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Gene: Tlx2 (T-cell leukemia homeobox 2) Rattus norvegicus
Symbol: Tlx2
Name: T-cell leukemia homeobox 2
RGD ID: 1595506
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including mesoderm formation; nervous system development; and positive regulation of transcription by RNA polymerase II. Predicted to localize to cytoplasm and nucleus. Orthologous to human TLX2 (T cell leukemia homeobox 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Hox11L.1; LOC680117; similar to T-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Homeobox TLX-2) (PMUR10F); T-cell leukemia, homeobox 2
Homo sapiens (human) : TLX2 (T cell leukemia homeobox 2)  HGNC  Alliance
Mus musculus (house mouse) : Tlx2 (T cell leukemia, homeobox 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlx2 (T cell leukemia homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TLX2 (T cell leukemia homeobox 2)
Canis lupus familiaris (dog) : TLX2 (T cell leukemia homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlx2 (T cell leukemia homeobox 2)
Sus scrofa (pig) : TLX2 (T cell leukemia homeobox 2)
Chlorocebus sabaeus (African green monkey) : TLX2 (T cell leukemia homeobox 2)
Heterocephalus glaber (naked mole-rat) : Tlx2 (T cell leukemia homeobox 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04114,766,401 - 114,768,243 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,766,714 - 114,768,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,900,556 - 113,902,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,585,662 - 178,587,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,279,091 - 117,281,693 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4104,568,477 - 104,570,295 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tlx2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1595506
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.