Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2332
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Cftr
Name:	CF transmembrane conductance regulator

Acc ID:	CHEBI:16188
Term:	octan-1-ol
Definition:	An octanol carrying the hydroxy group at position 1.
Chemical ID:	MESH:D020003

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Cftr	increases activity	ISO	RGD:619566	6480464	CTD	1-Octanol results in increased activity of CFTR protein 1-Octanol results in increased activity of CFTR protein mutant form	PMID:14967738
Cftr	multiple interactions	ISO	RGD:619566	6480464	CTD	Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein] N-2-4-bromocinnamylaminoethyl-5-isoquinolinesulfonamide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]	PMID:14967738

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