Imported Disease Annotations - ClinVarObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Gimap5 | Rat | long QT syndrome | | ISO | GIMAP5 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Long QT syndrome | ClinVar | PMID:10973849 more ... | Gimap5 | Rat | Noncirrhotic Portal Hypertension 2 | | ISO | GIMAP5 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Portal hypertension more ... | ClinVar | PMID:25741868 more ... | Gimap5 | Rat | portal hypertension | | ISO | GIMAP5 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Portal hypertension | ClinVar | PMID:25741868 more ... | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - OMIM
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Decreased core temperature and increased beta(3)-adrenergic sensitivity in diabetes-prone BB rats. | Akesson L, etal., Diabetes Technol Ther. 2007 Aug;9(4):354-62. |
| 2. | Increased Lipid Oxidation Heralds Diabetes Onset in DR.lyp/lyp Rats. | Akesson L, etal., Exp Clin Endocrinol Diabetes. 2008 May 9;. |
| 3. | The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats. | Bieg S, etal., Diabetologia 1997 Jul;40(7):786-92. |
| 4. | The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats. | Clark L, etal., FEMS Immunol Med Microbiol. 2002 Feb 18;32(3):205-9. |
| 5. | Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs. | Dion C, etal., Int Immunol. 2005 Sep;17(9):1257-68. Epub 2005 Aug 15. |
| 6. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 7. | The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. | Hornum L, etal., Diabetes 2002 Jun;51(6):1972-9. |
| 8. | Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes. | Ilangumaran S, etal., Mol Immunol. 2008 Nov 11. |
| 9. | GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment. | Keita M, etal., Biochem Biophys Res Commun. 2007 Sep 21;361(2):481-6. Epub 2007 Jul 23. |
| 10. | Loss of a gimap/ian gene leads to activation of NF-kappaB through a MAPK-dependent pathway. | Kupfer R, etal., Mol Immunol. 2007 Jan;44(4):479-87. Epub 2006 Apr 11. |
| 11. | Excessive production of nitric oxide by macrophages from DP-BB rats is secondary to the T-lymphopenic state of these animals. | Lau A, etal., Diabetes. 1998 Feb;47(2):197-205. |
| 12. | Lymphopenia in the BB Rat Model of Type 1 Diabetes is Due to a Mutation in a Novel Immune-Associated Nucleotide (Ian)-Related Gene. | MacMurray AJ, etal., Genome Res 2002 Jul;12(7):1029-39. |
| 13. | Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. | Michalkiewicz M, etal., Physiol Genomics 2004 Oct 4;19(2):228-32. Epub 2004 Aug 24. |
| 14. | A diabetogenic gene prevents T cells from receiving costimulatory signals. | Moore JK, etal., Cell Immunol. 1999 May 25;194(1):90-7. |
| 15. | Ian4 is required for mitochondrial integrity and T cell survival. | Pandarpurkar M, etal., Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10382-7. Epub 2003 Aug 20. |
| 16. | Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. | Poussier P, etal., J Immunol. 2005 Apr 1;174(7):4081-9. |
| 17. | Evidence for the extrathymic origin of intestinal TCRgammadelta(+) T cells in normal rats and for an impairment of this differentiation pathway in BB rats. | Ramanathan S, etal., J Immunol 2002 Mar 1;168(5):2182-7. |
| 18. | GOA pipeline | RGD automated data pipeline |
| 19. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 20. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 21. | Comprehensive gene review and curation | RGD comprehensive gene curation |
| 22. | Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background. | Sommandas V, etal., J Autoimmun. 2005 Aug;25(1):46-56. |
| 23. | Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymocytes from apoptosis in the BB-DP rat. | Sommandas V, etal., J Leukoc Biol. 2007 Oct;82(4):869-76. Epub 2007 Jun 28. |
| 24. | Deficiencies in gut NK cell number and function precede diabetes onset in BB rats. | Todd DJ, etal., J Immunol. 2004 May 1;172(9):5356-62. |
Additional References at PubMed
| PMID:12477932 | PMID:14624755 | PMID:15307172 | PMID:15474297 | PMID:15489334 | PMID:19351909 | PMID:19424493 | PMID:19996157 | PMID:21925515 | PMID:23098229 | PMID:26740263 | PMID:27023180 |
Genomics
Comparative Map Data
| Gimap5 (Rattus norvegicus - Norway rat) |
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| GIMAP5 (Homo sapiens - human) |
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| Gimap5 (Mus musculus - house mouse) |
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| GIMAP5 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| LOC100687459 (Canis lupus familiaris - dog) |
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| GIMAP5 (Sus scrofa - pig) |
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Variants
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Variants in Gimap5
50 total Variants 
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