Aqp9 (aquaporin 9) - Rat Genome Database

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Gene: Aqp9 (aquaporin 9) Rattus norvegicus
Analyze
Symbol: Aqp9
Name: aquaporin 9
RGD ID: 68433
Description: Enables channel activity and nucleobase transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; nucleobase transport; and response to pain. Located in basolateral plasma membrane. Orthologous to human AQP9 (aquaporin 9); PARTICIPATES IN water transport pathway; bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AQP-9; aquaglyceroporin-9; aquaporin-9; MGC93419; neutral solute channel aquaporin 9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8880,678,027 - 80,718,273 (-)NCBIGRCr8
mRatBN7.2871,797,231 - 71,837,485 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,797,234 - 71,837,395 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx877,331,526 - 77,371,805 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0875,604,495 - 75,644,778 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0873,441,536 - 73,481,821 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0877,559,621 - 77,599,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,559,624 - 77,599,781 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,483,006 - 75,523,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,611,485 - 75,651,646 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,630,541 - 75,670,700 (-)NCBI
Celera869,899,442 - 69,939,523 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (EXP,ISO)
3-hydroxybutyric acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
adenine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
androstane-3,17-diol  (EXP)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astragaloside IV  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
buta-1,3-diene  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
CGP 52608  (ISO)
cholesterol  (ISO)
choline  (ISO)
cobalt atom  (ISO)
copper(II) chloride  (ISO)
curcumin  (ISO)
cycloastragenol  (ISO)
cyclosporin A  (ISO)
D-glucitol  (EXP,ISO)
D-mannitol  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
diprotium oxide  (EXP,ISO)
endosulfan  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
glycerol  (EXP,ISO)
heptachlor  (EXP)
homovanillic acid  (ISO)
indirubin  (ISO)
indirubin-3'-monoxime  (ISO)
isoflavones  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
lonidamine  (EXP)
LY294002  (ISO)
malathion  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
mirex  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
nigericin  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phloretin  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenic acid  (ISO)
selenous acid  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
styrene  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thiourea  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
undecane  (EXP)
urea  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
water  (EXP,ISO)
zidovudine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
basolateral plasma membrane  (IBA,IDA,IEA,ISO)
membrane  (IEA,NAS)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression and regulation of aquaporins 1, 8, and 9 in the testis, efferent ducts, and epididymis of adult rats and during postnatal development. Badran HH and Hermo LS, J Androl 2002 May-Jun;23(3):358-73.
2. Changes in ocular aquaporin expression following optic nerve crush. Dibas A, etal., Mol Vis. 2010 Mar 3;16:330-40.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. Huebert RC, etal., J Biol Chem 2002 Jun 21;277(25):22710-7.
6. Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator. Jesus TT, etal., IUBMB Life. 2014 Sep;66(9):639-44. doi: 10.1002/iub.1312. Epub 2014 Oct 1.
7. Cloning and functional expression of rAOP9L a new member of aquaporin family from rat liver. Ko SB, etal., Biochem Mol Biol Int. 1999 Feb;47(2):309-18. doi: 10.1080/15216549900201333.
8. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Pastor-Soler N, etal., Biol Reprod 2002 Jun;66(6):1716-22.
13. At low doses ethanol maintains blood-brain barrier (BBB) integrity after hypoxia and reoxygenation: a brain slice study. Peng C, etal., Neurol Res. 2013 Oct;35(8):790-7. doi: 10.1179/1743132813Y.0000000198. Epub 2013 Apr 12.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Molecular characterization of a broad selectivity neutral solute channel. Tsukaguchi H, etal., J Biol Chem 1998 Sep 18;273(38):24737-43.
19. LncRNA MALAT1 promotes neuropathic pain progression through the miR‑154‑5p/AQP9 axis in CCI rat models. Wu J, etal., Mol Med Rep. 2020 Jan;21(1):291-303. doi: 10.3892/mmr.2019.10829. Epub 2019 Nov 20.
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:7530250   PMID:9369468   PMID:9405233   PMID:9514918   PMID:9806845   PMID:9829975   PMID:10318966   PMID:10510269   PMID:10564231   PMID:11001937  
PMID:11034202   PMID:11076974   PMID:11573934   PMID:11972053   PMID:12084581   PMID:12477932   PMID:12594337   PMID:12944406   PMID:14701836   PMID:15489334   PMID:15647391   PMID:15850448  
PMID:15948717   PMID:16446030   PMID:16596446   PMID:16857339   PMID:17178220   PMID:17337204   PMID:17525633   PMID:17636236   PMID:18053968   PMID:18055461   PMID:18202181   PMID:18501347  
PMID:18511455   PMID:18669624   PMID:18718702   PMID:18762715   PMID:19115411   PMID:19193945   PMID:19399395   PMID:19429018   PMID:19948840   PMID:20357197   PMID:20958229   PMID:21208160  
PMID:21251984   PMID:21851171   PMID:22114114   PMID:23040263   PMID:23415870   PMID:23464865   PMID:23506846   PMID:24828425   PMID:25479407   PMID:25604497   PMID:25903824   PMID:29523003  
PMID:30017933   PMID:30266683   PMID:30420639   PMID:31218464   PMID:31533210  


Genomics

Comparative Map Data
Aqp9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8880,678,027 - 80,718,273 (-)NCBIGRCr8
mRatBN7.2871,797,231 - 71,837,485 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,797,234 - 71,837,395 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx877,331,526 - 77,371,805 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0875,604,495 - 75,644,778 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0873,441,536 - 73,481,821 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0877,559,621 - 77,599,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,559,624 - 77,599,781 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,483,006 - 75,523,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,611,485 - 75,651,646 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,630,541 - 75,670,700 (-)NCBI
Celera869,899,442 - 69,939,523 (+)NCBICelera
Cytogenetic Map8q24NCBI
AQP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381558,138,169 - 58,185,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1558,138,169 - 58,185,911 (+)EnsemblGRCh38hg38GRCh38
GRCh371558,430,368 - 58,478,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,217,700 - 56,265,402 (+)NCBINCBI36Build 36hg18NCBI36
Build 341556,217,770 - 56,265,401NCBI
Celera1535,319,964 - 35,368,212 (+)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1535,253,376 - 35,301,102 (+)NCBIHuRef
CHM1_11558,548,384 - 58,596,089 (+)NCBICHM1_1
T2T-CHM13v2.01555,940,466 - 55,988,212 (+)NCBIT2T-CHM13v2.0
Aqp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39971,017,941 - 71,075,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl971,017,941 - 71,075,964 (-)EnsemblGRCm39 Ensembl
GRCm38971,110,659 - 71,167,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl971,110,659 - 71,168,682 (-)EnsemblGRCm38mm10GRCm38
MGSCv37970,958,468 - 71,011,096 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36970,909,221 - 70,961,849 (-)NCBIMGSCv36mm8
Celera968,318,271 - 68,366,608 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.85NCBI
Aqp9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545016,253,571 - 16,302,657 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545016,253,706 - 16,346,602 (-)NCBIChiLan1.0ChiLan1.0
AQP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21647,401,033 - 47,449,700 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11551,583,319 - 51,631,999 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01537,107,061 - 37,154,887 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11555,418,767 - 55,466,541 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,418,767 - 55,466,541 (+)Ensemblpanpan1.1panPan2
AQP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,223,413 - 23,271,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,225,331 - 23,269,076 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,195,554 - 23,244,048 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,381,591 - 23,430,109 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,383,410 - 23,429,056 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,314,125 - 23,361,613 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,398,650 - 23,446,048 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,540,476 - 23,589,012 (+)NCBIUU_Cfam_GSD_1.0
Aqp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,473,023 - 101,514,878 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647119,321,426 - 19,362,146 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647119,321,366 - 19,361,227 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,794,040 - 113,848,683 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,798,380 - 113,848,452 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,897,935 - 125,959,201 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12625,326,108 - 25,374,743 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2625,326,087 - 25,373,336 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048115,941,107 - 115,988,513 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478113,648,065 - 13,691,260 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478113,650,612 - 13,691,175 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aqp9
267 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:200
Count of miRNA genes:145
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000021442
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat

Markers in Region
RH141275  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,797,376 - 71,797,582 (+)MAPPERmRatBN7.2
Rnor_6.0877,559,767 - 77,559,972NCBIRnor6.0
Rnor_5.0875,523,072 - 75,523,277UniSTSRnor5.0
RGSC_v3.4875,611,631 - 75,611,836UniSTSRGSC3.4
Celera869,939,172 - 69,939,377UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 22 79 88 90 59 25 59 6 183 64 61 44 59 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000087980   ⟹   ENSRNOP00000069377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl871,797,234 - 71,837,395 (-)Ensembl
Rnor_6.0 Ensembl877,559,624 - 77,599,781 (-)Ensembl
RefSeq Acc Id: NM_022960   ⟹   NP_075249
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,718,188 (-)NCBI
mRatBN7.2871,797,231 - 71,837,395 (-)NCBI
Rnor_6.0877,559,621 - 77,599,781 (-)NCBI
Rnor_5.0875,483,006 - 75,523,423 (+)NCBI
RGSC_v3.4875,611,485 - 75,651,646 (-)RGD
Celera869,899,442 - 69,939,523 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243362   ⟹   XP_006243424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,718,273 (-)NCBI
mRatBN7.2871,797,231 - 71,837,485 (-)NCBI
Rnor_6.0877,559,621 - 77,598,767 (-)NCBI
Rnor_5.0875,483,006 - 75,523,423 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082095   ⟹   XP_038938023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,718,273 (-)NCBI
mRatBN7.2871,797,231 - 71,837,485 (-)NCBI
RefSeq Acc Id: XM_039082096   ⟹   XP_038938024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,718,254 (-)NCBI
mRatBN7.2871,797,231 - 71,836,728 (-)NCBI
RefSeq Acc Id: XM_039082097   ⟹   XP_038938025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,718,273 (-)NCBI
mRatBN7.2871,797,231 - 71,837,485 (-)NCBI
RefSeq Acc Id: XM_039082099   ⟹   XP_038938027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,718,273 (-)NCBI
mRatBN7.2871,797,231 - 71,837,485 (-)NCBI
RefSeq Acc Id: XM_039082100   ⟹   XP_038938028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,717,749 (-)NCBI
mRatBN7.2871,797,231 - 71,836,728 (-)NCBI
RefSeq Acc Id: XM_063266081   ⟹   XP_063122151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,714,765 (-)NCBI
RefSeq Acc Id: XM_063266082   ⟹   XP_063122152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,717,749 (-)NCBI
RefSeq Acc Id: XM_063266083   ⟹   XP_063122153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,717,749 (-)NCBI
RefSeq Acc Id: XM_063266084   ⟹   XP_063122154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,718,273 (-)NCBI
RefSeq Acc Id: XM_063266085   ⟹   XP_063122155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,714,765 (-)NCBI
RefSeq Acc Id: XM_063266086   ⟹   XP_063122156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8880,678,027 - 80,714,770 (-)NCBI
RefSeq Acc Id: NP_075249   ⟸   NM_022960
- UniProtKB: O88815 (UniProtKB/Swiss-Prot),   P56627 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243424   ⟸   XM_006243362
- Peptide Label: isoform X1
- UniProtKB: O88815 (UniProtKB/Swiss-Prot),   P56627 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069377   ⟸   ENSRNOT00000087980
RefSeq Acc Id: XP_038938025   ⟸   XM_039082097
- Peptide Label: isoform X1
- UniProtKB: P56627 (UniProtKB/Swiss-Prot),   O88815 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938023   ⟸   XM_039082095
- Peptide Label: isoform X1
- UniProtKB: P56627 (UniProtKB/Swiss-Prot),   O88815 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938027   ⟸   XM_039082099
- Peptide Label: isoform X1
- UniProtKB: P56627 (UniProtKB/Swiss-Prot),   O88815 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938028   ⟸   XM_039082100
- Peptide Label: isoform X1
- UniProtKB: P56627 (UniProtKB/Swiss-Prot),   O88815 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938024   ⟸   XM_039082096
- Peptide Label: isoform X1
- UniProtKB: P56627 (UniProtKB/Swiss-Prot),   O88815 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122154   ⟸   XM_063266084
- Peptide Label: isoform X1
- UniProtKB: P56627 (UniProtKB/Swiss-Prot),   O88815 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122152   ⟸   XM_063266082
- Peptide Label: isoform X1
- UniProtKB: P56627 (UniProtKB/Swiss-Prot),   O88815 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122153   ⟸   XM_063266083
- Peptide Label: isoform X1
- UniProtKB: P56627 (UniProtKB/Swiss-Prot),   O88815 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122156   ⟸   XM_063266086
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063122151   ⟸   XM_063266081
- Peptide Label: isoform X1
- UniProtKB: P56627 (UniProtKB/Swiss-Prot),   O88815 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122155   ⟸   XM_063266085
- Peptide Label: isoform X1
- UniProtKB: P56627 (UniProtKB/Swiss-Prot),   O88815 (UniProtKB/Swiss-Prot),   A6KER7 (UniProtKB/TrEMBL),   A6KER9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56627-F1-model_v2 AlphaFold P56627 1-295 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68433 AgrOrtholog
BioCyc Gene G2FUF-29903 BioCyc
Ensembl Genes ENSRNOG00000061883 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087980 ENTREZGENE
  ENSRNOT00000087980.2 UniProtKB/Swiss-Prot
  ENSRNOT00000142448 ENTREZGENE
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134715 IMAGE-MGC_LOAD
InterPro Aquaporin-like UniProtKB/Swiss-Prot
  Aquaporin_9 UniProtKB/Swiss-Prot
  MIP UniProtKB/Swiss-Prot
  MIP/Aquaporin UniProtKB/Swiss-Prot
  MIP_CS UniProtKB/Swiss-Prot
KEGG Report rno:65054 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93419 IMAGE-MGC_LOAD
NCBI Gene 65054 ENTREZGENE
PANTHER AQUAPORIN OR AQUAGLYCEROPORIN RELATED UniProtKB/Swiss-Prot
  PTHR43829:SF6 UniProtKB/Swiss-Prot
Pfam MIP UniProtKB/Swiss-Prot
PhenoGen Aqp9 PhenoGen
PRINTS AQUAPORIN9 UniProtKB/Swiss-Prot
  MINTRINSICP UniProtKB/Swiss-Prot
PROSITE MIP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061883 RatGTEx
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot
TIGR TC214842
UniProt A6KER7 ENTREZGENE, UniProtKB/TrEMBL
  A6KER9 ENTREZGENE, UniProtKB/TrEMBL
  AQP9_RAT UniProtKB/Swiss-Prot
  O88815 ENTREZGENE
  P56627 ENTREZGENE
UniProt Secondary O88815 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Aqp9  aquaporin 9      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization enriched in basolateral plasma membranes of hepatocytes 625402
gene_cellular_localization localized to the apical membrane 727570
gene_expression expressed in epididymal epithelium 727570