AKR1D1 (aldo-keto reductase family 1 member D1) - Rat Genome Database

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Gene: AKR1D1 (aldo-keto reductase family 1 member D1) Canis lupus familiaris
Analyze
Symbol: AKR1D1
Name: aldo-keto reductase family 1 member D1
RGD ID: 12192650
Description: ENCODES a protein that exhibits 3-oxo-5-beta-steroid 4-dehydrogenase activity (ortholog); INVOLVED IN bile acid biosynthetic process (ortholog); C21-steroid hormone metabolic process (ortholog); cholesterol catabolic process (ortholog); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH congenital bile acid synthesis defect (ortholog); congenital bile acid synthesis defect 2 (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 3-oxo-5-beta-steroid 4-dehydrogenase; 3-oxo-5-beta-steroid 4-dehydrogenase-like; aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase); LOC100683519; LOC102152630; LOC106559797; LOC106559798; LOC482711; LOC491379; stAR-related lipid transfer protein 5-like; uncharacterized LOC100683519; uncharacterized LOC106559797; uncharacterized LOC106559798
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,499,251 - 1,583,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1611,172,153 - 11,677,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01610,254,191 - 10,279,758 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11610,201,202 - 10,250,574 (-)NCBIUMICH_Zoey_3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)

References

Genomics

Comparative Map Data
AKR1D1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,499,251 - 1,583,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1611,172,153 - 11,677,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01610,254,191 - 10,279,758 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11610,201,202 - 10,250,574 (-)NCBIUMICH_Zoey_3.1
AKR1D1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387138,076,459 - 138,118,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7138,002,324 - 138,118,305 (+)EnsemblGRCh38hg38GRCh38
GRCh377137,761,205 - 137,803,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367137,411,736 - 137,453,590 (+)NCBINCBI36Build 36hg18NCBI36
Build 347137,218,450 - 137,260,305NCBI
Celera7132,499,985 - 132,541,839 (+)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7132,069,181 - 132,111,033 (+)NCBIHuRef
CHM1_17137,694,698 - 137,736,587 (+)NCBICHM1_1
T2T-CHM13v2.07139,311,690 - 139,427,796 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27137,106,397 - 137,148,256 (+)NCBI
Akr1d1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39637,506,913 - 37,551,856 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl637,507,108 - 37,545,750 (+)EnsemblGRCm39 Ensembl
GRCm38637,529,978 - 37,574,921 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl637,530,173 - 37,568,815 (+)EnsemblGRCm38mm10GRCm38
MGSCv37637,480,173 - 37,518,815 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36637,459,781 - 37,498,003 (+)NCBIMGSCv36mm8
Celera637,517,252 - 37,556,030 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map616.44NCBI
Akr1d1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8467,121,288 - 67,154,543 (+)NCBIGRCr8
mRatBN7.2466,154,246 - 66,187,505 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl466,154,248 - 66,186,372 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx471,096,251 - 71,129,493 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0467,017,336 - 67,050,578 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0465,407,781 - 65,440,769 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0465,110,706 - 65,143,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl465,110,746 - 65,143,941 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0464,933,143 - 64,965,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4464,972,908 - 65,005,896 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1465,249,037 - 65,282,026 (+)NCBI
Celera461,186,796 - 61,219,854 (+)NCBICelera
Cytogenetic Map4q23NCBI
Akr1d1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554944,799,450 - 4,854,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554944,799,706 - 4,856,100 (-)NCBIChiLan1.0ChiLan1.0
AKR1D1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26174,889,295 - 174,931,548 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1726,899,547 - 26,941,800 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07130,023,017 - 130,076,397 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17142,514,914 - 142,568,052 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7142,525,467 - 142,571,331 (+)Ensemblpanpan1.1panPan2
Akr1d1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511816,696,579 - 16,727,564 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365922,491,681 - 2,522,796 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365922,486,219 - 2,522,796 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1D1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1811,416,068 - 11,531,726 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11811,416,065 - 11,532,846 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21812,091,380 - 12,134,240 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKR1D1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121106,705,197 - 106,822,194 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21106,780,339 - 106,822,696 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660723,643,056 - 3,684,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akr1d1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476518,406,758 - 18,475,918 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476518,406,859 - 18,474,905 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AKR1D1
1187 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6 2 4
Low 3 4 15 5 4 4 8 8 8 3
Below cutoff 2 1 1 1 2 2 3

Sequence


Reference Sequences
RefSeq Acc Id: XM_014119864   ⟹   XP_013975339
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1161,535,643 - 1,583,965 (+)NCBI
Dog10K_Boxer_Tasha1611,172,153 - 11,218,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038452872   ⟹   XP_038308800
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1611,172,153 - 11,677,722 (-)NCBI
RefSeq Acc Id: XM_038452873   ⟹   XP_038308801
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1611,172,153 - 11,218,077 (-)NCBI
RefSeq Acc Id: XM_038452874   ⟹   XP_038308802
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1611,172,153 - 11,228,755 (-)NCBI
RefSeq Acc Id: XM_038498068   ⟹   XP_038353996
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11610,201,202 - 10,250,574 (-)NCBI
RefSeq Acc Id: XM_038688939   ⟹   XP_038544867
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01610,254,191 - 10,279,758 (-)NCBI
RefSeq Acc Id: XM_539827   ⟹   XP_539827
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1161,527,520 - 1,583,965 (+)NCBI
Dog10K_Boxer_Tasha1611,172,153 - 11,228,755 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_539827   ⟸   XM_539827
- Peptide Label: isoform X4
- UniProtKB: A0A8P0NMU5 (UniProtKB/TrEMBL),   A0A8C0LAQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013975339   ⟸   XM_014119864
- Peptide Label: isoform X3
- UniProtKB: A0A8C0N0V8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038353996   ⟸   XM_038498068
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038544867   ⟸   XM_038688939
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038308800   ⟸   XM_038452872
- Peptide Label: isoform X4
- UniProtKB: A0A8P0NMU5 (UniProtKB/TrEMBL),   A0A8C0LAQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038308802   ⟸   XM_038452874
- Peptide Label: isoform X6
- UniProtKB: A0A8C0LAQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038308801   ⟸   XM_038452873
- Peptide Label: isoform X5
- UniProtKB: A0A8C0N0V8 (UniProtKB/TrEMBL)
Protein Domains
NADP-dependent oxidoreductase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029647 UniProtKB/TrEMBL
  ENSCAFG00030012185 UniProtKB/TrEMBL
  ENSCAFG00040014111 UniProtKB/TrEMBL
  ENSCAFG00845011766 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000039234.4 UniProtKB/TrEMBL
  ENSCAFT00000077516.2 UniProtKB/TrEMBL
  ENSCAFT00030022791.1 UniProtKB/TrEMBL
  ENSCAFT00040026269.1 UniProtKB/TrEMBL
  ENSCAFT00845020893.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR UniProtKB/TrEMBL
  AKR1D1 UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
NCBI Gene LOC482711 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER D1 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A8C0LAQ6 ENTREZGENE
  A0A8C0N0V8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RWQ9_CANLF UniProtKB/TrEMBL
  A0A8P0NMU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NW78_CANLF UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 AKR1D1  aldo-keto reductase family 1 member D1  LOC100683519  uncharacterized LOC100683519  Data merged from RGD:12079303 737654 PROVISIONAL
2021-01-14 AKR1D1  aldo-keto reductase family 1 member D1  LOC491379  3-oxo-5-beta-steroid 4-dehydrogenase-like  Data merged from RGD:12121690 737654 PROVISIONAL
2021-01-14 AKR1D1  aldo-keto reductase family 1 member D1  AKR1D1  aldo-keto reductase family 1 member D1  Data merged from RGD:12120126 737654 PROVISIONAL
2021-01-14 AKR1D1  aldo-keto reductase family 1 member D1  LOC102152630  stAR-related lipid transfer protein 5-like  Data merged from RGD:12374240 737654 PROVISIONAL
2021-01-12 AKR1D1  aldo-keto reductase family 1 member D1  LOC482711  3-oxo-5-beta-steroid 4-dehydrogenase  Symbol and/or name change 5135510 APPROVED
2017-11-21 AKR1D1  aldo-keto reductase family 1 member D1  LOC106559797  uncharacterized LOC106559797  Data merged from RGD:12170579 737654 PROVISIONAL
2017-09-12 LOC100683519  uncharacterized LOC100683519    protein FAM32A pseudogene  Symbol and/or name change 5135510 APPROVED
2017-09-12 AKR1D1  aldo-keto reductase family 1 member D1  LOC106559798  uncharacterized LOC106559798  Symbol and/or name change 5135510 APPROVED