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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Acc ID: CHEBI:51232
Term: 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole
Definition: A bibenzimidazole that has formula C27H28N6O.
Chemical ID: MESH:C017807
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2decreases abundanceISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloridePMID:12869632
Abcg2decreases activityISOABCG2 (Homo sapiens)6480464CTDbisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 proteinPMID:27475308
Abcg2decreases exportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloridePMID:26850786
Abcg2increases exportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloridePMID:26850786 PMID:26907376 PMID:27450509 PMID:34717915
Abcg2increases transportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloridePMID:12869632
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; [bisphenol A results in decreased activity of ABCG2 protein] which results in decreased transport of bisbenzimide ethoxide trihydrochloride; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of bisbenzimide ethoxide trihydrochloride; [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride; Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; danofloxacin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Tobacco Smoke Pollution inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]PMID:12869632 PMID:19239227 PMID:26850786 PMID:26907376 PMID:27450509 PMID:34073890 PMID:34717915 PMID:34896433
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