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Gene: Edem1 (ER degradation enhancing alpha-mannosidase like protein 1) Rattus norvegicus
Symbol: Edem1
Name: ER degradation enhancing alpha-mannosidase like protein 1
Description: Predicted to have mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Predicted to be involved in mannose trimming involved in glycoprotein ERAD pathway; positive regulation of retrograde protein transport, ER to cytosol; and trimming of terminal mannose on C branch. Predicted to localize to the aggresome; endoplasmic reticulum; and integral component of endoplasmic reticulum membrane. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ER degradation enhancer, mannosidase alpha-like 1; ER degradation-enhancing alpha-mannosidase-like 1; ER degradation-enhancing alpha-mannosidase-like protein 1; LOC297504; RGD1563633; similar to mKIAA0212 protein
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04140,886,644 - 140,918,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04217,499,472 - 217,532,312 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44144,349,966 - 144,379,501 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4130,450,129 - 130,482,057 (+)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Edem1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1563633
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.