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Strain: SD-Abcg2em1Sage

Symbol: SD-Abcg2em1Sage
Strain: SD-Abcg2em1
Substrain: Sage
RGD ID: 12904063
Citation ID: RRID:RGD_12904063
Ontology ID: RS:0004434
Alleles: Abcg2em1Sage
Previously known as: TGRS4200 ; SD- Abcg2 tm1sage; Bcrp Knockout Rat ; SD-Abcg2em1Sage
Type: mutant
Source: Horizon Discovery
Origin: This ZFN model carries a 588-bp deletion within Abcg2 gene. Homozygous knockouts display total loss of protein via Western blot
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2017-05-16)
Research Usage Efflux Transporter
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,676,241 - 87,802,757RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0488,765,441 - 88,890,268RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04153,587,206 - 153,712,481RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4487,502,584 - 87,560,017RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Data curation from Horizon Discovery Data curation from Horizon Discovery (https://www.horizondiscovery.com/)
2. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. Zamek-Gliszczynski MJ, etal., Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18.

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