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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cftr
Name: CF transmembrane conductance regulator
Acc ID: CHEBI:74545
Term: acivicin
Definition: An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria.
Chemical ID: MESH:C006303
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cftrmultiple interactionsISORGD:6195666480464CTDacivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein] acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA]

PMID:14766015
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