Abcb1a (ATP-binding cassette, sub-family B (MDR/TAP), member 1A) - Rat Genome Database
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Gene: Abcb1a (ATP-binding cassette, sub-family B (MDR/TAP), member 1A) Mus musculus
Symbol: Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
RGD ID: 1620890
Description: Exhibits ATPase activity; ATPase-coupled intramembrane lipid transporter activity; and transmembrane transporter activity. Involved in lipid translocation; xenobiotic detoxification by transmembrane export across the plasma membrane; and xenobiotic transport across blood-brain barrier. Localizes to apical plasma membrane and intercellular canaliculus. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and integumental system. Used to study inflammatory bowel disease 13. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; allergic rhinitis; carcinoma (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Abcb4; ATP-binding cassette sub-family B member 1A; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, subfamily B, member 1A; ATP-dependent translocase ABCB1; ecotropic viral integration site 32; Evi; Evi32; Mdr; mdr-; mdr-3; Mdr1a; Mdr3; multi-drug resistance 3; multidrug resistance protein 1A; multidrug resistance protein 3; multiple drug resistant 1a; P; P glycoprotein 3; P-; P-glycoprotein 3; P-gp; Pgp; Pgy; Pgy-; Pgy-3; Pgy3; phospholipid transporter ABCB1
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3958,617,091 - 8,798,575 (+)NCBIGRCm39mm39
GRCm3858,567,091 - 8,748,575 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,660,077 - 8,748,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,660,092 - 8,748,570 (+)NCBIGRCm37mm9NCBIm37
MGSCv3658,666,098 - 8,754,525 (+)NCBImm8
Celera58,580,580 - 8,668,151 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
adrenocortical carcinoma  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (IMP)
Anthracycline-induced Cardiotoxicity  (ISO)
asthma  (ISO)
Behcet's disease  (ISO)
Breast Neoplasms  (ISO)
cannabis abuse  (ISO)
carcinoma  (ISO)
Chemical and Drug Induced Liver Injury  (EXP,IMP,ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
Critical Illness  (ISO)
Crohn's disease  (ISO)
Cronkhite-Canada syndrome  (IEP)
cryoglobulinemia  (ISO)
diarrhea  (EXP)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
disease of mental health  (ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (EXP,ISO)
encephalitis  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Eosinophilia  (ISO)
epilepsy  (ISO)
Escherichia Coli Infections  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP,ISO)
familial hyperlipidemia  (EXP,ISO)
familial Mediterranean fever  (ISO)
familial temporal lobe epilepsy 3  (ISO)
Fetal Growth Retardation  (ISO)
Genetic Predisposition to Disease  (ISO)
Genetic Translocation  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (EXP)
Helicobacter Infections  (ISO)
Hematologic Neoplasms  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Inflammation  (ISO)
inflammatory bowel disease 13  (IEA,ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (EXP)
Kidney Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
malaria  (ISO)
Mammary Neoplasms, Experimental  (IEP)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Nausea  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
nervous system disease  (ISO)
neuroblastoma  (ISO)
neutropenia  (ISO)
non-alcoholic fatty liver disease  (ISO)
obstructive sleep apnea  (ISO)
Orthostatic Hypotension  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (EXP)
Pain, Postoperative  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (IMP)
peripheral nervous system disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Poisoning  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (EXP)
rheumatoid arthritis  (ISO)
secondary Parkinson disease  (ISO)
ST Elevation Myocardial Infarction  (ISO)
status epilepticus  (EXP)
temporal lobe epilepsy  (ISO)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
visual epilepsy  (EXP,ISO)
Vomiting  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (ISO)
(+)-alpha-tocopherol  (ISO)
(+)-artemisinin  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (EXP,ISO)
(-)-antofine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (ISO)
(E,E)-hydramethylnon  (ISO)
(R)-lipoic acid  (EXP)
(S)-colchicine  (ISO)
(S)-glaucine  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
1,9-dideoxyforskolin  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
16alpha,17beta-Estriol 17-(beta-D-glucuronide)  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-deoxy-D-glucose  (ISO)
2-methyl-1H-indole  (ISO)
2-nitrofluorene  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3',4',7-trihydroxyisoflavone  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)