Reg3b (regenerating family member 3 beta) - Rat Genome Database

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Gene: Reg3b (regenerating family member 3 beta) Rattus norvegicus
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Symbol: Reg3b
Name: regenerating family member 3 beta
RGD ID: 3254
Description: Enables growth factor binding activity and identical protein binding activity. Involved in several processes, including cellular response to L-arginine; estrous cycle; and negative regulation of neuron death. Located in apical part of cell; extracellular space; and zymogen granule. Part of protein-containing complex. Used to study acute pancreatitis and pneumonia. Biomarker of sciatic neuropathy; type 2 diabetes mellitus; and visual epilepsy. Orthologous to several human genes including REG3A (regenerating family member 3 alpha); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: pancreatic beta cell growth factor; pancreatitis-associated protein; Pancreatitis-associated protein 1; Pap; Pap1; peptide 23; reg III-beta; REG-2; REG-3-beta; regenerating islet-derived 3 beta; regenerating islet-derived protein 3 beta; regenerating islet-derived protein 3-beta; regenerating islet-derived protein III-beta
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24110,861,775 - 110,865,015 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4110,861,775 - 110,865,015 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4116,267,336 - 116,270,574 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04112,042,437 - 112,045,675 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04110,662,632 - 110,665,870 (+)NCBIRnor_WKY
Rnor_6.04109,467,272 - 109,470,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4109,467,272 - 109,470,510 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04174,173,099 - 174,176,337 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,355,773 - 112,359,011 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14112,600,253 - 112,603,492 (+)NCBI
Celera499,893,732 - 99,896,970 (+)NCBICelera
Cytogenetic Map4q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Induction of pancreatitis-associated protein (PAP) family members in neurons after traumatic brain injury. Ampo K, etal., J Neurotrauma. 2009 Oct;26(10):1683-93. doi: 10.1089/neu.2008-0847.
2. Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis. Bimmler D, etal., J Surg Res 2004 May 15;118(2):122-35.
3. PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha. Bodeker H, etal., Mol Cell Biol Res Commun. 1999 Sep-Dec;2(3):150-4.
4. Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats. Calderari S, etal., PLoS One. 2014 Feb 26;9(2):e90045. doi: 10.1371/journal.pone.0090045. eCollection 2014.
5. Age-related changes in peptide-23/pancreatitis-associated protein and pancreatic stone protein/reg gene expression in the rat and regulation by growth hormone-releasing hormone. Chakraborty C, etal., Endocrinology. 1995 May;136(5):1843-9.
6. Expression of pituitary peptide 23 in the rat uterus: regulation by estradiol. Chakraborty C, etal., Mol Cell Endocrinol. 1995 Feb 27;108(1-2):149-54.
7. Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells. Christa L, etal., Am J Pathol. 1999 Nov;155(5):1525-33.
8. Structural organization of the gene encoding the rat pancreatitis-associated protein. Analysis of its evolutionary history reveals an ancient divergence from the other carbohydrate-recognition domain-containing genes. Dusetti NJ, etal., J Biol Chem 1993 Jul 5;268(19):14470-5.
9. The pancreatitis-associated protein induces lung inflammation in the rat through activation of TNFalpha expression in hepatocytes. Folch-Puy E, etal., J Pathol. 2003 Mar;199(3):398-408.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation. Graf R, etal., J Biol Chem. 2001 Jun 15;276(24):21028-38. Epub 2001 Mar 16.
12. Messenger RNA sequence and expression of rat pancreatitis-associated protein, a lectin-related protein overexpressed during acute experimental pancreatitis. Iovanna J, etal., J Biol Chem 1991 Dec 25;266(36):24664-9.
13. PAP, a pancreatic secretory protein induced during acute pancreatitis, is expressed in rat intestine. Iovanna JL, etal., Am J Physiol 1993 Oct;265(4 Pt 1):G611-8.
14. Sequence of a cDNA clone encoding a rat Reg-2 protein. Kamimura T, etal., Gene 1992 Sep 10;118(2):299-300.
15. Molecular cloning and expression of peptide 23, a growth hormone-releasing hormone-inducible pituitary protein. Katsumata N, etal., Endocrinology 1995 Apr;136(4):1332-9.
16. Pancreatitis-associated protein-I and pancreatitis-associated protein-III expression in a rat model of kainic acid-induced seizure. Kawahara S, etal., Neuroscience. 2011 Feb 23;175:273-80. doi: 10.1016/j.neuroscience.2010.11.020. Epub 2010 Nov 18.
17. Rat pancreatitis-associated protein is expressed in relation to severity of experimental pancreatitis. Keim V, etal., Pancreas. 1994 Sep;9(5):606-12.
18. Patterns of pain: meta-analysis of microarray studies of pain. LaCroix-Fralish ML, etal., Pain. 2011 Aug;152(8):1888-98. doi: 10.1016/j.pain.2011.04.014. Epub 2011 May 10.
19. Small-interference RNA gene knockdown of pancreatitis-associated proteins in rat acute pancreatitis. Lin YY, etal., Pancreas. 2008 May;36(4):402-10. doi: 10.1097/MPA.0b013e31815f3933.
20. Tumor necrosis factor alpha triggers antiapoptotic mechanisms in rat pancreatic cells through pancreatitis-associated protein I activation. Malka D, etal., Gastroenterology. 2000 Sep;119(3):816-28.
21. Expression of pancreatitis-associated protein after traumatic brain injury: a mechanism potentially contributing to neuroprotection in human brain. Marz-Weiss P, etal., Cell Mol Neurobiol. 2011 Nov;31(8):1141-9. doi: 10.1007/s10571-011-9715-0. Epub 2011 Jun 5.
22. Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells. Masamune A, etal., Pancreas. 2002 Mar;24(2):130-8.
23. Secretory apparatus assessed by analysis of pancreatic secretory stress protein expression in a rat model of chronic pancreatitis. Meili S, etal., Cell Tissue Res. 2003 Jun;312(3):291-9. Epub 2003 May 23.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Arginine induces apoptosis and gene expression of pancreatitis-associated protein (PAP) in rat pancreatic acinar AR4-2J cells. Motoo Y, etal., Pancreas. 2000 Jan;20(1):61-6.
26. Expression of Reg/PAP family members during motor nerve regeneration in rat. Namikawa K, etal., Biochem Biophys Res Commun. 2005 Jun 24;332(1):126-34.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Pancreatic beta cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene. Ota H, etal., Life Sci. 2013 Nov 4;93(18-19):664-72. doi: 10.1016/j.lfs.2013.09.001. Epub 2013 Sep 17.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Developmental, nutritional, and hormonal regulation of the pancreatitis-associated protein I and III gene expression in the rat small intestine. Sansonetti A, etal., Scand J Gastroenterol. 1995 Jul;30(7):664-9.
33. Expression of pancreatitis-associated protein (PAP) in rat spontaneous chronic pancreatitis: effect of herbal medicine Saiko-keishi-to (TJ-10). Su SB, etal., Pancreas. 1999 Oct;19(3):239-47.
34. Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis. Viterbo D, etal., JOP. 2009 Jan 8;10(1):15-23.
35. Gene expression profiles of cardiomyocytes in rat autoimmune myocarditis by DNA microarray and increase of regenerating gene family. Watanabe R, etal., Transl Res. 2008 Sep;152(3):119-27. doi: 10.1016/j.trsl.2008.07.006. Epub 2008 Aug 20.
36. Pancreatic islet-specific overexpression of Reg3beta protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus. Xiong X, etal., Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E669-80. doi: 10.1152/ajpendo.00600.2010. Epub 2011 Jan 18.
37. Comparison of reg I and reg III levels during acute pancreatitis in the rat. Zenilman ME, etal., Ann Surg. 2000 Nov;232(5):646-52.
Additional References at PubMed
PMID:15211109   PMID:16517747   PMID:18223607   PMID:18295254   PMID:19434369   PMID:19571575   PMID:19723102   PMID:21694778   PMID:21926556   PMID:22807607   PMID:23012479   PMID:23303201  
PMID:23370676   PMID:24256734   PMID:24465846   PMID:25751817   PMID:29305881   PMID:31744864   PMID:32084646  


Genomics

Comparative Map Data
Reg3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24110,861,775 - 110,865,015 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4110,861,775 - 110,865,015 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4116,267,336 - 116,270,574 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04112,042,437 - 112,045,675 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04110,662,632 - 110,665,870 (+)NCBIRnor_WKY
Rnor_6.04109,467,272 - 109,470,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4109,467,272 - 109,470,510 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04174,173,099 - 174,176,337 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,355,773 - 112,359,011 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14112,600,253 - 112,603,492 (+)NCBI
Celera499,893,732 - 99,896,970 (+)NCBICelera
Cytogenetic Map4q33NCBI
REG3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38279,157,006 - 79,159,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl279,157,003 - 79,159,753 (-)EnsemblGRCh38hg38GRCh38
GRCh37279,384,132 - 79,386,879 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36279,237,641 - 79,240,387 (-)NCBINCBI36Build 36hg18NCBI36
Celera279,212,862 - 79,215,608 (-)NCBICelera
Cytogenetic Map2p12NCBI
HuRef279,119,456 - 79,122,204 (-)NCBIHuRef
CHM1_1279,313,660 - 79,316,408 (-)NCBICHM1_1
T2T-CHM13v2.0279,157,332 - 79,160,079 (-)NCBIT2T-CHM13v2.0
Reg3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,347,868 - 78,350,449 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl678,347,640 - 78,350,449 (+)EnsemblGRCm39 Ensembl
GRCm38678,370,885 - 78,373,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,370,657 - 78,373,466 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,320,879 - 78,323,460 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36678,300,394 - 78,302,975 (+)NCBIMGSCv36mm8
Celera680,394,075 - 80,396,656 (+)NCBICelera
Cytogenetic Map6C3NCBI

Variants

.
Variants in Reg3b
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:124
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000008212
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4103194805112478794Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat

Markers in Region
RH130184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24110,864,764 - 110,864,984 (+)MAPPERmRatBN7.2
Rnor_6.04109,470,260 - 109,470,479NCBIRnor6.0
Rnor_5.04174,176,087 - 174,176,306UniSTSRnor5.0
RGSC_v3.44112,358,761 - 112,358,980UniSTSRGSC3.4
Celera499,896,720 - 99,896,939UniSTS
RH 3.4 Map4660.47UniSTS
Cytogenetic Map4q33-q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 1 3 7 1 6 1 1
Low 1 25 3 1 7 1 8 1 6 7
Below cutoff 5 6 5 3 5 4 4 23 9 11 3 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008212   ⟹   ENSRNOP00000008212
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4110,861,775 - 110,865,015 (+)Ensembl
Rnor_6.0 Ensembl4109,467,272 - 109,470,510 (+)Ensembl
RefSeq Acc Id: NM_053289   ⟹   NP_445741
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24110,861,775 - 110,865,015 (+)NCBI
Rnor_6.04109,467,272 - 109,470,510 (+)NCBI
Rnor_5.04174,173,099 - 174,176,337 (+)NCBI
RGSC_v3.44112,355,773 - 112,359,011 (+)RGD
Celera499,893,732 - 99,896,970 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445741   ⟸   NM_053289
- Peptide Label: precursor
- UniProtKB: P25031 (UniProtKB/Swiss-Prot),   A0A0H2UHE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008212   ⟸   ENSRNOT00000008212
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25031-F1-model_v2 AlphaFold P25031 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693153
Promoter ID:EPDNEW_R3677
Type:multiple initiation site
Name:Reg3b_1
Description:regenerating family member 3 beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04109,467,272 - 109,467,332EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3254 AgrOrtholog
BioCyc Gene G2FUF-44087 BioCyc
Ensembl Genes ENSRNOG00000006151 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008212 ENTREZGENE
  ENSRNOP00000008212.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008212 ENTREZGENE
  ENSRNOT00000008212.3 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24618 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24618 ENTREZGENE
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Reg3b PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHE4 ENTREZGENE, UniProtKB/TrEMBL
  P25031 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q64102 UniProtKB/Swiss-Prot
  Q64231 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-23 Reg3b  regenerating family member 3 beta  Reg3b  regenerating islet-derived 3 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-17 Reg3b  regenerating islet-derived 3 beta  Pap  pancreatitis-associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Pap  pancreatitis-associated protein  Pap1  Pancreatitis-associated protein 1  Symbol and Name updated 625702 APPROVED
2002-06-10 Pap1  Pancreatitis-associated protein 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_evolution gene may have evolved from a common ancestor gene by intron gain 729614
gene_expression overexpressed during acute pancreatitis; constitutively expressed in duodenum, jejunum, and ileum, at similar levels as in pancreas during the acute phase of pancreatitis 729614
gene_expression expressed in intestine; intestinal expression is not altered during acute pancreatitis 729577
gene_function may be involved in stress response to control bacterial proliferation 729652
gene_product protein is secreted 729577
gene_transcript promoter region contains pancreas-specific consensus sequences for two Pan1 (pancreas-specific) transcription activators, and contains one glucocorticoid response element and two IL-6 response elements 729614