Cftr (CF transmembrane conductance regulator) - Rat Genome Database

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Gene: Cftr (CF transmembrane conductance regulator) Chinchilla lanigera
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Symbol: Cftr
Name: CF transmembrane conductance regulator
RGD ID: 9007908
Description: ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (ortholog); chaperone binding (ortholog); chloride channel activity (ortholog); INVOLVED IN aging (ortholog); amelogenesis (ortholog); bicarbonate transport (ortholog); ASSOCIATED WITH alcoholic pancreatitis (ortholog); allergic bronchopulmonary aspergillosis (ortholog); Alzheimer's disease (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543223,178,866 - 23,328,382 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543223,179,645 - 23,328,347 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcoholic pancreatitis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
Alzheimer's disease  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
autosomal recessive congenital bilateral absence of vas deferens  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
azoospermia  (ISO)
Breast Neoplasms  (ISO)
bronchiectasis  (ISO)
bronchiectasis 1  (ISO)
choledochal cyst  (ISO)
cholelithiasis  (ISO)
cholestasis  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pancreatitis  (ISO)
Colorectal Neoplasms  (ISO)
congenital bilateral absence of vas deferens  (ISO)
cryptorchidism  (ISO)
cystic fibrosis  (ISO)
dental enamel hypoplasia  (ISO)
Diaphragmatic Hernia  (ISO)
duodenal atresia  (ISO)
duodenal ulcer  (ISO)
exocrine pancreatic insufficiency  (ISO)
Experimental Diabetes Mellitus  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
Hereditary Pancreatitis  (ISO)
Hirschsprung's disease  (ISO)
Hypertriglyceridemia  (ISO)
infertility  (ISO)
influenza  (ISO)
Liver Injury  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
male infertility  (ISO)
Metabolic Bone Diseases  (ISO)
multiple intestinal atresia  (ISO)
myocardial infarction  (ISO)
Nontuberculous Mycobacterium Infections  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
papillary renal cell carcinoma  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
primary sclerosing cholangitis  (ISO)
prostatic hypertrophy  (ISO)
Pseudomonas Infections  (ISO)
pulmonary sarcoidosis  (ISO)
renal agenesis  (ISO)
renal cell carcinoma  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rhinitis  (ISO)
salpingitis  (ISO)
sinusitis  (ISO)
Staphylococcal Pneumonia  (ISO)
substance-related disorder  (ISO)
tracheal disease  (ISO)
typhoid fever  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
amelogenesis  (ISO)
bicarbonate transport  (ISO)
cellular response to anoxia  (ISO)
cellular response to cAMP  (ISO)
cellular response to forskolin  (ISO)
cellular response to heat  (ISO)
cellular response to hormone stimulus  (ISO)
chloride transmembrane transport  (ISO)
chloride transport  (ISO)
cholesterol biosynthetic process  (ISO)
cholesterol transport  (ISO)
enamel mineralization  (ISO)
intracellular pH elevation  (ISO)
liver regeneration  (ISO)
lung development  (ISO)
membrane hyperpolarization  (ISO)
multicellular organismal water homeostasis  (ISO)
negative regulation of type B pancreatic cell development  (ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of cyclic nucleotide-gated ion channel activity  (ISO)
positive regulation of enamel mineralization  (ISO)
positive regulation of establishment of Sertoli cell barrier  (ISO)
positive regulation of exocytosis  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of mast cell activation  (ISO)
positive regulation of voltage-gated chloride channel activity  (ISO)
regulation of membrane depolarization  (ISO)
response to amiloride  (ISO)
response to cytokine  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to estrogen  (ISO)
response to peptide hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sodium ion transmembrane transport  (ISO)
sperm capacitation  (ISO)
transepithelial chloride transport  (ISO)
transepithelial water transport  (ISO)
vasodilation  (ISO)
vesicle docking involved in exocytosis  (ISO)
water transport  (ISO)

References


Genomics

Comparative Map Data
Cftr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543223,178,866 - 23,328,382 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543223,179,645 - 23,328,347 (+)NCBIChiLan1.0ChiLan1.0
CFTR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7117,287,120 - 117,715,971 (+)EnsemblGRCh38hg38GRCh38
GRCh387117,480,025 - 117,668,665 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377117,120,079 - 117,308,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367116,907,253 - 117,095,955 (+)NCBINCBI36hg18NCBI36
Build 347116,713,967 - 116,902,666NCBI
Celera7111,928,196 - 112,116,895 (+)NCBI
Cytogenetic Map7q31.2NCBI
HuRef7111,485,640 - 111,674,189 (+)NCBIHuRef
CHM1_17117,053,369 - 117,242,163 (+)NCBICHM1_1
CRA_TCAGchr7v27116,515,451 - 116,704,154 (+)NCBI
Cftr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39618,170,686 - 18,322,769 (+)NCBIGRCm39mm39
GRCm39 Ensembl618,170,686 - 18,322,767 (+)Ensembl
GRCm38618,170,687 - 18,322,770 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl618,170,687 - 18,322,768 (+)EnsemblGRCm38mm10GRCm38
MGSCv37618,120,687 - 18,272,770 (+)NCBIGRCm37mm9NCBIm37
MGSCv36618,120,687 - 18,272,767 (+)NCBImm8
Celera618,244,038 - 18,394,318 (+)NCBICelera
Cytogenetic Map6A2NCBI
cM Map68.1NCBI
Cftr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2446,561,269 - 46,728,759 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl442,692,836 - 42,860,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0442,693,263 - 42,860,679 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0442,281,040 - 42,448,571 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,874,852 - 44,041,870 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1444,147,212 - 44,195,889 (+)NCBI
Celera441,826,966 - 41,988,614 (+)NCBICelera
Cytogenetic Map4q21NCBI
CFTR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17122,144,821 - 122,327,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7122,129,798 - 122,327,864 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07109,449,847 - 109,633,023 (+)NCBIMhudiblu_PPA_v0panPan3
CFTR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11456,290,417 - 56,452,919 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1456,290,275 - 56,453,977 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1455,685,755 - 55,848,173 (+)NCBI
ROS_Cfam_1.01456,330,071 - 56,492,372 (+)NCBI
UMICH_Zoey_3.11456,368,632 - 56,531,008 (+)NCBI
UNSW_CanFamBas_1.01456,049,412 - 56,212,168 (+)NCBI
UU_Cfam_GSD_1.01456,421,094 - 56,583,513 (+)NCBI
Cftr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,970,647 - 45,124,331 (+)NCBI
SpeTri2.0NW_0049365891,565,933 - 1,719,208 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFTR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1828,627,728 - 28,817,950 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11828,627,717 - 28,818,209 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21830,396,465 - 30,566,680 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CFTR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12186,154,313 - 86,332,436 (+)NCBI
Vero_WHO_p1.0NW_02366604217,387,997 - 17,576,802 (-)NCBI
Cftr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248271,704,733 - 1,893,579 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000005000   ⟹   ENSCLAP00000004908
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543223,178,866 - 23,328,382 (+)Ensembl
RefSeq Acc Id: XM_005388136   ⟹   XP_005388193
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543223,179,647 - 23,328,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013515961   ⟹   XP_013371415
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543223,179,645 - 23,328,347 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005388193 (Get FASTA)   NCBI Sequence Viewer  
  XP_013371415 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005388193   ⟸   XM_005388136
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013371415   ⟸   XM_013515961
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000004908   ⟸   ENSCLAT00000005000


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003484 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000004908 ENTREZGENE
Ensembl Transcript ENSCLAT00000005000 ENTREZGENE
NCBI Gene Cftr ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-21 Cftr  CF transmembrane conductance regulator  Cftr  cystic fibrosis transmembrane conductance regulator  Symbol and/or name change 5135510 APPROVED
2016-08-16 Cftr  cystic fibrosis transmembrane conductance regulator    cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)  Symbol and/or name change 5135510 APPROVED