mental health  (EXP)
Disease Progression  (EXP)
Drug-induced Neutropenia  (IAGP)
Drug-Related Side Effects and Adverse Reactions  (EXP,ISO)
encephalitis  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Eosinophilia  (IEP)
epilepsy  (EXP,IAGP,ISO)
Escherichia Coli Infections  (EXP)
Esophageal Neoplasms  (EXP)
Experimental Arthritis  (EXP,ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP,ISO)
familial hyperlipidemia  (IAGP,ISO)
familial Mediterranean fever  (IAGP)
familial temporal lobe epilepsy 3  (IAGP,IEP)
Fetal Growth Retardation  (ISO)
Genetic Predisposition to Disease  (EXP)
Genetic Translocation  (EXP)
Germ Cell and Embryonal Neoplasms  (IEP)
head and neck squamous cell carcinoma  (EXP)
heart disease  (ISO)
Helicobacter Infections  (IAGP)
Hematologic Neoplasms  (EXP)
hepatocellular carcinoma  (EXP,IAGP,ISO)
hereditary breast ovarian cancer syndrome  (IAGP)
human immunodeficiency virus infectious disease  (IAGP,IEP,ISO)
Inflammation  (ISO)
inflammatory bowel disease 13  (IAGP)
invasive ductal carcinoma  (IDA)
kidney disease  (ISO)
Kidney Neoplasms  (EXP)
Latent Tuberculosis  (HEP)
lung non-small cell carcinoma  (EXP,IAGP)
malaria  (IAGP,IDA)
Mammary Neoplasms, Experimental  (ISO)
Nasal Polyps  (IEP)
nasal type extranodal NK/T-cell lymphoma  (IEP)
Nausea  (EXP)
Neoplasm Metastasis  (EXP)
nephroblastoma  (IEP)
nervous system disease  (EXP)
neuroblastoma  (EXP)
neutropenia  (EXP)
non-alcoholic fatty liver disease  (ISO)
obstructive sleep apnea  (ISO)
Orthostatic Hypotension  (EXP)
ovarian cancer  (IEP)
Ovarian Neoplasms  (IAGP)
Pain  (ISO)
Pain, Postoperative  (EXP)
Parkinson's disease  (EXP)
perinatal necrotizing enterocolitis  (ISO)
peripheral nervous system disease  (EXP)
pleomorphic xanthoastrocytoma  (IAGP)
Poisoning  (EXP)
pulmonary tuberculosis  (IAGP)
renal cell carcinoma  (IAGP,IEP)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (EXP)
secondary Parkinson disease  (EXP)
ST Elevation Myocardial Infarction  (IAGP)
status epilepticus  (ISO)
temporal lobe epilepsy  (ISO)
toxic encephalopathy  (EXP,IAGP)
type 2 diabetes mellitus  (IAGP)
ulcerative colitis  (IAGP)
visual epilepsy  (ISO)
Vomiting  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (EXP)
(+)-alpha-tocopherol  (ISO)
(+)-artemisinin  (EXP)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (EXP,ISO)
(-)-antofine  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-gambogic acid  (EXP)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (ISO)
(E,E)-germacrone  (EXP)
(E,E)-hydramethylnon  (EXP)
(R)-lipoic acid  (ISO)
(S)-colchicine  (EXP)
(S)-glaucine  (EXP)
(S)-naringenin  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1,9-dideoxyforskolin  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (EXP)
1-naphthyl isothiocyanate  (ISO)
16alpha,17beta-Estriol 17-(beta-D-glucuronide)  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-deoxy-D-glucose  (EXP)
2-methyl-1H-indole  (EXP)
2-nitrofluorene  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3',4',7-trihydroxyisoflavone  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (EXP)
3,4-Methylenedioxyamphetamine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4'-epidoxorubicin  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxypsoralen  (EXP)
6-bromoindirubin-3'-oxime  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
8-(4-chlorophenylthio)-cAMP  (ISO)
abamectin  (EXP,ISO)
abietic acid  (EXP)
acenocoumarol  (EXP)
acetochlor  (EXP)
acetylsalicylic acid  (EXP,ISO)
aconitine  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
aldehydo-D-glucose  (EXP)
aldosterone  (EXP)
aliskiren  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide  (EXP)
alpha-tocotrienol  (EXP)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amprenavir  (EXP)
anandamide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
apocynin  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP,ISO)
auraptene  (EXP)
avermectin  (ISO)
azathioprine  (EXP)
azelastine  (EXP)
Azidopine  (EXP)
barnidipine  (EXP)
beclomethasone  (EXP)
benidipine  (EXP)
benzbromarone  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (EXP)
Benzo[k]fluoranthene  (EXP,ISO)
benzoylaconine  (EXP)
benzoylhypaconine  (EXP)
benzoylmesaconine  (EXP)
bepridil  (EXP)
berberine  (ISO)
bergomottin  (EXP)
beryllium difluoride  (EXP)
beta-pinene  (EXP)
beta-tocotrienol  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bis-4-nitrophenyl phosphate  (ISO)
bisoprolol  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bortezomib  (EXP,ISO)
bosentan  (EXP)
bromobenzene  (ISO)
bromocriptine  (ISO)
budesonide  (EXP)
bufalin  (EXP)
buta-1,3-diene  (ISO)
butanal  (EXP)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcein  (EXP,ISO)
calcein am  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
camptothecin  (EXP)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (EXP)
cardenolides  (EXP)
carmustine  (EXP)
carvedilol  (EXP,ISO)
celecoxib  (EXP,ISO)
cepharanthine  (EXP)
cerivastatin  (EXP)
cetirizine  (EXP)
chlorambucil  (EXP)
chlordecone  (EXP)
chloroform  (EXP,ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
chlorpyrifos-methyl  (EXP)
cholic acid  (ISO)
choline  (ISO)
chrysene  (EXP)
chrysin  (EXP)
Ciclesonide  (EXP)
cilastatin  (EXP)
cinchonine  (EXP)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
citronellal  (EXP)
citronellol  (EXP)
clofibrate  (ISO)
clomipramine  (ISO)
clopidogrel  (EXP,ISO)
closantel  (ISO)
clotrimazole  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coptisine  (ISO)
cortisol  (EXP)
crizotinib  (EXP)
crocidolite asbestos  (EXP)
cucurbitacin I  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cyazofamid  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
Cymarin  (EXP)
cyproconazole  (ISO)
cytarabine  (EXP)
D-glucose  (EXP)
D-mannitol  (ISO)
daunorubicin  (EXP,ISO)
delta-tocotrienol  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP)
desloratadine  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextropropoxyphene  (ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
digitoxin  (EXP)
digoxigenin  (EXP)
digoxin </