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Gene: Trpv6 (transient receptor potential cation channel, subfamily V, member 6) Rattus norvegicus

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Symbol:

Trpv6

Name:

transient receptor potential cation channel, subfamily V, member 6

RGD ID:

69335

Description:

Enables calcium channel activity and identical protein binding activity. Involved in calcium ion import across plasma membrane and protein homotetramerization. Predicted to be located in apical plasma membrane. Predicted to be part of calcium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hyperparathyroidism. Orthologous to human TRPV6 (transient receptor potential cation channel subfamily V member 6); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

calcium transport protein 1; CaT1; Ecac2; epithelial apical membrane calcium transporter/channel CaT1; epithelial calcium channel 2; osmosensitive transient receptor potential channel 3; Otrpc3; transient receptor potential cation channel subfamily V member 6; transient receptor potential cation channel, subfamily 5, member 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	71,474,006 - 71,489,667 (-)	NCBI		GRCr8
mRatBN7.2	4	70,507,347 - 70,523,013 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	70,507,348 - 70,523,017 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	75,424,871 - 75,440,482 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	71,338,124 - 71,353,735 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	69,746,459 - 69,762,055 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	70,918,631 - 70,934,291 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	70,918,632 - 70,934,295 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	135,705,692 - 135,721,356 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	69,331,973 - 69,347,633 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	69,608,103 - 69,623,760 (-)	NCBI
Celera	4	65,472,398 - 65,488,058 (-)	NCBI		Celera
Cytogenetic Map	4	q23	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Trpv6	Rat	gestational diabetes		ISO	RGD:731367	401901174	mRNA:decreased expression:placenta (human)	RGD
Trpv6	Rat	pre-eclampsia		ISO	RGD:731367	401901174	mRNA:decreased expression:placenta (human)	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Trpv6	Rat	genetic disease		ISO	RGD:731367	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868\|PMID:28492532\|PMID:29068549\|PMID:31930989\|PMID:34923708\|PMID:37810884
Trpv6	Rat	Hereditary Pancreatitis		ISO	RGD:731367	8554872	ClinVar Annotator: match by term: Hereditary pancreatitis	ClinVar	PMID:25741868
Trpv6	Rat	hyperparathyroidism		ISO	RGD:731367	8554872	ClinVar Annotator: match by term: Hyperparathyroidism	ClinVar	PMID:25741868\|PMID:30144375
Trpv6	Rat	Transient Neonatal Hyperparathyroidism		ISO	RGD:731367	8554872	ClinVar Annotator: match by term: Hyperparathyroidism, transient neonatal \| ClinVar Annotator: match by term: TRPV6-related more ...	ClinVar	PMID:25741868\|PMID:25741888\|PMID:27296226\|PMID:28492532\|PMID:28878326\|PMID:29068549\|PMID:29258289\|PMID:29861107\|PMID:30820485\|PMID:31930989\|PMID:32383311\|PMID:32646367\|PMID:36599151

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Trpv6	Rat	polycystic ovary syndrome		ISO	RGD:731367	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:21411543

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Trpv6	Rat	Transient Neonatal Hyperparathyroidism		ISO	RGD:731367	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Trpv6	Rat	17alpha-ethynylestradiol	increases expression	EXP		6480464	Ethinyl Estradiol results in increased expression of TRPV6 mRNA	CTD	PMID:17557909
Trpv6	Rat	17alpha-ethynylestradiol	multiple interactions	ISO	RGD:735419	6480464	[Ethinyl Estradiol co-treated with Streptozocin] results in increased expression of TRPV6 mRNA	CTD	PMID:29935216
Trpv6	Rat	17alpha-ethynylestradiol	decreases expression	ISO	RGD:735419	6480464	Ethinyl Estradiol analog results in decreased expression of TRPV6 mRNA; Ethinyl Estradiol analog results in more ...	CTD	PMID:23142789\|PMID:27690074
Trpv6	Rat	17beta-estradiol	multiple interactions	EXP		6480464	[Progesterone co-treated with Estradiol] results in increased expression of TRPV6 mRNA	CTD	PMID:21228508
Trpv6	Rat	17beta-estradiol	increases expression	ISO	RGD:735419	6480464	Estradiol results in increased expression of TRPV6 mRNA; Estradiol results in increased expression of TRPV6 more ...	CTD	PMID:30061528
Trpv6	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:731367	6480464	Tetrachlorodibenzodioxin results in increased expression of TRPV6 mRNA	CTD	PMID:26159488
Trpv6	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of TRPV6 mRNA	CTD	PMID:33387578
Trpv6	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:731367	6480464	Endosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TRPV6 mRNA]	CTD	PMID:26159488
Trpv6	Rat	3,3',4,4',5-pentachlorobiphenyl	multiple interactions	ISO	RGD:731367	6480464	[3,4,5,3',4'-pentachlorobiphenyl co-treated with Cholecalciferol] results in decreased expression of TRPV6 mRNA	CTD	PMID:31820026
Trpv6	Rat	3,7-dihydropurine-6-thione	increases expression	EXP		6480464	Mercaptopurine results in increased expression of TRPV6 mRNA	CTD	PMID:23358152
Trpv6	Rat	4,4'-sulfonyldiphenol	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Trpv6	Rat	4-hydroxyphenyl retinamide	increases expression	ISO	RGD:735419	6480464	Fenretinide results in increased expression of TRPV6 mRNA	CTD	PMID:28973697
Trpv6	Rat	4-tert-Octylphenol	affects expression	ISO	RGD:735419	6480464	4-tert-octylphenol affects the expression of TRPV6 mRNA; 4-tert-octylphenol affects the expression of TRPV6 protein	CTD	PMID:30061528
Trpv6	Rat	4-tert-Octylphenol	multiple interactions	ISO	RGD:735419	6480464	Fulvestrant promotes the reaction [4-tert-octylphenol results in increased expression of TRPV6 mRNA]	CTD	PMID:30061528
Trpv6	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of TRPV6 mRNA	CTD	PMID:30047161
Trpv6	Rat	actinomycin D	multiple interactions	ISO	RGD:731367	6480464	Dactinomycin inhibits the reaction [1,25-dihydroxyvitamin D results in increased expression of TRPV6 mRNA]	CTD	PMID:16362534
Trpv6	Rat	aflatoxin B1	increases expression	ISO	RGD:731367	6480464	Aflatoxin B1 results in increased expression of TRPV6 mRNA	CTD	PMID:22100608
Trpv6	Rat	aflatoxin B1	decreases methylation	ISO	RGD:731367	6480464	Aflatoxin B1 results in decreased methylation of TRPV6 exon	CTD	PMID:30157460
Trpv6	Rat	alfacalcidol	increases expression	ISO	RGD:735419	6480464	alfacalcidol results in increased expression of TRPV6 mRNA	CTD	PMID:18180267
Trpv6	Rat	amitrole	decreases expression	EXP		6480464	Amitrole results in decreased expression of TRPV6 mRNA	CTD	PMID:38685447
Trpv6	Rat	amitrole	increases expression	EXP		6480464	Amitrole results in increased expression of TRPV6 mRNA	CTD	PMID:30047161
Trpv6	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of TRPV6 mRNA	CTD	PMID:16483693
Trpv6	Rat	Aroclor 1254	decreases expression	ISO	RGD:735419	6480464	Chlorodiphenyl (54% Chlorine) results in decreased expression of TRPV6 protein	CTD	PMID:22406624
Trpv6	Rat	arsenite(3-)	increases methylation	ISO	RGD:731367	6480464	arsenite results in increased methylation of TRPV6 promoter	CTD	PMID:23974009
Trpv6	Rat	Azoxymethane	multiple interactions	ISO	RGD:735419	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TRPV6 more ...	CTD	PMID:29950665
Trpv6	Rat	barium(0)	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Barium	CTD	PMID:19996302\|PMID:21146870
Trpv6	Rat	benzo[a]pyrene	increases expression	ISO	RGD:735419	6480464	Benzo(a)pyrene results in increased expression of TRPV6 mRNA	CTD	PMID:23735875
Trpv6	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:731367	6480464	Benzo(a)pyrene results in increased methylation of TRPV6 3' UTR	CTD	PMID:27901495
Trpv6	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:731367	6480464	Benzo(a)pyrene results in decreased methylation of TRPV6 exon	CTD	PMID:27901495
Trpv6	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:731367	6480464	Benzo(a)pyrene affects the methylation of TRPV6 promoter	CTD	PMID:27901495
Trpv6	Rat	beta-lapachone	decreases expression	ISO	RGD:731367	6480464	beta-lapachone results in decreased expression of TRPV6 mRNA	CTD	PMID:38218311
Trpv6	Rat	bis(2-ethylhexyl) phthalate	multiple interactions	ISO	RGD:735419	6480464	[Streptozocin co-treated with Diethylhexyl Phthalate] results in decreased expression of TRPV6 mRNA	CTD	PMID:31606821
Trpv6	Rat	bisphenol A	decreases expression	ISO	RGD:735419	6480464	bisphenol A results in decreased expression of TRPV6 mRNA; bisphenol A results in decreased expression more ...	CTD	PMID:23142789\|PMID:26063408\|PMID:30061528
Trpv6	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Trpv6	Rat	bisphenol A	multiple interactions	ISO	RGD:731367	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of TRPV6 gene	CTD	PMID:31601247
Trpv6	Rat	bisphenol A	decreases methylation	ISO	RGD:731367	6480464	bisphenol A results in decreased methylation of TRPV6 gene	CTD	PMID:31601247
Trpv6	Rat	bisphenol A	increases expression	ISO	RGD:735419	6480464	bisphenol A results in increased expression of TRPV6 protein	CTD	PMID:30061528
Trpv6	Rat	bisphenol A	multiple interactions	ISO	RGD:735419	6480464	[bisphenol A co-treated with Streptozocin] results in increased expression of TRPV6 mRNA; [Fulvestrant co-treated with more ...	CTD	PMID:29935216\|PMID:30061528
Trpv6	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of TRPV6 mRNA	CTD	PMID:25181051
Trpv6	Rat	bisphenol F	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Trpv6	Rat	cadmium atom	multiple interactions	ISO	RGD:731367	6480464	2-aminoethoxydiphenyl borate inhibits the reaction [TRPV6 protein results in increased import of Cadmium]; Cadmium inhibits more ...	CTD	PMID:21146870\|PMID:23968883
Trpv6	Rat	cadmium atom	multiple interactions	ISO	RGD:735419	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TRPV6 more ...	CTD	PMID:37325564
Trpv6	Rat	cadmium atom	increases import	ISO	RGD:731367	6480464	TRPV6 protein results in increased import of Cadmium	CTD	PMID:23968883
Trpv6	Rat	cadmium atom	increases expression	EXP		6480464	Cadmium results in increased expression of TRPV6 mRNA	CTD	PMID:32879253
Trpv6	Rat	cadmium atom	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Cadmium	CTD	PMID:21146870
Trpv6	Rat	cadmium dichloride	multiple interactions	ISO	RGD:735419	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TRPV6 more ...	CTD	PMID:37325564
Trpv6	Rat	calciol	multiple interactions	ISO	RGD:731367	6480464	[3,4,5,3',4'-pentachlorobiphenyl co-treated with Cholecalciferol] results in decreased expression of TRPV6 mRNA	CTD	PMID:31820026
Trpv6	Rat	calcitriol	multiple interactions	ISO	RGD:731367	6480464	[Calcitriol binds to and results in increased activity of VDR protein] which results in increased more ...	CTD	PMID:15489543\|PMID:17293108\|PMID:18180267\|PMID:21592394\|PMID:33033332
Trpv6	Rat	calcitriol	increases expression	ISO	RGD:731367	6480464	Calcitriol results in increased expression of TRPV6 mRNA; Calcitriol results in increased expression of TRPV6 more ...	CTD	PMID:16491319\|PMID:17293108\|PMID:21592394\|PMID:26485663\|PMID:27107558\|PMID:33033332
Trpv6	Rat	calcium atom	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Calcium	CTD	PMID:19996302\|PMID:21146870
Trpv6	Rat	calcium atom	multiple interactions	ISO	RGD:735419	6480464	[[USP2 gene mutant form results in increased expression of NHERF4 protein] which results in increased more ...	CTD	PMID:26756164
Trpv6	Rat	calcium atom	increases expression	ISO	RGD:735419	6480464	Calcium deficiency results in increased expression of TRPV6 mRNA	CTD	PMID:18648087
Trpv6	Rat	calcium atom	increases transport	ISO	RGD:731367	6480464	TRPV6 protein results in increased transport of Calcium	CTD	PMID:12584203
Trpv6	Rat	calcium atom	multiple interactions	ISO	RGD:731367	6480464	4-O-methyl-12-O-tetradecanoylphorbol 13-acetate inhibits the reaction [Tamoxifen inhibits the reaction [TRPV6 protein results in increased uptake more ...	CTD	PMID:17292493\|PMID:19996302\|PMID:21146870
Trpv6	Rat	calcium(0)	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Calcium	CTD	PMID:19996302\|PMID:21146870
Trpv6	Rat	calcium(0)	multiple interactions	ISO	RGD:735419	6480464	[[USP2 gene mutant form results in increased expression of NHERF4 protein] which results in increased more ...	CTD	PMID:26756164
Trpv6	Rat	calcium(0)	increases expression	ISO	RGD:735419	6480464	Calcium deficiency results in increased expression of TRPV6 mRNA	CTD	PMID:18648087
Trpv6	Rat	calcium(0)	increases transport	ISO	RGD:731367	6480464	TRPV6 protein results in increased transport of Calcium	CTD	PMID:12584203
Trpv6	Rat	calcium(0)	multiple interactions	ISO	RGD:731367	6480464	4-O-methyl-12-O-tetradecanoylphorbol 13-acetate inhibits the reaction [Tamoxifen inhibits the reaction [TRPV6 protein results in increased uptake more ...	CTD	PMID:17292493\|PMID:19996302\|PMID:21146870
Trpv6	Rat	Calphostin C	multiple interactions	ISO	RGD:731367	6480464	calphostin C inhibits the reaction [TRPV6 protein results in increased uptake of Calcium]	CTD	PMID:19996302
Trpv6	Rat	capsaicin	multiple interactions	ISO	RGD:731367	6480464	TRPV6 protein promotes the reaction [Capsaicin results in increased abundance of Calcium]; TRPV6 protein promotes more ...	CTD	PMID:17292493
Trpv6	Rat	capsaicin	increases response to substance	ISO	RGD:731367	6480464	TRPV6 protein results in increased susceptibility to Capsaicin	CTD	PMID:17292493
Trpv6	Rat	carbon nanotube	increases expression	ISO	RGD:735419	6480464	Nanotubes, Carbon analog results in increased expression of TRPV6 mRNA; Nanotubes, Carbon results in increased more ...	CTD	PMID:25554681
Trpv6	Rat	CGP 52608	multiple interactions	ISO	RGD:731367	6480464	CGP 52608 promotes the reaction [RORA protein binds to TRPV6 gene]	CTD	PMID:28238834
Trpv6	Rat	chlordecone	decreases expression	ISO	RGD:735419	6480464	Chlordecone results in decreased expression of TRPV6 mRNA	CTD	PMID:33711761
Trpv6	Rat	chlorpyrifos	decreases expression	ISO	RGD:735419	6480464	Chlorpyrifos results in decreased expression of TRPV6 mRNA	CTD	PMID:37019170
Trpv6	Rat	copper atom	increases expression	EXP		6480464	Copper deficiency results in increased expression of TRPV6 mRNA	CTD	PMID:26033743
Trpv6	Rat	copper(0)	increases expression	EXP		6480464	Copper deficiency results in increased expression of TRPV6 mRNA	CTD	PMID:26033743
Trpv6	Rat	curcumin	multiple interactions	ISO	RGD:731367	6480464	[Curcumin binds to and results in increased activity of VDR protein] which results in increased more ...	CTD	PMID:20153625
Trpv6	Rat	dextran sulfate	multiple interactions	ISO	RGD:735419	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TRPV6 more ...	CTD	PMID:29950665
Trpv6	Rat	dimethylarsinic acid	multiple interactions	ISO	RGD:735419	6480464	[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ...	CTD	PMID:34876320
Trpv6	Rat	endosulfan	multiple interactions	ISO	RGD:731367	6480464	Endosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TRPV6 mRNA]	CTD	PMID:26159488
Trpv6	Rat	ethylparaben	increases expression	ISO	RGD:731367	6480464	ethyl-p-hydroxybenzoate results in increased expression of TRPV6 mRNA	CTD	PMID:37690743
Trpv6	Rat	flavonoids	decreases expression	EXP		6480464	Flavonoids results in decreased expression of TRPV6 mRNA	CTD	PMID:18035473
Trpv6	Rat	formononetin	multiple interactions	ISO	RGD:735419	6480464	formononetin inhibits the reaction [Streptozocin results in decreased expression of TRPV6 mRNA]	CTD	PMID:35315182
Trpv6	Rat	fulvestrant	multiple interactions	ISO	RGD:735419	6480464	[Fulvestrant co-treated with bisphenol A] results in increased expression of TRPV6 mRNA; Fulvestrant promotes the more ...	CTD	PMID:30061528
Trpv6	Rat	fulvestrant	multiple interactions	ISO	RGD:731367	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of TRPV6 gene	CTD	PMID:31601247
Trpv6	Rat	fulvestrant	increases expression	ISO	RGD:735419	6480464	Fulvestrant results in increased expression of TRPV6 protein	CTD	PMID:30061528
Trpv6	Rat	furosemide	increases expression	ISO	RGD:735419	6480464	Furosemide results in increased expression of TRPV6 mRNA	CTD	PMID:17652376
Trpv6	Rat	gadolinium atom	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Gadolinium	CTD	PMID:21146870
Trpv6	Rat	gadolinium atom	multiple interactions	ISO	RGD:731367	6480464	Gadolinium inhibits the reaction [TRPV6 protein results in increased uptake of Calcium]	CTD	PMID:21146870
Trpv6	Rat	gentamycin	increases expression	ISO	RGD:735419	6480464	Gentamicins results in increased expression of TRPV6 mRNA	CTD	PMID:17652376
Trpv6	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of TRPV6 mRNA	CTD	PMID:33387578
Trpv6	Rat	lanthanum atom	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Lanthanum	CTD	PMID:21146870
Trpv6	Rat	lanthanum atom	multiple interactions	ISO	RGD:731367	6480464	Lanthanum inhibits the reaction [TRPV6 protein results in increased uptake of Calcium]	CTD	PMID:21146870
Trpv6	Rat	lithocholic acid	multiple interactions	ISO	RGD:731367	6480464	[Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results more ...	CTD	PMID:15489543\|PMID:18180267
Trpv6	Rat	lithocholic acid	increases expression	EXP		6480464	Lithocholic Acid results in increased expression of TRPV6 mRNA	CTD	PMID:17535892
Trpv6	Rat	manganese atom	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Manganese	CTD	PMID:21146870
Trpv6	Rat	manganese(0)	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Manganese	CTD	PMID:21146870
Trpv6	Rat	mercaptopurine	increases expression	EXP		6480464	Mercaptopurine results in increased expression of TRPV6 mRNA	CTD	PMID:23358152
Trpv6	Rat	methimazole	increases expression	EXP		6480464	Methimazole results in increased expression of TRPV6 mRNA	CTD	PMID:30047161
Trpv6	Rat	methotrexate	increases expression	ISO	RGD:731367	6480464	Methotrexate results in increased expression of TRPV6 mRNA	CTD	PMID:21678067
Trpv6	Rat	methylarsonic acid	multiple interactions	ISO	RGD:735419	6480464	[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ...	CTD	PMID:34876320
Trpv6	Rat	okadaic acid	increases expression	ISO	RGD:731367	6480464	Okadaic Acid results in increased expression of TRPV6 mRNA	CTD	PMID:38832940
Trpv6	Rat	p-tert-Amylphenol	multiple interactions	ISO	RGD:735419	6480464	Fulvestrant promotes the reaction [4-tert-octylphenol results in increased expression of TRPV6 mRNA]	CTD	PMID:30061528
Trpv6	Rat	p-tert-Amylphenol	affects expression	ISO	RGD:735419	6480464	4-tert-octylphenol affects the expression of TRPV6 mRNA; 4-tert-octylphenol affects the expression of TRPV6 protein	CTD	PMID:30061528
Trpv6	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of TRPV6 mRNA	CTD	PMID:33387578
Trpv6	Rat	perfluorohexanesulfonic acid	decreases expression	ISO	RGD:731367	6480464	perfluorohexanesulfonic acid results in decreased expression of TRPV6 mRNA	CTD	PMID:25812627
Trpv6	Rat	perfluorononanoic acid	decreases expression	ISO	RGD:731367	6480464	perfluoro-n-nonanoic acid results in decreased expression of TRPV6 mRNA	CTD	PMID:25812627
Trpv6	Rat	perfluorooctane-1-sulfonic acid	decreases expression	ISO	RGD:731367	6480464	perfluorooctane sulfonic acid results in decreased expression of TRPV6 mRNA	CTD	PMID:25812627
Trpv6	Rat	perfluorooctanoic acid	multiple interactions	ISO	RGD:731367	6480464	perfluorooctanoic acid inhibits the reaction [Calcitriol results in increased expression of TRPV6 mRNA]	CTD	PMID:33033332
Trpv6	Rat	perfluorooctanoic acid	decreases expression	ISO	RGD:731367	6480464	perfluorooctanoic acid results in decreased expression of TRPV6 mRNA	CTD	PMID:25812627
Trpv6	Rat	potassium dichromate	decreases expression	ISO	RGD:735419	6480464	Potassium Dichromate results in decreased expression of TRPV6 mRNA	CTD	PMID:23608068
Trpv6	Rat	progesterone	multiple interactions	EXP		6480464	[Progesterone co-treated with Estradiol] results in increased expression of TRPV6 mRNA	CTD	PMID:21228508
Trpv6	Rat	purine-6-thiol	increases expression	EXP		6480464	Mercaptopurine results in increased expression of TRPV6 mRNA	CTD	PMID:23358152
Trpv6	Rat	quercetin	multiple interactions	ISO	RGD:731367	6480464	VDR promotes the reaction [Quercetin results in increased expression of TRPV6 mRNA]	CTD	PMID:26366751
Trpv6	Rat	quercetin	increases expression	ISO	RGD:731367	6480464	Quercetin results in increased expression of TRPV6 mRNA	CTD	PMID:26366751
Trpv6	Rat	resveratrol	multiple interactions	ISO	RGD:731367	6480464	[Plant Extracts co-treated with Resveratrol] results in decreased expression of TRPV6 mRNA	CTD	PMID:23557933
Trpv6	Rat	sodium arsenate	multiple interactions	ISO	RGD:735419	6480464	[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ...	CTD	PMID:34876320
Trpv6	Rat	sodium arsenite	decreases expression	ISO	RGD:731367	6480464	sodium arsenite results in decreased expression of TRPV6 mRNA	CTD	PMID:34032870
Trpv6	Rat	sodium arsenite	increases expression	ISO	RGD:735419	6480464	sodium arsenite results in increased expression of TRPV6 mRNA	CTD	PMID:37682722
Trpv6	Rat	sodium arsenite	multiple interactions	ISO	RGD:735419	6480464	[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ...	CTD	PMID:34876320
Trpv6	Rat	sodium dichromate	increases expression	ISO	RGD:735419	6480464	sodium bichromate results in increased expression of TRPV6 mRNA	CTD	PMID:22155349
Trpv6	Rat	sodium dichromate	decreases expression	EXP		6480464	sodium bichromate results in decreased expression of TRPV6 mRNA	CTD	PMID:22561333
Trpv6	Rat	streptozocin	decreases expression	ISO	RGD:735419	6480464	Streptozocin results in decreased expression of TRPV6 mRNA	CTD	PMID:29935216\|PMID:35315182
Trpv6	Rat	streptozocin	increases expression	ISO	RGD:735419	6480464	Streptozocin results in increased expression of TRPV6 mRNA	CTD	PMID:31606821
Trpv6	Rat	streptozocin	multiple interactions	ISO	RGD:735419	6480464	[bisphenol A co-treated with Streptozocin] results in increased expression of TRPV6 mRNA; [Ethinyl Estradiol co-treated more ...	CTD	PMID:29935216\|PMID:31606821\|PMID:35315182
Trpv6	Rat	strontium atom	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Strontium	CTD	PMID:21146870
Trpv6	Rat	tamoxifen	multiple interactions	ISO	RGD:731367	6480464	4-O-methyl-12-O-tetradecanoylphorbol 13-acetate inhibits the reaction [Tamoxifen inhibits the reaction [TRPV6 protein results in increased uptake more ...	CTD	PMID:19996302
Trpv6	Rat	tebuconazole	decreases expression	ISO	RGD:731367	6480464	tebuconazole results in decreased expression of TRPV6 mRNA	CTD	PMID:30458266
Trpv6	Rat	testosterone	multiple interactions	ISO	RGD:731367	6480464	[Testosterone co-treated with Calcitriol] results in increased expression of TRPV6 mRNA; Testosterone affects the reaction more ...	CTD	PMID:21592394
Trpv6	Rat	testosterone	multiple interactions	ISO	RGD:735419	6480464	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane inhibits the reaction [Testosterone deficiency results in decreased expression of TRPV6 mRNA]	CTD	PMID:33848595
Trpv6	Rat	testosterone	decreases expression	ISO	RGD:735419	6480464	Testosterone deficiency results in decreased expression of TRPV6 mRNA	CTD	PMID:33848595
Trpv6	Rat	testosterone	decreases expression	ISO	RGD:731367	6480464	Testosterone results in decreased expression of TRPV6 mRNA	CTD	PMID:21592394
Trpv6	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of TRPV6 mRNA	CTD	PMID:34492290
Trpv6	Rat	titanium dioxide	increases expression	ISO	RGD:735419	6480464	titanium dioxide results in increased expression of TRPV6 mRNA	CTD	PMID:23557971\|PMID:27760801
Trpv6	Rat	titanium dioxide	multiple interactions	ISO	RGD:735419	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TRPV6 more ...	CTD	PMID:29950665
Trpv6	Rat	triclosan	increases expression	ISO	RGD:731367	6480464	Triclosan results in increased expression of TRPV6 mRNA	CTD	PMID:30510588
Trpv6	Rat	valproic acid	increases methylation	ISO	RGD:731367	6480464	Valproic Acid results in increased methylation of TRPV6 gene	CTD	PMID:29154799
Trpv6	Rat	zinc atom	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Zinc	CTD	PMID:21146870
Trpv6	Rat	zinc(0)	increases uptake	ISO	RGD:731367	6480464	TRPV6 protein results in increased uptake of Zinc	CTD	PMID:21146870

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Trpv6	Rat	calcium ion homeostasis	acts_upstream_of_or_within	IEA	UniProtKB:Q91WD2\|ensembl:ENSMUSP00000031902	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	calcium ion homeostasis	involved_in	ISO	RGD:735419	1624291	PMID:22878123	RGD	PMID:22878123
Trpv6	Rat	calcium ion homeostasis	acts_upstream_of_or_within	ISO	RGD:735419	1624291	MGI:3778644 PMID:17129178	RGD	PMID:17129178
Trpv6	Rat	calcium ion homeostasis	involved_in	ISS	UniProtKB:Q91WD2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Trpv6	Rat	calcium ion import		IDA		632623		RGD
Trpv6	Rat	calcium ion import across plasma membrane	involved_in	ISS	UniProtKB:Q91WD2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Trpv6	Rat	calcium ion import across plasma membrane	involved_in	ISO	RGD:735419	1624291	PMID:22878123	RGD	PMID:22878123
Trpv6	Rat	calcium ion import across plasma membrane	involved_in	IEA	UniProtKB:Q9H1D0\|ensembl:ENSP00000352358	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	calcium ion import across plasma membrane	involved_in	IBA	MGI:1927259\|PANTHER:PTN000061616\|RGD:628841\|RGD:69335\|UniProtKB:Q8NER1\|UniProtKB:Q9H1D0\|UniProtKB:Q9NQA5	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Trpv6	Rat	calcium ion import across plasma membrane	involved_in	ISO	RGD:731367	1624291	PMID:11097838, PMID:29861107	RGD	PMID:11097838\|PMID:29861107
Trpv6	Rat	calcium ion import across plasma membrane	involved_in	IEA	UniProtKB:Q91WD2\|ensembl:ENSMUSP00000031902	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	calcium ion import across plasma membrane	involved_in	IMP		68825	PMID:10428857	UniProt
Trpv6	Rat	calcium ion import across plasma membrane	involved_in	ISS	UniProtKB:Q9H1D0	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Trpv6	Rat	calcium ion transmembrane transport	involved_in	ISO	RGD:735419	1624291	PMID:12574114	RGD	PMID:12574114
Trpv6	Rat	calcium ion transmembrane transport	involved_in	IEA	UniProtKB:Q91WD2\|ensembl:ENSMUSP00000031902	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	calcium ion transmembrane transport	involved_in	IEA	UniProtKB:Q9H1D0\|ensembl:ENSP00000352358	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	calcium ion transmembrane transport	involved_in	IEA	UniProtKB-KW:KW-0107	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Trpv6	Rat	calcium ion transmembrane transport	involved_in	IDA		11344952	PMID:27296226	UniProt
Trpv6	Rat	calcium ion transmembrane transport	involved_in	IDA		68825	PMID:10428857	UniProt
Trpv6	Rat	calcium ion transmembrane transport	involved_in	ISO	RGD:731367	1624291	PMID:11097838	RGD	PMID:11097838
Trpv6	Rat	calcium ion transport	involved_in	ISO	RGD:731367	1624291	PMID:23612980, PMID:29861107	RGD	PMID:23612980\|PMID:29861107
Trpv6	Rat	calcium ion transport	acts_upstream_of_or_within	IEA	UniProtKB:Q91WD2\|ensembl:ENSMUSP00000031902	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	calcium ion transport	acts_upstream_of_or_within	ISO	RGD:735419	1624291	PMID:12077127	RGD	PMID:12077127
Trpv6	Rat	calcium ion transport	involved_in	IEA	InterPro:IPR008344\|InterPro:IPR008345	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Trpv6	Rat	calcium ion transport	involved_in	IEA	UniProtKB:Q9H1D0\|ensembl:ENSP00000352358	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	calcium ion transport	involved_in	IEA	UniProtKB-KW:KW-0109	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Trpv6	Rat	monoatomic ion transmembrane transport	involved_in	IEA	UniProtKB-KW:KW-0407	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Trpv6	Rat	monoatomic ion transport	involved_in	IEA	UniProtKB-KW:KW-0406	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Trpv6	Rat	monoatomic ion transport	involved_in	IEA	InterPro:IPR005821\|InterPro:IPR024862	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Trpv6	Rat	parathyroid hormone secretion	acts_upstream_of_or_within	ISO	RGD:735419	1624291	MGI:3778644 PMID:17129178	RGD	PMID:17129178
Trpv6	Rat	parathyroid hormone secretion	acts_upstream_of_or_within	IEA	UniProtKB:Q91WD2\|ensembl:ENSMUSP00000031902	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	protein homotetramerization	involved_in	IPI	UniProtKB:Q9R186	11344952	PMID:27296226	UniProt
Trpv6	Rat	response to calcium ion	involved_in	IEA	UniProtKB:Q91WD2\|ensembl:ENSMUSP00000031902	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	response to calcium ion	involved_in	ISO	RGD:735419	1624291	PMID:22878123	RGD	PMID:22878123
Trpv6	Rat	response to calcium ion	involved_in	ISS	UniProtKB:Q91WD2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Trpv6	Rat	transmembrane transport	involved_in	IEA	InterPro:IPR005821	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Trpv6	Rat	apical plasma membrane		IC	GO:0070509	632623		RGD
Trpv6	Rat	calcium channel complex	part_of	IEA	UniProtKB:Q91WD2\|ensembl:ENSMUSP00000031902	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	calcium channel complex	part_of	ISO	RGD:735419	1624291	PMID:12574114	RGD	PMID:12574114
Trpv6	Rat	membrane	located_in	IEA	InterPro:IPR005821\|InterPro:IPR008344\|InterPro:IPR008345\|InterPro:IPR024862	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Trpv6	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Trpv6	Rat	membrane	located_in	IEA	ARBA:ARBA00028763	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Trpv6	Rat	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Trpv6	Rat	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Trpv6	Rat	plasma membrane	located_in	IEA	UniProtKB:Q9H1D0\|ensembl:ENSP00000352358	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	plasma membrane	is_active_in	IBA	FB:FBgn0036414\|FB:FBgn0086693\|MGI:1341787\|MGI:1341836\|MGI:1926945\|MGI:2429764\|PANTHER:PTN000061616\|RGD:3965\|RGD:620636\|RGD:628841\|RGD:69337\|UniProtKB:Q8NET8\|UniProtKB:Q9H1D0\|UniProtKB:Q9HBA0\|UniProtKB:Q9NQA5\|UniProtKB:Q9Y5S1\|WB:WBGene00003839	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Trpv6	Rat	plasma membrane	located_in	ISO	RGD:731367	1624291	PMID:11097838, PMID:23612980	RGD	PMID:11097838\|PMID:23612980
Trpv6	Rat	plasma membrane	located_in	ISS	UniProtKB:Q9H1D0	1600115	GO_REF:0000024	UniProt	GO_REF:0000024

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Trpv6	Rat	calcium channel activity	enables	IDA		68825	PMID:10428857	UniProt
Trpv6	Rat	calcium channel activity		IDA		632623		RGD
Trpv6	Rat	calcium channel activity	enables	IEA	UniProtKB:Q9H1D0\|ensembl:ENSP00000352358	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	calcium channel activity	enables	ISO	RGD:735419	1624291	PMID:12077127, PMID:12574114	RGD	PMID:12077127\|PMID:12574114
Trpv6	Rat	calcium channel activity	enables	IEA	UniProtKB:Q91WD2\|ensembl:ENSMUSP00000031902	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	calcium channel activity	enables	IEA	UniProtKB-KW:KW-0107	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Trpv6	Rat	calcium channel activity	enables	IEA	InterPro:IPR008344\|InterPro:IPR008345	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Trpv6	Rat	calcium channel activity	enables	IEA	ARBA:ARBA00026607	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Trpv6	Rat	calcium channel activity	enables	IBA	MGI:1341787\|MGI:1341836\|MGI:1926945\|MGI:1927259\|MGI:2429764\|PANTHER:PTN000832860\|RGD:3965\|RGD:620636\|RGD:628841\|RGD:69335\|RGD:69337\|SGD:S000005613\|UniProtKB:Q8NET8\|UniProtKB:Q9H1D0\|UniProtKB:Q9HBA0\|UniProtKB:Q9NQA5\|WB:WBGene00003889\|ZFIN:ZDB-GENE-040624-12	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Trpv6	Rat	calcium channel activity	enables	ISO	RGD:731367	1624291	PMID:11097838, PMID:15184369, PMID:23612980	RGD	PMID:11097838\|PMID:15184369\|PMID:23612980
Trpv6	Rat	calcium channel activity	enables	IDA		11344952	PMID:27296226	UniProt
Trpv6	Rat	calcium-activated cation channel activity		TAS		634425		RGD
Trpv6	Rat	calmodulin binding	enables	ISS	UniProtKB:Q9H1D0	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Trpv6	Rat	calmodulin binding	enables	IEA	UniProtKB-KW:KW-0112	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Trpv6	Rat	calmodulin binding	enables	ISO	RGD:731367	1624291	PMID:11278579	RGD	PMID:11278579
Trpv6	Rat	calmodulin binding	enables	IEA	UniProtKB:Q9H1D0\|ensembl:ENSP00000352358	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	identical protein binding	enables	ISO	RGD:735419	1624291	UniProtKB:Q91WD2 PMID:12574114	RGD	PMID:12574114
Trpv6	Rat	identical protein binding	enables	IEA	UniProtKB:Q91WD2\|ensembl:ENSMUSP00000031902	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Trpv6	Rat	identical protein binding	enables	IPI	UniProtKB:Q9R186	11344952	PMID:27296226	IntAct
Trpv6	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Trpv6	Rat	monoatomic ion channel activity	enables	IEA	InterPro:IPR005821\|InterPro:IPR024862	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Trpv6	Rat	protein binding	enables	ISO	RGD:731367	1624291	UniProtKB:P18031\|UniProtKB:Q9Y4C2 PMID:15894168, PMID:17197020, PMID:25559186	RGD	PMID:15894168\|PMID:17197020\|PMID:25559186
Trpv6	Rat	protein binding	enables	ISO	RGD:735419	1624291	UniProtKB:P69744 PMID:12574114	RGD	PMID:12574114

Molecular Pathway Annotations Click to see Annotation Detail View

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Trpv6	Rat	calcium transport pathway		ISO	RGD:731367	7204689		RGD
Trpv6	Rat	calcium/calcium-mediated signaling pathway		ISO	RGD:731367	7204689		RGD

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

gestational diabetes (ISO)

Hereditary Pancreatitis (ISO)

hyperparathyroidism (ISO)

polycystic ovary syndrome (ISO)

pre-eclampsia (ISO)

Transient Neonatal Hyperparathyroidism (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,7-dihydropurine-6-thione (EXP)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (ISO)

4-tert-Octylphenol (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

alfacalcidol (ISO)

amitrole (EXP)

ammonium chloride (EXP)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

Azoxymethane (ISO)

barium(0) (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium atom (EXP,ISO)

cadmium dichloride (ISO)

calciol (ISO)

calcitriol (ISO)

calcium atom (ISO)

calcium(0) (ISO)

Calphostin C (ISO)

capsaicin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

copper atom (EXP)

copper(0) (EXP)

curcumin (ISO)

dextran sulfate (ISO)

dimethylarsinic acid (ISO)

endosulfan (ISO)

ethylparaben (ISO)

flavonoids (EXP)

formononetin (ISO)

fulvestrant (ISO)

furosemide (ISO)

gadolinium atom (ISO)

gentamycin (EXP,ISO)

lanthanum atom (ISO)

lithocholic acid (EXP,ISO)

manganese atom (ISO)

manganese(0) (ISO)

mercaptopurine (EXP)

methimazole (EXP)

methotrexate (ISO)

methylarsonic acid (ISO)

okadaic acid (ISO)

p-tert-Amylphenol (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

potassium dichromate (ISO)

progesterone (EXP)

purine-6-thiol (EXP)

quercetin (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP,ISO)

streptozocin (ISO)

strontium atom (ISO)

tamoxifen (ISO)

tebuconazole (ISO)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triclosan (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion homeostasis (IEA,ISO,ISS)

calcium ion import (IDA)

calcium ion import across plasma membrane (IBA,IEA,IMP,ISO,ISS)

calcium ion transmembrane transport (IDA,IEA,ISO)

calcium ion transport (IEA,ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

parathyroid hormone secretion (IEA,ISO)

protein homotetramerization (IPI)

response to calcium ion (IEA,ISO,ISS)

transmembrane transport (IEA)

Cellular Component

apical plasma membrane (IC)

calcium channel complex (IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

calcium channel activity (IBA,IDA,IEA,ISO)

calcium-activated cation channel activity (TAS)

calmodulin binding (IEA,ISO,ISS)

identical protein binding (IEA,IPI,ISO)

metal ion binding (IEA)

monoatomic ion channel activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium transport pathway (ISO)

calcium/calcium-mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cells.	Bodding M, etal., J Biol Chem 2002 Sep 27;277(39):36656-64.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption.	Peng JB, etal., J Biol Chem 1999 Aug 6;274(32):22739-46.
7.	A rat kidney-specific calcium transporter in the distal nephron.	Peng JB, etal., J Biol Chem 2000 Sep 8;275(36):28186-94.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Crystal structure of the epithelial calcium channel TRPV6.	Saotome K, etal., Nature. 2016 Jun 13;534(7608):506-11. doi: 10.1038/nature17975.
12.	Store depletion-activated CaT1 currents in rat basophilic leukemia mast cells are inhibited by 2-aminoethoxydiphenyl borate. Evidence for a regulatory component that controls activation of both CaT1 and CRAC (Ca(2+) release-activated Ca(2+) channel) channels.	Schindl R, etal., J Biol Chem 2002 Jul 26;277(30):26950-8.
13.	Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients.	Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
14.	International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family.	Wu LJ, etal., Pharmacol Rev. 2010 Sep;62(3):381-404. doi: 10.1124/pr.110.002725.

Additional References at PubMed

PMID:11097838	PMID:11278579	PMID:11287959	PMID:12077127	PMID:12574114	PMID:12620887	PMID:15184369	PMID:16825604	PMID:17129178	PMID:17234578	PMID:19056662	PMID:19457270
PMID:22878123	PMID:23376485	PMID:23612980	PMID:26384871	PMID:27481714	PMID:28063212	PMID:29505720	PMID:29861107

Genomics

Comparative Map Data

Trpv6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	71,474,006 - 71,489,667 (-)	NCBI		GRCr8
mRatBN7.2	4	70,507,347 - 70,523,013 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	70,507,348 - 70,523,017 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	75,424,871 - 75,440,482 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	71,338,124 - 71,353,735 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	69,746,459 - 69,762,055 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	70,918,631 - 70,934,291 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	70,918,632 - 70,934,295 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	135,705,692 - 135,721,356 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	69,331,973 - 69,347,633 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	69,608,103 - 69,623,760 (-)	NCBI
Celera	4	65,472,398 - 65,488,058 (-)	NCBI		Celera
Cytogenetic Map	4	q23	NCBI

TRPV6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	142,871,208 - 142,885,745 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	142,871,208 - 142,885,745 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	142,568,961 - 142,583,490 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	142,279,082 - 142,293,599 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	142,085,796 - 142,100,314	NCBI
Celera	7	137,406,262 - 137,420,596 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI
HuRef	7	136,907,167 - 136,921,549 (-)	NCBI		HuRef
CHM1_1	7	142,505,175 - 142,519,717 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	144,227,023 - 144,241,552 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	141,970,820 - 141,985,355 (-)	NCBI

Trpv6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	41,597,553 - 41,613,339 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	41,597,558 - 41,613,339 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	41,620,619 - 41,636,405 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	41,620,624 - 41,636,405 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	41,570,618 - 41,586,404 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	41,550,232 - 41,565,942 (-)	NCBI		MGSCv36	mm8
Celera	6	41,573,210 - 41,588,993 (-)	NCBI		Celera
Cytogenetic Map	6	B2.1	NCBI
cM Map	6	19.79	NCBI

Trpv6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955494	818,643 - 836,126 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955494	820,801 - 835,931 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100990398
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	179,719,619 - 179,734,609 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	31,729,875 - 31,744,866 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	134,862,223 - 134,877,051 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	147,353,684 - 147,368,475 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	147,353,684 - 147,368,475 (-)	Ensembl	panpan1.1		panPan2

TRPV6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	6,691,521 - 6,706,205 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	6,691,254 - 6,706,207 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	16	6,602,597 - 6,617,275 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	6,602,330 - 6,617,284 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	6,555,020 - 6,570,553 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	6,407,357 - 6,422,030 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	6,466,102 - 6,480,792 (+)	NCBI		UU_Cfam_GSD_1.0

Trpv6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	12,543,552 - 12,558,192 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	345,626 - 359,942 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	345,237 - 359,877 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRPV5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	7,332,222 - 7,348,381 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	7,332,253 - 7,348,383 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	7,626,724 - 7,652,621 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRPV6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	111,750,821 - 111,766,274 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	111,750,945 - 111,765,450 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	8,474,129 - 8,489,168 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trpv6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	12,074,999 - 12,090,049 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624800	12,074,997 - 12,090,141 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Trpv6
70 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	85
Count of miRNA genes:	61
Interacting mature miRNAs:	79
Transcripts:	ENSRNOT00000020616
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
1549843	Bw53	Body weight QTL 53		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	61697658	103194791	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	40433388	85433388	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	43457976	88457976	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	26775591	168368347	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	57486946	102486946	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	70362013	132642728	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114705	78881294	Rat
1549839	Bw52	Body weight QTL 52		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	61697658	115089733	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	26907285	75585128	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	39505275	73892441	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	40433414	85433414	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	29494195	81006281	Rat
2317577	Eae24	Experimental allergic encephalomyelitis QTL 24			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	4	66993185	72752834	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	26907285	75585128	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat
2300179	Bmd50	Bone mineral density QTL 50	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	4	60928534	105928534	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	50119848	146803430	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	62933508	114921294	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	39524264	116179656	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	56647873	149491524	Rat
1578657	Bss12	Bone structure and strength QTL 12	8.9		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	4	60220938	105220938	Rat
1578658	Bss13	Bone structure and strength QTL 13	8		femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	4	60220938	105220938	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	56647776	78882945	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	56647776	78882945	Rat
6478684	Anxrr30	Anxiety related response QTL 30		0.00087	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	56647776	78882945	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	56647776	78882945	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	39524264	74726312	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	57114432	81266970	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	59948935	154902892	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	45456990	146803430	Rat
6478772	Anxrr49	Anxiety related response QTL 49		0.15488	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
2312569	Pur19	Proteinuria QTL 19	3.4	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	4	65882107	96130297	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	36303261	103194984	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	34430484	82490359	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
8552807	Vie4	Viral induced encephalitis QTL 4	7.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	62933508	82490359	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	62277855	128289560	Rat
631651	Bp124	Blood pressure QTL 124	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	62879517	107879517	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	58432133	92991462	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	56698790	126192555	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114432	91360801	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	64528739	157573521	Rat
6478743	Anxrr40	Anxiety related response QTL 40		0.83076	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
7394826	Bw126	Body weight QTL 126		0.002	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	62933269	87483707	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	32583980	114627242	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	58635877	78886137	Rat

Markers in Region

RH129621

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	70,507,017 - 70,507,219 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	70,918,302 - 70,918,503	NCBI	Rnor6.0
Rnor_5.0	4	135,705,367 - 135,705,568	UniSTS	Rnor5.0
RGSC_v3.4	4	69,331,644 - 69,331,845	UniSTS	RGSC3.4
Celera	4	65,472,069 - 65,472,270	UniSTS
RH 3.4 Map	4	419.81	UniSTS
Cytogenetic Map	4	q22	UniSTS

AI412357

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	70,509,277 - 70,509,441 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	70,920,562 - 70,920,725	NCBI	Rnor6.0
Rnor_5.0	4	135,707,627 - 135,707,790	UniSTS	Rnor5.0
RGSC_v3.4	4	69,333,904 - 69,334,067	UniSTS	RGSC3.4
Celera	4	65,474,329 - 65,474,492	UniSTS
RH 3.4 Map	4	419.61	UniSTS
Cytogenetic Map	4	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	10	12	63	52	51	21	25	21	6	137	54	43	45	57	30

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB205146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC109737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF160798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020616 ⟹ ENSRNOP00000020616

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	70,507,348 - 70,523,017 (-)	Ensembl
Rnor_6.0 Ensembl	4	70,918,632 - 70,934,295 (-)	Ensembl

RefSeq Acc Id:

NM_053686 ⟹ NP_446138

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	71,474,006 - 71,489,667 (-)	NCBI
mRatBN7.2	4	70,507,347 - 70,523,013 (-)	NCBI
Rnor_6.0	4	70,918,631 - 70,934,291 (-)	NCBI
Rnor_5.0	4	135,705,692 - 135,721,356 (-)	NCBI
RGSC_v3.4	4	69,331,973 - 69,347,633 (-)	RGD
Celera	4	65,472,398 - 65,488,058 (-)	RGD

Sequence:

show sequence

CCACGCGTCCGCACAGCTCCTGCTCACTCCCAACAGGAGCTCCGATATACAAGCCCAGCAGATT
TCCAGCTCTGCCAAGTGGAACAAAGCAGGAGCCCTCTTCGGACTCCTAAGAGCAGCCACGGGAA
GCCTCACCAGCTCCACAGGTGAAGTAGGAGGCAGAACACAGGAGACGGGACCTCTACAGAGAGA
GGGTAGGCCGGCTCTTGGGGATGCCAATGTGGCCCCAGGGTCGAGCCCAGGTGGGGTCTGGCAT
CAGCCTCAGCCCCCCAAGGACTCAGCCTTCCACCCCATGGGGTGGTCACTGCCCAAGGAGAAGG
GGTTAATACTCTGCCTATGGAACAAGTTCTGCAGATGGTTCCACAGACGAGAGTCCTGGGCTCA
GAGCCGAGATGAGCAGAACCTGCTGCAGCAGAAGAGGATCTGGGAGTCGCCTCTTCTTCTAGCT
GCCAAAGAAAACAATGTCCAGGCTCTGATCAAACTGCTCAAGTTTGAAGGATGTGAGGTGCACC
AGAAAGGAGCCATGGGGGAAACTGCACTTCACATAGCTGCCCTCTATGATAACCTGGAGGCTGC
CATGGTGCTAATGGAGGCTGCCCCAGAACTGGTTTTTGAGCCCATGACTTCAGAGCTATATGAA
GGTCAGACTGCACTGCACATTGCAGTAATAAACCAGAATGTGAACTTGGTCCGTGCTCTGCTTG
CCCGAGGGGCCAGTGTCTCCGCCAGAGCTACGGGCTCTGTCTTCCACTACAGGCCTCACAATCT
CATTTACTATGGAGAACATCCTTTGTCCTTTGCTGCCTGTGTGGGTAGTGAGGAGATTGTTAGA
CTGCTCATCGAGCATGGGGCTGACATTCGGGCCCAGGACTCCTTGGGAAATACAGTACTACACA
TACTCATCTTGCAGCCCAACAAAACCTTTGCCTGCCAGATGTACAACCTGCTACTGTCCTATGA
TGGGGGAGACCACCTGAAGTCCCTTGAACTTGTGCCCAATAACCAAGGACTCACCCCTTTCAAG
TTGGCTGGGGTGGAAGGCAACATTGTGATGTTCCAACACCTGATGCAGAAGCGGAAACACATCC
AGTGGACTTATGGGCCATTGACTTCCACACTTTATGACCTCACTGAGATTGACTCCTCAGGGGA
TGATCAATCTCTACTGGAACTTATTGTTACCACCAAGAAGCGGGAGGCTCGCCAGATCCTGGAC
CAGACACCTGTGAAGGAACTGGTGAGCCTCAAGTGGAAGAGGTATGGGCGGCCCTACTTCTGTG
TGCTGGGTGCCATCTACGTGCTCTACATCATCTGCTTTACCATGTGCTGTGTCTACCGCCCACT
CAAGCCCAGGATCACTAACCGCACCAACCCCAGGGACAATACCCTCCTGCAGCAGAAGCTCCTT
CAGGAGGCCTATGTGACCCCCAAGGATGATCTCCGGCTGGTGGGGGAGCTGGTGAGCATCGTTG
GGGCTGTGATCATCCTGCTGGTGGAGATTCCAGACATCTTCAGGTTGGGGGTCACTCGATTTTT
TGGGCAGACCATTCTTGGGGGGCCATTCCATGTCATCATTGTCACTTATGCCTTCATGGTGCTG
GTGACCATGGTGATGCGGCTCACCAACTCAGATGGAGAGGTGGTGCCCATGTCGTTTGCTCTGG
TGTTGGGCTGGTGCAATGTCATGTACTTTGCCAGAGGATTCCAAATGCTGGGTCCCTTCACCAT
CATGATCCAGAAGATGATTTTTGGTGACTTGATGCGATTCTGCTGGCTGATGGCTGTGGTAATC
TTGGGATTTGCTTCAGCCTTCTATATCATCTTCCAGACAGAGGACCCCGATGAGCTGGGCCATT
TCTATGACTACCCCATGGCACTGTTCAGCACCTTTGAACTCTTCCTCACCATCATCGATGGCCC
TGCCAACTATGACGTGGATCTGCCCTTCATGTACAGCATCACCTACGCTGCCTTTGCCATCATC
GCCACACTGCTCATGCTCAACCTCCTAATTGCCATGATGGGTGACACTCACTGGAGAGTTGCCC
ATGAGCGGGATGAGCTCTGGAGAGCACAGGTTGTGGCTACTACCGTGATGCTAGAACGGAAGCT
GCCTCGCTGCCTGTGGCCTCGATCTGGGATATGTGGGCGAGAGTATGGTCTTGGGGACCGCTGG
TTCTTGAGGGTGGAAGATAGACAAGATCTCAACAGACAACGCATCCGCCGCTATGCACAGGCCT
TCCAGCAACAAGATGACCTCTACTCTGAGGACTTGGAAAAAGACTCAGGAGAAAAACTGGAGAT
GGCACGACCCTTTGGTGCCTATCTGTCCTTTCCTACACCCTCAGTGTCTCGAAGTACCTCCCGA
AGCAGCACCAATTGGGACAGGCTTCGACAAGGGGCCCTAAGGAAGGACCTTCAAGGGATAATCA
ACCGGGGCCTGGAAGATGGGGAGGGCTGGGAGTACCAGATCTAAATGTTGGCTCTCACCAAACA
TCAAAACAGAATGAAAGAAAACCAGTTCAAAACTAGAAGTCATCCTGCAAGTCCAAGGAGAAGG
GGGAGGAACATGCTAAGGAATGTACAATAAATCCTTCAGAGCTCCACAACTCCACCTTGGGGCA
GAAAGAAGAAGATTCTGTGGTCCTTGCCTCAACCAAGCATTCCTTGTTCTCTTATGGAAGCTCC
CCTGCACACCAGAGCACTTTAAAGACAGGCTTCCCGTCACAGGCACCTGTCTCCACCCAGGTCT
AATAAGTGGGAGGGCACAGAACTCTACCCAGAGTGCTTCAGAGGACCGGTGGAGAACACTCAGA
TTGTGGGAAAGCGTGTGATGGAGAGATACAGGCACCAGTCTAGGGGTGGGGAAACTAGGCTGAG
CCTTGCCACCTTCCAGTAAAGTCATTTCCTGATCCCCAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_446138	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD47636	(Get FASTA)	NCBI Sequence Viewer
	BAH03203	(Get FASTA)	NCBI Sequence Viewer
	EDM15484	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020616
GenBank Protein	Q9R186	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446138 ⟸ NM_053686

- UniProtKB:

Q9R186 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MGWSLPKEKGLILCLWNKFCRWFHRRESWAQSRDEQNLLQQKRIWESPLLLAAKENNVQALIKL
LKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQ
NVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQ
DSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQ
HLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELIVTTKKREARQILDQTPVKELVSLKW
KRYGRPYFCVLGAIYVLYIICFTMCCVYRPLKPRITNRTNPRDNTLLQQKLLQEAYVTPKDDLR
LVGELVSIVGAVIILLVEIPDIFRLGVTRFFGQTILGGPFHVIIVTYAFMVLVTMVMRLTNSDG
EVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQ
TEDPDELGHFYDYPMALFSTFELFLTIIDGPANYDVDLPFMYSITYAAFAIIATLLMLNLLIAM
MGDTHWRVAHERDELWRAQVVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNR
QRIRRYAQAFQQQDDLYSEDLEKDSGEKLEMARPFGAYLSFPTPSVSRSTSRSSTNWDRLRQGA
LRKDLQGIINRGLEDGEGWEYQI

hide sequence

Ensembl Acc Id:

ENSRNOP00000020616 ⟸ ENSRNOT00000020616

Protein Domains

Ion transport

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9R186-F1-model_v2	AlphaFold	Q9R186	1-767	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693003

Promoter ID:

EPDNEW_R3526

Type:

multiple initiation site

Name:

Trpv6_1

Description:

transient receptor potential cation channel, subfamily V, member6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	70,934,223 - 70,934,283	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69335	AgrOrtholog
BioCyc Gene	G2FUF-45109	BioCyc
Ensembl Genes	ENSRNOG00000014714	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000020616	ENTREZGENE
Gene3D-CATH	1.25.40.20	UniProtKB/Swiss-Prot
InterPro	Ankyrin_rpt	UniProtKB/Swiss-Prot
	Ankyrin_rpt-contain_sf	UniProtKB/Swiss-Prot
	Ion_trans_dom	UniProtKB/Swiss-Prot
	TRPV	UniProtKB/Swiss-Prot
	TRPV5/TRPV6	UniProtKB/Swiss-Prot
	TRPV6_channel	UniProtKB/Swiss-Prot
KEGG Report	rno:114246	UniProtKB/Swiss-Prot
NCBI Gene	Trpv6	ENTREZGENE
PANTHER	PTHR10582	UniProtKB/Swiss-Prot
	TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6	UniProtKB/Swiss-Prot
Pfam	Ank_2	UniProtKB/Swiss-Prot
	Ion_trans	UniProtKB/Swiss-Prot
PhenoGen	Trpv6	PhenoGen
PRINTS	ANKYRIN	UniProtKB/Swiss-Prot
	ECACCHANNEL	UniProtKB/Swiss-Prot
	ECACCHANNEL1	UniProtKB/Swiss-Prot
PROSITE	ANK_REP_REGION	UniProtKB/Swiss-Prot
	ANK_REPEAT	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000014714	RatGTEx
SMART	ANK	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48403	UniProtKB/Swiss-Prot
UniProt	A6IF47_RAT	UniProtKB/TrEMBL
	B6ZDS2_RAT	UniProtKB/TrEMBL
	G3V7Y1_RAT	UniProtKB/TrEMBL
	Q6TU30_RAT	UniProtKB/TrEMBL
	Q9R186	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2003-04-09	Trpv6	transient receptor potential cation channel, subfamily V, member 6			Symbol and Name updated	629477	APPROVED
2003-03-19	Trpv6	transient receptor potential cation channel, subfamily V, member 6	Ecac2	epithelial apical membrane calcium transporter/channel CaT1	Data merged from RGD:620637	628472	PROVISIONAL
2002-08-07	Ecac2	epithelial apical membrane calcium transporter/channel CaT1			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-06-10	Trpv6	transient receptor potential cation channel, subfamily 5, member 6			Name updated	70584	APPROVED
2002-02-27	Ecac2	epithelial calcium channel 2			Symbol and Name updated to reflect Human and Mouse nomenclature	70292	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	activated following Ca2+ store depletion	634426

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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