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Gene: Nrf1 (nuclear respiratory factor 1) Rattus norvegicus
Symbol: Nrf1
Name: nuclear respiratory factor 1
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including response to estradiol; response to folic acid; and response to lipopolysaccharide. Localizes to the cytoplasm and nucleus. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human NRF1 (nuclear respiratory factor 1); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH (R)-noradrenaline; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol.
Type: protein-coding
Also known as: alpha palindromic-binding protein; alpha-pal; LOC312195; Nfe2l1_retired; NRF-1; nuclear factor (erythroid-derived 2)-like 1; nuclear respiratory factor-1
Homo sapiens (human) : NRF1 (nuclear respiratory factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Nrf1 (nuclear respiratory factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nrf1 (nuclear respiratory factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NRF1 (nuclear respiratory factor 1)
Canis lupus familiaris (dog) : NRF1 (nuclear respiratory factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nrf1 (nuclear respiratory factor 1)
Sus scrofa (pig) : NRF1 (nuclear respiratory factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0457,335,732 - 57,445,317 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0457,097,471 - 57,207,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,949,553 - 57,048,149 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1457,267,163 - 57,331,137 (+)NCBI
Celera453,766,265 - 53,861,921 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Nrf1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1304603
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-06-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.