Aoc1 (amine oxidase, copper containing 1) - Rat Genome Database

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Gene: Aoc1 (amine oxidase, copper containing 1) Rattus norvegicus
Analyze
Symbol: Aoc1
Name: amine oxidase, copper containing 1
RGD ID: 61296
Description: Enables diamine oxidase activity and organic cyclic compound binding activity. Involved in cellular response to copper ion starvation and response to antibiotic. Acts upstream of or within amiloride transport. Located in bicellular tight junction. Orthologous to human AOC1 (amine oxidase copper containing 1); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH (R)-adrenaline; (S)-timolol (anhydrous); 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abp; Abp1; amiloride binding protein 1; amiloride binding protein 1 (amine oxidase, copper-containing); amiloride-binding protein; amiloride-binding protein 1; amiloride-sensitive amine oxidase; amiloride-sensitive amine oxidase [copper-containing]; amine oxidase copper domain-containing protein 1; DAO; diamine oxidase; histaminase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp45   Bw10  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2477,812,260 - 77,831,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,812,260 - 77,831,840 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx483,019,777 - 83,039,389 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0478,795,250 - 78,814,860 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0477,235,544 - 77,255,152 (+)NCBIRnor_WKY
Rnor_6.0478,496,043 - 78,515,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,496,043 - 78,515,584 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04143,183,686 - 143,203,225 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4476,957,477 - 76,977,643 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1477,247,444 - 77,253,779 (+)NCBI
Celera472,749,277 - 72,768,814 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
(S)-timolol (anhydrous)  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
amiloride  (EXP,ISO)
aminoguanidine  (EXP,ISO)
ammonium chloride  (EXP)
Benzamil  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
chloroprene  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
ethylisopropylamiloride  (EXP,ISO)
folic acid  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (ISO)
histamine  (ISO)
hydralazine  (ISO)
isoprenaline  (EXP)
L-methionine  (ISO)
methotrexate  (EXP,ISO)
N(tele)-methylhistamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
Phenylamil  (EXP,ISO)
PhIP  (EXP)
pirinixic acid  (EXP)
putrescine  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
spermidine  (EXP)
tacrolimus hydrate  (ISO)
terbutaline  (EXP)
theophylline  (EXP,ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
trimellitic anhydride  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Inhibition of diamine oxidase activity by metronidazole. Befani O, etal., Biochem Biophys Res Commun. 1995 Jul 17;212(2):589-94.
2. Plasma diamine oxidase activities in renal dialysis patients, a human with spontaneous copper deficiency and marginally copper deficient rats. DiSilvestro RA, etal., Clin Biochem. 1997 Oct;30(7):559-63.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Ippolito JE, etal., Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12505-10. Epub 2006 Aug 8.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat. Kojima H, etal., Biochem Biophys Res Commun. 1992 Jul 15;186(1):398-404.
8. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
9. Molecular cloning and functional expression of different molecular forms of rat amiloride-binding proteins. Lingueglia E, etal., Eur J Biochem 1993 Sep 1;216(2):679-87.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Effects of cardiopulmonary bypass on tight junction protein expressions in intestinal mucosa of rats. Sun YJ, etal., World J Gastroenterol. 2008 Oct 14;14(38):5868-75.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2217167   PMID:8023885   PMID:8144586   PMID:12072962   PMID:12477932   PMID:16846222   PMID:19764817   PMID:21082674   PMID:22024144   PMID:23376485   PMID:23413254   PMID:23533145  


Genomics

Comparative Map Data
Aoc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2477,812,260 - 77,831,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,812,260 - 77,831,840 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx483,019,777 - 83,039,389 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0478,795,250 - 78,814,860 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0477,235,544 - 77,255,152 (+)NCBIRnor_WKY
Rnor_6.0478,496,043 - 78,515,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,496,043 - 78,515,584 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04143,183,686 - 143,203,225 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4476,957,477 - 76,977,643 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1477,247,444 - 77,253,779 (+)NCBI
Celera472,749,277 - 72,768,814 (+)NCBICelera
Cytogenetic Map4q24NCBI
AOC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,852,120 - 150,861,504 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7150,824,627 - 150,861,504 (+)EnsemblGRCh38hg38GRCh38
GRCh377150,549,605 - 150,558,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,180,506 - 150,189,312 (+)NCBINCBI36Build 36hg18NCBI36
Build 347149,987,239 - 149,996,025NCBI
Celera7145,106,596 - 145,115,402 (+)NCBICelera
Cytogenetic Map7q36.1ENTREZGENE
HuRef7144,361,610 - 144,370,427 (+)NCBIHuRef
CHM1_17150,557,803 - 150,566,593 (+)NCBICHM1_1
T2T-CHM13v2.07152,025,287 - 152,034,270 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,878,851 - 149,887,665 (+)NCBI
Aoc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39648,872,189 - 48,886,122 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl648,849,830 - 48,886,122 (+)EnsemblGRCm39 Ensembl
GRCm38648,895,255 - 48,909,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl648,872,896 - 48,909,188 (+)EnsemblGRCm38mm10GRCm38
MGSCv37648,845,254 - 48,859,186 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36648,824,840 - 48,838,774 (+)NCBIMGSCv36mm8
Celera649,405,009 - 49,418,946 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map623.78NCBI
Aoc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,316,476 - 5,326,305 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,316,482 - 5,326,262 (+)NCBIChiLan1.0ChiLan1.0
AOC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17154,586,931 - 154,595,248 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,563,523 - 154,595,248 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07142,434,732 - 142,443,050 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AOC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11614,955,528 - 14,963,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1614,958,658 - 15,036,651 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,563,706 - 15,571,546 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,671,139 - 16,678,130 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11615,049,911 - 15,057,763 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,631,448 - 15,639,287 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,681,981 - 15,689,844 (+)NCBIUU_Cfam_GSD_1.0
Aoc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,590,547 - 6,597,512 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,308,682 - 6,312,815 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365276,309,210 - 6,312,869 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AOC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,309,594 - 6,320,974 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,309,583 - 6,321,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,738,053 - 6,749,392 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AOC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,037,498 - 119,046,875 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,038,356 - 119,047,279 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,014,229 - 15,018,767 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aoc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,739,034 - 5,749,608 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,739,076 - 5,749,567 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aoc1
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:47
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000059136
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)457114432102114432Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat

Markers in Region
RH128193  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2477,831,492 - 77,831,672 (+)MAPPERmRatBN7.2
Rnor_6.0478,515,230 - 78,515,409NCBIRnor6.0
Rnor_5.04143,202,873 - 143,203,052UniSTSRnor5.0
RGSC_v3.4476,977,295 - 76,977,474UniSTSRGSC3.4
Celera472,768,466 - 72,768,645UniSTS
RH 3.4 Map4499.61UniSTS
Cytogenetic Map4q24UniSTS
RH129281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2477,824,783 - 77,824,966 (+)MAPPERmRatBN7.2
Rnor_6.0478,508,521 - 78,508,703NCBIRnor6.0
Rnor_5.04143,196,164 - 143,196,346UniSTSRnor5.0
RGSC_v3.4476,970,586 - 76,970,768UniSTSRGSC3.4
Celera472,761,757 - 72,761,939UniSTS
Cytogenetic Map4q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 6 6 1
Low 10 8 13 8 22 17 10
Below cutoff 6 18 17 17 1 22 12 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000059136   ⟹   ENSRNOP00000055909
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl477,812,260 - 77,831,840 (+)Ensembl
Rnor_6.0 Ensembl478,496,043 - 78,515,577 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082905   ⟹   ENSRNOP00000070272
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl478,513,459 - 78,515,584 (+)Ensembl
RefSeq Acc Id: NM_022935   ⟹   NP_075224
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2477,812,260 - 77,831,841 (+)NCBI
Rnor_6.0478,496,043 - 78,515,578 (+)NCBI
Rnor_5.04143,183,686 - 143,203,225 (+)NCBI
RGSC_v3.4476,957,477 - 76,977,643 (+)RGD
Celera472,749,277 - 72,768,814 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236471   ⟹   XP_006236533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2477,827,740 - 77,831,846 (+)NCBI
Rnor_6.0478,509,121 - 78,515,582 (+)NCBI
Rnor_5.04143,183,686 - 143,203,225 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075224   ⟸   NM_022935
- Peptide Label: precursor
- UniProtKB: Q498N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236533   ⟸   XM_006236471
- Peptide Label: isoform X1
- UniProtKB: Q498N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070272   ⟸   ENSRNOT00000082905
RefSeq Acc Id: ENSRNOP00000055909   ⟸   ENSRNOT00000059136
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36633-F1-model_v2 AlphaFold P36633 1-746 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61296 AgrOrtholog
BioCyc Gene G2FUF-44935 BioCyc
BioCyc Pathway PWY-6181 [histamine degradation] BioCyc
Ensembl Genes ENSRNOG00000008575 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000055909 ENTREZGENE
  ENSRNOP00000055909.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059136 ENTREZGENE
  ENSRNOT00000059136.3 UniProtKB/TrEMBL
Gene3D-CATH 2.70.98.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7460184 IMAGE-MGC_LOAD
InterPro Cu_amine_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidase_N-reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidase_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidase_N3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65029 UniProtKB/TrEMBL
MGC_CLONE MGC:114316 IMAGE-MGC_LOAD
NCBI Gene 65029 ENTREZGENE
PANTHER PTHR10638 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cu_amine_oxid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aoc1 PhenoGen
PRINTS CUDAOXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE COPPER_AMINE_OXID_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COPPER_AMINE_OXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49998 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54416 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219547
UniProt AOC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q498N2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q63973 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Aoc1  amine oxidase, copper containing 1  Abp1  amiloride binding protein 1 (amine oxidase, copper-containing)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Abp1  amiloride binding protein 1 (amine oxidase, copper-containing)    amiloride binding protein 1  Name updated 1299863 APPROVED
2001-06-22 Abp1  Amiloride binding protein 1      Symbol and Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-22 Abp  Amiloride binding protein      Symbol and Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the degradation of compounds such as putrescine or histamine 724707
gene_mapping mapped between Lyp and Npy genes, 0.2 cM distal to Lyp 631162