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Gene: Actr3 (actin related protein 3) Rattus norvegicus
Symbol: Actr3
Name: actin related protein 3
Description: Exhibits ATPase binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Involved in several processes, including neurogenesis; positive regulation of cellular component organization; and positive regulation of protein localization to membrane. Localizes to several cellular components, including apical ectoplasmic specialization; apical tubulobulbar complex; and basal ectoplasmic specialization. Colocalizes with actin filament. Used to study focal segmental glomerulosclerosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. Human ortholog(s) of this gene implicated in opisthorchiasis. Orthologous to human ACTR3 (actin related protein 3); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,4-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
Also known as: actin-like protein 3; actin-related protein 3; actin-related protein 3 homolog (yeast); actin-related protein 3 homolog (yest); Arp3; ARP3 actin related protein 3 homolog; ARP3 actin-related protein 3 homolog; ARP3 actin-related protein 3 homolog (yeast); MGC116163
Homo sapiens (human) : ACTR3 (actin related protein 3)  HGNC  Alliance
Mus musculus (house mouse) : Actr3 (ARP3 actin-related protein 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actr3 (actin related protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTR3 (actin related protein 3)
Canis lupus familiaris (dog) : ACTR3 (actin related protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actr3 (actin related protein 3)
Sus scrofa (pig) : ACTR3 (actin related protein 3)
Chlorocebus sabaeus (African green monkey) : ACTR3 (actin related protein 3)
Heterocephalus glaber (naked mole-rat) : Actr3 (actin related protein 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01341,695,520 - 41,738,622 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1341,695,183 - 41,738,658 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01346,808,187 - 46,850,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41337,861,558 - 37,904,589 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11337,876,286 - 37,879,398 (-)NCBI
Celera1336,607,886 - 36,650,420 (-)NCBICelera
Cytogenetic Map13q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Actr3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 71024
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.