RGD Reference Report - Osteopenia in Cftr-deltaF508 mice. - Rat Genome Database

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Osteopenia in Cftr-deltaF508 mice.

Authors: Paradis, J  Wilke, M  Haston, CK 
Citation: Paradis J, etal., J Cyst Fibros. 2010 Jul;9(4):239-45. doi: 10.1016/j.jcf.2010.05.001. Epub 2010 May 31.
RGD ID: 11566031
Pubmed: PMID:20570219   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jcf.2010.05.001   (Journal Full-text)

BACKGROUND: Mice with the cystic fibrosis transmembrane conductance regulator (Cftr) gene knocked out develop osteopenia. To determine whether this phenotype is present in cystic fibrosis mouse models with the DeltaF508 Cftr mutation we assessed the femora of adult FVB/N Cftr(tm1Eur) and C57BL/6 Cftr(tm1Kth) mice. METHODS: Bone disease, relative to littermate controls, was measured using histology, densitometry and quantitative imaging. RESULTS: C57BL/6 Cftr(tm1Kth) mice had shorter femurs and bones of lower volume due to thinner trabeculae, compared to wild type littermates. FVB/N Cftr(tm1Eur) mice also presented a lower bone volume which was due to significantly fewer trabeculae in this strain. Osteoblast and osteoclast numbers did not differ between CF and controls, for either of FVB/N Cftr(tm1Eur) or C57BL/6 Cftr(tm1Kth) mice. The bone architecture of FVB/N Cftr(tm1Eur) mice did not significantly differ from that of C57BL/6 Cftr(tm1Kth) mice. CONCLUSIONS: An osteopenic bone disease is evident in adult DeltaF508-Cftr cystic fibrosis mouse models.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CFTRHumanMetabolic Bone Diseases  ISOCftr (Mus musculus)associated with Cystic Fibrosis and DNA:deletion: :p.F508del (mouse)RGD 
CftrRatMetabolic Bone Diseases  ISOCftr (Mus musculus)associated with Cystic Fibrosis and DNA:deletion: :p.F508del (mouse)RGD 
CftrMouseMetabolic Bone Diseases  IAGP associated with Cystic Fibrosis and DNA:deletion: :p.F508del (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cftr  (CF transmembrane conductance regulator)

Genes (Mus musculus)
Cftr  (cystic fibrosis transmembrane conductance regulator)

Genes (Homo sapiens)
CFTR  (CF transmembrane conductance regulator)


Additional Information