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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Acc ID: CHEBI:75095
Term: chrysin
Definition: A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.
Chemical ID: MESH:C043561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2decreases activityEXP 6480464CTDchrysin results in decreased activity of ABCG2 proteinPMID:17093006
Abcg2multiple interactionsEXP 6480464CTDchrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]PMID:19732493
Abcg2decreases activityISOABCG2 (Homo sapiens)6480464CTDchrysin results in decreased activity of ABCG2 proteinPMID:20457140
Abcg2decreases expressionISOABCG2 (Homo sapiens)6480464CTDchrysin results in decreased expression of ABCG2 mRNAPMID:20816778
Abcg2increases expressionISOABCG2 (Homo sapiens)6480464CTDchrysin results in increased expression of ABCG2 mRNA; chrysin results in increased expression of ABCG2 proteinPMID:17077187 PMID:20457140
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTD[chrysin results in decreased activity of ABCG2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]PMID:17093006 PMID:20457140
Abcg2multiple interactionsISOAbcg2 (Mus musculus)6480464CTDchrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]PMID:17093006
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