Enables growth factor binding activity and identical protein binding activity. Involved in several processes, including cellular response to L-arginine; estrous cycle; and negative regulation of cellular response to oxidative stress. Located in apical part of cell; extracellular space; and zymogen granule. Part of protein-containing complex. Used to study acute pancreatitis and pneumonia. Biomarker of sciatic neuropathy; type 2 diabetes mellitus; and visual epilepsy. Orthologous to several human genes including REG3A (regenerating family member 3 alpha); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Trinitrobenzenesulfonic Acid results in increased expression of REG3A mRNA and Trinitrobenzenesulfonic Acid results in increased expression of REG3B mRNA
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of REG3B mRNA
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of REG3B mRNA
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of REG3B mRNA
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of REG3B mRNA
Age-related changes in peptide-23/pancreatitis-associated protein and pancreatic stone protein/reg gene expression in the rat and regulation by growth hormone-releasing hormone.
Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells.
Structural organization of the gene encoding the rat pancreatitis-associated protein. Analysis of its evolutionary history reveals an ancient divergence from the other carbohydrate-recognition domain-containing genes.
Messenger RNA sequence and expression of rat pancreatitis-associated protein, a lectin-related protein overexpressed during acute experimental pancreatitis.
Pancreatic islet-specific overexpression of Reg3beta protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus.
overexpressed during acute pancreatitis; constitutively expressed in duodenum, jejunum, and ileum, at similar levels as in pancreas during the acute phase of pancreatitis
promoter region contains pancreas-specific consensus sequences for two Pan1 (pancreas-specific) transcription activators, and contains one glucocorticoid response element and two IL-6 response elements