Actr3 (actin related protein 3) - Rat Genome Database

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Gene: Actr3 (actin related protein 3) Rattus norvegicus
Analyze
Symbol: Actr3
Name: actin related protein 3
RGD ID: 71024
Description: Enables ATPase binding activity and actin binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of protein localization to membrane; and regulation of neurogenesis. Located in several cellular components, including apical ectoplasmic specialization; basal ectoplasmic specialization; and concave side of sperm head. Part of apical tubulobulbar complex. Is active in glutamatergic synapse and postsynapse. Colocalizes with actin filament. Used to study focal segmental glomerulosclerosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. Human ortholog(s) of this gene implicated in opisthorchiasis. Orthologous to human ACTR3 (actin related protein 3); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin-like protein 3; actin-related protein 3; actin-related protein 3 homolog (yeast); actin-related protein 3 homolog (yest); Arp3; ARP3 actin related protein 3 homolog; ARP3 actin-related protein 3 homolog; ARP3 actin-related protein 3 homolog (yeast); MGC116163
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Pur16
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21336,800,739 - 36,843,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1336,800,093 - 36,844,124 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1339,401,982 - 39,443,515 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01340,689,982 - 40,731,516 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01337,949,578 - 37,992,708 (-)NCBIRnor_WKY
Rnor_6.01341,695,520 - 41,738,622 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1341,695,183 - 41,738,658 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01346,808,187 - 46,850,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41337,861,558 - 37,904,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11337,876,286 - 37,879,398 (-)NCBI
Celera1336,607,886 - 36,650,420 (-)NCBICelera
Cytogenetic Map13q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
heparin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
ivermectin  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylephrine  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
trichostatin A  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
Arp2/3 complex-mediated actin nucleation  (IBA,ISO,ISS)
astrocyte differentiation  (IMP)
asymmetric cell division  (ISO)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to pyrimidine ribonucleotide  (IEP)
cellular response to transforming growth factor beta stimulus  (IDA)
cellular response to trichostatin A  (IEP)
cellular response to triterpenoid  (IEP)
cellular response to tumor necrosis factor  (IDA)
cellular response to type II interferon  (ISO)
cilium assembly  (ISO,ISS)
establishment or maintenance of cell polarity  (ISO)
meiotic cell cycle  (ISO)
meiotic chromosome movement towards spindle pole  (ISO)
meiotic cytokinesis  (ISO)
negative regulation of axon extension  (IMP)
negative regulation of bleb assembly  (IMP)
positive regulation of actin filament polymerization  (IMP)
positive regulation of astrocyte differentiation  (IMP)
positive regulation of dendrite morphogenesis  (IMP)
positive regulation of dendritic spine morphogenesis  (IMP)
positive regulation of fibroblast migration  (IMP)
positive regulation of filopodium assembly  (IMP)
positive regulation of lamellipodium assembly  (IMP,ISO,ISS)
positive regulation of neuron differentiation  (IMP)
positive regulation of protein binding  (IMP)
positive regulation of protein localization to plasma membrane  (IMP)
positive regulation of protein targeting to membrane  (IMP)
positive regulation of synapse assembly  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
postsynapse organization  (IDA,IMP)
postsynaptic actin cytoskeleton organization  (IDA,IMP)
regulation of actin cytoskeleton organization  (IMP)
regulation of myosin II filament organization  (IMP)
response to estradiol  (IEP)
response to heparin  (IEP)
Sertoli cell barrier remodeling  (IEP)
spermatogenesis  (IEP)
spindle localization  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats. Akiyama K, et al., Mamm Genome. 2008 Jan;19(1):41-50. Epub 2007 Dec 7.
2. Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation. Bailly M, etal., J Cell Biol. 1999 Apr 19;145(2):331-45.
3. Cell mechanics control rapid transitions between blebs and lamellipodia during migration. Bergert M, etal., Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14434-9. doi: 10.1073/pnas.1207968109. Epub 2012 Jul 11.
4. Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes. Chen JL, etal., FEBS Lett. 2004 May 21;566(1-3):281-6.
5. Adjudin disrupts spermatogenesis via the action of some unlikely partners: Eps8, Arp2/3 complex, drebrin E, PAR6 and 14-3-3. Cheng CY, etal., Spermatogenesis. 2011 Oct;1(4):291-297. Epub 2011 Oct 1.
6. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
7. A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia. Clark D, etal., Mol Psychiatry. 2006 May;11(5):459-70, 423.
8. Disruption of tubulobulbar complex by high intratesticular estrogens leading to failed spermiation. D'Souza R, etal., Endocrinology. 2009 Apr;150(4):1861-9. doi: 10.1210/en.2008-1232. Epub 2008 Dec 18.
9. Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension. DesMarais V, etal., J Cell Sci. 2004 Jul 15;117(Pt 16):3499-510.
10. Effect of Heme Oxygenase-1 Deficiency on Glomerular Proteomics. Detsika MG, etal., Am J Nephrol. 2016;43(6):441-50. doi: 10.1159/000446859. Epub 2016 Jun 2.
11. F-BAR proteins of the syndapin family shape the plasma membrane and are crucial for neuromorphogenesis. Dharmalingam E, etal., J Neurosci. 2009 Oct 21;29(42):13315-27. doi: 10.1523/JNEUROSCI.3973-09.2009.
12. Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. El-Sibai M, etal., J Cell Sci. 2007 Oct 1;120(Pt 19):3465-74. Epub 2007 Sep 12.
13. Alterations in cytoskeletal and immune function-related proteome profiles in whole rat lung following intratracheal instillation of heparin. Gabr AA, etal., Respir Res. 2007 May 8;8:36.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Regulation of spine density and morphology by IQGAP1 protein domains. Jausoro I, etal., PLoS One. 2013;8(2):e56574. doi: 10.1371/journal.pone.0056574. Epub 2013 Feb 18.
16. Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells. Korobova F and Svitkina T, Mol Biol Cell. 2008 Apr;19(4):1561-74. Epub 2008 Feb 6.
17. RasGRP3 regulates the migration of glioma cells via interaction with Arp3. Lee HK, etal., Oncotarget. 2015 Jan 30;6(3):1850-64.
18. Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis. Li MW, etal., Spermatogenesis. 2011 Apr;1(2):123-136.
19. Interleukin-1alpha is a regulator of the blood-testis barrier. Lie PP, etal., FASEB J. 2011 Apr;25(4):1244-53. doi: 10.1096/fj.10-169995. Epub 2010 Dec 29.
20. Restricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesis. Lie PP, etal., Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11411-6. doi: 10.1073/pnas.1001823107. Epub 2010 Jun 7.
21. Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat. Lie PP, etal., Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12562-7. doi: 10.1073/pnas.1202316109. Epub 2012 Jul 12.
22. UTP affects the Schwannoma cell line proteome through P2Y receptors leading to cytoskeletal reorganisation. Martiáñez T, etal., Proteomics. 2012 Jan;12(1):145-56. doi: 10.1002/pmic.201100187. Epub 2011 Dec 9.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation. Morita T, etal., J Biol Chem. 2007 Mar 16;282(11):8454-63. Epub 2007 Jan 15.
25. The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology. Murk K, etal., J Cell Sci. 2013 Sep 1;126(Pt 17):3873-83. doi: 10.1242/jcs.125146. Epub 2013 Jul 10.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Involvement of Arp2/3 complex in the process of colorectal carcinogenesis. Otsubo T, etal., Mod Pathol. 2004 Apr;17(4):461-7.
28. Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment. Ottis P, etal., PLoS One. 2013 Sep 19;8(9):e75112. doi: 10.1371/journal.pone.0075112. eCollection 2013.
29. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. Peng J, etal., J Biol Chem. 2004 May 14;279(20):21003-11. doi: 10.1074/jbc.M400103200. Epub 2004 Mar 12.
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis. Qian X, etal., Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E757-69. doi: 10.1152/ajpendo.00645.2012. Epub 2013 Feb 12.
32. Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes. Qian X, etal., Endocrinology. 2013 May;154(5):1907-20. doi: 10.1210/en.2012-2269. Epub 2013 Apr 1.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. Rombouts K, etal., J Hepatol. 2002 Dec;37(6):788-96.
37. Plasma IgG autoantibody against actin-related protein 3 in liver fluke Opisthorchis viverrini infection. Rucksaken R, etal., Parasite Immunol. 2015 Jul;37(7):340-8. doi: 10.1111/pim.12188.
38. A dynamic podosome-like structure of epithelial cells. Spinardi L, etal., Exp Cell Res. 2004 May 1;295(2):360-74.
39. Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization. To C, etal., J Biol Chem. 2010 Sep 3;285(36):27944-57. doi: 10.1074/jbc.M110.103036. Epub 2010 Jun 21.
40. N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. Wegner AM, etal., J Biol Chem. 2008 Jun 6;283(23):15912-20. Epub 2008 Apr 21.
41. A combined metabonomic and proteomic approach identifies frontal cortex changes in a chronic phencyclidine rat model in relation to human schizophrenia brain pathology. Wesseling H, etal., Neuropsychopharmacology. 2013 Nov;38(12):2532-44. doi: 10.1038/npp.2013.160. Epub 2013 Jul 3.
42. The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner. Xie C, etal., J Biol Chem. 2011 Oct 14;286(41):35933-42. Epub 2011 Aug 15.
43. CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinomas of gallbladder. Yang ZL, etal., Cancer Invest. 2013 Feb;31(2):132-9. doi: 10.3109/07357907.2012.756113. Epub 2013 Jan 15.
44. Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces. Yu CH, etal., Cell Rep. 2013 Dec 12;5(5):1456-68. doi: 10.1016/j.celrep.2013.10.040. Epub 2013 Nov 27.
Additional References at PubMed
PMID:9230079   PMID:11741539   PMID:12477932   PMID:14657280   PMID:16767080   PMID:16854843   PMID:17220302   PMID:18297063   PMID:19056867   PMID:19144319   PMID:19946888   PMID:20393563  
PMID:20458337   PMID:21423176   PMID:21494665   PMID:22114352   PMID:23376485   PMID:23439682   PMID:23533145   PMID:23793062   PMID:29058690   PMID:29476059   PMID:31505169   PMID:31975378  


Genomics

Comparative Map Data
Actr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21336,800,739 - 36,843,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1336,800,093 - 36,844,124 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1339,401,982 - 39,443,515 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01340,689,982 - 40,731,516 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01337,949,578 - 37,992,708 (-)NCBIRnor_WKY
Rnor_6.01341,695,520 - 41,738,622 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1341,695,183 - 41,738,658 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01346,808,187 - 46,850,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41337,861,558 - 37,904,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11337,876,286 - 37,879,398 (-)NCBI
Celera1336,607,886 - 36,650,420 (-)NCBICelera
Cytogenetic Map13q12NCBI
ACTR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,889,934 - 113,962,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2113,890,063 - 113,962,596 (+)EnsemblGRCh38hg38GRCh38
GRCh372114,647,511 - 114,720,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362114,364,007 - 114,432,637 (+)NCBINCBI36Build 36hg18NCBI36
Build 342114,363,766 - 114,432,397NCBI
Celera2107,963,979 - 108,036,693 (+)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,964,108 - 107,039,652 (+)NCBIHuRef
CHM1_12114,651,066 - 114,722,668 (+)NCBICHM1_1
T2T-CHM13v2.02114,314,590 - 114,387,240 (+)NCBIT2T-CHM13v2.0
Actr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391125,320,642 - 125,363,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1125,320,642 - 125,363,464 (-)EnsemblGRCm39 Ensembl
GRCm381125,392,905 - 125,435,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1125,392,905 - 125,435,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv371127,289,483 - 127,332,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361127,220,452 - 127,263,036 (-)NCBIMGSCv36mm8
Celera1128,040,526 - 128,085,756 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
Actr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545915,216,914 - 15,284,013 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545915,216,914 - 15,284,013 (-)NCBIChiLan1.0ChiLan1.0
ACTR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B114,373,392 - 114,445,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B114,373,392 - 114,445,729 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B827,184 - 900,424 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACTR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11935,097,968 - 35,133,330 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1935,098,639 - 35,169,724 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1935,329,635 - 35,387,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01936,533,033 - 36,590,987 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1936,533,040 - 36,591,315 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11935,181,031 - 35,238,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01935,342,002 - 35,399,933 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01936,561,512 - 36,619,469 (-)NCBIUU_Cfam_GSD_1.0
Actr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530385,918,173 - 85,977,081 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646955,639,068 - 55,699,640 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493646955,639,345 - 55,699,330 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1520,104,812 - 20,167,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11520,104,808 - 20,171,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21522,725,584 - 22,786,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11016,296,350 - 16,369,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1016,297,502 - 16,369,220 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660616,176,980 - 6,250,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473231,361,147 - 31,427,811 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473231,360,804 - 31,427,885 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Actr3
185 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:88
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000004520
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61453Pur1Proteinuria QTL 118.06urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133453521837415726Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
2292232Pur16Proteinuria QTL 1617.2urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133615572341961389Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004520   ⟹   ENSRNOP00000004520
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1336,800,405 - 36,828,429 (-)Ensembl
Rnor_6.0 Ensembl1341,695,521 - 41,738,622 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084552   ⟹   ENSRNOP00000071780
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1336,800,404 - 36,844,124 (-)Ensembl
Rnor_6.0 Ensembl1341,695,183 - 41,738,658 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099931   ⟹   ENSRNOP00000084415
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1336,800,093 - 36,843,935 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116695   ⟹   ENSRNOP00000078984
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1336,800,405 - 36,829,102 (-)Ensembl
RefSeq Acc Id: NM_031068   ⟹   NP_112330
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21336,800,739 - 36,843,837 (-)NCBI
Rnor_6.01341,695,520 - 41,738,622 (-)NCBI
Rnor_5.01346,808,187 - 46,850,658 (-)NCBI
RGSC_v3.41337,861,558 - 37,904,589 (-)RGD
Celera1336,607,886 - 36,650,420 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112330   ⟸   NM_031068
- UniProtKB: A9CM90 (UniProtKB/Swiss-Prot),   Q4V7C7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071780   ⟸   ENSRNOT00000084552
RefSeq Acc Id: ENSRNOP00000004520   ⟸   ENSRNOT00000004520
RefSeq Acc Id: ENSRNOP00000084415   ⟸   ENSRNOT00000099931
RefSeq Acc Id: ENSRNOP00000078984   ⟸   ENSRNOT00000116695

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V7C7-F1-model_v2 AlphaFold Q4V7C7 1-418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698773
Promoter ID:EPDNEW_R9298
Type:initiation region
Name:Actr3_1
Description:ARP3 actin related protein 3 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01341,738,694 - 41,738,754EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71024 AgrOrtholog
BioCyc Gene G2FUF-18460 BioCyc
Ensembl Genes ENSRNOG00000003206 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004520.7 UniProtKB/TrEMBL
  ENSRNOP00000071780 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000078984.1 UniProtKB/TrEMBL
  ENSRNOP00000084415.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004520.7 UniProtKB/TrEMBL
  ENSRNOT00000084552 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000099931.1 UniProtKB/TrEMBL
  ENSRNOT00000116695.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7454624 IMAGE-MGC_LOAD
InterPro Actin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arp3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81732 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116163 IMAGE-MGC_LOAD
NCBI Gene 81732 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11937:SF175 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Actin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Actr3 PhenoGen
PROSITE ACTINS_ACT_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ACTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K1C0_RAT UniProtKB/TrEMBL
  A0A8I5ZLW6_RAT UniProtKB/TrEMBL
  A0A8I5ZZI1_RAT UniProtKB/TrEMBL
  A0A8L2Q115_RAT UniProtKB/TrEMBL
  A9CM90 ENTREZGENE
  ARP3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A9CM89 UniProtKB/Swiss-Prot
  A9CM90 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-25 Actr3  actin related protein 3  Actr3  ARP3 actin related protein 3 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-21 Actr3  ARP3 actin related protein 3 homolog  Actr3  ARP3 actin-related protein 3 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Actr3  ARP3 actin-related protein 3 homolog (yeast)    actin-related protein 3 homolog (yeast)  Name updated 1299863 APPROVED
2002-07-09 Actr3  actin-related protein 3 homolog (yeast)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference