GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cftr | increases activity | ISO | CFTR (Homo sapiens) | 6480464 | CTD | ivacaftor results in increased activity of CFTR protein; ivacaftor results in increased activity of CFTR protein mutant form | PMID:19846789 PMID:21083385 PMID:21602569 | Cftr | multiple interactions | ISO | CFTR (Homo sapiens) | 6480464 | CTD | [ivacaftor co-treated with Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin] results in increased activity of CFTR protein; [ivacaftor results in increased activity of CFTR protein mutant form] which affects the transport of Sodium; [ivacaftor results in increased activity of CFTR protein mutant form] which results in increased secretion of Chlorides; ivacaftor inhibits the reaction [Vehicle Emissions results in decreased activity of CFTR protein] | PMID:19846789 PMID:32374624 PMID:34601066 | |
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