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Gene: Add2 (adducin 2) Rattus norvegicus
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Symbol: Add2
Name: adducin 2
Description: Predicted to have several functions, including cytoskeletal protein binding activity; protein dimerization activity; and structural molecule activity. Involved in ion transport. Localizes to the glutamatergic synapse and postsynapse. Used to study hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and hypertension. Orthologous to human ADD2 (adducin 2); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adducin 2 (beta); adducin 2, beta; adducin beta; Adducin, beta; adducin-63; beta adducin; beta-ADD; beta-adducin; erythrocyte adducin subunit beta
Orthologs:
Homo sapiens (human) : ADD2 (adducin 2)  HGNC  Alliance
Mus musculus (house mouse) : Add2 (adducin 2 (beta))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Add2 (adducin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ADD2 (adducin 2)
Canis lupus familiaris (dog) : ADD2 (adducin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Add2 (adducin 2)
Sus scrofa (pig) : ADD2 (adducin 2)
more info ...
Is Marker For: Strains:   MHS/N  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04117,691,294 - 117,887,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04182,417,932 - 182,454,565 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,221,140 - 120,275,351 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,465,620 - 120,510,931 (+)NCBI
Celera4107,471,489 - 107,504,523 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Add2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2042
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.