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Gene: AKR1D1 (aldo-keto reductase family 1 member D1) Homo sapiens
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Symbol: AKR1D1
Name: aldo-keto reductase family 1 member D1
Description: Predicted to have alditol:NADP+ 1-oxidoreductase activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity. Involved in several processes, including bile acid biosynthetic process; cellular hormone metabolic process; and cholesterol catabolic process. Localizes to cytosol. Implicated in congenital bile acid synthesis defect 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3-oxo-5-beta-steroid 4-dehydrogenase; 3o5bred; aldo-keto reductase family 1, member D1; CBAS2; delta 4-3-ketosteroid-5-beta-reductase; delta(4)-3-ketosteroid 5-beta-reductase; delta(4)-3-oxosteroid 5-beta-reductase; SRD5B1; steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydrogenase beta 1)
Orthologs:
Mus musculus (house mouse) : Akr1d1 (aldo-keto reductase family 1, member D1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Akr1d1 (aldo-keto reductase family 1, member D1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akr1d1 (aldo-keto reductase family 1 member D1)
Pan paniscus (bonobo/pygmy chimpanzee) : AKR1D1 (aldo-keto reductase family 1 member D1)
Canis lupus familiaris (dog) : LOC491379 (3-oxo-5-beta-steroid 4-dehydrogenase-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akr1d1 (aldo-keto reductase family 1 member D1)
Sus scrofa (pig) : AKR1D1 (aldo-keto reductase family 1 member D1)
Chlorocebus sabaeus (African green monkey) : AKR1D1 (aldo-keto reductase family 1 member D1)
Heterocephalus glaber (naked mole-rat) : Akr1d1 (aldo-keto reductase family 1 member D1)
more info ...
Related Pseudogenes: AKR1D1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl7138,002,324 - 138,118,305 (+)EnsemblGRCh38hg38GRCh38
GRCh387138,076,459 - 138,118,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377137,761,178 - 137,803,050 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367137,411,736 - 137,453,590 (+)NCBINCBI36hg18NCBI36
Build 347137,218,450 - 137,260,305NCBI
Celera7132,499,985 - 132,541,839 (+)NCBI
Cytogenetic Map7q33NCBI
HuRef7132,069,181 - 132,111,033 (+)NCBIHuRef
CHM1_17137,694,698 - 137,736,587 (+)NCBICHM1_1
CRA_TCAGchr7v27137,106,397 - 137,148,256 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AKR1D1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736637
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-04-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.