RGD Reference Report - Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP. - Rat Genome Database

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Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP.

Authors: Cantarelli, Vlademir V  Kodama, Toshio  Nijstad, Niels  Abolghait, Said Kamal  Nada, Shigeyuki  Okada, Masato  Iida, Tetsuya  Honda, Takeshi 
Citation: Cantarelli VV, etal., Cell Microbiol. 2007 Jul;9(7):1782-95. doi: 10.1111/j.1462-5822.2007.00913.x. Epub 2007 Apr 19.
RGD ID: 21201258
Pubmed: PMID:17451412   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1462-5822.2007.00913.x   (Journal Full-text)

Enterohaemorrhagic Escherichia coli (EHEC) is an important food-borne pathogen that, upon infection, causes destruction of the microvilli brush border of intestinal cells. EHEC is able to recruit several host cell proteins and induce actin accumulation beneath its adherence site, forming a pedestal-like structure upon which the bacterium is firmly attached. Injection of bacterial effectors into the host cells is required to trigger the recruitment and activation of proteins, such as cortactin, neural Wiskott-Aldrich syndrome protein (N-WASP) and Arp2/3 complex, directly involved in the actin polymerization process. We found that cortactin, an actin-binding protein, has a pivotal role during pedestal formation by EHEC. Cortactin was found to bind directly to two important virulence factors of EHEC, Tir and EspF(u), which are translocated into the host cells during infection. Binding of cortactin to these effectors is dependent upon tyrosine phosphorylation and a balance between tyrosine phosphorylation and dephosphorylation of cortactin is required to regulate pedestal formation by EHEC.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding enablesIPIUniProtKB:Q6059821201258PMID:17451412IntAct 
protein binding enablesIPIUniProtKB:Q8X48221201258PMID:17451412IntAct 

Objects Annotated

Genes (Rattus norvegicus)
Wasl  (WASP like actin nucleation promoting factor)


Additional Information