Mad2l1 (mitotic arrest deficient 2 like 1) - Rat Genome Database

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Gene: Mad2l1 (mitotic arrest deficient 2 like 1) Rattus norvegicus
Analyze
Symbol: Mad2l1
Name: mitotic arrest deficient 2 like 1
RGD ID: 1310889
Description: Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including establishment of centrosome localization; establishment of mitotic spindle orientation; and regulation of mitotic metaphase/anaphase transition. Predicted to act upstream of or within mitotic sister chromatid segregation and negative regulation of mitotic cell cycle. Predicted to be located in several cellular components, including chromosome, centromeric region; perinuclear region of cytoplasm; and spindle. Predicted to be part of mitotic checkpoint complex; mitotic spindle assembly checkpoint MAD1-MAD2 complex; and nuclear pore nuclear basket. Predicted to be active in cytoplasm; kinetochore; and nucleoplasm. Orthologous to human MAD2L1 (mitotic arrest deficient 2 like 1); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC297176; MAD2 (mitotic arrest deficient, homolog)-like 1; MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast) ; MAD2 mitotic arrest deficient-like 1; MAD2 mitotic arrest deficient-like 1 (yeast); mitotic spindle assembly checkpoint protein MAD2A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,236,419 - 97,247,603 (+)NCBIGRCr8
mRatBN7.2495,906,692 - 95,918,885 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl495,906,817 - 95,913,470 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4101,156,297 - 101,162,300 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0496,931,268 - 96,937,271 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0495,357,365 - 95,363,282 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0497,530,993 - 97,543,179 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,531,083 - 97,537,086 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,316,330 - 162,328,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,380,039 - 96,386,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1496,624,574 - 96,635,493 (+)NCBI
Celera490,603,845 - 90,609,848 (+)NCBICelera
Cytogenetic Map4q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
fipronil  (EXP)
fulvestrant  (ISO)
furan  (EXP)
geraniol  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
heptachlor  (EXP)
hydroxyurea  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
melatonin  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
O-methyleugenol  (EXP)
oxaliplatin  (EXP)
oxfendazole  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
promethazine  (EXP)
propanal  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8824189   PMID:10892650   PMID:10964468   PMID:11201745   PMID:11459825   PMID:12355205   PMID:16525508   PMID:17325031   PMID:17363900   PMID:17504913   PMID:18022367   PMID:18318601  
PMID:18981471   PMID:19075002   PMID:19229290   PMID:19376971   PMID:19468067   PMID:20133940   PMID:20870947   PMID:21041666   PMID:21274008   PMID:21772247   PMID:22100920   PMID:23509069  
PMID:37530743  


Genomics

Comparative Map Data
Mad2l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,236,419 - 97,247,603 (+)NCBIGRCr8
mRatBN7.2495,906,692 - 95,918,885 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl495,906,817 - 95,913,470 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4101,156,297 - 101,162,300 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0496,931,268 - 96,937,271 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0495,357,365 - 95,363,282 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0497,530,993 - 97,543,179 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,531,083 - 97,537,086 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,316,330 - 162,328,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,380,039 - 96,386,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1496,624,574 - 96,635,493 (+)NCBI
Celera490,603,845 - 90,609,848 (+)NCBICelera
Cytogenetic Map4q31NCBI
MAD2L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384120,055,623 - 120,066,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4120,055,623 - 120,066,858 (-)EnsemblGRCh38hg38GRCh38
GRCh374120,976,778 - 120,988,003 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364121,200,037 - 121,207,411 (-)NCBINCBI36Build 36hg18NCBI36
Build 344121,338,194 - 121,345,566NCBI
Celera4118,360,054 - 118,367,490 (-)NCBICelera
Cytogenetic Map4q27NCBI
HuRef4116,701,809 - 116,709,245 (-)NCBIHuRef
CHM1_14120,957,099 - 120,964,533 (-)NCBICHM1_1
T2T-CHM13v2.04123,359,722 - 123,370,945 (-)NCBIT2T-CHM13v2.0
Mad2l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39666,512,205 - 66,518,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl666,512,374 - 66,524,204 (+)EnsemblGRCm39 Ensembl
GRCm38666,535,221 - 66,541,107 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl666,535,390 - 66,547,220 (+)EnsemblGRCm38mm10GRCm38
MGSCv37666,485,462 - 66,490,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36666,465,046 - 66,470,569 (+)NCBIMGSCv36mm8
Celera668,657,930 - 68,663,453 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map630.56NCBI
Mad2l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542820,421,723 - 20,430,307 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542820,421,718 - 20,443,394 (+)NCBIChiLan1.0ChiLan1.0
MAD2L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23117,833,740 - 117,844,585 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14118,132,823 - 118,140,957 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04112,247,808 - 112,255,202 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14123,397,355 - 123,405,535 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4123,397,355 - 123,405,535 (-)Ensemblpanpan1.1panPan2
LOC476070
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11855,653,677 - 55,661,017 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha843,837,242 - 43,841,863 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0844,376,539 - 44,382,150 (+)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.0844,076,394 - 44,106,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0844,436,805 - 44,442,590 (+)NCBIUU_Cfam_GSD_1.0
Mad2l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530167,021,248 - 67,027,363 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493666292,328 - 99,517 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493666292,421 - 98,531 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAD2L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8103,927,353 - 103,936,664 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18103,927,358 - 103,936,669 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28111,496,849 - 111,506,085 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAD2L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1767,351,785 - 67,360,244 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603746,274,527 - 46,283,741 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Mad2l1
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:41
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000007285
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)488656681103194984Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478885890102684881Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat

Markers in Region
RH140557  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2495,912,441 - 95,912,625 (+)MAPPERmRatBN7.2
Rnor_6.0497,536,743 - 97,536,926NCBIRnor6.0
Rnor_5.04162,322,086 - 162,322,269UniSTSRnor5.0
RGSC_v3.4496,385,699 - 96,385,882UniSTSRGSC3.4
Celera490,609,505 - 90,609,688UniSTS
RH 3.4 Map4588.8UniSTS
Cytogenetic Map4q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 35 26 18 26 55 22 35 1
Low 17 22 15 1 15 8 11 19 13 6 10 8
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000007285   ⟹   ENSRNOP00000007285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl495,906,817 - 95,913,470 (+)Ensembl
Rnor_6.0 Ensembl497,531,083 - 97,537,086 (+)Ensembl
RefSeq Acc Id: NM_001106594   ⟹   NP_001100064
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,236,509 - 97,242,512 (+)NCBI
mRatBN7.2495,906,782 - 95,912,785 (+)NCBI
Rnor_6.0497,531,083 - 97,537,086 (+)NCBI
Rnor_5.04162,316,330 - 162,328,522 (+)NCBI
RGSC_v3.4496,380,039 - 96,386,042 (+)RGD
Celera490,603,845 - 90,609,848 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236619   ⟹   XP_006236681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,236,419 - 97,246,303 (+)NCBI
mRatBN7.2495,906,692 - 95,913,497 (+)NCBI
Rnor_6.0497,530,993 - 97,537,798 (+)NCBI
Rnor_5.04162,316,330 - 162,328,522 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236620   ⟹   XP_006236682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,236,419 - 97,246,303 (+)NCBI
mRatBN7.2495,906,692 - 95,913,497 (+)NCBI
Rnor_6.0497,530,993 - 97,537,798 (+)NCBI
Rnor_5.04162,316,330 - 162,328,522 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236621   ⟹   XP_006236683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,236,419 - 97,247,603 (+)NCBI
mRatBN7.2495,906,692 - 95,918,885 (+)NCBI
Rnor_6.0497,530,993 - 97,543,179 (+)NCBI
Rnor_5.04162,316,330 - 162,328,522 (+)NCBI
Sequence:
RefSeq Acc Id: XR_010065624
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,236,419 - 97,247,603 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100064 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236681 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236682 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236683 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL91587 (Get FASTA)   NCBI Sequence Viewer  
  EDL91588 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007285.4
RefSeq Acc Id: NP_001100064   ⟸   NM_001106594
- UniProtKB: D4ACM2 (UniProtKB/TrEMBL),   A6KF36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236683   ⟸   XM_006236621
- Peptide Label: isoform X1
- UniProtKB: D4ACM2 (UniProtKB/TrEMBL),   A6KF36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236682   ⟸   XM_006236620
- Peptide Label: isoform X1
- UniProtKB: D4ACM2 (UniProtKB/TrEMBL),   A6KF36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236681   ⟸   XM_006236619
- Peptide Label: isoform X1
- UniProtKB: D4ACM2 (UniProtKB/TrEMBL),   A6KF36 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007285   ⟸   ENSRNOT00000007285
Protein Domains
HORMA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACM2-F1-model_v2 AlphaFold D4ACM2 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693101
Promoter ID:EPDNEW_R3625
Type:initiation region
Name:Mad2l1_1
Description:mitotic arrest deficient 2 like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0497,531,136 - 97,531,196EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310889 AgrOrtholog
BioCyc Gene G2FUF-44583 BioCyc
Ensembl Genes ENSRNOG00000005376 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007285.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.900.10 UniProtKB/TrEMBL
InterPro HORMA_DNA-bd UniProtKB/TrEMBL
  HORMA_dom_sf UniProtKB/TrEMBL
  Mad2-like UniProtKB/TrEMBL
KEGG Report rno:297176 UniProtKB/TrEMBL
NCBI Gene 297176 ENTREZGENE
PANTHER MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A UniProtKB/TrEMBL
  PTHR11842 UniProtKB/TrEMBL
Pfam HORMA UniProtKB/TrEMBL
PhenoGen Mad2l1 PhenoGen
PROSITE HORMA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005376 RatGTEx
Superfamily-SCOP HORMA_DNA_bd UniProtKB/TrEMBL
UniProt A6KF36 ENTREZGENE, UniProtKB/TrEMBL
  D4ACM2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-10 Mad2l1  mitotic arrest deficient 2 like 1  Mad2l1  MAD2 mitotic arrest deficient-like 1 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Mad2l1  MAD2 mitotic arrest deficient-like 1 (yeast)  Mad2l1  MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mad2l1  MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast)   Mad2l1_predicted  MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mad2l1_predicted  MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED