Creb3l2 (cAMP responsive element binding protein 3-like 2) - Rat Genome Database

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Gene: Creb3l2 (cAMP responsive element binding protein 3-like 2) Rattus norvegicus
Analyze
Symbol: Creb3l2
Name: cAMP responsive element binding protein 3-like 2
RGD ID: 1306040
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of gene expression; positive regulation of neuron projection development; and response to endoplasmic reticulum stress. Located in perinuclear endoplasmic reticulum. Part of chromatin. Orthologous to human CREB3L2 (cAMP responsive element binding protein 3 like 2); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Huntington's disease pathway; prostate cancer pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cAMP-responsive element-binding protein 3-like protein 2; cyclic AMP-responsive element-binding protein 3-like protein 2; LOC102552017; LOC362339; Ra69; SCI-related protein Ra69; SCIRR69; uncharacterized LOC102552017
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8466,874,623 - 66,990,962 (-)NCBIGRCr8
mRatBN7.2465,907,570 - 66,112,078 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl465,907,655 - 66,023,763 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx470,849,613 - 70,965,757 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0466,770,691 - 66,886,837 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0465,160,628 - 65,276,768 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0464,869,285 - 64,981,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,869,026 - 64,981,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0464,691,125 - 64,803,069 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4464,703,458 - 64,816,668 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1464,979,587 - 65,092,798 (-)NCBI
Celera460,932,138 - 61,044,664 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (ISO)
isobutanol  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
metformin  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
starch  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption. Bell RL, etal., Pharmacol Biochem Behav. 2009 Nov;94(1):131-47. doi: 10.1016/j.pbb.2009.07.019. Epub 2009 Aug 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Transcription factor SCIRR69 involved in the activation of brain-derived neurotrophic factor gene promoter II in mechanically injured neurons. Liu Y, etal., Neuromolecular Med. 2013 Sep;15(3):605-22. doi: 10.1007/s12017-013-8245-y. Epub 2013 Jul 11.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. The impact of the unfolded protein response on human disease. Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.
Additional References at PubMed
PMID:17178827   PMID:19767744   PMID:22535319   PMID:22705851   PMID:27488499   PMID:31597097   PMID:37555472  


Genomics

Comparative Map Data
Creb3l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8466,874,623 - 66,990,962 (-)NCBIGRCr8
mRatBN7.2465,907,570 - 66,112,078 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl465,907,655 - 66,023,763 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx470,849,613 - 70,965,757 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0466,770,691 - 66,886,837 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0465,160,628 - 65,276,768 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0464,869,285 - 64,981,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,869,026 - 64,981,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0464,691,125 - 64,803,069 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4464,703,458 - 64,816,668 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1464,979,587 - 65,092,798 (-)NCBI
Celera460,932,138 - 61,044,664 (-)NCBICelera
Cytogenetic Map4q22NCBI
CREB3L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387137,874,979 - 138,002,086 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7137,874,979 - 138,002,086 (-)EnsemblGRCh38hg38GRCh38
GRCh377137,559,725 - 137,686,832 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367137,210,265 - 137,337,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 347137,016,979 - 137,144,101NCBI
Celera7132,298,692 - 132,425,654 (-)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7131,867,554 - 131,994,857 (-)NCBIHuRef
CHM1_17137,493,293 - 137,620,361 (-)NCBICHM1_1
T2T-CHM13v2.07139,184,080 - 139,311,621 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27136,905,109 - 137,032,069 (-)NCBI
Creb3l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39637,307,956 - 37,419,083 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl637,304,190 - 37,419,081 (-)EnsemblGRCm39 Ensembl
GRCm38637,327,255 - 37,442,276 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl637,327,255 - 37,442,146 (-)EnsemblGRCm38mm10GRCm38
MGSCv37637,281,021 - 37,392,148 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36637,260,627 - 37,371,747 (-)NCBIMGSCv36mm8
Celera637,307,243 - 37,429,201 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map616.18NCBI
Creb3l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554945,045,272 - 5,089,121 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554945,014,509 - 5,094,220 (+)NCBIChiLan1.0ChiLan1.0
CREB3L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26174,688,367 - 174,816,921 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1726,698,619 - 26,827,174 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07129,833,446 - 129,960,145 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17142,326,266 - 142,452,438 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7142,331,759 - 142,452,438 (-)Ensemblpanpan1.1panPan2
CREB3L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11610,683,169 - 10,803,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1610,682,935 - 11,248,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1611,696,999 - 11,817,077 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01610,643,987 - 10,764,606 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1610,644,016 - 10,760,664 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11611,106,597 - 11,226,365 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01610,209,275 - 10,329,400 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01610,351,793 - 10,471,726 (+)NCBIUU_Cfam_GSD_1.0
Creb3l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511816,806,312 - 16,916,844 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365922,308,156 - 2,413,510 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365922,302,921 - 2,413,486 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CREB3L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1811,533,183 - 11,666,113 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11811,533,184 - 11,666,132 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21812,205,340 - 12,338,168 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CREB3L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121106,572,893 - 106,705,080 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21106,578,422 - 106,705,089 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660723,436,572 - 3,563,264 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Creb3l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476518,157,132 - 18,276,029 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476518,152,099 - 18,275,614 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Creb3l2
885 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:635
Count of miRNA genes:265
Interacting mature miRNAs:320
Transcripts:ENSRNOT00000017338
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat

Markers in Region
D4Rat122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,957,850 - 65,958,103 (+)MAPPERmRatBN7.2
Rnor_6.0464,915,651 - 64,915,903NCBIRnor6.0
Rnor_5.0464,737,491 - 64,737,743UniSTSRnor5.0
RGSC_v3.4464,749,824 - 64,750,077RGDRGSC3.4
RGSC_v3.4464,749,825 - 64,750,077UniSTSRGSC3.4
RGSC_v3.1465,025,955 - 65,026,207RGD
Celera460,978,883 - 60,979,135UniSTS
RH 3.4 Map4412.7UniSTS
RH 3.4 Map4412.7RGD
SHRSP x BN Map434.0UniSTS
SHRSP x BN Map434.0RGD
Cytogenetic Map4q22UniSTS
RH138526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,932,682 - 65,932,829 (+)MAPPERmRatBN7.2
Rnor_6.0464,890,486 - 64,890,632NCBIRnor6.0
Rnor_5.0464,712,326 - 64,712,472UniSTSRnor5.0
RGSC_v3.4464,724,659 - 64,724,805UniSTSRGSC3.4
Celera460,953,345 - 60,953,491UniSTS
RH 3.4 Map4409.7UniSTS
Cytogenetic Map4q22UniSTS
AU048281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,983,016 - 65,983,132 (+)MAPPERmRatBN7.2
Rnor_6.0464,940,464 - 64,940,579NCBIRnor6.0
Rnor_5.0464,762,014 - 64,762,129UniSTSRnor5.0
RGSC_v3.4464,775,047 - 64,775,162UniSTSRGSC3.4
Celera461,004,019 - 61,004,134UniSTS
Cytogenetic Map4q22UniSTS
BF409996  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2466,005,778 - 66,005,908 (+)MAPPERmRatBN7.2
Rnor_6.0464,963,225 - 64,963,354NCBIRnor6.0
Rnor_5.0464,784,775 - 64,784,904UniSTSRnor5.0
RGSC_v3.4464,797,812 - 64,797,941UniSTSRGSC3.4
Celera461,026,742 - 61,026,871UniSTS
RH 3.4 Map4414.6UniSTS
Cytogenetic Map4q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 26 20 9 20 1 1 14 35 34 11 1
Low 3 6 31 21 10 21 7 10 60 7 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000017338   ⟹   ENSRNOP00000017338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,907,655 - 66,023,763 (-)Ensembl
Rnor_6.0 Ensembl464,869,026 - 64,981,384 (-)Ensembl
RefSeq Acc Id: NM_001012188   ⟹   NP_001012188
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,874,623 - 66,990,832 (-)NCBI
mRatBN7.2465,907,570 - 66,023,779 (-)NCBI
Rnor_6.0464,869,285 - 64,981,519 (-)NCBI
Rnor_5.0464,691,125 - 64,803,069 (-)NCBI
RGSC_v3.4464,703,458 - 64,816,668 (-)RGD
Celera460,932,138 - 61,044,664 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107780   ⟹   XP_038963708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,879,867 - 66,990,962 (-)NCBI
mRatBN7.2465,907,570 - 66,023,812 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001012188 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963708 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS49162 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017338
  ENSRNOP00000017338.5
  ENSRNOP00065021832
GenBank Protein Q6QDP7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012188   ⟸   NM_001012188
- UniProtKB: Q6QDP7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017338   ⟸   ENSRNOT00000017338
RefSeq Acc Id: XP_038963708   ⟸   XM_039107780
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q9L4 (UniProtKB/TrEMBL),   A6IEQ6 (UniProtKB/TrEMBL)
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QDP7-F1-model_v2 AlphaFold Q6QDP7 1-521 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306040 AgrOrtholog
BioCyc Gene G2FUF-45223 BioCyc
Ensembl Genes ENSRNOG00000012826 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065016633 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017338.6 UniProtKB/TrEMBL
  ENSRNOT00065027712 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362339 UniProtKB/Swiss-Prot
NCBI Gene 362339 ENTREZGENE
PANTHER CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46004:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Creb3l2 PhenoGen
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012826 RatGTEx
  ENSRNOG00065016633 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q9L4 ENTREZGENE, UniProtKB/TrEMBL
  A6IEQ6 ENTREZGENE, UniProtKB/TrEMBL
  CR3L2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Creb3l2  cAMP responsive element binding protein 3-like 2  LOC102552017  uncharacterized LOC102552017  Data merged from RGD:7729742 737654 PROVISIONAL
2013-12-18 LOC102552017  uncharacterized LOC102552017      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Creb3l2  cAMP responsive element binding protein 3-like 2  Creb3l2_predicted  cAMP responsive element binding protein 3-like 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Creb3l2_predicted  cAMP responsive element binding protein 3-like 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED