Abcb1a (ATP binding cassette subfamily B member 1A) - Rat Genome Database

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Gene: Abcb1a (ATP binding cassette subfamily B member 1A) Rattus norvegicus
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
RGD ID: 619951
Description: Predicted to have several functions, including ATP binding activity; ATPase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to lipid; response to alkaloid; and response to vitamin. Localizes to apical plasma membrane and brush border membrane. Biomarker of several diseases, including end stage renal disease; epilepsy (multiple); human immunodeficiency virus infectious disease; non-alcoholic fatty liver disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); PARTICIPATES IN axitinib pharmacokinetics pathway; clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-pilocarpine; (+)-schisandrin B.
Type: protein-coding
Also known as: Abcb1; ATP binding cassette subfamily B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1A; ATP-binding cassette, subfamily B (MDR/TAP), member 1A; Mdr1a; multiple drug resistant 1a
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Abcb1aem1Sage   Abcb1aem2Sage   Abcb1aem3Sage  
Genetic Models: WI-Abcb1aem2Sage WI-Abcb1aem3Sage SD-Abcb1aem1Sage -/- SD-Abcb1aem1Sage Abcg2em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2425,357,467 - 25,529,941 (-)NCBI
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0422,339,829 - 22,517,642 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0422,276,390 - 22,448,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,709,855 - 21,796,628 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1421,709,854 - 21,796,626 (+)NCBI
Celera420,849,575 - 20,934,573 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
adrenocortical carcinoma  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
Anthracycline-induced Cardiotoxicity  (ISO)
asthma  (ISO)
Behcet's disease  (ISO)
Breast Neoplasms  (ISO)
cannabis abuse  (ISO)
carcinoma  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
Critical Illness  (ISO)
Crohn's disease  (ISO)
Cronkhite-Canada syndrome  (ISO)
cryoglobulinemia  (ISO)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
disease of mental health  (ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
encephalitis  (IEP)
end stage renal disease  (IEP)
Endotoxemia  (IEP)
Eosinophilia  (ISO)
epilepsy  (IEP,ISO)
Escherichia Coli Infections  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (IEP,ISO)
Experimental Diabetes Mellitus  (IAGP,IDA,IEP)
Experimental Liver Cirrhosis  (ISO)
familial hyperlipidemia  (ISO)
familial Mediterranean fever  (ISO)
familial temporal lobe epilepsy 3  (ISO)
Fetal Growth Retardation  (IEP)
Genetic Predisposition to Disease  (ISO)
Genetic Translocation  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
Helicobacter Infections  (ISO)
Hematologic Neoplasms  (ISO)
hepatocellular carcinoma  (IEP,ISO)
human immunodeficiency virus infectious disease  (IEP,ISO)
Inflammation  (IEP)
inflammatory bowel disease 13  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Latent Tuberculosis  (ISO)
lung non-small cell carcinoma  (ISO)
malaria  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Nausea  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
nervous system disease  (ISO)
neuroblastoma  (ISO)
neutropenia  (ISO)
non-alcoholic fatty liver disease  (IEP)
obstructive sleep apnea  (IEP)
Orthostatic Hypotension  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
Pain, Postoperative  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
peripheral nervous system disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Poisoning  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
secondary Parkinson disease  (ISO)
ST Elevation Myocardial Infarction  (ISO)
status epilepticus  (ISO)
temporal lobe epilepsy  (IEP)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
visual epilepsy  (IEP,ISO)
Vomiting  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (ISO)
(+)-alpha-tocopherol  (EXP)
(+)-artemisinin  (ISO)
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-antofine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (EXP)
(E,E)-germacrone  (ISO)
(E,E)-hydramethylnon  (ISO)
(R)-lipoic acid  (ISO)
(S)-colchicine  (ISO)
(S)-glaucine  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1,9-dideoxyforskolin  (EXP)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
16alpha,17beta-Estriol 17-(beta-D-glucuronide)  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-deoxy-D-glucose  (ISO)
2-methyl-1H-indole  (ISO)
2-nitrofluorene  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4'-epidoxorubicin  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxypsoralen  (ISO)
6-bromoindirubin-3'-oxime  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
abamectin  (EXP,ISO)
abietic acid  (ISO)
acenocoumarol  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
aliskiren  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide  (ISO)
alpha-tocotrienol  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amprenavir  (ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
apocynin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
auraptene  (ISO)
avermectin  (ISO)
azathioprine  (ISO)
azelastine  (ISO)
Azidopine  (ISO)
barnidipine  (ISO)
beclomethasone  (ISO)
benidipine  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoylaconine  (ISO)
benzoylhypaconine  (ISO)
benzoylmesaconine  (ISO)
bepridil  (ISO)
berberine  (EXP)
bergomottin  (ISO)
beryllium difluoride  (ISO)
beta-pinene  (ISO)
beta-tocotrienol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bis-4-nitrophenyl phosphate  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
bosentan  (ISO)
bromobenzene  (EXP)
bromocriptine  (EXP)
budesonide  (ISO)
bufalin  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcein  (ISO)
calcein am  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
cardenolides  (ISO)
carmustine  (ISO)
carvedilol  (EXP,ISO)
celecoxib  (ISO)
cepharanthine  (ISO)
cerivastatin  (ISO)
cetirizine  (ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chloroform  (EXP,ISO)
chlorohydrocarbon  (ISO)
chloroprene  (EXP)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chrysene  (ISO)
chrysin  (ISO)
Ciclesonide  (ISO)
cilastatin  (ISO)
cinchonine  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
citronellal  (ISO)
citronellol  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (EXP)
clopidogrel  (EXP,ISO)
closantel  (ISO)
clotrimazole  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coptisine  (EXP)
cortisol  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin I  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyazofamid  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
Cymarin  (ISO)
cyproconazole  (EXP,ISO)
cytarabine  (ISO)
D-glucose  (ISO)
D-mannitol  (EXP)
daunorubicin  (EXP,ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desloratadine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextropropoxyphene  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
digoxigenin  (ISO)
digoxin  (EXP,ISO)
diltiazem  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioscin  (EXP,ISO)
dioxygen  (ISO)
diphenyl(4-piperidinyl)methanol  (ISO)
disulfiram  (ISO)
domperidone  (ISO)
Doramectin  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxepin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
efonidipine hydrochloride  (ISO)
emamectin  (ISO)
emodin  (EXP,ISO)
endosulfan  (ISO)
epinastine  (ISO)
epoxiconazole  (EXP)
eprinomectin  (ISO)
eriodictyol  (ISO)
erythromycin A  (EXP,ISO)
erythromycin estolate  (EXP)
erythrosin B  (ISO)
estriol  (ISO)
estriol 16-O-(beta-D-glucuronide)  (EXP)
estrone  (ISO)
ethanol  (ISO)
etoposide  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
fenoxycarb  (ISO)
fentanyl  (EXP,ISO)
fenvalerate  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
fipronil  (ISO)
flavonol  (ISO)
flupenthixol  (ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
fluvoxamine  (