Strain Report - Rat Genome Database

Name: LEW/Maas
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: LEW/Maas
Symbol:	LEW/Maas
Strain:	LEW
Substrain:	Maas
RGD ID:	737905
Citation ID:	RRID:RGD_737905
Ontology ID:	RS:0000518
Type:	inbred
Source:	University of Limburg, Netherlands
Origin:	Strain originated from Dr. Margaret Lewis from Wistar stock, to Aptekman and Bogden 1954 at F20, to Silvers in 1958 at F31. Subsequently distributed by Silvers.
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

proteinuria (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

kidney microaneurysm (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

urine total protein excretion rate

ratio of number of glomeruli with microaneurysms to number of total glomeruli

ratio of glomerular area occupied by activated mesangial cells to total glomerular area

References

References - curated

#	Reference Title	Reference Citation
1.	Biochemical markers in inbred strains of the rat (Rattus norvegicus).	Bender K, etal., Immunogenetics 1984;19(3):257-66.
2.	Genetic characterization of inbred strains of the rat (Rattus norvegicus).	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
3.	Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants.	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
4.	Genetic predisposition for glomerulonephritis-induced glomerulosclerosis in rats is linked to chromosome 1.	Ijpelaar DH, etal., Physiol Genomics. 2008 Oct 8;35(2):173-81. Epub 2008 Aug 5.
5.	Institute for Animal Experimentation University of Tokushima School of Medicine	Institute for Animal Experimentation University of Tokushima School of Medicine
6.	Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains.	Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
7.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
8.	Genetic variation in coding regions between and within commonly used inbred rat strains.	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

Region

Strain QTL Data

Symbol	Name	Trait
Glom17	Glomerulus QTL 17	kidney glomerulus morphology trait (VT:0005325)
Glom18	Glomerulus QTL 18	kidney glomerulus morphology trait (VT:0005325)
Glom19	Glomerulus QTL 19	kidney glomerulus morphology trait (VT:0005325)
Glom20	Glomerulus QTL 20	kidney glomerulus morphology trait (VT:0005325)
Glom21	Glomerulus QTL 21	kidney glomerulus morphology trait (VT:0005325)
Pur18	Proteinuria QTL 18	urine total protein amount (VT:0000032)
Pur19	Proteinuria QTL 19	urine total protein amount (VT:0000032)
Pur20	Proteinuria QTL 20	urine total protein amount (VT:0000032)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_phys_biochem	This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203.	737878

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: LEW/Maas

Mammalian Phenotype

Related Phenotype Data for Term "LEW/Maas" (RS:0000518)