Il5ra (interleukin 5 receptor subunit alpha) - Rat Genome Database

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Gene: Il5ra (interleukin 5 receptor subunit alpha) Rattus norvegicus
Analyze
Symbol: Il5ra
Name: interleukin 5 receptor subunit alpha
RGD ID: 70938
Description: Predicted to enable interleukin-5 receptor activity. Predicted to be involved in immunoglobulin mediated immune response and interleukin-5-mediated signaling pathway. Predicted to act upstream of or within inflammatory response to antigenic stimulus and regulation of interleukin-5 production. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5RA (interleukin 5 receptor subunit alpha); PARTICIPATES IN interleukin-5 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH all-trans-retinoic acid; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interleukin 5 receptor, alpha; interleukin-5 receptor subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84141,186,749 - 141,221,348 (-)NCBIGRCr8
mRatBN7.24139,630,652 - 139,664,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4139,632,066 - 139,668,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4145,061,194 - 145,092,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04140,841,888 - 140,872,856 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04139,485,817 - 139,516,790 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04138,796,165 - 138,834,164 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4138,795,327 - 138,830,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04203,264,446 - 203,298,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44142,067,108 - 142,098,051 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14142,311,948 - 142,342,892 (-)NCBI
Celera4128,345,037 - 128,375,976 (-)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. Busse WW, etal., J Allergy Clin Immunol. 2010 Jun;125(6):1237-1244.e2.
2. Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. Cheong HS, etal., J Hum Genet. 2005;50(12):628-34. Epub 2005 Oct 6.
3. Regulation of IL-5 and IL-5 receptor expression in the bone marrow of allergic asthmatics. Denburg JA, etal., Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):101-3.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis. Gevaert P, etal., Allergy. 2003 May;58(5):371-9.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Systemic eosinophil response induced by respiratory syncytial virus. Lindemans CA, etal., Clin Exp Immunol. 2006 Jun;144(3):409-17.
8. Effect of interleukin-5 receptor-alpha short hairpin RNA-expressing vector on bone marrow eosinophilopoiesis in asthmatic mice. Mao H, etal., Adv Ther. 2006 Nov-Dec;23(6):938-56.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Eosinophilic bronchitis, eosinophilia associated genetic variants, and notch signaling in asthma. Park CS Allergy Asthma Immunol Res. 2010 Jul;2(3):188-94. Epub 2010 May 17.
13. Cloning of the rat IL-5Ralpha gene: analysis of 5'-upstream region and expression by B cells. Pierrot C, etal., Biochem Biophys Res Commun 2001 Oct 26;288(2):328-39.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Soluble interleukin-5 receptor alpha is increased in acute exacerbation of chronic obstructive pulmonary disease. Rohde G, etal., Int Arch Allergy Immunol. 2004 Sep;135(1):54-61. Epub 2004 Jul 29.
19. Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency. Saito H, etal., J Immunol. 2002 Mar 15;168(6):3017-23.
20. Allergen-induced airway inflammation and bronchial responsiveness in interleukin-5 receptor alpha chain-deficient mice. Tanaka H, etal., Clin Exp Allergy. 2000 Jun;30(6):874-81.
21. IL-5 receptor alpha levels in patients with marked eosinophilia or mastocytosis. Wilson TM, etal., J Allergy Clin Immunol. 2011 Nov;128(5):1086-92.e1-3. doi: 10.1016/j.jaci.2011.05.032. Epub 2011 Jul 16.
Additional References at PubMed
PMID:28132394  


Genomics

Comparative Map Data
Il5ra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84141,186,749 - 141,221,348 (-)NCBIGRCr8
mRatBN7.24139,630,652 - 139,664,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4139,632,066 - 139,668,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4145,061,194 - 145,092,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04140,841,888 - 140,872,856 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04139,485,817 - 139,516,790 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04138,796,165 - 138,834,164 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4138,795,327 - 138,830,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04203,264,446 - 203,298,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44142,067,108 - 142,098,051 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14142,311,948 - 142,342,892 (-)NCBI
Celera4128,345,037 - 128,375,976 (-)NCBICelera
Cytogenetic Map4q41NCBI
IL5RA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3833,066,324 - 3,110,374 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl33,066,324 - 3,126,613 (-)EnsemblGRCh38hg38GRCh38
GRCh3733,108,008 - 3,152,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3633,086,421 - 3,127,031 (-)NCBINCBI36Build 36hg18NCBI36
Build 3433,106,856 - 3,127,031NCBI
Celera33,050,635 - 3,091,288 (-)NCBICelera
Cytogenetic Map3p26.2NCBI
HuRef33,042,189 - 3,086,251 (-)NCBIHuRef
CHM1_133,057,999 - 3,102,013 (-)NCBICHM1_1
T2T-CHM13v2.033,060,643 - 3,104,729 (-)NCBIT2T-CHM13v2.0
Il5ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396106,687,336 - 106,725,998 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6106,687,318 - 106,725,998 (-)EnsemblGRCm39 Ensembl
GRCm386106,710,375 - 106,749,037 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6106,710,357 - 106,749,037 (-)EnsemblGRCm38mm10GRCm38
MGSCv376106,660,369 - 106,699,031 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366106,676,152 - 106,714,814 (-)NCBIMGSCv36mm8
Celera6108,526,308 - 108,566,269 (-)NCBICelera
Cytogenetic Map6E1NCBI
cM Map649.19NCBI
Il5ra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542110,221,694 - 10,259,885 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542110,211,594 - 10,259,760 (+)NCBIChiLan1.0ChiLan1.0
IL5RA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v223,063,000 - 3,103,991 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan133,067,759 - 3,132,152 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v033,009,780 - 3,051,604 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.133,112,355 - 3,156,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl33,112,355 - 3,156,282 (-)Ensemblpanpan1.1panPan2
IL5RA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12014,309,805 - 14,349,433 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2014,314,227 - 14,343,793 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2014,274,082 - 14,309,507 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02014,340,643 - 14,376,680 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2014,340,517 - 14,375,235 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12014,042,324 - 14,077,731 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02014,376,619 - 14,412,004 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02014,367,796 - 14,403,236 (+)NCBIUU_Cfam_GSD_1.0
Il5ra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049429,821,165 - 9,841,919 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365772,776,721 - 2,797,300 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365772,776,608 - 2,797,303 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL5RA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1359,652,271 - 59,690,176 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11359,651,184 - 59,692,211 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21365,950,136 - 65,987,845 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL5RA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12239,156,711 - 39,199,394 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2239,158,023 - 39,192,861 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041127,504,673 - 127,547,396 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il5ra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477313,311,583 - 13,347,315 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477313,309,888 - 13,347,318 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il5ra
183 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:67
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000008403
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat

Markers in Region
D4Rat274  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24139,648,159 - 139,648,368 (+)MAPPERmRatBN7.2
Rnor_6.04138,813,963 - 138,814,171NCBIRnor6.0
Rnor_5.04203,281,978 - 203,282,186UniSTSRnor5.0
RGSC_v3.44142,082,241 - 142,082,450RGDRGSC3.4
RGSC_v3.44142,082,242 - 142,082,450UniSTSRGSC3.4
RGSC_v3.14142,327,082 - 142,327,291RGD
Celera4128,360,191 - 128,360,399UniSTS
SHRSP x BN Map463.41RGD
SHRSP x BN Map463.41UniSTS
Cytogenetic Map4q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 3 7 39 65 69 39 25 39 6 101 46 24 5 41 30

Sequence


Ensembl Acc Id: ENSRNOT00000008403   ⟹   ENSRNOP00000008403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4139,632,066 - 139,668,544 (-)Ensembl
Rnor_6.0 Ensembl4138,795,327 - 138,830,117 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117395   ⟹   ENSRNOP00000085475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4139,632,066 - 139,668,544 (-)Ensembl
RefSeq Acc Id: NM_053645   ⟹   NP_446097
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84141,189,122 - 141,220,065 (-)NCBI
mRatBN7.24139,633,025 - 139,663,969 (-)NCBI
Rnor_6.04138,798,829 - 138,829,772 (-)NCBI
Rnor_5.04203,264,446 - 203,298,645 (-)NCBI
RGSC_v3.44142,067,108 - 142,098,051 (-)RGD
Celera4128,345,037 - 128,375,976 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236977   ⟹   XP_006237039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84141,186,749 - 141,221,348 (-)NCBI
mRatBN7.24139,630,652 - 139,664,593 (-)NCBI
Rnor_6.04138,796,165 - 138,834,164 (-)NCBI
Rnor_5.04203,264,446 - 203,298,645 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_446097 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237039 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK97344 (Get FASTA)   NCBI Sequence Viewer  
  BAB32866 (Get FASTA)   NCBI Sequence Viewer  
  EDL91469 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008403.2
  ENSRNOP00000085475.1
RefSeq Acc Id: NP_446097   ⟸   NM_053645
- Peptide Label: precursor
- UniProtKB: Q99PS3 (UniProtKB/TrEMBL),   A6IBK1 (UniProtKB/TrEMBL),   Q920B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237039   ⟸   XM_006236977
- Peptide Label: isoform X1
- UniProtKB: G3V6S7 (UniProtKB/TrEMBL),   A6IBK1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008403   ⟸   ENSRNOT00000008403
Ensembl Acc Id: ENSRNOP00000085475   ⟸   ENSRNOT00000117395
Protein Domains
Type I cytokine receptor cytokine-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6S7-F1-model_v2 AlphaFold G3V6S7 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70938 AgrOrtholog
BioCyc Gene G2FUF-43467 BioCyc
Ensembl Genes ENSRNOG00000005954 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008403.4 UniProtKB/TrEMBL
  ENSRNOT00000117395.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  IL6_recept-bd UniProtKB/TrEMBL
  Short_hematopoietin_rcpt_2_CS UniProtKB/TrEMBL
KEGG Report rno:114103 UniProtKB/TrEMBL
NCBI Gene 114103 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  INTERLEUKIN-21 RECEPTOR UniProtKB/TrEMBL
Pfam IL6Ra-bind UniProtKB/TrEMBL
PhenoGen Il5ra PhenoGen
PROSITE HEMATOPO_REC_S_F2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005954 RatGTEx
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt A0A8I6A448_RAT UniProtKB/TrEMBL
  A6IBK1 ENTREZGENE, UniProtKB/TrEMBL
  G3V6S7 ENTREZGENE, UniProtKB/TrEMBL
  Q920B8 ENTREZGENE, UniProtKB/TrEMBL
  Q99PS3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il5ra  interleukin 5 receptor subunit alpha  Il5ra  interleukin 5 receptor, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Il5ra  interleukin 5 receptor, alpha      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an extracellular domain, one transmembrane segment and a cytoplasmic domain 70772
gene_expression expressed in the lung, spleen, liver, and purified rat B cells 70772
gene_transcript cDNA 25 kb and has 12 exons 70772