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Gene: Egr4 (early growth response 4) Rattus norvegicus
Symbol: Egr4
Name: early growth response 4
RGD ID: 2546
Description: Exhibits RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to growth factor stimulus and positive regulation of transcription by RNA polymerase II. Predicted to localize to nuclear chromatin. Biomarker of middle cerebral artery infarction. Orthologous to human EGR4 (early growth response 4); INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
Also known as: early growth response protein 4; early response protein NGFI-C; EGR-4; Egr4l1; nerve growth factor-induced protein C; NGFI-C; zinc-finger transcription factor NGFI-C; zinc-finger transcription factor NGFI-C (early response gene); Zinc-finger transcription factor NGFI-C (early response gene) member of the GCGGGGGCG (GSG) element-binding protein family see D4Arb6; Zinc-finger transcription factor NGFI-C (early response gene), member of the GCGGGGGCG (GSG) element-binding protein family, see D4Arb6
Homo sapiens (human) : EGR4 (early growth response 4)  HGNC  Alliance
Mus musculus (house mouse) : Egr4 (early growth response 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egr4 (early growth response 4)
Pan paniscus (bonobo/pygmy chimpanzee) : EGR4 (early growth response 4)
Canis lupus familiaris (dog) : EGR4 (early growth response 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egr4 (early growth response 4)
Sus scrofa (pig) : EGR4 (early growth response 4)
Chlorocebus sabaeus (African green monkey) : EGR4 (early growth response 4)
Heterocephalus glaber (naked mole-rat) : Egr4 (early growth response 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04117,293,620 - 117,296,082 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,293,620 - 117,296,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04181,870,041 - 181,872,503 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44119,765,289 - 119,767,612 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,009,769 - 120,012,093 (-)NCBI
Celera4107,029,479 - 107,031,938 (-)NCBICelera
Cytogenetic Map4q34NCBI
RH 3.4 Map4690.8RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Egr4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2546
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.