GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcg2 | decreases abundance | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | ABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloride | PMID:12869632 | Abcg2 | decreases activity | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 protein | PMID:27475308 | Abcg2 | decreases export | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride | PMID:26850786 | Abcg2 | increases export | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride | PMID:26850786 PMID:26907376 PMID:27450509 PMID:34717915 | Abcg2 | increases transport | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride | PMID:12869632 | Abcg2 | multiple interactions | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; [bisphenol A results in decreased activity of ABCG2 protein] which results in decreased transport of bisbenzimide ethoxide trihydrochloride; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of bisbenzimide ethoxide trihydrochloride; [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride; Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; danofloxacin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Tobacco Smoke Pollution inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] | PMID:12869632 PMID:19239227 PMID:26850786 PMID:26907376 PMID:27450509 PMID:34073890 PMID:34717915 PMID:34896433 | |
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