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Gene: Nrf1 (nuclear respiratory factor 1) Rattus norvegicus
Symbol: Nrf1
Name: nuclear respiratory factor 1
RGD ID: 1304603
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including response to estradiol; response to folic acid; and response to lipopolysaccharide. Localizes to cytoplasm and nucleus. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human NRF1 (nuclear respiratory factor 1); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 17beta-estradiol.
Type: protein-coding
Also known as: alpha palindromic-binding protein; alpha-pal; LOC312195; Nfe2l1_retired; NRF-1; nuclear factor (erythroid-derived 2)-like 1; nuclear respiratory factor-1
Homo sapiens (human) : NRF1 (nuclear respiratory factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Nrf1 (nuclear respiratory factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nrf1 (nuclear respiratory factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NRF1 (nuclear respiratory factor 1)
Canis lupus familiaris (dog) : NRF1 (nuclear respiratory factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nrf1 (nuclear respiratory factor 1)
Sus scrofa (pig) : NRF1 (nuclear respiratory factor 1)
Chlorocebus sabaeus (African green monkey) : NRF1 (nuclear respiratory factor 1)
Heterocephalus glaber (naked mole-rat) : Nrf1 (nuclear respiratory factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0457,335,732 - 57,445,317 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl457,378,069 - 57,445,341 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0457,097,471 - 57,207,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,949,553 - 57,048,149 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1457,267,163 - 57,331,137 (+)NCBI
Celera453,766,265 - 53,861,921 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Nrf1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1304603
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.