Pals2 (protein associated with LIN7 2, MAGUK p55 family member) - Rat Genome Database

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Gene: Pals2 (protein associated with LIN7 2, MAGUK p55 family member) Rattus norvegicus
Analyze
Symbol: Pals2
Name: protein associated with LIN7 2, MAGUK p55 family member
RGD ID: 1311833
Description: Predicted to be active in cell-cell junction and plasma membrane. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CH474011:EDL88200; LOC362359; MAGUK p55 subfamily member 6; membrane palmitoylated protein 6; membrane protein, palmitoylated 6; membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6); MGC189400; Mpp6; protein associated with LIN7 2, MAGUK family member
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,504,298 - 80,584,951 (+)NCBIGRCr8
mRatBN7.2479,173,488 - 79,257,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl479,124,806 - 79,254,140 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx484,389,410 - 84,474,228 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0480,164,949 - 80,249,755 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,605,243 - 78,690,062 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,846,506 - 79,928,977 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,846,521 - 79,926,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04144,471,089 - 144,602,046 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4478,343,494 - 78,424,470 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1478,619,775 - 78,684,435 (+)NCBI
Celera474,082,633 - 74,162,987 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
furan  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. An overview of pre-ribosomal RNA processing in eukaryotes. Henras AK, etal., Wiley Interdiscip Rev RNA. 2015 Mar-Apr;6(2):225-42. doi: 10.1002/wrna.1269. Epub 2014 Oct 27.
4. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10753959   PMID:12477932   PMID:15632090   PMID:20458337  


Genomics

Comparative Map Data
Pals2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,504,298 - 80,584,951 (+)NCBIGRCr8
mRatBN7.2479,173,488 - 79,257,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl479,124,806 - 79,254,140 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx484,389,410 - 84,474,228 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0480,164,949 - 80,249,755 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,605,243 - 78,690,062 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,846,506 - 79,928,977 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,846,521 - 79,926,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04144,471,089 - 144,602,046 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4478,343,494 - 78,424,470 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1478,619,775 - 78,684,435 (+)NCBI
Celera474,082,633 - 74,162,987 (+)NCBICelera
Cytogenetic Map4q24NCBI
PALS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38724,573,452 - 24,694,193 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl724,573,268 - 24,694,193 (+)EnsemblGRCh38hg38GRCh38
GRCh37724,613,071 - 24,733,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36724,579,610 - 24,694,023 (+)NCBINCBI36Build 36hg18NCBI36
Build 34724,386,324 - 24,500,737NCBI
Celera724,601,884 - 24,715,973 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef724,544,555 - 24,612,058 (+)NCBIHuRef
CHM1_1724,614,653 - 24,729,063 (+)NCBICHM1_1
T2T-CHM13v2.0724,711,447 - 24,832,205 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2724,664,991 - 24,779,052 (+)NCBI
Pals2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39650,087,206 - 50,176,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl650,087,221 - 50,175,919 (+)EnsemblGRCm39 Ensembl
GRCm38650,110,228 - 50,199,154 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl650,110,241 - 50,198,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv37650,060,240 - 50,148,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36650,039,963 - 50,128,169 (+)NCBIMGSCv36mm8
Celera650,618,750 - 50,708,304 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map624.13NCBI
Pals2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541026,610,758 - 26,697,553 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541026,593,123 - 26,697,553 (+)NCBIChiLan1.0ChiLan1.0
PALS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2629,430,673 - 29,550,813 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1777,755,407 - 77,873,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0725,248,710 - 25,368,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1724,853,266 - 24,973,190 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl724,899,798 - 24,967,402 (+)Ensemblpanpan1.1panPan2
PALS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11438,095,892 - 38,206,730 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1438,095,716 - 38,213,418 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1437,645,606 - 37,756,631 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01438,032,148 - 38,142,984 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1438,031,672 - 38,142,243 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11438,145,746 - 38,256,586 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01437,838,258 - 37,949,172 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01438,180,110 - 38,291,374 (+)NCBIUU_Cfam_GSD_1.0
Pals2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511882,276,116 - 82,439,288 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364781,554,293 - 1,647,787 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364781,554,314 - 1,647,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PALS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1847,593,049 - 47,710,570 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11847,589,547 - 47,711,433 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21852,549,819 - 52,660,892 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PALS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12133,681,859 - 33,785,699 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2133,682,127 - 33,737,196 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604270,861,748 - 70,976,955 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pals2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247395,884,253 - 5,970,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247395,880,989 - 5,971,570 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pals2
440 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:254
Count of miRNA genes:168
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000029332
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
2317586Eae25Experimental allergic encephalomyelitis QTL 259.300000190734863nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)47888281783007655Rat
2317586Eae25Experimental allergic encephalomyelitis QTL 259.300000190734863nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)47888281783007655Rat
2317586Eae25Experimental allergic encephalomyelitis QTL 259.300000190734863nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)47888281783007655Rat
2317586Eae25Experimental allergic encephalomyelitis QTL 259.300000190734863nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)47888281783007655Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478885890102684881Rat

Markers in Region
RH127669  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2479,257,277 - 79,257,496 (+)MAPPERmRatBN7.2
Rnor_6.0479,929,841 - 79,930,059NCBIRnor6.0
Rnor_5.04144,601,782 - 144,602,000UniSTSRnor5.0
RGSC_v3.4478,427,607 - 78,427,825UniSTSRGSC3.4
Celera474,166,124 - 74,166,342UniSTS
RH 3.4 Map4499.4UniSTS
Cytogenetic Map4q24UniSTS
RH133592  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2479,174,587 - 79,174,802 (+)MAPPERmRatBN7.2
Rnor_6.0479,847,621 - 79,847,835NCBIRnor6.0
Rnor_5.04144,520,440 - 144,520,654UniSTSRnor5.0
RGSC_v3.4478,344,594 - 78,344,808UniSTSRGSC3.4
Celera474,083,733 - 74,083,947UniSTS
RH 3.4 Map4501.4UniSTS
Cytogenetic Map4q24UniSTS
BF399535  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2479,258,825 - 79,259,075 (+)MAPPERmRatBN7.2
Rnor_6.0479,931,389 - 79,931,638NCBIRnor6.0
Rnor_5.04144,603,330 - 144,603,579UniSTSRnor5.0
RGSC_v3.4478,429,155 - 78,429,404UniSTSRGSC3.4
Celera474,167,667 - 74,167,916UniSTS
RH 3.4 Map4499.5UniSTS
Cytogenetic Map4q24UniSTS
RH138424  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2479,253,453 - 79,253,590 (+)MAPPERmRatBN7.2
Rnor_6.0479,926,017 - 79,926,153NCBIRnor6.0
Rnor_5.04144,597,958 - 144,598,094UniSTSRnor5.0
Celera474,162,300 - 74,162,436UniSTS
RH 3.4 Map11555.9UniSTS
Cytogenetic Map4q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 48 41 18 41 8 10 74 35 38 10 8
Low 15 9 1 1 3 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001134982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC169025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000029332   ⟹   ENSRNOP00000037380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl479,173,488 - 79,254,140 (+)Ensembl
Rnor_6.0 Ensembl479,846,521 - 79,926,703 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089973   ⟹   ENSRNOP00000073113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl479,124,806 - 79,253,583 (+)Ensembl
Rnor_6.0 Ensembl479,868,442 - 79,926,078 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096577   ⟹   ENSRNOP00000097400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl479,173,488 - 79,254,140 (+)Ensembl
RefSeq Acc Id: NM_001134982   ⟹   NP_001128454
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,298 - 80,584,951 (+)NCBI
mRatBN7.2479,173,488 - 79,254,141 (+)NCBI
Rnor_6.0479,846,521 - 79,926,704 (+)NCBI
Rnor_5.04144,471,089 - 144,602,046 (+)NCBI
RGSC_v3.4478,343,494 - 78,424,470 (+)RGD
Celera474,082,633 - 74,162,987 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236496   ⟹   XP_006236558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,346 - 80,584,172 (+)NCBI
mRatBN7.2479,173,542 - 79,257,539 (+)NCBI
Rnor_6.0479,846,506 - 79,928,977 (+)NCBI
Rnor_5.04144,471,089 - 144,602,046 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236497   ⟹   XP_006236559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,777 - 80,584,172 (+)NCBI
mRatBN7.2479,173,982 - 79,257,539 (+)NCBI
Rnor_6.0479,846,879 - 79,928,977 (+)NCBI
Rnor_5.04144,471,089 - 144,602,046 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762897   ⟹   XP_008761119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,968 - 80,584,172 (+)NCBI
mRatBN7.2479,174,168 - 79,257,542 (+)NCBI
Rnor_6.0479,847,153 - 79,928,977 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107784   ⟹   XP_038963712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,348 - 80,584,172 (+)NCBI
mRatBN7.2479,173,538 - 79,257,539 (+)NCBI
RefSeq Acc Id: XM_039107785   ⟹   XP_038963713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,784 - 80,584,172 (+)NCBI
mRatBN7.2479,173,974 - 79,257,539 (+)NCBI
RefSeq Acc Id: XM_039107786   ⟹   XP_038963714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,909 - 80,584,172 (+)NCBI
mRatBN7.2479,174,168 - 79,257,542 (+)NCBI
RefSeq Acc Id: XM_039107787   ⟹   XP_038963715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,504,336 - 80,584,172 (+)NCBI
mRatBN7.2479,173,532 - 79,257,539 (+)NCBI
RefSeq Acc Id: XM_039107788   ⟹   XP_038963716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,527,493 - 80,584,172 (+)NCBI
mRatBN7.2479,207,654 - 79,257,542 (+)NCBI
RefSeq Acc Id: XM_063286254   ⟹   XP_063142324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,527,493 - 80,584,172 (+)NCBI
RefSeq Acc Id: XM_063286255   ⟹   XP_063142325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,527,422 - 80,584,172 (+)NCBI
RefSeq Acc Id: XM_063286256   ⟹   XP_063142326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,527,422 - 80,584,172 (+)NCBI
RefSeq Acc Id: XR_005503249
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,527,493 - 80,581,662 (+)NCBI
mRatBN7.2479,207,654 - 79,250,958 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001128454   ⟸   NM_001134982
- UniProtKB: B5DFE0 (UniProtKB/TrEMBL),   D3ZW03 (UniProtKB/TrEMBL),   A0A9K3Y6Q0 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236558   ⟸   XM_006236496
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236559   ⟸   XM_006236497
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761119   ⟸   XM_008762897
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073113   ⟸   ENSRNOT00000089973
RefSeq Acc Id: ENSRNOP00000037380   ⟸   ENSRNOT00000029332
RefSeq Acc Id: XP_038963715   ⟸   XM_039107787
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963712   ⟸   XM_039107784
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963713   ⟸   XM_039107785
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963714   ⟸   XM_039107786
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GMH8 (UniProtKB/TrEMBL),   A6K0L7 (UniProtKB/TrEMBL),   A0A0G2K4N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963716   ⟸   XM_039107788
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000097400   ⟸   ENSRNOT00000096577
RefSeq Acc Id: XP_063142325   ⟸   XM_063286255
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142326   ⟸   XM_063286256
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063142324   ⟸   XM_063286254
- Peptide Label: isoform X1
Protein Domains
Guanylate kinase-like   L27   PDZ   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K4N7-F1-model_v2 AlphaFold A0A0G2K4N7 1-557 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693042
Promoter ID:EPDNEW_R3566
Type:initiation region
Name:Mpp6_1
Description:membrane palmitoylated protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0479,846,486 - 79,846,546EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311833 AgrOrtholog
BioCyc Gene G2FUF-44899 BioCyc
Ensembl Genes ENSRNOG00000021579 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029332 ENTREZGENE
  ENSRNOT00000029332.7 UniProtKB/TrEMBL
  ENSRNOT00000089973.2 UniProtKB/TrEMBL
  ENSRNOT00000096577.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  L27 domain UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Guanylate_kin UniProtKB/TrEMBL
  Guanylate_kin/L-typ_Ca_channel UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  L27_C UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/TrEMBL
  MPP6_SH3 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report rno:362359 UniProtKB/TrEMBL
NCBI Gene 362359 ENTREZGENE
PANTHER MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK UniProtKB/TrEMBL
  PROTEIN PALS2 UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PhenoGen Pals2 PhenoGen
PROSITE GUANYLATE_KINASE_1 UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021579 RatGTEx
SMART GuKc UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF101288 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K4N7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y6Q0 ENTREZGENE, UniProtKB/TrEMBL
  A6K0L7 ENTREZGENE, UniProtKB/TrEMBL
  B5DFE0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZW03 ENTREZGENE
UniProt Secondary D3ZW03 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-09-23 Pals2  protein associated with LIN7 2, MAGUK p55 family member  Pals2  protein associated with LIN7 2, MAGUK family member  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Pals2  protein associated with LIN7 2, MAGUK family member  Mpp6  membrane palmitoylated protein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-14 Mpp6  membrane palmitoylated protein 6  Mpp6  membrane protein, palmitoylated 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-10 Mpp6  membrane protein, palmitoylated 6  Mpp6  membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mpp6  membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)   Mpp6_predicted  membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mpp6_predicted  membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (predicted)      Symbol and Name status set to approved 70820 APPROVED