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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cftr
Name: CF transmembrane conductance regulator
Acc ID: CHEBI:66901
Term: ivacaftor
Definition: An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis.
Chemical ID: MESH:C545203
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cftrincreases activityISORGD:6195666480464CTDivacaftor results in increased activity of CFTR protein ivacaftor results in increased activity of CFTR protein mutant form

PMID:19846789 PMID:21083385 PMID:21602569
Cftrmultiple interactionsISORGD:6195666480464CTD[ivacaftor co-treated with Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form [ivacaftor co-treated with Colforsin] results in increased activity of CFTR protein [ivacaftor results in increased activity of CFTR protein mutant form] which affects the transport of Sodium [ivacaftor results in increased activity of CFTR protein mutant form] which results in increased secretion of Chlorides

PMID:19846789 PMID:32374624
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