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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Acc ID: CHEBI:63632
Term: topotecan
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Chemical ID: MESH:D019772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2decreases expressionEXP 6480464CTDTopotecan results in decreased expression of ABCG2 mRNAPMID:25729387
Abcg2multiple interactionsEXP 6480464CTD[oxaliplatin co-treated with Topotecan] results in decreased expression of ABCG2 mRNAPMID:25729387
Abcg2affects exportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein affects the export of TopotecanPMID:15695404
Abcg2affects transportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein affects the transport of TopotecanPMID:15875186 PMID:17032904
Abcg2affects transportISOAbcg2 (Mus musculus)6480464CTDABCG2 protein affects the transport of TopotecanPMID:15722455 PMID:17032904
Abcg2decreases response to substanceISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in decreased susceptibility to Topotecan; ABCG2 results in decreased susceptibility to TopotecanPMID:10606239 PMID:18829547 PMID:19232821 PMID:25058526
Abcg2increases exportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in increased export of TopotecanPMID:10606239
Abcg2increases expressionISOABCG2 (Homo sapiens)6480464CTDTopotecan results in increased expression of ABCG2 proteinPMID:20457140
Abcg2increases response to substanceISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in increased susceptibility to TopotecanPMID:16954373
Abcg2increases transportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in increased transport of TopotecanPMID:17032904
Abcg2increases transportISOAbcg2 (Mus musculus)6480464CTDABCG2 protein results in increased transport of TopotecanPMID:17032904
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTD[chrysin results in decreased activity of ABCG2 protein] which results in decreased export of Topotecan; [tryptoquivaline results in decreased activity of ABCG2 protein] which results in decreased export of Topotecan; lapatinib inhibits the reaction [ABCG2 protein results in decreased susceptibility to Topotecan]; Protons promotes the reaction [ABCG2 protein results in increased transport of Topotecan]; sunitinib inhibits the reaction [ABCG2 results in decreased susceptibility to Topotecan]; tryptoquivaline inhibits the reaction [ABCG2 protein results in decreased susceptibility to Topotecan]PMID:17032904 PMID:18829547 PMID:19232821 PMID:20457140 PMID:25058526
Abcg2multiple interactionsISOAbcg2 (Mus musculus)6480464CTDProtons promotes the reaction [ABCG2 protein results in increased transport of Topotecan]PMID:17032904
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