Pax4 (paired box 4) - Rat Genome Database

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Gene: Pax4 (paired box 4) Rattus norvegicus
Analyze
Symbol: Pax4
Name: paired box 4
RGD ID: 620433
Description: Enables double-stranded DNA binding activity. Involved in several processes, including negative regulation of DNA-templated transcription; response to cAMP; and retina development in camera-type eye. Predicted to be located in nucleus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in diabetic ketoacidosis; maturity-onset diabetes of the young type 9; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human PAX4 (paired box 4); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: paired box gene 4; paired box protein Pax-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,023,873 - 58,032,265 (-)NCBIGRCr8
mRatBN7.2457,058,453 - 57,065,995 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,058,462 - 57,063,408 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx462,041,683 - 62,046,628 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0457,957,636 - 57,962,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0456,359,732 - 56,364,677 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0455,735,640 - 55,753,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl455,735,682 - 55,740,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0455,483,073 - 55,501,087 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4455,313,500 - 55,318,995 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1455,563,656 - 55,569,152 (-)NCBI
Celera452,169,993 - 52,174,904 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Biason-Lauber A, etal., Diabetologia. 2005 May;48(5):900-5. Epub 2005 Apr 15.
2. The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells. Brun T, etal., Oncogene. 2007 Jun 21;26(29):4261-71. Epub 2007 Jan 29.
3. Inhibitory effect of pax4 on the human insulin and islet amyloid polypeptide (IAPP) promoters. Campbell SC, etal., FEBS Lett 1999 Dec 10;463(1-2):53-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. PAX4 gene variations predispose to ketosis-prone diabetes. Mauvais-Jarvis F, etal., Hum Mol Genet. 2004 Dec 15;13(24):3151-9. Epub 2004 Oct 27.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PAX4 mutations in Thais with maturity onset diabetes of the young. Plengvidhya N, etal., J Clin Endocrinol Metab. 2007 Jul;92(7):2821-6. Epub 2007 Apr 10.
11. Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signaling. Rath MF, etal., Endocrinology. 2009 Feb;150(2):803-11. Epub 2008 Sep 25.
12. Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells. Rath MF, etal., J Neurochem. 2009 Jan;108(1):285-94. Epub 2008 Nov 19.
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. PAX4 mutation (R121W) as a prodiabetic variant in Okinawans. Shimajiri Y, etal., Biochem Biophys Res Commun. 2003 Mar 7;302(2):342-4.
16. Molecular cloning of rat Pax4: identification of four isoforms in rat insulinoma cells. Tokuyama Y, etal., Biochem Biophys Res Commun 1998 Jul 9;248(1):153-6.
Additional References at PubMed
PMID:10567552   PMID:14729487   PMID:14970313   PMID:15596543   PMID:15930104   PMID:16732298   PMID:21734788  


Genomics

Comparative Map Data
Pax4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,023,873 - 58,032,265 (-)NCBIGRCr8
mRatBN7.2457,058,453 - 57,065,995 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,058,462 - 57,063,408 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx462,041,683 - 62,046,628 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0457,957,636 - 57,962,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0456,359,732 - 56,364,677 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0455,735,640 - 55,753,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl455,735,682 - 55,740,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0455,483,073 - 55,501,087 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4455,313,500 - 55,318,995 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1455,563,656 - 55,569,152 (-)NCBI
Celera452,169,993 - 52,174,904 (-)NCBICelera
Cytogenetic Map4q22NCBI
PAX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387127,610,292 - 127,618,142 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7127,610,292 - 127,618,142 (-)EnsemblGRCh38hg38GRCh38
GRCh377127,250,346 - 127,258,196 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367127,037,582 - 127,043,016 (-)NCBINCBI36Build 36hg18NCBI36
Build 347126,844,296 - 126,849,731NCBI
Celera7122,054,068 - 122,059,509 (-)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7121,611,239 - 121,616,685 (-)NCBIHuRef
CHM1_17127,183,648 - 127,189,085 (-)NCBICHM1_1
T2T-CHM13v2.07128,921,978 - 128,929,835 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27126,633,785 - 126,639,226 (-)NCBI
Pax4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39628,442,333 - 28,449,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl628,442,333 - 28,449,352 (-)EnsemblGRCm39 Ensembl
GRCm38628,442,334 - 28,449,340 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl628,442,334 - 28,449,353 (-)EnsemblGRCm38mm10GRCm38
MGSCv37628,392,334 - 28,399,340 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36628,392,350 - 28,399,285 (-)NCBIMGSCv36mm8
Celera628,449,374 - 28,456,380 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map611.99NCBI
Pax4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554798,660,089 - 8,664,463 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554798,660,089 - 8,664,463 (-)NCBIChiLan1.0ChiLan1.0
PAX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26164,469,513 - 164,483,506 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1716,479,764 - 16,492,993 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07119,605,924 - 119,613,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17132,260,859 - 132,266,384 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7132,260,859 - 132,268,516 (-)Ensemblpanpan1.1panPan2
PAX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,714,251 - 8,719,387 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,714,949 - 8,719,371 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha148,405,492 - 8,412,207 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0148,486,208 - 8,492,923 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,486,089 - 8,492,911 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,690,433 - 8,697,148 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,424,792 - 8,431,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0148,578,658 - 8,585,374 (+)NCBIUU_Cfam_GSD_1.0
Pax4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511853,683,725 - 53,724,528 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647914,807,538 - 14,812,575 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647914,807,503 - 14,812,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1820,673,114 - 20,680,287 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11820,675,874 - 20,680,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21821,676,916 - 21,683,984 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12196,425,496 - 96,435,846 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2196,425,656 - 96,429,874 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660426,977,047 - 6,981,546 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pax4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247838,340,098 - 8,344,371 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247838,340,098 - 8,344,371 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pax4
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:80
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000010658, ENSRNOT00000052386
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)44917811657114705Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 1 5 91 34 34 20 6 20 2 53 17 86 6 40 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF198155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF198156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010658   ⟹   ENSRNOP00000010658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl457,058,462 - 57,063,408 (-)Ensembl
Rnor_6.0 Ensembl455,735,682 - 55,740,627 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113994   ⟹   ENSRNOP00000082503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl457,058,462 - 57,063,408 (-)Ensembl
RefSeq Acc Id: NM_031799   ⟹   NP_113987
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,023,914 - 58,028,858 (-)NCBI
mRatBN7.2457,058,462 - 57,063,408 (-)NCBI
Rnor_6.0455,735,682 - 55,740,627 (-)NCBI
Rnor_5.0455,483,073 - 55,501,087 (-)NCBI
RGSC_v3.4455,313,500 - 55,318,995 (-)RGD
Celera452,169,993 - 52,174,904 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236232   ⟹   XP_006236294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,023,873 - 58,032,265 (-)NCBI
mRatBN7.2457,058,453 - 57,065,995 (-)NCBI
Rnor_6.0455,735,640 - 55,753,461 (-)NCBI
Rnor_5.0455,483,073 - 55,501,087 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063286762   ⟹   XP_063142832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,023,873 - 58,028,906 (-)NCBI
RefSeq Acc Id: NP_113987   ⟸   NM_031799
- UniProtKB: O88436 (UniProtKB/Swiss-Prot),   O88438 (UniProtKB/Swiss-Prot),   O88437 (UniProtKB/Swiss-Prot),   O88439 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236294   ⟸   XM_006236232
- Peptide Label: isoform X1
- UniProtKB: O88436 (UniProtKB/Swiss-Prot),   O88438 (UniProtKB/Swiss-Prot),   O88437 (UniProtKB/Swiss-Prot),   O88439 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010658   ⟸   ENSRNOT00000010658
Ensembl Acc Id: ENSRNOP00000082503   ⟸   ENSRNOT00000113994
RefSeq Acc Id: XP_063142832   ⟸   XM_063286762
- Peptide Label: isoform X2
Protein Domains
Homeobox   Paired

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88436-F1-model_v2 AlphaFold O88436 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620433 AgrOrtholog
BioCyc Gene G2FUF-45419 BioCyc
Ensembl Genes ENSRNOG00000008020 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010658.7 UniProtKB/Swiss-Prot
  ENSRNOT00000113994.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAIRED_DNA-bd_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Paired_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAX_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83630 UniProtKB/Swiss-Prot
NCBI Gene 83630 ENTREZGENE
PANTHER PAIRED BOX PROTEIN PAX-4 UniProtKB/TrEMBL
  PAIRED BOX PROTEIN PAX-6-RELATED-RELATED UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  PTHR45636:SF8 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pax4 PhenoGen
PRINTS PAIREDBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAIRED_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAIRED_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008020 RatGTEx
  ENSRNOG00055021207 RatGTEx
  ENSRNOG00060028214 RatGTEx
  ENSRNOG00065024865 RatGTEx
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IEA9_RAT UniProtKB/TrEMBL
  A6IEB0_RAT UniProtKB/TrEMBL
  O88436 ENTREZGENE
  O88437 ENTREZGENE
  O88438 ENTREZGENE
  O88439 ENTREZGENE
  PAX4_RAT UniProtKB/Swiss-Prot
UniProt Secondary O88437 UniProtKB/Swiss-Prot
  O88438 UniProtKB/Swiss-Prot
  O88439 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-30 Pax4  paired box 4  Pax4  paired box gene 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pax4  paired box gene 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pax4  paired box gene 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in pancreatic islets 729525