Akr1d1 (aldo-keto reductase family 1, member D1)

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Gene: Akr1d1 (aldo-keto reductase family 1, member D1) Rattus norvegicus

Analyze

Symbol:

Akr1d1

Name:

aldo-keto reductase family 1, member D1

RGD ID:

620752

Description:

Enables 3-oxo-5-beta-steroid 4-dehydrogenase activity. Predicted to be involved in several processes, including C21-steroid hormone metabolic process; androgen metabolic process; and cholesterol catabolic process. Predicted to act upstream of or within bile acid biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 2. Orthologous to human AKR1D1 (aldo-keto reductase family 1 member D1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

3-oxo-5-beta-steroid 4-dehydrogenase; aldo-keto reductase family 1 member D1; aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase); delta(4)-3-ketosteroid 5-beta-reductase; delta(4)-3-oxosteroid 5-beta-reductase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AKR1D1 (aldo-keto reductase family 1 member D1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Akr1d1 (aldo-keto reductase family 1, member D1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Akr1d1 (aldo-keto reductase family 1 member D1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AKR1D1 (aldo-keto reductase family 1 member D1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AKR1D1 (aldo-keto reductase family 1 member D1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Akr1d1 (aldo-keto reductase family 1 member D1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AKR1D1 (aldo-keto reductase family 1 member D1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AKR1D1 (aldo-keto reductase family 1 member D1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Akr1d1 (aldo-keto reductase family 1 member D1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Akr1d1 (aldo-keto reductase family 1, member D1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1D1 (aldo-keto reductase family 1 member D1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12766	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG6083	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6084	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	GCY1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GRE3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder)
Caenorhabditis elegans (roundworm):	T08H10.1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	YPR1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10638	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ZC443.1	Alliance	DIOPT (OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	C56G3.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	66,154,246 - 66,187,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	66,154,248 - 66,186,372 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	71,096,251 - 71,129,493 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	67,017,336 - 67,050,578 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	65,407,781 - 65,440,769 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	65,110,706 - 65,143,930 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	65,110,746 - 65,143,941 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	64,933,143 - 64,965,930 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	64,972,908 - 65,005,896 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	65,249,037 - 65,282,026 (+)	NCBI
Celera	4	61,186,796 - 61,219,854 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital bile acid synthesis defect (ISO)

congenital bile acid synthesis defect 2 (ISO)

genetic disease (ISO)

hemochromatosis (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP,ISO)

3-chloropropane-1,2-diol (EXP)

3alpha-hydroxy-5beta-androstan-17-one (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

5-Dihydrocortisol (ISO)

5alpha-pregnane-3,20-dione (ISO)

7alpha-hydroxycholest-4-en-3-one (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aldosterone (ISO)

ammonium chloride (EXP)

androst-4-ene-3,17-dione (ISO)

androstane-3,17-dione (ISO)

atazanavir sulfate (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

butan-1-ol (ISO)

cadmium atom (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chenodeoxycholic acid (ISO)

chloropicrin (ISO)

cholest-4-en-3-one (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

cocaine (EXP)

copper(II) sulfate (ISO)

corticosterone (ISO)

cortisol (ISO)

cortisone (ISO)

coumarin (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

deoxycholic acid (ISO)

dicrotophos (ISO)

endosulfan (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

formaldehyde (ISO)

gentamycin (EXP)

glutathione (EXP)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

iodide salt (EXP)

ivermectin (ISO)

Lasiocarpine (ISO)

limonene (EXP)

lipopolysaccharide (ISO)

metacetamol (ISO)

methapyrilene (EXP,ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

NADP zwitterion (ISO)

NADP(+) (ISO)

nefazodone (EXP,ISO)

nickel dichloride (EXP)

nitrofen (EXP)

O-methyleugenol (ISO)

obeticholic acid (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

propiconazole (ISO)

Propiverine (EXP)

quercetin (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

simvastatin (EXP)

sodium arsenite (EXP,ISO)

sodium dichromate (EXP)

Sunset Yellow FCF (ISO)

tartrazine (ISO)

tauroursodeoxycholic acid (EXP)

testosterone (ISO)

tetrachloromethane (ISO)

tetracycline (ISO)

thioacetamide (EXP)

tolcapone (EXP)

troglitazone (EXP)

urethane (ISO)

valproic acid (EXP,ISO)

vancomycin (ISO)

vinclozolin (EXP)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen metabolic process (IBA,ISO)

bile acid biosynthetic process (IEA,ISO)

bile acid catabolic process (IEA)

C21-steroid hormone metabolic process (ISO)

cholesterol catabolic process (ISO)

digestion (ISO)

Cellular Component

cytosol (IBA,ISO)

Molecular Function

3-oxo-5-beta-steroid 4-dehydrogenase activity (IDA)

alditol:NADP+ 1-oxidoreductase activity (IBA)

delta4-3-oxosteroid 5beta-reductase activity (IEA)

ketosteroid monooxygenase activity (IBA)

steroid dehydrogenase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

11-beta-hydroxylase deficiency pathway (ISO)

17-alpha-hydroxylase deficiency pathway (ISO)

21-alpha-hydroxylase deficiency pathway (ISO)

apparent mineralocorticoid excess syndrome pathway (ISO)

bile acid biosynthetic pathway (IEA,ISO)

cerebrotendinous xanthomatosis pathway (ISO)

congenital bile acid synthesis defect pathway (ISO)

familial hypercholanemia pathway (ISO)

lipoid congenital adrenal hyperplasia pathway (ISO)

primary bile acid biosynthetic pathway (IEA)

steroid hormone biosynthetic pathway (IEA,ISO)

Zellweger syndrome pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	delta 4-3-Oxosteroid 5 beta-reductase. Structure and function.	Onishi Y, etal., Biol Chem Hoppe Seyler. 1991 Dec;372(12):1039-49.
6.	Molecular cloning and sequence analysis of cDNA encoding delta 4-3-ketosteroid 5 beta-reductase of rat liver.	Onishi Y, etal., FEBS Lett 1991 Jun 3;283(2):215-8.
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7508385	PMID:8550030	PMID:23376485

Genomics

Comparative Map Data

Akr1d1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	66,154,246 - 66,187,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	66,154,248 - 66,186,372 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	71,096,251 - 71,129,493 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	67,017,336 - 67,050,578 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	65,407,781 - 65,440,769 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	65,110,706 - 65,143,930 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	65,110,746 - 65,143,941 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	64,933,143 - 64,965,930 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	64,972,908 - 65,005,896 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	65,249,037 - 65,282,026 (+)	NCBI
Celera	4	61,186,796 - 61,219,854 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

AKR1D1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	138,076,459 - 138,118,305 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	7	138,002,324 - 138,118,305 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	137,761,205 - 137,803,051 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	137,411,736 - 137,453,590 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	137,218,450 - 137,260,305	NCBI
Celera	7	132,499,985 - 132,541,839 (+)	NCBI		Celera
Cytogenetic Map	7	q33	NCBI
HuRef	7	132,069,181 - 132,111,033 (+)	NCBI		HuRef
CHM1_1	7	137,694,698 - 137,736,587 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	139,386,001 - 139,427,796 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	137,106,397 - 137,148,256 (+)	NCBI

Akr1d1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	37,506,913 - 37,551,856 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	37,507,108 - 37,545,750 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	37,529,978 - 37,574,921 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	37,530,173 - 37,568,815 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	37,480,173 - 37,518,815 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	37,459,781 - 37,498,003 (+)	NCBI		MGSCv36	mm8
Celera	6	37,517,252 - 37,556,030 (+)	NCBI		Celera
Cytogenetic Map	6	B1	NCBI

Akr1d1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955494	4,799,450 - 4,854,696 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955494	4,799,706 - 4,856,100 (-)	NCBI	ChiLan1.0	ChiLan1.0

AKR1D1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	142,514,914 - 142,568,052 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	142,525,467 - 142,571,331 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	130,023,017 - 130,076,397 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

AKR1D1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	1,499,251 - 1,583,965 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	11,172,153 - 11,677,722 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	10,254,191 - 10,279,758 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	16	10,201,202 - 10,250,574 (-)	NCBI		UMICH_Zoey_3.1

Akr1d1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	16,696,579 - 16,727,564 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936592	2,491,681 - 2,522,796 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936592	2,486,219 - 2,522,796 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AKR1D1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	11,416,068 - 11,531,726 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	11,416,065 - 11,532,846 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	12,091,380 - 12,134,240 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AKR1D1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	106,705,197 - 106,822,194 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	106,780,339 - 106,822,696 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	3,643,056 - 3,684,108 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Akr1d1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	18,406,758 - 18,475,918 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624765	18,406,859 - 18,474,905 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Akr1d1
303 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	309
Count of miRNA genes:	205
Interacting mature miRNAs:	232
Transcripts:	ENSRNOT00000017675
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	percent change in mean arterial blood pressure (CMO:0002035)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	percent change in systolic blood pressure (CMO:0000747)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in pulse pressure (CMO:0001882)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	62933508	114921294	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	56647873	149491524	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
1578657	Bss12	Bone structure and strength QTL 12	8.9		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	4	60220938	105220938	Rat
1578658	Bss13	Bone structure and strength QTL 13	8		femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	4	60220938	105220938	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	40433388	85433388	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	39505275	73892441	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	50119848	146803430	Rat
631651	Bp124	Blood pressure QTL 124	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	62879517	107879517	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	58635877	78886137	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	64528739	157573521	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	39524264	74726312	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	59948935	154902892	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114432	91360801	Rat
2300179	Bmd50	Bone mineral density QTL 50	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	4	60928534	105928534	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	57114432	102114432	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	56698790	126192555	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	39524264	116179656	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	58432133	92991462	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	57486946	102486946	Rat
1549839	Bw52	Body weight QTL 52		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	61697658	115089733	Rat
1549843	Bw53	Body weight QTL 53		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	61697658	103194791	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	45456990	146803430	Rat
2312569	Pur19	Proteinuria QTL 19	3.4	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	4	65882107	96130297	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114705	78881294	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	62277855	128289560	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	56647776	78882945	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	56647776	78882945	Rat
6478743	Anxrr40	Anxiety related response QTL 40		0.83076	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
6478772	Anxrr49	Anxiety related response QTL 49		0.15488	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	56647776	78882945	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	56647776	78882945	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	43457976	88457976	Rat
6478684	Anxrr30	Anxiety related response QTL 30		0.00087	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	40433414	85433414	Rat
7394826	Bw126	Body weight QTL 126		0.002	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	62933269	87483707	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	36303261	103194984	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	26907285	75585128	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	26907285	75585128	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	29494195	81006281	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	34430484	82490359	Rat
8552807	Vie4	Viral induced encephalitis QTL 4	7.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	62933508	82490359	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	32583980	114627242	Rat

Markers in Region

RH130325

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	66,187,157 - 66,187,355 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	65,143,598 - 65,143,795	NCBI	Rnor6.0
Rnor_5.0	4	64,965,598 - 64,965,795	UniSTS	Rnor5.0
RGSC_v3.4	4	65,005,564 - 65,005,761	UniSTS	RGSC3.4
Celera	4	61,219,522 - 61,219,719	UniSTS
RH 3.4 Map	4	414.6	UniSTS
Cytogenetic Map	4	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			36	33	3	33			8		5	8
Low	3	10	17	4	16	4	8	10	3	11	4	3	8
Below cutoff		1	4	4		4		1	6	12	21

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005503146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	D17309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LC462238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S80431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000017675 ⟹ ENSRNOP00000017675

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	66,154,248 - 66,183,520 (+)	Ensembl
Rnor_6.0 Ensembl	4	65,110,746 - 65,141,728 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083672 ⟹ ENSRNOP00000075542

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	66,156,504 - 66,186,372 (+)	Ensembl
Rnor_6.0 Ensembl	4	65,112,944 - 65,143,941 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103598 ⟹ ENSRNOP00000080261

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	66,154,267 - 66,186,372 (+)	Ensembl

RefSeq Acc Id:

NM_138884 ⟹ NP_620239

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	66,154,247 - 66,187,505 (+)	NCBI
Rnor_6.0	4	65,110,706 - 65,143,930 (+)	NCBI
Rnor_5.0	4	64,933,143 - 64,965,930 (+)	NCBI
RGSC_v3.4	4	64,972,908 - 65,005,896 (+)	RGD
Celera	4	61,186,796 - 61,219,854 (+)	RGD

Sequence:

show sequence

TTCAGAATCACTACTTGAAGCTTCAGATCCCTTCTCTACAATGAACCTCAGCACTGCAAACCAC
CACATACCCCTAAATGATGGTAACAGCATTCCGATCATCGGGCTTGGAACCTACTCAGACCCTA
GACCGGTACCTGGCAAGACCTTTATAGCAGTGAAGACAGCTATTGACGAGGGGTACCGGCATAT
TGATGGGGCCTACGTCTACCGAAATGAACATGAAGTCGGTGAGGCCATCAGAGAAAAGGTGGCA
GAAGGGAAGGTAAAGAGGGAAGAGATTTTCTACTGTGGAAAGTTATGGAGTACAGACCATGATC
CAGAGATGGTCCGCCCAGCCCTGGAAAGGACCCTGCAGACCCTCAAGCTAGATTACATAGACCT
TTATATCATTGAGATGCCCATGGCCTTTAAGCCTGGAGAGGAATTTTATCCTAAAGATGAGAAT
GGCCGAGTGATATACCACAAATCAAATCTGTGTGCCACGTGGGAGGCACTGGAAGCTTGCAAAG
ACGCTGGCTTGGTGAAATCCCTTGGGGTGTCTAATTTTAACCGCAGGCAGCTGGAGGTCATCTT
GAACAAGCCAGGACTCAAGTACAAGCCTGTCACCAACCAGGTGGAGTGCCACCCGTATTTCACC
CAGACAAAACTCCTTGAAGTTTCTGCCAGCAGCATGACATCGTTCATTGTCGCATACAGCCCCT
TAGGGACCTGTCGCAACCCGTTATGGGTGAATGTATCTTCTCCACCCTTGTTAAAGGATGAACT
CCTAACCTCGCTGGGGAAAAAGTACAATAAGACACAAGCTCAAATTGTGTTGCGTTTCGACATC
CAGCGAGGGTTGGTTGTCATCCCTAAAAGTACTACCCCTGAAAGGATCAAAGAAAACTTTCAGA
TCTTTGACTTCTCTCTCACCAAAGAAGAAATGAAGGACATTGAAGCCTTGAATAAAAACGTGCG
CTTTGTGGAGATGCTCATGTGGAGTGATCATCCTGAATACCCATTTCATGACGAATACTGAACA
TGGAAATTTCTTCAGTGGAGTTTTTTTTTTGTCTTTCATTCGGGATCTTGAGCTGATTAATCCC
CTCCAGTCGTAGAAATAAATGGGGTCTTGCTATCTTCAGATTAAGTTGAGCAGAATACACCATG
CTTAACTTGTGTATAGTATTAATTCAACTTAGCTCTGATGAAGAGAAGATTTAAATATATCTAA
ATAGTTTGTTGGAAAATGCTTTACTAGTATCTTTAGCTCAATGTGTTCTAGATTGTTGATGGAA
ATTACCGAACTTTAATTCAAAAATAACAAAATATATAAAATACAAGATACAATATAAAATATAA
AATACAAAAATATAAAAACAGGTTCTAACCCAGGAGTCTGAGACTACCATAGGGAGTTTGATTT
GTTTAGCATTTAGCAGGACAACAAAAGAGGTTGGCATGCTTCCAGGTGCTGACCATAACCATGA
CCCAAACAAGGTCATGGACACAAGATGGACACAGCCAAGACACAAATCCACATACCAATATTAA
TGCACCTTGAGTATAGACAGAACTGAAAGTCTAGAAAGTCTAAAGAAGAACATAAAGCAGGATG
TCCCGGGGCTAGAGGTTCTCACTGGAGGACTTGCCTGGCAGACTGGAGACCCAGGGTGAGGGTG
TGGGTGAGGACTATCAGCAAAGCCATAACGATTCTGTTTTTACCCTTTGTTTCCATCCAGTGTG
CCCATTCAGCTTTTAATGTGCTTGAAGGACAGACAGTTACCGATTCCTTCTTAAATTGTTTTTG
TTCAGGGCAGTGGGGAATTGAGACAGGGTCTCAGGTAGTCTGCTCATGTAGCTGCTTACAAACT
TGCTGTGCAGCTGAGACCAGTTTTGAATTCTGAACCCCTGGTCTCTCTTCCATTTTTCATGGCC
TGAGCTTCCACCTGACTGGTAAGTCCCCACTTGTACTGTGCTGTAATCATTCTTGCCCACTTCA
TCAAGGAAACCACCATGTAAAGTGGCAAGAAACAATCAATATATACAACCAAGATTTGTATACA
ATATGGTCTGAAGATGGTGATTTTTAAAAGAATGATATTTAAATAGCCATTTCTTTCTTTCTTT
CTGAATCTTTAAAAATTATTTTATTTATGTGCATTGGTGTTAGCTGCATGTGTATCTATGAGGA
ATTGTTTGAACTCATGGAACTGGAGTTACAGACAGTGGTGAGCTGTAGGTAGGTGCTGGGAATT
GAACCCAAGTCATTGGGAAGAGCTGCAAGTGCTCTTAACTGCTGAGCCATCTCCCCAGCCCCCA
AATGAATTTGGGAAATACTAGAAGATAAAGCTTTGTAAAGTAGTTTTTAAGATCTTAAGAATAT
TTGAGGTACGTATCTGAATTTTGACAAAGCTGCAAGTTCTTTTTTTTAAATTGGATTTTTAAAA
ATTTATTTACATTTCAAATGTTATCCCCTCTCCTGGGTTCCCATCCACAGACCTCCCTATCTCA
TCCCCCCTCTCCCTTCTTCTATGAGAGTGTTCACCCACCTACCCACTCCTTCCCTCCTCCCTGC
CCTGACATTCCCCTACACTAGGGGGTCGAGTCTTGGCAGGACCAAGGGCCTCTCCTCCCATTGG
TGCCCAACAAGGCCATCCTCTGCTACATAGGCAGCTGGAGCCATGGGTCTGTCCATGTGTCTCT
CTGGATGGTGGTTTAGTCCCTGGGAGCTCTGGTTGGTTGGTTCTGTTGTTATGGGGTTGCAAAC
CCTTCAGCTCCTTTAATCCTTTCTCTAATTCCTCCATTGGGGACCCTGTTCTCAGTTCTATGGT
TGGCTGTGAGCATCCACCTGTGTATTTGTCATGCTCTGGCAGAGCCTCTCAGGAGAATCAGGCT
CCTGTCAGCAGAGCACAAGTAATTTTAGCGTATATAAATTTTTAAAAAGTGATAAATGATTACA
ACTGTATCTATTTTTAATTCATCTGAAATACAGTACATTTGTTTATATTAGATCACTTCCAAAG
GGTGAGAGATCTCTAATATATTTAATTCATAGAGAATCAATGGCCGAAGAGAATAAGTTTTGAG
AATTATCACTTAAAAATGTGATCAACATGAACCATTTTTGTTCAATACTGTTCAATATTGTTAA
CAATGCTGTTCTCTGGAAAATATTTTATTCACATGAATTAATAAAATATAATG

hide sequence

RefSeq Acc Id:

XM_006236285 ⟹ XP_006236347

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	66,156,456 - 66,187,505 (+)	NCBI
Rnor_6.0	4	65,112,908 - 65,143,150 (+)	NCBI
Rnor_5.0	4	64,933,143 - 64,965,930 (+)	NCBI

Sequence:

show sequence

TGTCCAGACCTTGGGCTCTGCACACTGCTTTGGCAATACTGGTGAAATCACATTTCTGAAGCTC
CAGTGCCAAGCCCAGAGAGCATAGATGGAATGCTGAATGAGGCAGTCCACCACAGTTTCTCTTA
CCTCTACGATCTTCCAATCATCAAAGTACCCGGCAAGACCTTTATAGCAGTGAAGACAGCTATT
GACGAGGGGTACCGGCATATTGATGGGGCCTACGTCTACCGAAATGAACATGAAGTTGGTGAGG
CCATCAGAGAAAAGGTGGCAGAAGGGAAGGTAAAGAGGGAAGAGATTTTCTACTGTGGAAAGTT
ATGGAGTACAGACCATGATCCAGAGATGGTCCGCCCAGCCCTGGAAAGGACCCTGCAGACCCTC
AAGCTAGATTACATAGACCTTTATATCATTGAGATGCCCATGGCCTTTAAGCCTGGAGAGGAAT
TTTATCCTAAAGATGAGAATGGCCGAGTGATATACCACAAATCAAATCTGTGTGCCACGTGGGA
GGCACTGGAAGCTTGCAAAGACGCTGGCTTGGTGAAATCCCTTGGGGTGTCTAATTTTAACCGC
AGGCAGCTGGAGGTCATCTTGAACAAGCCAGGACTCAAGTACAAGCCTGTCACCAACCAGGTGG
AGTGCCACCCGTATTTCACCCAGACAAAACTCTTGAAGTTCTGCCAGCAGCATGACATCGTCAT
TGTCGCATACAGCCCCTTAGGGACCTGTCGCAACCCGTTATGGGTGAATGTATCTTCTCCACCC
TTGTTAAAGGATGAACTCCTAACCTCGCTGGGGAAAAAGTACAATAAGACACAAGCTCAAATTG
TGTTGCGTTTCGACATCCAGCGAGGGTTGGTTGTCATCCCTAAAAGTACTACCCCTGAAAGGAT
CAAAGAAAACTTTCAGATCTTTGACTTCTCTCTCACCAAAGAAGAAATGAAGGACATTGAAGCC
TTGAATAAAAACGTGCGCTTTGTGGAGATGCTCATGTGGAGTGATCATCCTGAATACCCATTTC
ATGACGAATACTGAACATGGAAATTTCTTCAGTGGAGTTTTTTTTGTCTTTCATTCGGGATCTT
GAGCTGATTAATCCCCTCCAGTCGTAGAAATAAATGGGGTCTTGCTATCTTCAGATTAAGTTGA
GCAGAATACACCATGCTTAACTTGTGTATAGTATTAATTCAACTTAGCTCTGATGAAGAGAAGA
TTTAAATATATCTAAATAGTTTGTTGGAAAATGCTTTACTAGTATCTTTAGCTCAATGTGTTCT
AGATTGTTGATGGAAATTACCGAACTTTAATTCAAAAATAACAAAATATATAAAATACAAGATA
CAATATAAAATATAAAATACAAAAATATAAAAACAGGTTCTAACCCAGGAGTCTGAGACTACCA
TAGGGAGTTTGATTTGTTTAGCATTTAGCAGGACAACAAAGAGGTTGGCATGCTTCCAGGTGCT
GACCATAACCATGACCCAAACAAGGTCATGGACACAAGATGGACACAGCCAAGACACAAATCCA
CATACCAATATTAATGCACCTTGAGTATAGACAGAACTGGAAGTCTAGAAAGTCCTAAAGAAGA
ACATAAAGCAGGATGTCCCGGGGCTAGAGGTTCTCACTGGAGGACTTGCCTGGCAGACTGGAGA
CCCAGGGTGAGGGTGTGGGTGAGGACTATCAGCAAAGCCATAACGATTCTGTTTTTACCCTTTG
TTTCCATCCAGTGTGCCCATTCAGCTTTTAATGTGCTTGAAGGACAGACAGTTACCGATTCCTT
CTTAAATTGTTTTTGTTCAGGGCAGTGGGGAATTGAGACAGGGTCTCAGGTAGTCTGCTCATGT
AGCTGCTTACAAACTTGCTGTGCAGCTGAGACCAGTTTTGAATTCTGAACCCCTGGTCTCTCTT
CCATTTTTCATGGCCTGAGCTTCCACCTGACTGGTAAGCCCCACTTGTACTGTGCTGTAATCAT
TCTTGCCCACATTCATCAAGGAAACCACCATGTAAAGTGGCAAGAAACAATCAATATATACAAA
CCAAGATTTGTATCATAAAATGGTCTGAAGATGGTGATTTTTAAAAGAATGATATTTTAAAATA
GCCCATTTCTTTCTTTCTTTCTGAATCTTTTAAAAATTATTTTTATTTTATGTGCATTGGTGTT
TAGCCTGCATGTGTATCTATGAGAATTGTTTGAACTCATGGAACTGGAGTTACAGACAGTGGTG
AGCTGTAGGTAGGTGCTGGGAATTGAACCCAAGTCATTGGGAAGAGCTGCAAGTGCTCTTAACT
GCTGAGCCATCTCCCCAGCCCCCAAATGAATTTGGGAAATACTAGAAGATAAAGCTTTGTAAAA
GTAGTTTTTTAAGATCTTAAGAATATATTGAGGTAGCTATCTGAATTTTGACAAAGCTGCAAGT
TCTTTTTTTTAAATTGGATTTTTAAAAA

hide sequence

RefSeq Acc Id:

XM_039106993 ⟹ XP_038962921

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	66,154,246 - 66,187,505 (+)	NCBI

RefSeq Acc Id:

XR_005503146

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	66,154,246 - 66,187,505 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_620239	(Get FASTA)	NCBI Sequence Viewer
	XP_006236347	(Get FASTA)	NCBI Sequence Viewer
	XP_038962921	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB35916	(Get FASTA)	NCBI Sequence Viewer
	BAA04131	(Get FASTA)	NCBI Sequence Viewer
	BBI47307	(Get FASTA)	NCBI Sequence Viewer
	P31210	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_620239 ⟸ NM_138884

- UniProtKB:

A0A8I5ZSN6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNLSTANHHIPLNDGNSIPIIGLGTYSDPRPVPGKTFIAVKTAIDEGYRHIDGAYVYRNEHEVG
EAIREKVAEGKVKREEIFYCGKLWSTDHDPEMVRPALERTLQTLKLDYIDLYIIEMPMAFKPGE
EFYPKDENGRVIYHKSNLCATWEALEACKDAGLVKSLGVSNFNRRQLEVILNKPGLKYKPVTNQ
VECHPYFTQTKLLEVSASSMTSFIVAYSPLGTCRNPLWVNVSSPPLLKDELLTSLGKKYNKTQA
QIVLRFDIQRGLVVIPKSTTPERIKENFQIFDFSLTKEEMKDIEALNKNVRFVEMLMWSDHPEY
PFHDEY

hide sequence

RefSeq Acc Id:	XP_006236347 ⟸ XM_006236285
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAV5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLNEAVHHSFSYLYDLPIIKVPGKTFIAVKTAIDEGYRHIDGAYVYRNEHEVGEAIREKVAEGK VKREEIFYCGKLWSTDHDPEMVRPALERTLQTLKLDYIDLYIIEMPMAFKPGEEFYPKDENGRV IYHKSNLCATWEALEACKDAGLVKSLGVSNFNRRQLEVILNKPGLKYKPVTNQVECHPYFTQTK LLKFCQQHDIVIVAYSPLGTCRNPLWVNVSSPPLLKDELLTSLGKKYNKTQAQIVLRFDIQRGL VVIPKSTTPERIKENFQIFDFSLTKEEMKDIEALNKNVRFVEMLMWSDHPEYPFHDEY hide sequence

RefSeq Acc Id:

ENSRNOP00000075542 ⟸ ENSRNOT00000083672

RefSeq Acc Id:

ENSRNOP00000017675 ⟸ ENSRNOT00000017675

RefSeq Acc Id:	XP_038962921 ⟸ XM_039106993
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000080261 ⟸ ENSRNOT00000103598

Protein Domains

NADP-dependent oxidoreductase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P31210-F1-model_v2	AlphaFold	P31210	1-326	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692964

Promoter ID:

EPDNEW_R3488

Type:

initiation region

Name:

Akr1d1_1

Description:

aldo-keto reductase family 1, member D1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	65,110,686 - 65,110,746	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620752	AgrOrtholog
BioCyc Gene	G2FUF-45222	BioCyc
Ensembl Genes	ENSRNOG00000013004	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000017675.5	UniProtKB/TrEMBL
	ENSRNOP00000075542	ENTREZGENE
	ENSRNOP00000075542.1	UniProtKB/TrEMBL
	ENSRNOP00000080261	ENTREZGENE
	ENSRNOP00000080261.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017675.8	UniProtKB/TrEMBL
	ENSRNOT00000083672	ENTREZGENE
	ENSRNOT00000083672.2	UniProtKB/TrEMBL
	ENSRNOT00000103598	ENTREZGENE
	ENSRNOT00000103598.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.100	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	AKR1D1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldo/ket_reductase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldo/keto_reductase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NADP_OxRdtase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NADP_OxRdtase_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:192242	UniProtKB/Swiss-Prot
NCBI Gene	192242	ENTREZGENE
PANTHER	ALDO-KETO REDUCTASE FAMILY 1 MEMBER D1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDO/KETO REDUCTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Aldo_ket_red	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Akr1d1	PhenoGen
PIRSF	AKR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	ALDKETRDTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ALDOKETO_REDUCTASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDOKETO_REDUCTASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDOKETO_REDUCTASE_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF51430	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2KAV5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZSN6	ENTREZGENE, UniProtKB/TrEMBL
	AK1D1_RAT	UniProtKB/Swiss-Prot
	F1LML3_RAT	UniProtKB/TrEMBL
	P31210	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-12-18	Akr1d1	aldo-keto reductase family 1, member D1	Akr1d1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Akr1d1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	Akr1d1	aldo-keto reductase family 1, member D1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-12-14	Akr1d1	aldo-keto reductase family 1, member D1		aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	Name updated	1299863	APPROVED
2002-08-07	Akr1d1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	catalyzes the reduction of the delta(4) double bond of bile acid intermediates and steroid hormones carrying the delta(4)-3-one structure in the a/b cis configuration. shows similar activity against both types of substrate	724707

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)