Abcb1a (ATP binding cassette subfamily B member 1A)

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Gene: Abcb1a (ATP binding cassette subfamily B member 1A) Rattus norvegicus

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Symbol:

Abcb1a

Name:

ATP binding cassette subfamily B member 1A

RGD ID:

619951

Description:

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including cellular hyperosmotic salinity response; cellular response to L-glutamate; and cellular response to borneol. Located in apical plasma membrane and brush border membrane. Biomarker of brain disease (multiple); end stage renal disease; human immunodeficiency virus infectious disease; liver disease (multiple); and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); PARTICIPATES IN axitinib pharmacokinetics pathway; clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; INTERACTS WITH (+)-isoborneol; (+)-pilocarpine; (+)-schisandrin B.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Abcb1; ATP binding cassette subfamily B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1A; ATP-binding cassette, subfamily B (MDR/TAP), member 1A; Mdr1a; multiple drug resistant 1a

RGD Orthologs

Alliance Orthologs

More Info

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Allele / Splice:

Abcb1a^em1Sage Abcb1a^em2Sage Abcb1a^em3Sage

Genetic Models:

WI-Abcb1a^em2Sage WI-Abcb1a^em3Sage SD-Abcb1a^{em1Sage -/-} SD-Abcb1a^em1Sage Abcg2^em1Sage

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	26,312,403 - 26,488,456 (-)	NCBI		GRCr8
mRatBN7.2	4	25,357,467 - 25,529,941 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	25,158,362 - 25,442,709 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	30,355,700 - 30,438,098 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	26,281,938 - 26,364,336 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	24,656,062 - 24,738,283 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	22,339,829 - 22,517,642 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	22,133,521 - 22,425,515 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	22,276,390 - 22,448,913 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	21,709,855 - 21,796,628 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	21,709,854 - 21,796,626 (+)	NCBI
Celera	4	20,849,575 - 20,934,573 (-)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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