Cftr (CF transmembrane conductance regulator) - Rat Genome Database

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Gene: Cftr (CF transmembrane conductance regulator) Rattus norvegicus
Symbol: Cftr
Name: CF transmembrane conductance regulator
RGD ID: 2332
Description: Predicted to enable several functions, including ATP hydrolysis activity; PDZ domain binding activity; and anion transmembrane transporter activity. Involved in several processes, including animal organ development; anion transport; and regulation of cell development. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and microvillus. Colocalizes with early endosome. Used to study congenital bilateral absence of vas deferens; cystic fibrosis; dental enamel hypoplasia; duodenal ulcer; and gastric ulcer. Biomarker of autosomal recessive polycystic kidney disease; cholestasis; and salpingitis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH 17beta-estradiol; 3',5'-cyclic AMP; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
Also known as: ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog (human); LOC500041; RGD1561193; similar to cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cftrem1Sage   Cftrem1Ang   Cftrem2Ang  
Genetic Models: SD-Cftrem1Ang SD-Cftrem2Ang SD-Cftrem1Sage+/- SD-Cftrem1Sage-/-
Is Marker For: Strains:   BB/OK  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2446,561,269 - 46,728,759 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl446,560,885 - 46,728,756 (+)Ensembl
Rnor_6.0442,693,263 - 42,860,679 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl442,692,836 - 42,860,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0442,281,040 - 42,448,571 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,874,852 - 44,041,870 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1444,147,212 - 44,195,889 (+)NCBI
Celera441,826,966 - 41,988,614 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)