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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Chemical and Drug Induced Liver Injury | | ISO | RGD:1347655 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:25226513 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Chemical and Drug Induced Liver Injury | | ISO | RGD:1347655 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:25226513 | |
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# | Reference Title | Reference Citation |
1. | Abl silencing inhibits CAS-mediated process and constriction in resistance arteries. | Anfinogenova Y, etal., Circ Res. 2007 Aug 17;101(4):420-8. Epub 2007 Jul 5. |
2. | Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis. | Bu W, etal., PLoS One. 2010 Aug 13;5(8):e12153. doi: 10.1371/journal.pone.0012153. |
3. | EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly. | Campellone KG, etal., Dev Cell. 2004 Aug;7(2):217-28. doi: 10.1016/j.devcel.2004.07.004. |
4. | Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly. | Campellone KG, etal., PLoS Pathog. 2008 Oct;4(10):e1000191. doi: 10.1371/journal.ppat.1000191. Epub 2008 Oct 31. |
5. | Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP. | Cantarelli VV, etal., Cell Microbiol. 2007 Jul;9(7):1782-95. doi: 10.1111/j.1462-5822.2007.00913.x. Epub 2007 Apr 19. |
6. | Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes. | Chen JL, etal., FEBS Lett. 2004 May 21;566(1-3):281-6. |
7. | N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. | Desmarais V, etal., Cell Motil Cytoskeleton. 2009 Jun;66(6):303-16. doi: 10.1002/cm.20361. |
8. | Identification of N-WASP homologs in human and rat brain. | Fukuoka M, etal., Gene 1997 Sep 1;196(1-2):43-8. |
9. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
10. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
11. | NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. | Icking A, etal., J Cell Sci. 2005 Nov 1;118(Pt 21):5059-69. Epub 2005 Oct 18. |
12. | Syndapins integrate N-WASP in receptor-mediated endocytosis. | Kessels MM and Qualmann B, EMBO J 2002 Nov 15;21(22):6083-94. |
13. | SPIN90/WISH interacts with PSD-95 and regulates dendritic spinogenesis via an N-WASP-independent mechanism. | Lee S, etal., EMBO J. 2006 Oct 18;25(20):4983-95. Epub 2006 Sep 21. |
14. | Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat. | Lie PP, etal., Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12562-7. doi: 10.1073/pnas.1202316109. Epub 2012 Jul 12. |
15. | Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. | Martinez-Quiles N, etal., Mol Cell Biol. 2004 Jun;24(12):5269-80. doi: 10.1128/MCB.24.12.5269-5280.2004. |
16. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
17. | Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. | Miki H, etal., Nature. 1998 Jan 1;391(6662):93-6. |
18. | SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane. | Park J, etal., J Cell Sci. 2010 May 15;123(Pt 10):1742-50. doi: 10.1242/jcs.064170. Epub 2010 Apr 27. |
19. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
20. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
21. | Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. | Prehoda KE, etal., Science. 2000 Oct 27;290(5492):801-6. |
22. | GOA pipeline | RGD automated data pipeline |
23. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
24. | The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. | Sallee NA, etal., Nature. 2008 Aug 21;454(7207):1005-8. doi: 10.1038/nature07170. Epub 2008 Jul 23. |
25. | The essential role of profilin in the assembly of actin for microspike formation. | Suetsugu S, etal., EMBO J. 1998 Nov 16;17(22):6516-26. |
26. | Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization. | To C, etal., J Biol Chem. 2010 Sep 3;285(36):27944-57. doi: 10.1074/jbc.M110.103036. Epub 2010 Jun 21. |
27. | Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. | Volkman BF, etal., Cell 2002 Nov 15;111(4):565-76. |
28. | N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. | Wegner AM, etal., J Biol Chem. 2008 Jun 6;283(23):15912-20. Epub 2008 Apr 21. |
PMID:9950691 | PMID:10704453 | PMID:11559594 | PMID:11584276 | PMID:12477932 | PMID:14732713 | PMID:15148305 | PMID:15489334 | PMID:15664188 | PMID:15791211 | PMID:15797550 | PMID:16767080 |
PMID:16885158 | PMID:17049400 | PMID:17092940 | PMID:17229736 | PMID:17350575 | PMID:17405146 | PMID:17635999 | PMID:17681954 | PMID:18362183 | PMID:18388313 | PMID:19056867 | PMID:19379711 |
PMID:19509061 | PMID:19759398 | PMID:21464958 | PMID:21874009 | PMID:22250195 | PMID:22389406 | PMID:22585739 | PMID:22966049 | PMID:23376485 | PMID:23750457 | PMID:23843614 | PMID:25321392 |
PMID:25851601 | PMID:26554011 | PMID:31859439 | PMID:37296607 |
Wasl (Rattus norvegicus - Norway rat) |
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WASL (Homo sapiens - human) |
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Wasl (Mus musculus - house mouse) |
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Wasl (Chinchilla lanigera - long-tailed chinchilla) |
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WASL (Pan paniscus - bonobo/pygmy chimpanzee) |
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WASL (Canis lupus familiaris - dog) |
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Wasl (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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WASL (Sus scrofa - pig) |
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WASL (Chlorocebus sabaeus - green monkey) |
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Wasl (Heterocephalus glaber - naked mole-rat) |
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Variants in Wasl
213 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH128038 |
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AI231276 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 37 | 57 | 41 | 19 | 41 | 2 | 2 | 74 | 35 | 40 | 11 | 2 |
Low | 6 | 6 | 9 | 1 | 6 | ||||||||
Below cutoff |
RefSeq Transcripts | NM_001110365 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_039108349 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | CH473959 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
FQ215931 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JACYVU010000141 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000009261 ⟹ ENSRNOP00000009261 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000106852 ⟹ ENSRNOP00000097692 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000114717 ⟹ ENSRNOP00000091229 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000116006 ⟹ ENSRNOP00000090815 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001110365 ⟹ NP_001103835 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039108349 ⟹ XP_038964277 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001103835 | (Get FASTA) | NCBI Sequence Viewer |
XP_038964277 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | EDM15175 | (Get FASTA) | NCBI Sequence Viewer |
EDM15176 | (Get FASTA) | NCBI Sequence Viewer | |
O08816 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001103835 ⟸ NM_001110365 |
- UniProtKB: | O08816 (UniProtKB/Swiss-Prot), F1LSG0 (UniProtKB/TrEMBL), A6IE88 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000009261 ⟸ ENSRNOT00000009261 |
RefSeq Acc Id: | XP_038964277 ⟸ XM_039108349 |
- Peptide Label: | isoform X1 |
- UniProtKB: | O08816 (UniProtKB/Swiss-Prot) |
RefSeq Acc Id: | ENSRNOP00000097692 ⟸ ENSRNOT00000106852 |
RefSeq Acc Id: | ENSRNOP00000090815 ⟸ ENSRNOT00000116006 |
RefSeq Acc Id: | ENSRNOP00000091229 ⟸ ENSRNOT00000114717 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-O08816-F1-model_v2 | AlphaFold | O08816 | 1-501 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:735144 | AgrOrtholog |
BioCyc Gene | G2FUF-45479 | BioCyc |
Ensembl Genes | ENSRNOG00000006975 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000009261 | ENTREZGENE |
ENSRNOP00000009261.6 | UniProtKB/TrEMBL | |
ENSRNOP00000090815.1 | UniProtKB/TrEMBL | |
ENSRNOP00000091229.1 | UniProtKB/TrEMBL | |
ENSRNOP00000097692.1 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000009261 | ENTREZGENE |
ENSRNOT00000009261.7 | UniProtKB/TrEMBL | |
ENSRNOT00000106852.1 | UniProtKB/TrEMBL | |
ENSRNOT00000114717.1 | UniProtKB/TrEMBL | |
ENSRNOT00000116006.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.30.29.30 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
3.90.810.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:7454794 | IMAGE-MGC_LOAD |
InterPro | CRIB_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CRIB_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
IQUB | UniProtKB/TrEMBL | |
PH-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
WASP_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
WASPfam_EVH1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
WH1/EVH1_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
WH2_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:682507 | UniProtKB/TrEMBL |
MGC_CLONE | MGC:116166 | IMAGE-MGC_LOAD |
NCBI Gene | 682507 | ENTREZGENE |
PANTHER | FORMIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN | UniProtKB/TrEMBL | |
NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UNCHARACTERIZED | UniProtKB/TrEMBL | |
Pfam | PBD | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
WH1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
WH2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Wasl | PhenoGen |
PROSITE | CRIB | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
WH1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
WH2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SMART | PBD | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
WH1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
WH2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | PH domain-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF47912 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A8I6ABN7_RAT | UniProtKB/TrEMBL |
A0A8I6AE95_RAT | UniProtKB/TrEMBL | |
A0A8I6B641_RAT | UniProtKB/TrEMBL | |
A6IE81_RAT | UniProtKB/TrEMBL | |
A6IE88 | ENTREZGENE, UniProtKB/TrEMBL | |
F1LSG0 | ENTREZGENE, UniProtKB/TrEMBL | |
O08816 | ENTREZGENE, UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2019-04-02 | Wasl | WASP like actin nucleation promoting factor | Wasl | Wiskott-Aldrich syndrome-like | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2013-05-24 | Wasl | Wiskott-Aldrich syndrome-like | LOC685687 | hypothetical protein LOC685687 | Data Merged | 1643240 | APPROVED |
2009-12-15 | Wasl | Wiskott-Aldrich syndrome-like | Iqub | IQ motif and ubiquitin domain containing | Data Merged | 737654 | APPROVED |
2008-09-22 | Wasl | Wiskott-Aldrich syndrome-like | LOC682507 | similar to Neural Wiskott-Aldrich syndrome protein (N-WASP) | Data Merged | 737654 | APPROVED |
2008-03-04 | Wasl | Wiskott-Aldrich syndrome-like | Iqub | IQ motif and ubiquitin domain containing | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2007-11-07 | Iqub | IQ motif and ubiquitin domain containing | Wasl | Wiskott-Aldrich syndrome-like (human) | Symbol and Name updated | 1299863 | APPROVED |
2006-11-20 | LOC682507 | similar to Neural Wiskott-Aldrich syndrome protein (N-WASP) | Symbol and Name status set to provisional | 70820 | PROVISIONAL | ||
2006-11-20 | LOC685687 | hypothetical protein LOC685687 | Symbol and Name status set to provisional | 70820 | PROVISIONAL | ||
2005-07-08 | Wasl | Wiskott-Aldrich syndrome-like (human) | N-WASP | neural Wiskott-Aldrich syndrome protein | Symbol and Name updated | 1299863 | APPROVED |