Irak2 (interleukin-1 receptor-associated kinase 2)

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Gene: Irak2 (interleukin-1 receptor-associated kinase 2) Rattus norvegicus

Analyze

Symbol:

Irak2

Name:

interleukin-1 receptor-associated kinase 2

RGD ID:

1309584

Description:

Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including interleukin-1-mediated signaling pathway; regulation of DNA-binding transcription factor activity; and regulation of cytokine-mediated signaling pathway. Predicted to act upstream of or within lipopolysaccharide-mediated signaling pathway and negative regulation of DNA-binding transcription factor activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human IRAK2 (interleukin 1 receptor associated kinase 2); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

interleukin-1 receptor-associated kinase-like 2; IRAK-2; LOC362418

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	146,786,004 - 146,842,615 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	146,786,100 - 146,842,602 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	152,170,673 - 152,227,276 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	147,951,537 - 148,008,146 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	146,579,755 - 146,636,399 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	145,594,575 - 145,651,066 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	145,594,575 - 145,651,053 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	208,890,974 - 208,947,453 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	149,543,029 - 149,599,463 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	149,787,869 - 149,844,303 (+)	NCBI
Celera	4	135,340,439 - 135,396,939 (+)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Atrioventricular Septal Defect 2 (ISO)

genetic disease (ISO)

myoclonic-atonic epilepsy (ISO)

Neurodevelopmental Disorders (ISO)

von Hippel-Lindau disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

aripiprazole (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bortezomib (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium selenide (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chromium(6+) (ISO)

cobalt dichloride (EXP)

crocidolite asbestos (ISO)

curcumin (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

fenofibrate (ISO)

ferulic acid (ISO)

fluoranthene (ISO)

folic acid (ISO)

formaldehyde (ISO)

gemcitabine (ISO)

genistein (EXP,ISO)

gentamycin (EXP)

glyphosate (EXP)

graphite (EXP)

imiquimod (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (ISO)

lidocaine (EXP)

lipopolysaccharide (EXP,ISO)

methamphetamine (EXP)

methylisothiazolinone (ISO)

mifepristone (ISO)

N-nitrosodiethylamine (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

o-anisidine (ISO)

obeticholic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

pentanal (ISO)

perfluorononanoic acid (ISO)

pirinixic acid (ISO)

progesterone (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

selenium atom (ISO)

serpentine asbestos (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

sotorasib (ISO)

succimer (ISO)

sulindac (EXP)

sunitinib (ISO)

T-2 toxin (ISO)

tamibarotene (ISO)

temozolomide (ISO)

thioacetamide (EXP)

titanium atom (EXP)

titanium dioxide (ISO)

trametinib (ISO)

trichloroethene (EXP)

triptonide (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of NF-kappaB-inducing kinase activity (ISO)

biological_process (ND)

I-kappaB kinase/NF-kappaB signaling (IEA,ISO)

interleukin-1-mediated signaling pathway (IBA,ISO)

intracellular signal transduction (IBA)

lipopolysaccharide-mediated signaling pathway (ISO)

negative regulation of DNA-binding transcription factor activity (ISO)

negative regulation of NF-kappaB transcription factor activity (ISO)

positive regulation of NF-kappaB transcription factor activity (IBA,ISO)

protein autophosphorylation (ISO)

protein phosphorylation (IEA)

regulation of cytokine-mediated signaling pathway (ISO)

response to interleukin-1 (ISO)

signal transduction (IEA)

Cellular Component

cellular_component (ND)

cytoplasm (IBA)

cytosol (TAS)

nucleus (IBA)

plasma membrane (IBA)

Molecular Function

ATP binding (IEA)

molecular adaptor activity (IEA,ISO)

molecular_function (ND)

protein binding (ISO)

protein heterodimerization activity (ISO)

protein homodimerization activity (ISO)

protein kinase activity (IBA,IEA)

protein serine/threonine kinase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

apoptotic cell death pathway (IEA)

interleukin-1 signaling pathway (ISO)

neurotrophic factor signaling pathway (IEA)

Toll-like receptor signaling pathway (ISO)

tuberculosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Pathogen recognition by the innate immune system.	Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	Interleukin-1 (IL-1) pathway.	Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.

Additional References at PubMed

PMID:10383454	PMID:12034707	PMID:12220507	PMID:12477932	PMID:15082713	PMID:15489334	PMID:18996842	PMID:19103603	PMID:26394923

Genomics

Comparative Map Data

Irak2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	146,786,004 - 146,842,615 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	146,786,100 - 146,842,602 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	152,170,673 - 152,227,276 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	147,951,537 - 148,008,146 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	146,579,755 - 146,636,399 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	145,594,575 - 145,651,066 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	145,594,575 - 145,651,053 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	208,890,974 - 208,947,453 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	149,543,029 - 149,599,463 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	149,787,869 - 149,844,303 (+)	NCBI
Celera	4	135,340,439 - 135,396,939 (+)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

IRAK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	10,164,919 - 10,243,745 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	10,164,919 - 10,243,745 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	10,206,603 - 10,285,429 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	10,181,563 - 10,260,427 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	10,181,562 - 10,260,427	NCBI
Celera	3	10,142,206 - 10,221,236 (+)	NCBI		Celera
Cytogenetic Map	3	p25.3	NCBI
HuRef	3	10,142,464 - 10,221,162 (+)	NCBI		HuRef
CHM1_1	3	10,156,570 - 10,235,592 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	10,157,816 - 10,237,049 (+)	NCBI		T2T-CHM13v2.0

Irak2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	113,615,428 - 113,671,987 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	113,615,428 - 113,671,987 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	113,638,467 - 113,695,026 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	113,638,467 - 113,695,026 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	113,588,461 - 113,645,020 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	113,604,280 - 113,660,528 (+)	NCBI		MGSCv36	mm8
Celera	6	115,465,268 - 115,520,422 (+)	NCBI		Celera
Cytogenetic Map	6	E3	NCBI
cM Map	6	52.82	NCBI

Irak2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955561	1,585,827 - 1,653,197 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955561	1,585,842 - 1,650,268 (+)	NCBI	ChiLan1.0	ChiLan1.0

IRAK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	10,453,329 - 10,532,629 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	10,453,329 - 10,532,629 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	10,100,279 - 10,179,487 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

VHL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	8,206,616 - 8,211,347 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	8,206,616 - 8,211,323 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	8,240,602 - 8,245,270 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	8,235,897 - 8,240,567 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	8,234,824 - 8,240,587 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	7,958,176 - 7,962,844 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	8,303,525 - 8,308,231 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	8,277,313 - 8,281,981 (-)	NCBI		UU_Cfam_GSD_1.0

Irak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	15,776,320 - 15,835,825 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936602	3,073,889 - 3,129,408 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936602	3,073,910 - 3,129,344 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IRAK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	66,350,606 - 66,416,827 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	66,350,606 - 66,416,834 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	73,509,351 - 73,515,894 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IRAK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	46,204,600 - 46,279,863 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	46,204,893 - 46,278,260 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	120,261,210 - 120,339,634 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Irak2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	5,294,431 - 5,348,481 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	5,294,464 - 5,348,426 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Irak2
284 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	158
Count of miRNA genes:	125
Interacting mature miRNAs:	150
Transcripts:	ENSRNOT00000029819
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	45456990	146803430	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	50119848	146803430	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	56647873	149491524	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	59948935	154902892	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	64528739	157573521	Rat
70177	Xhs1	X-ray hypersensitivity QTL 1	25.1		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	82798864	152731274	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	83428419	177635233	Rat
1582232	Gluco25	Glucose level QTL 25	3.6	0.0023	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	85253748	148090731	Rat
12798523	Anxrr56	Anxiety related response QTL 56	2.83	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	85253748	150276390	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	85379421	167139601	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	93308457	167139447	Rat
61434	Cia3	Collagen induced arthritis QTL 3	4.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	103194656	148194656	Rat
2302049	Pia32	Pristane induced arthritis QTL 32	5.1	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	105789505	150789505	Rat
731165	Uae21	Urinary albumin excretion QTL 21	2.4	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	106649412	151649412	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	106805662	151805662	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	109827074	154827074	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	109827074	154827074	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	109866907	167139601	Rat
1331759	Hrtrt13	Heart rate QTL 13	3.54628		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	110275411	168266883	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	110870972	155870972	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	110870972	155870972	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	114627026	159627026	Rat
1300116	Hrtrt5	Heart rate QTL 5	3.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	116179486	151161268	Rat
724535	Cm18	Cardiac mass QTL 18	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	4	118856416	163856416	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	119428175	157578333	Rat
12798527	Anxrr58	Anxiety related response QTL 58	4.11	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	119463257	147278687	Rat
70201	Gcr1	Gastric cancer resistance QTL 1	2.7		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	4	120260281	147278687	Rat
2293840	Kiddil9	Kidney dilation QTL 9	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	4	120926564	148090731	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	123143783	168143783	Rat
631683	Bp116	Blood pressure QTL 116		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	124303370	169303370	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	124778595	169778595	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	125590636	170590636	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	126395976	167139601	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	131730738	167139601	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	131730738	167139601	Rat
1549827	Scl46	Serum cholesterol level QTL 46	3.5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	132396220	177396220	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	132422778	177422778	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	132642577	167139601	Rat
2303623	Vencon2	Ventilatory control QTL 2	3.8		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	4	135204660	180204660	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	135699135	180699135	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	137755016	181392681	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	138503169	173369699	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	138503169	173369699	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	138503169	179293946	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	144639524	182687754	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	144639524	182687754	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	145568712	182687754	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	146565735	175236377	Rat

Markers in Region

D4Rat60

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	146,803,311 - 146,803,430 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	145,611,768 - 145,611,886	NCBI	Rnor6.0
Rnor_5.0	4	208,908,167 - 208,908,285	UniSTS	Rnor5.0
RGSC_v3.4	4	149,560,221 - 149,560,340	RGD	RGSC3.4
RGSC_v3.4	4	149,560,222 - 149,560,340	UniSTS	RGSC3.4
RGSC_v3.1	4	149,805,063 - 149,805,181	RGD
Celera	4	135,357,633 - 135,357,751	UniSTS
RH 3.4 Map	4	942.7	UniSTS
RH 3.4 Map	4	942.7	RGD
SHRSP x BN Map	4	71.41	UniSTS
SHRSP x BN Map	4	71.41	RGD
FHH x ACI Map	4	87.92	RGD
Cytogenetic Map	4	q42	UniSTS

RH134608

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	146,842,135 - 146,842,322 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	145,650,587 - 145,650,773	NCBI	Rnor6.0
Rnor_5.0	4	208,946,986 - 208,947,172	UniSTS	Rnor5.0
RGSC_v3.4	4	149,598,996 - 149,599,182	UniSTS	RGSC3.4
Celera	4	135,396,472 - 135,396,658	UniSTS
RH 3.4 Map	4	948.4	UniSTS
Cytogenetic Map	4	q42	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3		2		10				4	27	1	11
Low		43	55	41	9	41	8	11	70	8	40		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025422	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763194	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000029819 ⟹ ENSRNOP00000034508

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	146,786,100 - 146,842,598 (+)	Ensembl
Rnor_6.0 Ensembl	4	145,594,575 - 145,651,053 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000096002 ⟹ ENSRNOP00000082209

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	146,786,153 - 146,842,602 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000112620 ⟹ ENSRNOP00000097081

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	146,786,100 - 146,842,598 (+)	Ensembl

RefSeq Acc Id:

NM_001025422 ⟹ NP_001020593

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	146,786,118 - 146,842,603 (+)	NCBI
Rnor_6.0	4	145,594,575 - 145,651,054 (+)	NCBI
Rnor_5.0	4	208,890,974 - 208,947,453 (+)	NCBI
RGSC_v3.4	4	149,543,029 - 149,599,463 (+)	RGD
Celera	4	135,340,439 - 135,396,939 (+)	RGD

Sequence:

show sequence

CTCCGCCACCGGCTCAGTCGCCGCGCAGTCTCGCCATGGCTTGCTACATCTACCAGCTGCCGTC
CTGGGTACTGGACGACCTGTGCCGCAATATCGACACGCTCAGTGAGTGGGACTGGATGCAGTTC
GCTTCCTATGTGATCACAGACCTGACACAGCTGAGGAAGATCAAGTCCATGGAGAGGGTTCAGG
GGGTGAGCATCACCCGGGAGCTGCTGTGGTGGTGGTCCATGCGGCAGGCCACTGTCCAGCAGCT
GGTGGACCTCCTGTGTCACCTGGAACTCTACCGAGCTGCCCAGATTGTCCTGAGCTGGAAGCCG
GCTCCTGACAGCTTGTCTCCCCTCTCGGCCTTCCCAGAGGCTGTGAAGCCAGGTCCTGTGGCTA
CTTCTGGAAGAAACCTCAAGGATGACCAGAAGAAGGGCCAGCCTGTGAAACCATGCTCCTTTCT
GAGCTCAGGGACCACCATGGCTGGCGCCCAGCAGCAGGCCTCATGCCAACGTCCATGCGAGGAG
GATGCCCCTTGTTCCCTGAAAACTGATGTACCTGACTCTCTCCAATCTAAGTATTGTAGCACGT
CCATCCCCAAGCAGGAAAAGCTTTTGAATTTGCCCGGAGACAGGCTTTTCTGGAGTGAAGCAGA
TATCGTTCAAGCAACTGAGGACTTTGACCAAAGCCACCGAATCAGTGAGGGGACCTTTGCCGAT
ATCTACCGGGGACAAAGGAATGGCGTGGCCTTTGCCTTCAAGAGGCTCAGGGAGGTGACTGGCT
CAAGTCCAGGGTCCATGGACAGATTCCTGCAGGCGGAGATGCAGCTCTGCCTCAGATGCTGCCA
CCCCAACATCCTACCTCTGCTGGGCTTCTGCACTGGAAGACAGTTCCACAGCCTCATCTACCCC
TACATGGCCAATGGCTCTCTGCAGGACAGACTCTGGGCTCAGGGCGACTCAGACATGTTGTCCT
GGCCACAGCGTGCCAGCATCTGCTCAGGGCTTCTTCTAGCTGTGGAACACCTGCATAGCCTGGA
TATCATCCACAGTAATGTGAAGAGTGCCAACGTTTTGCTGGACCAGCATCTTAACCCCAAGCTA
GCCCATCCAGTAGCTCACCCGTGTCCCACCAATAAAAAGACCAAATATACTGTAATGAAGACTC
ACCTGTTCCAGGCCTCAGCTGCGTATCTGCCTGAAAACTTCATCCGAGTGGGACAGCTCACCAA
GCAAGTAGACATCTTCAGCTGTGGAATTGTATTGGCCGAGGTTCTCACCGGCATCCCTGCAATG
GACAAGGACCGCAGTCCAGTTTACCTGAAGGATTTGCTTCTCAGTGAGATTCCCAGCAATACTT
CCTCAGTCCACTCCAGGAAGACCAGCATGGGGAAGGTGGTGGTGAAAGAGATCTGCCAGAAGCA
CTTGGAGAGGAAGGCAGGGCTACTGCCTGAGGCCTGCGCGGAAACCTGGGCCACCGCTGTGAGC
GTCTGCCTGCGGAGACGGGAGGCCAGCCTGGAGGAGGCACGAGTCTCCATGGCTGGGGTAGAGG
AGCAGCTCAGAGGGCAGCTGTCCCTCCCCTGGAGCAGGGTTTCTGAGGATACGGGCTCATCTTC
TAATACCCCAGAGGAAACGGATGACGTTGACAATTCCAGCCTCAGTGTCCCCTCTTCTGTTATG
GTGGTGTCATGTGCAAGGGTTTCCTCCCCTCCACCATCCATGGGAAATGGGACAGCACAGCCAT
CTACCAGTGGGAGGCAGGAGGCTGACTCCTCCTCCGAGGCTTGTGCAGGCCCACAGCCACCTCA
GGAAGCTACAGAGACTTCATGGAAAATTGAGATCAATGAGGCCAAAAGGAGACTGATGGAGAAC
ATCCTACTGTATAAAGAAGAGAAACTGGACAGCGTTGAGCTTTTTGGACCCTGATGACCAGAGC
ACATCTGAAGACCCTTATTCTCAACTGGATAGACAAATGTCCAGTCAAGGAAGAGGTCTTTGAC
TGCCCAAGTTCGGTTGAGATCCATACAACCCAAATGTCAGCCTGAACAGAAGGAAACATTGTTT
CATCAGAGTCAAGTTGCAGGGAGGGGGGCAGGGGGACATCAACTTACACAGACACCAAACTCCA
GGAAGTACTCCTCCTCTTTGAGACTGCTTAGTCAGAGGGCTATGAAGTGGAACATCTTGTACGT
GACCCAAGGATTTGGGTGGTTTTGTGGTTCCAGAGAGCCCGTGTTGATTACCACCCTAAGAGAT
GCTTGCCCCAAAAGCTTTTATTCCTCCACAACGGACAAAGGGGTATAGCACCCATGGTGTTTTC
CAGAGTTATCATCTGTCAGTCATATTTGCAGACAGTTTTCTACAAATTTCCACTTCTTAAAAGA
CCTTCAGCCAGTGTCTCAGCAATGCTTGACTCATCTCTCAAGTTCAGGACTACAGAGGCAAGAC
AGTTGGCAAAGGACTCCTTAGGCTTACTCCTTCAGTTGGAGATCTTGTAAGCCACTGGTATTTG
GGAACTGCTTGCTTTTCACCTTCGCCCTCCTGTCATACCTATGTTTATTTTAATGAAGACTCCG
AGGTTGTATGTTATTTATAACTAGGTGAAGAAGCATGAGAAACAGTCTCATGTTTGATTCTGCT
GCTAGTAAAGTCAGTCACTCAGTGGCGGTAACTCAGTTTCCTTGTAAGATGACCCCTCTTCTAT
TCAGAGCTGTTCTATTCAGCTTTTGGGAGGTGAGGTGCAGTGGCTATAGAAGCACTTTGAAAAT
GTATCTGTTCTGTTTTATAAATTAAGTAAAAGGTATTTAGTTCATGTTTCTGCCCTGTAGAAAA
TGTTTATGAAGTGAATATATTTTTGAAAAGTCATGTTGCAAACCTTTTTTGTAAAAGAAACTAT
TTCTAATTCACTATTTAAAAATAATTCCACTATAGTGACAAAATAAAAATGTTTGTTATCTAGC
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039107857 ⟹ XP_038963785

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	146,786,188 - 146,842,615 (+)	NCBI

RefSeq Acc Id:

XM_039107858 ⟹ XP_038963786

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	146,786,004 - 146,842,615 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020593	(Get FASTA)	NCBI Sequence Viewer
	XP_038963785	(Get FASTA)	NCBI Sequence Viewer
	XP_038963786	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98060	(Get FASTA)	NCBI Sequence Viewer
	EDL91554	(Get FASTA)	NCBI Sequence Viewer
	EDL91555	(Get FASTA)	NCBI Sequence Viewer
	Q4QQS0	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001020593 ⟸ NM_001025422

- UniProtKB:

Q4QQS0 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MACYIYQLPSWVLDDLCRNIDTLSEWDWMQFASYVITDLTQLRKIKSMERVQGVSITRELLWWW
SMRQATVQQLVDLLCHLELYRAAQIVLSWKPAPDSLSPLSAFPEAVKPGPVATSGRNLKDDQKK
GQPVKPCSFLSSGTTMAGAQQQASCQRPCEEDAPCSLKTDVPDSLQSKYCSTSIPKQEKLLNLP
GDRLFWSEADIVQATEDFDQSHRISEGTFADIYRGQRNGVAFAFKRLREVTGSSPGSMDRFLQA
EMQLCLRCCHPNILPLLGFCTGRQFHSLIYPYMANGSLQDRLWAQGDSDMLSWPQRASICSGLL
LAVEHLHSLDIIHSNVKSANVLLDQHLNPKLAHPVAHPCPTNKKTKYTVMKTHLFQASAAYLPE
NFIRVGQLTKQVDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPSNTSSVHSRKTSMGK
VVVKEICQKHLERKAGLLPEACAETWATAVSVCLRRREASLEEARVSMAGVEEQLRGQLSLPWS
RVSEDTGSSSNTPEETDDVDNSSLSVPSSVMVVSCARVSSPPPSMGNGTAQPSTSGRQEADSSS
EACAGPQPPQEATETSWKIEINEAKRRLMENILLYKEEKLDSVELFGP

hide sequence

RefSeq Acc Id:

ENSRNOP00000034508 ⟸ ENSRNOT00000029819

RefSeq Acc Id:	XP_038963786 ⟸ XM_039107858
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6ATU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963785 ⟸ XM_039107857
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000082209 ⟸ ENSRNOT00000096002

RefSeq Acc Id:

ENSRNOP00000097081 ⟸ ENSRNOT00000112620

Protein Domains

Death Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4QQS0-F1-model_v2	AlphaFold	Q4QQS0	1-624	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693312

Promoter ID:

EPDNEW_R3835

Type:

single initiation site

Name:

Irak2_1

Description:

interleukin-1 receptor-associated kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	145,594,590 - 145,594,650	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309584	AgrOrtholog
BioCyc Gene	G2FUF-43369	BioCyc
Ensembl Genes	ENSRNOG00000021817	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000034508	ENTREZGENE
	ENSRNOP00000034508.4	UniProtKB/Swiss-Prot
	ENSRNOP00000082209.1	UniProtKB/TrEMBL
	ENSRNOP00000097081	ENTREZGENE
	ENSRNOP00000097081.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000029819	ENTREZGENE
	ENSRNOT00000029819.5	UniProtKB/Swiss-Prot
	ENSRNOT00000096002.1	UniProtKB/TrEMBL
	ENSRNOT00000112620	ENTREZGENE
	ENSRNOT00000112620.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7458113	IMAGE-MGC_LOAD
InterPro	DEATH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Death_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Death_IRAK2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:362418	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116221	IMAGE-MGC_LOAD
NCBI Gene	362418	ENTREZGENE
PANTHER	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OS01G0253100 PROTEIN	UniProtKB/TrEMBL
	PROLINE-RICH RECEPTOR-LIKE PROTEIN KINASE PERK8	UniProtKB/TrEMBL
	PTHR24419:SF2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Death	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Irak2	PhenoGen
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47986	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZWK6_RAT	UniProtKB/TrEMBL
	A0A8I6ATU6	ENTREZGENE, UniProtKB/TrEMBL
	IRAK2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Irak2	interleukin-1 receptor-associated kinase 2	Irak2_predicted	interleukin-1 receptor-associated kinase 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Irak2_predicted	interleukin-1 receptor-associated kinase 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)