Add2 (adducin 2) - Rat Genome Database

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Gene: Add2 (adducin 2) Rattus norvegicus
Analyze
Symbol: Add2
Name: adducin 2
RGD ID: 2042
Description: Predicted to have cytoskeletal protein binding activity; protein dimerization activity; and protein kinase binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in ion transport. Localizes to glutamatergic synapse and postsynapse. Used to study hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and hypertension. Orthologous to human ADD2 (adducin 2); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adducin 2 (beta); adducin 2, beta; adducin beta; Adducin, beta; adducin-63; beta adducin; beta-ADD; beta-adducin; erythrocyte adducin subunit beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   MHS/N  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24118,444,594 - 118,538,505 (+)NCBI
Rnor_6.0 Ensembl4117,743,710 - 117,882,464 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04117,691,294 - 117,887,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04182,417,932 - 182,454,565 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,221,140 - 120,275,351 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,465,620 - 120,510,931 (+)NCBI
Celera4107,471,489 - 107,504,523 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:3693401   PMID:7642559   PMID:8626479   PMID:8889548   PMID:10485892   PMID:10602987   PMID:12646192   PMID:15528469   PMID:16414955   PMID:17114649   PMID:18347014   PMID:18634768  
PMID:19292454   PMID:21150638   PMID:21435558   PMID:25425738   PMID:26639316   PMID:29476059   PMID:30053369  


Genomics

Candidate Gene Status
Add2 is a candidate Gene for QTL Bp116
Comparative Map Data
Add2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24118,444,594 - 118,538,505 (+)NCBI
Rnor_6.0 Ensembl4117,743,710 - 117,882,464 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04117,691,294 - 117,887,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04182,417,932 - 182,454,565 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,221,140 - 120,275,351 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,465,620 - 120,510,931 (+)NCBI
Celera4107,471,489 - 107,504,523 (+)NCBICelera
Cytogenetic Map4q34NCBI
ADD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl270,607,618 - 70,768,225 (-)EnsemblGRCh38hg38GRCh38
GRCh38270,656,784 - 70,768,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37270,883,916 - 70,995,332 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36270,742,770 - 70,848,837 (-)NCBINCBI36hg18NCBI36
Build 34270,800,919 - 70,906,984NCBI
Celera270,739,895 - 70,846,052 (-)NCBI
Cytogenetic Map2p13.3NCBI
HuRef270,626,283 - 70,732,257 (-)NCBIHuRef
CHM1_1270,818,535 - 70,924,705 (-)NCBICHM1_1
Add2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,005,663 - 86,101,391 (+)NCBIGRCm39mm39
GRCm39 Ensembl686,005,663 - 86,101,391 (+)Ensembl
GRCm38686,028,681 - 86,124,409 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,028,681 - 86,124,409 (+)EnsemblGRCm38mm10GRCm38
MGSCv37686,028,078 - 86,069,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36686,043,718 - 86,085,189 (+)NCBImm8
Celera688,013,744 - 88,055,678 (+)NCBICelera
Cytogenetic Map6C3- D1NCBI
cM Map637.55NCBI
Add2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542414,411,124 - 14,517,813 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542414,411,279 - 14,517,813 (+)NCBIChiLan1.0ChiLan1.0
ADD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A71,839,470 - 71,944,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A71,839,470 - 71,895,106 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A70,724,454 - 70,831,248 (-)NCBIMhudiblu_PPA_v0panPan3
ADD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11069,056,367 - 69,098,775 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1069,057,267 - 69,098,521 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1068,939,411 - 69,031,911 (-)NCBI
ROS_Cfam_1.01070,074,115 - 70,166,872 (-)NCBI
UMICH_Zoey_3.11069,792,050 - 69,885,391 (-)NCBI
UNSW_CanFamBas_1.01070,054,471 - 70,147,033 (-)NCBI
UU_Cfam_GSD_1.01070,356,179 - 70,411,965 (-)NCBI
Add2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629213,599,879 - 13,714,530 (+)NCBI
SpeTri2.0NW_00493649114,856,764 - 14,971,161 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl371,730,002 - 71,840,862 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1371,729,882 - 71,845,761 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2375,131,802 - 75,191,268 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADD2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11436,343,978 - 36,450,685 (+)NCBI
ChlSab1.1 Ensembl1436,344,022 - 36,449,315 (+)Ensembl
Add2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247622,619,371 - 2,726,586 (+)NCBI

Position Markers
D4Got91  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,509,866 - 118,510,108 (+)MAPPER
Rnor_6.04117,848,346 - 117,848,588NCBIRnor6.0
Rnor_6.04117,853,932 - 117,854,171NCBIRnor6.0
Rnor_5.04182,420,290 - 182,420,532UniSTSRnor5.0
Rnor_5.04182,425,876 - 182,426,115UniSTSRnor5.0
RGSC_v3.44120,240,909 - 120,241,146UniSTSRGSC3.4
RGSC_v3.44120,246,489 - 120,246,729RGDRGSC3.4
RGSC_v3.44120,240,908 - 120,241,146RGDRGSC3.4
RGSC_v3.44120,246,490 - 120,246,729UniSTSRGSC3.4
RGSC_v3.14120,490,971 - 120,491,210RGD
Celera4107,483,238 - 107,483,479UniSTS
RH 3.4 Map4696.1RGD
RH 3.4 Map4696.1UniSTS
Cytogenetic Map4q34UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)436615599145611886Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)443414605155469929Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)443414792146942075Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)443414792146942075Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)446898276145611886Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)449906054145611886Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)455324953148360954Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)455375865125671711Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)458640017154427984Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)461038901127777403Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)462947687125671711Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)463537179157286626Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470773471132455556Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473786419132455556Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)475258970120258970Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)475258970120258970Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)476567036121567036Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)479555067124555067Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481874073119546974Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)481959983152055009Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)484475257178931073Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)485794049129615056Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486312589146942261Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486312589147702403Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486438317168047091Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486532519131532519Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487136446132136446Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487136446132136446Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)494414208139414208Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494893247168046938Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)499066823144066823Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105277348150277348Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4105682594150682594Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4105971071168047091Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106347236151347236Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4108876717169215811Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109636356154636356Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109636356154636356Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110702761155702761Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110702761155702761Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4112807675157807675Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4115372758150038284Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4116726724157291438Rat


Related Rat Strains
The following Strains have been annotated to Add2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:52
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000021491
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 18 18 11 18 72 2
Low 30 21 11 2 11 2 16 29 11
Below cutoff 3 3 17 12 5 12 8 10 19 10 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF130338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY226987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE121149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ231568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY315967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV762188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000021491   ⟹   ENSRNOP00000021491
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4117,743,710 - 117,882,464 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081173   ⟹   ENSRNOP00000073973
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4117,744,075 - 117,873,700 (+)Ensembl
RefSeq Acc Id: NM_001109880   ⟹   NP_001103350
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24118,497,416 - 118,538,505 (+)NCBI
Rnor_6.04117,744,075 - 117,882,427 (+)NCBI
Rnor_5.04182,417,932 - 182,454,565 (+)NCBI
RGSC_v3.44120,221,140 - 120,275,351 (+)RGD
Celera4107,471,489 - 107,504,523 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012491   ⟹   NP_036623
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24118,497,416 - 118,529,659 (+)NCBI
Rnor_6.04117,744,075 - 117,873,701 (+)NCBI
Rnor_5.04182,417,932 - 182,454,565 (+)NCBI
RGSC_v3.44120,221,140 - 120,275,351 (+)RGD
Celera4107,471,489 - 107,503,009 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592432   ⟹   XP_017447921
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04117,691,295 - 117,887,556 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592433   ⟹   XP_017447922
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04117,691,294 - 117,882,053 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107004   ⟹   XP_038962932
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24118,497,321 - 118,532,390 (+)NCBI
RefSeq Acc Id: XM_039107005   ⟹   XP_038962933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24118,444,594 - 118,532,390 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036623   ⟸   NM_012491
- Peptide Label: isoform b
- UniProtKB: Q05764 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001103350   ⟸   NM_001109880
- Peptide Label: isoform a
- UniProtKB: Q05764 (UniProtKB/Swiss-Prot),   F8WFS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447922   ⟸   XM_017592433
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017447921   ⟸   XM_017592432
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000021491   ⟸   ENSRNOT00000021491
RefSeq Acc Id: ENSRNOP00000073973   ⟸   ENSRNOT00000081173
RefSeq Acc Id: XP_038962933   ⟸   XM_039107005
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962932   ⟸   XM_039107004
- Peptide Label: isoform X1
Protein Domains
Aldolase_II

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693202
Promoter ID:EPDNEW_R3726
Type:single initiation site
Name:Add2_1
Description:adducin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04117,744,065 - 117,744,125EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 182444360 182444361 G A snv ACI/EurMcwi (MCW), BDIX.Cg-Tal/NemOda (KyushuU), GH/OmrMcwi (MCW), ACI/N (KNAW), ACI/EurMcwi (KNAW), BUF/N (KNAW), DA/BklArbNsi (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), M520/N (KNAW), MNS/Gib (KNAW), LE/OrlBarth (UDEL), HWY/Slc (KyushuU), BDIX/NemOda (KyushuU), COP/CrCrl (MCW & UW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 117872222 117872223 G A snv M520/N (MCW), ACI/N (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 120264972 120264973 G A snv ACI/N (KNAW), M520/N (KNAW), ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), ACI/EurMcwi (ICL), DA/BklArbNsi (ICAHN), LEW/NCrl (ICL), MNS/Gib (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), HCR/2Mco (UMich), LCR/2Mco (UMich), LEW/Crl (ICL)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2042 AgrOrtholog
Ensembl Genes ENSRNOG00000015903 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021491 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000073973 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021491 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000081173 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.225.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_II/adducin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_II/adducin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24171 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24171 ENTREZGENE
PANTHER PTHR10672:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldolase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Add2 PhenoGen
SMART Aldolase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53639 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216666
UniProt ADDB_RAT UniProtKB/Swiss-Prot
  F8WFS9 ENTREZGENE, UniProtKB/TrEMBL
  Q05764 ENTREZGENE
  Q80UA1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Add2  adducin 2  Add2  adducin 2 (beta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Add2  adducin 2 (beta)    adducin 2, beta  Name updated 1299863 APPROVED
2002-11-06 Add2  adducin 2, beta    Adducin, beta  Name updated 625702 APPROVED
2002-06-10 Add2  Adducin, beta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytoskeleton 631736
gene_disease Gln to Arg substitution is associated with altered ion transport and blood pressure variation in the Milan hypertensive strain (MHS) 631712
gene_function interacts with other proteins of the membrane cytoskeleton 631736
gene_physical_interaction forms a heterodimer with alpha adducin (Add1) 631736
gene_process plays a role in membrane ion transport 631712
gene_process plays a role in membrane ion transport 631736
gene_protein 63 kDa protein 631712
gene_protein 63 kDa protein 631736