Enables thyrotropin-releasing hormone activity. Involved in several processes, including negative regulation of feeding behavior; regulation of secretion; and response to corticosterone. Located in secretory granule. Used to study hypertension. Biomarker of hypothyroidism. Orthologous to human TRH (thyrotropin releasing hormone); INTERACTS WITH (+)-pilocarpine; 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol.
Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein] and Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein]
bisphenol A inhibits the reaction [TRH protein results in increased secretion of PRL protein] and bisphenol A inhibits the reaction [TRH protein results in increased secretion of TSHB protein]
Okadaic Acid inhibits the reaction [TRH protein results in decreased activity of ACO1 protein] and Okadaic Acid inhibits the reaction [TRH protein results in decreased activity of IREB2 protein]
[Levodopa co-treated with Oxidopamine] results in increased expression of TRH mRNA and [Levodopa co-treated with Oxidopamine] results in increased expression of TRH protein
Tetradecanoylphorbol Acetate inhibits the reaction [TRH protein results in increased activity of ACO1 protein] and Tetradecanoylphorbol Acetate inhibits the reaction [TRH protein results in increased activity of IREB2 protein]
Protein Kinase Inhibitors inhibits the reaction [TRH protein results in increased activity of ACO1 protein] and Protein Kinase Inhibitors inhibits the reaction [TRH protein results in increased activity of IREB2 protein]
Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein] and Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein]
Colchicine treatment differently affects releasable thyrotropin-releasing hormone (TRH) pools in the hypothalamic paraventricular nucleus (PVN) and the median eminence (ME).
Cold stress induces metabolic activation of thyrotrophin-releasing hormone-synthesising neurones in the magnocellular division of the hypothalamic paraventricular nucleus and concomitantly changes ovarian sympathetic activity parameters.
