Predicted to enable several functions, including histone H3K9me/H3K9me2 demethylase activity; iron ion binding activity; and nuclear androgen receptor binding activity. Involved in male gonad development; positive regulation of gene expression; and response to hypoxia. Predicted to be located in cytoplasm; male germ cell nucleus; and nucleoplasm. Predicted to be part of chromatin and histone deacetylase complex. Human ortholog(s) of this gene implicated in cervical cancer and colon cancer. Orthologous to human KDM3A (lysine demethylase 3A); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Metribolone promotes the reaction [KDM3A protein binds to KLK3 enhancer] and Metribolone promotes the reaction [KDM3A protein binds to NKX3-1 enhancer]
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of KDM3A protein
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of KDM3A protein
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of KDM3A protein
Oxygen deficiency promotes the reaction [HIF3A protein binds to KDM3A promoter] and Oxygen deficiency promotes the reaction [KDM3A protein binds to SPRY2 promoter]
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of KDM3A protein
Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A mRNA] and Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A protein]
Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A mRNA] and Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A protein]
[Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased oxidation of KDM3A mRNA and [Air Pollutants results in increased abundance of Ozone] which affects the expression of KDM3A mRNA
Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion.
