WASL (WASP like actin nucleation promoting factor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: WASL (WASP like actin nucleation promoting factor) Sus scrofa
Analyze
Symbol: WASL
Name: WASP like actin nucleation promoting factor
RGD ID: 14287704
Description: ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cell projection assembly (ortholog); membrane invagination (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN cell leading edge (ortholog); cytoplasmic vesicle (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neural Wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1823,722,188 - 23,789,506 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11823,722,188 - 23,789,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21825,318,931 - 25,386,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WASL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1823,722,188 - 23,789,506 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11823,722,188 - 23,789,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21825,318,931 - 25,386,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WASL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387123,681,943 - 123,749,003 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7123,681,943 - 123,749,003 (-)EnsemblGRCh38hg38GRCh38
GRCh377123,321,997 - 123,389,057 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367123,109,233 - 123,176,352 (-)NCBINCBI36Build 36hg18NCBI36
Build 347122,915,949 - 122,983,067NCBI
Celera7118,125,741 - 118,192,900 (-)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7117,685,121 - 117,752,321 (-)NCBIHuRef
CHM1_17123,255,296 - 123,322,481 (-)NCBICHM1_1
T2T-CHM13v2.07124,998,697 - 125,065,742 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27122,710,608 - 122,777,749 (-)NCBI
Wasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39624,613,809 - 24,665,185 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl624,613,804 - 24,665,008 (-)EnsemblGRCm39 Ensembl
GRCm38624,613,810 - 24,664,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl624,613,805 - 24,665,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv37624,563,810 - 24,614,995 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36624,563,815 - 24,614,981 (-)NCBIMGSCv36mm8
Celera624,624,846 - 24,676,054 (-)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.28NCBI
Wasl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8454,049,081 - 54,097,653 (-)NCBIGRCr8
mRatBN7.2453,083,536 - 53,132,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl453,083,536 - 53,132,022 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx458,070,385 - 58,118,872 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0453,977,276 - 54,025,972 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0452,411,758 - 52,460,472 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0451,677,722 - 51,726,212 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,677,722 - 51,726,212 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0451,455,978 - 51,504,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4451,063,710 - 51,092,848 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1451,294,288 - 51,323,128 (-)NCBI
Celera448,249,249 - 48,297,692 (-)NCBICelera
Cytogenetic Map4q22NCBI
Wasl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554795,166,393 - 5,200,512 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554795,167,851 - 5,200,512 (-)NCBIChiLan1.0ChiLan1.0
WASL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26160,537,416 - 160,606,388 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1712,550,222 - 12,614,145 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07115,675,170 - 115,741,498 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17128,357,909 - 128,388,395 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7128,360,495 - 128,385,393 (-)Ensemblpanpan1.1panPan2
WASL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11411,828,298 - 11,901,190 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1411,828,687 - 11,899,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1411,512,373 - 11,585,271 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01411,605,958 - 11,678,914 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1411,606,343 - 11,678,904 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11411,795,524 - 11,868,439 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01411,533,495 - 11,606,377 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01411,774,079 - 11,846,981 (+)NCBIUU_Cfam_GSD_1.0
Wasl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511850,387,234 - 50,461,160 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366051,742,776 - 1,816,690 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366051,741,832 - 1,816,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WASL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12192,480,392 - 92,546,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2192,482,918 - 92,546,481 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604210,917,558 - 10,985,328 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wasl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478312,254,715 - 12,323,232 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478312,239,467 - 12,322,403 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WASL
1520 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000018077   ⟹   ENSSSCP00000017588
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1823,722,543 - 23,787,247 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000043210   ⟹   ENSSSCP00000047552
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1823,722,188 - 23,789,506 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000080111   ⟹   ENSSSCP00000061208
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1823,722,188 - 23,784,506 (+)Ensembl
RefSeq Acc Id: XM_003134725   ⟹   XP_003134773
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11823,722,188 - 23,789,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021079051   ⟹   XP_020934710
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11823,722,393 - 23,789,516 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003134773   ⟸   XM_003134725
- Peptide Label: isoform X2
- UniProtKB: A0A287ATX4 (UniProtKB/TrEMBL),   A0A4X1W3Z3 (UniProtKB/TrEMBL),   A0A8D0TWJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020934710   ⟸   XM_021079051
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VWS1 (UniProtKB/TrEMBL),   F1SMK2 (UniProtKB/TrEMBL),   A0A8D0TWJ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000061208   ⟸   ENSSSCT00000080111
Ensembl Acc Id: ENSSSCP00000017588   ⟸   ENSSSCT00000018077
Ensembl Acc Id: ENSSSCP00000047552   ⟸   ENSSSCT00000043210
Protein Domains
CRIB   WH1   WH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015013699 UniProtKB/TrEMBL
  ENSSSCG00025057619 UniProtKB/TrEMBL
  ENSSSCG00030063208 UniProtKB/TrEMBL
  ENSSSCG00035067388 UniProtKB/TrEMBL
  ENSSSCG00040005608 UniProtKB/TrEMBL
  ENSSSCG00045027902 UniProtKB/TrEMBL
  ENSSSCG00050043922 UniProtKB/TrEMBL
  ENSSSCG00055012784 UniProtKB/TrEMBL
  ENSSSCG00060020144 UniProtKB/TrEMBL
  ENSSSCG00065058593 UniProtKB/TrEMBL
  ENSSSCG00070028298 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018077 ENTREZGENE
  ENSSSCT00000018077.5 UniProtKB/TrEMBL
  ENSSSCT00000043210 ENTREZGENE
  ENSSSCT00000043210.2 UniProtKB/TrEMBL
  ENSSSCT00000080111.2 UniProtKB/TrEMBL
  ENSSSCT00015018188.1 UniProtKB/TrEMBL
  ENSSSCT00015018281.1 UniProtKB/TrEMBL
  ENSSSCT00015018345.1 UniProtKB/TrEMBL
  ENSSSCT00015018411.1 UniProtKB/TrEMBL
  ENSSSCT00015018474.1 UniProtKB/TrEMBL
  ENSSSCT00025078886.1 UniProtKB/TrEMBL
  ENSSSCT00025079264.1 UniProtKB/TrEMBL
  ENSSSCT00025079503.1 UniProtKB/TrEMBL
  ENSSSCT00030088434.1 UniProtKB/TrEMBL
  ENSSSCT00030088451.1 UniProtKB/TrEMBL
  ENSSSCT00030088464.1 UniProtKB/TrEMBL
  ENSSSCT00030088492.1 UniProtKB/TrEMBL
  ENSSSCT00035090890.1 UniProtKB/TrEMBL
  ENSSSCT00035090909.1 UniProtKB/TrEMBL
  ENSSSCT00035090918.1 UniProtKB/TrEMBL
  ENSSSCT00035090932.1 UniProtKB/TrEMBL
  ENSSSCT00035090950.1 UniProtKB/TrEMBL
  ENSSSCT00040007406.1 UniProtKB/TrEMBL
  ENSSSCT00040007418.1 UniProtKB/TrEMBL
  ENSSSCT00040007428.1 UniProtKB/TrEMBL
  ENSSSCT00045047587.1 UniProtKB/TrEMBL
  ENSSSCT00045047675.1 UniProtKB/TrEMBL
  ENSSSCT00045047756.1 UniProtKB/TrEMBL
  ENSSSCT00045047862.1 UniProtKB/TrEMBL
  ENSSSCT00045047949.1 UniProtKB/TrEMBL
  ENSSSCT00050059789.1 UniProtKB/TrEMBL
  ENSSSCT00050059810.1 UniProtKB/TrEMBL
  ENSSSCT00050059822.1 UniProtKB/TrEMBL
  ENSSSCT00055025154.1 UniProtKB/TrEMBL
  ENSSSCT00055025226.1 UniProtKB/TrEMBL
  ENSSSCT00055025281.1 UniProtKB/TrEMBL
  ENSSSCT00055025338.1 UniProtKB/TrEMBL
  ENSSSCT00055025409.1 UniProtKB/TrEMBL
  ENSSSCT00060027241.1 UniProtKB/TrEMBL
  ENSSSCT00060027244.1 UniProtKB/TrEMBL
  ENSSSCT00060027252.1 UniProtKB/TrEMBL
  ENSSSCT00065080177.1 UniProtKB/TrEMBL
  ENSSSCT00065080194.1 UniProtKB/TrEMBL
  ENSSSCT00065080209.1 UniProtKB/TrEMBL
  ENSSSCT00065080214.1 UniProtKB/TrEMBL
  ENSSSCT00065080230.1 UniProtKB/TrEMBL
  ENSSSCT00070056751.1 UniProtKB/TrEMBL
  ENSSSCT00070056753.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.90.810.10 UniProtKB/TrEMBL
InterPro CRIB_dom UniProtKB/TrEMBL
  CRIB_dom_sf UniProtKB/TrEMBL
  Formin_Homology_Diaphanous_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  WASP_C UniProtKB/TrEMBL
  WASPfam_EVH1 UniProtKB/TrEMBL
  WH1/EVH1_dom UniProtKB/TrEMBL
  WH2_dom UniProtKB/TrEMBL
KEGG Report ssc:100525017 UniProtKB/TrEMBL
NCBI Gene WASL ENTREZGENE
PANTHER NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN UniProtKB/TrEMBL
  PROTEIN DIAPHANOUS UniProtKB/TrEMBL
  PROTEIN DIAPHANOUS UniProtKB/TrEMBL
  SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/TrEMBL
Pfam PBD UniProtKB/TrEMBL
  WH1 UniProtKB/TrEMBL
  WH2 UniProtKB/TrEMBL
PROSITE CRIB UniProtKB/TrEMBL
  WH1 UniProtKB/TrEMBL
  WH2 UniProtKB/TrEMBL
SMART PBD UniProtKB/TrEMBL
  WH1 UniProtKB/TrEMBL
  WH2 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47912 UniProtKB/TrEMBL
UniProt A0A287ATX4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VWS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1W3Z3 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QSR4_PIG UniProtKB/TrEMBL
  A0A8D0MQG8_PIG UniProtKB/TrEMBL
  A0A8D0TWJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1B405_PIG UniProtKB/TrEMBL
  A0A8D1BQ32_PIG UniProtKB/TrEMBL
  A0A8D1CFE6_PIG UniProtKB/TrEMBL
  A0A8D1IGE3_PIG UniProtKB/TrEMBL
  A0A8D1QMX9_PIG UniProtKB/TrEMBL
  A0A8D1U1L4_PIG UniProtKB/TrEMBL
  F1SMK2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:96604 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 WASL  WASP like actin nucleation promoting factor    Wiskott-Aldrich syndrome like  Symbol and/or name change 5135510 APPROVED