Kcnd2 (potassium voltage-gated channel subfamily D member 2) - Rat Genome Database

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Gene: Kcnd2 (potassium voltage-gated channel subfamily D member 2) Rattus norvegicus
Analyze
Symbol: Kcnd2
Name: potassium voltage-gated channel subfamily D member 2
RGD ID: 68393
Description: Enables A-type (transient outward) potassium channel activity. Involved in several processes, including cellular response to hypoxia; cellular response to mechanical stimulus; and potassium ion transmembrane transport. Located in several cellular components, including T-tubule; neuronal cell body membrane; and perinuclear endoplasmic reticulum. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse and postsynaptic membrane. Orthologous to human KCND2 (potassium voltage-gated channel subfamily D member 2); PARTICIPATES IN excitatory synaptic transmission pathway; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-type voltage-gated potassium channel KCND2; Kv4.2; potassium channel, voltage-gated Shal-related subfamily D, member 2; potassium voltage gated channel, Shal-related family, member 2; potassium voltage-gated channel, Shal-related subfamily, member 2; RK5; Shal1; voltage-gated potassium channel subunit Kv4.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8450,741,595 - 51,243,540 (+)NCBIGRCr8
mRatBN7.2449,775,812 - 50,277,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl449,776,246 - 50,277,728 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx454,749,390 - 55,256,964 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0450,670,509 - 51,178,050 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0449,094,034 - 49,606,328 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0448,309,283 - 48,816,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0448,099,455 - 48,609,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4447,541,787 - 48,047,924 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1447,772,679 - 48,277,046 (+)NCBI
Celera444,984,114 - 45,483,230 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
ATP  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
carmustine  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
Cuprizon  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
dichlorine  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
formaldehyde  (ISO)
furan  (EXP)
glucose  (ISO)
glyphosate  (EXP)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ouabain  (EXP,ISO)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
pirinixic acid  (ISO)
potassium chloride  (EXP)
progesterone  (ISO)
rac-lactic acid  (ISO)
reserpine  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
scopolamine  (EXP)
serpentine asbestos  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
testosterone  (EXP,ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triticonazole  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (IMP)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term potentiation  (TAS)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. alpha1-adrenoceptors regulate only the caveolae-located subpopulation of cardiac K(V)4 channels. Alday A, etal., Channels (Austin). 2010 May-Jun;4(3):168-78.
2. Clustering of KV4.2 potassium channels in postsynaptic membrane of rat supraoptic neurons: an ultrastructural study. Alonso G and Widmer H, Neuroscience. 1997 Apr;77(3):617-21.
3. Functional characterization of RK5, a voltage-gated K+ channel cloned from the rat cardiovascular system. Blair TA, etal., FEBS Lett 1991 Dec 16;295(1-3):211-3.
4. Expression and high glucose-mediated regulation of K+ channel interacting protein 3 (KChIP3) and KV4 channels in retinal Muller glial cells. Chavira-Suarez E, etal., Biochem Biophys Res Commun. 2011 Jan 14;404(2):678-83. doi: 10.1016/j.bbrc.2010.12.041. Epub 2010 Dec 11.
5. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Dabrowska J and Rainnie DG, Neuroscience. 2010 Dec 15;171(3):721-33. doi: 10.1016/j.neuroscience.2010.09.011. Epub 2010 Sep 16.
6. Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. Deschenes I, etal., J Mol Cell Cardiol. 2008 Sep;45(3):336-46. Epub 2008 May 12.
7. SAP97 directs the localization of Kv4.2 to spines in hippocampal neurons: regulation by CaMKII. Gardoni F, etal., J Biol Chem. 2007 Sep 28;282(39):28691-9. Epub 2007 Jul 16.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. Holmqvist MH, etal., Proc Natl Acad Sci U S A 2002 Jan 22;99(2):1035-40.
11. Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. Jerng HH, etal., J Physiol. 2005 Nov 1;568(Pt 3):767-88. Epub 2005 Aug 25.
12. Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones. Kim J, etal., J Physiol. 2005 Nov 15;569(Pt 1):41-57. Epub 2005 Sep 1.
13. Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons. Kim J, etal., Neuron. 2007 Jun 21;54(6):933-47.
14. Contribution of KChIP2 to the developmental increase in transient outward current of rat cardiomyocytes. Kobayashi T, etal., J Mol Cell Cardiol. 2003 Sep;35(9):1073-82.
15. KChIP3 rescues the functional expression of Shal channel tetramerization mutants. Kunjilwar K, etal., J Biol Chem. 2004 Dec 24;279(52):54542-51. doi: 10.1074/jbc.M409721200. Epub 2004 Oct 12.
16. Regulation of Kv4.2 A-Type Potassium Channels in HEK-293 Cells by Hypoxia. Liu YQ, etal., Front Cell Neurosci. 2014 Oct 14;8:329. doi: 10.3389/fncel.2014.00329. eCollection 2014.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels. Nadal MS, etal., Neuron. 2003 Feb 6;37(3):449-61.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Altered K(+) channel gene expression in diabetic rat ventricle: isoform switching between Kv4.2 and Kv1.4. Nishiyama A, etal., Am J Physiol Heart Circ Physiol 2001 Oct;281(4):H1800-7.
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. The Kv4.2 N-terminal restores fast inactivation and confers KChlP2 modulatory effects on N-terminal-deleted Kv1.4 channels. Pourrier M, etal., Pflugers Arch. 2004 Dec;449(3):235-47. doi: 10.1007/s00424-004-1328-8.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain. Rhodes KJ, etal., J Neurosci. 2004 Sep 8;24(36):7903-15.
27. Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. Roberds SL and Tamkun MM, Proc Natl Acad Sci U S A 1991 Mar 1;88(5):1798-802.
28. Localization of Kv4.2 and KChIP2 in lipid rafts and modulation of outward K+ currents by membrane cholesterol content in rat left ventricular myocytes. Rudakova E, etal., Pflugers Arch. 2015 Feb;467(2):299-309. doi: 10.1007/s00424-014-1521-3. Epub 2014 May 6.
29. Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Sanguinetti MC, etal., Mol Pharmacol. 1997 Mar;51(3):491-8.
30. Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes. Saygili E, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2898-905. Epub 2007 Feb 9.
31. PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. Schrader LA, etal., J Neurosci. 2002 Dec 1;22(23):10123-33. doi: 10.1523/JNEUROSCI.22-23-10123.2002.
32. The role of Zn2+ in Shal voltage-gated potassium channel formation. Strang C, etal., J Biol Chem. 2003 Aug 15;278(33):31361-71. doi: 10.1074/jbc.M304268200. Epub 2003 May 15.
33. Light and electron microscopic analysis of KChIP and Kv4 localization in rat cerebellar granule cells. Strassle BW, etal., J Comp Neurol. 2005 Apr 4;484(2):144-55.
34. Voltage-gated K(+)Channel, Kv4.2, localizes predominantly to the transverse-axial tubular system of the rat myocyte. Takeuchi S, etal., J Mol Cell Cardiol. 2000 Jul;32(7):1361-9.
35. Molecular structure of cardiac Ito channels: Kv4.2, Kv4.3, and other possibilities? Tseng GN Cardiovasc Res 1999 Jan;41(1):16-8.
36. Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle. Wickenden AD, etal., Am J Physiol 1999 May;276(5 Pt 2):H1599-607.
37. Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes. Ye W, etal., Mol Cell. 2022 Jul 7;82(13):2427-2442.e4. doi: 10.1016/j.molcel.2022.04.032. Epub 2022 May 20.
38. Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current. Yeola SW and Snyders DJ, Cardiovasc Res. 1997 Mar;33(3):540-7.
39. Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels. Zhou W, etal., Neuron. 2004 Feb 19;41(4):573-86.
40. Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes. Zobel C, etal., Circulation 2002 Oct 29;106(18):2385-91.
Additional References at PubMed
PMID:1840649   PMID:10676964   PMID:11040264   PMID:11606724   PMID:11847232   PMID:11923279   PMID:12592409   PMID:12626328   PMID:12829703   PMID:12835418   PMID:12843309   PMID:14551056  
PMID:14613857   PMID:14980207   PMID:15454437   PMID:15671030   PMID:15946675   PMID:16176357   PMID:16271805   PMID:16553778   PMID:16636498   PMID:16648177   PMID:16820361   PMID:17026528  
PMID:17122053   PMID:17475505   PMID:17725325   PMID:18045912   PMID:18088376   PMID:18363830   PMID:18371079   PMID:18463498   PMID:18513371   PMID:18515646   PMID:18603586   PMID:18815185  
PMID:19213956   PMID:19261906   PMID:19267230   PMID:19453640   PMID:19713751   PMID:19857555   PMID:20573902   PMID:20920553   PMID:21034530   PMID:21252158   PMID:21273417   PMID:21451062  
PMID:21472817   PMID:21511008   PMID:21895522   PMID:21943606   PMID:22098631   PMID:22245500   PMID:22511771   PMID:22700470   PMID:22815518   PMID:23066017   PMID:24037673   PMID:24404150  
PMID:24486512   PMID:24811166   PMID:25043828   PMID:25756524   PMID:26179130   PMID:27259067   PMID:27322747   PMID:28566490   PMID:29996472   PMID:31935048   PMID:32554946  


Genomics

Comparative Map Data
Kcnd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8450,741,595 - 51,243,540 (+)NCBIGRCr8
mRatBN7.2449,775,812 - 50,277,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl449,776,246 - 50,277,728 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx454,749,390 - 55,256,964 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0450,670,509 - 51,178,050 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0449,094,034 - 49,606,328 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0448,309,283 - 48,816,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0448,099,455 - 48,609,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4447,541,787 - 48,047,924 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1447,772,679 - 48,277,046 (+)NCBI
Celera444,984,114 - 45,483,230 (+)NCBICelera
Cytogenetic Map4q22NCBI
KCND2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387120,272,908 - 120,750,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7120,273,175 - 120,750,337 (+)EnsemblGRCh38hg38GRCh38
GRCh377119,913,229 - 120,390,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367119,700,958 - 120,177,623 (+)NCBINCBI36Build 36hg18NCBI36
Build 347119,507,672 - 119,984,338NCBI
Celera7114,723,245 - 115,199,902 (+)NCBICelera
Cytogenetic Map7q31.31NCBI
HuRef7114,276,961 - 114,753,560 (+)NCBIHuRef
CHM1_17119,847,044 - 120,323,690 (+)NCBICHM1_1
T2T-CHM13v2.07121,573,495 - 122,065,688 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27119,308,832 - 119,785,474 (+)NCBI
Kcnd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39621,212,101 - 21,729,804 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl621,215,502 - 21,729,804 (+)EnsemblGRCm39 Ensembl
GRCm38621,215,346 - 21,729,805 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl621,215,503 - 21,729,805 (+)EnsemblGRCm38mm10GRCm38
MGSCv37621,166,109 - 21,679,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36621,166,110 - 21,679,806 (+)NCBIMGSCv36mm8
Celera621,270,473 - 21,783,671 (+)NCBICelera
Cytogenetic Map6A2- A3.1NCBI
cM Map68.49NCBI
Kcnd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554792,062,608 - 2,543,125 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554792,062,607 - 2,545,576 (+)NCBIChiLan1.0ChiLan1.0
KCND2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26157,137,701 - 157,618,726 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan179,147,110 - 9,628,983 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07112,277,018 - 112,751,896 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17124,965,851 - 125,439,913 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7124,966,816 - 125,437,430 (+)Ensemblpanpan1.1panPan2
LOC607881
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1460,421,540 - 60,422,657 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014126,284 - 155,942 (+)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.01468,634 - 98,256 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01449,808 - 79,444 (+)NCBIUU_Cfam_GSD_1.0
Kcnd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511847,376,410 - 47,833,708 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366054,372,671 - 4,825,423 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366054,370,222 - 4,828,972 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCND2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1826,139,457 - 26,623,233 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11826,139,457 - 26,624,210 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21827,744,043 - 27,759,304 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCND2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12189,091,939 - 89,575,464 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604214,004,421 - 14,488,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478315,351,870 - 15,891,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478315,349,416 - 15,892,011 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnd2
2890 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:24
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000051611
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)44917811657114705Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat

Markers in Region
D4Rat15  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8451,085,655 - 51,085,803 (+)Marker Load Pipeline
mRatBN7.2450,119,848 - 50,119,996 (+)MAPPERmRatBN7.2
Rnor_6.0448,656,252 - 48,656,399NCBIRnor6.0
Rnor_6.0446,898,276 - 46,898,423NCBIRnor6.0
Rnor_5.0448,448,661 - 48,448,808UniSTSRnor5.0
Rnor_5.0446,704,280 - 46,704,427UniSTSRnor5.0
RGSC_v3.4447,889,730 - 47,890,193RGDRGSC3.4
RGSC_v3.4447,890,039 - 47,890,186UniSTSRGSC3.4
RGSC_v3.1448,120,304 - 48,120,767RGD
Celera445,326,958 - 45,327,119UniSTS
RH 2.0 Map4373.2RGD
SHRSP x BN Map429.41RGD
Cytogenetic Map4q22UniSTS
D4Got29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2449,943,823 - 49,944,098 (+)MAPPERmRatBN7.2
Rnor_6.0448,477,569 - 48,477,843NCBIRnor6.0
Rnor_5.0448,269,332 - 48,269,606UniSTSRnor5.0
RGSC_v3.4447,709,493 - 47,709,768RGDRGSC3.4
RGSC_v3.4447,709,494 - 47,709,768UniSTSRGSC3.4
RGSC_v3.1447,940,068 - 47,940,342RGD
Celera445,151,415 - 45,151,680UniSTS
RH 3.4 Map4284.9UniSTS
RH 3.4 Map4284.9RGD
RH 2.0 Map4346.3RGD
Cytogenetic Map4q22UniSTS
RH144078  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2450,158,389 - 50,158,622 (+)MAPPERmRatBN7.2
Rnor_6.0448,696,267 - 48,696,499NCBIRnor6.0
Rnor_6.0446,937,142 - 46,937,374NCBIRnor6.0
Rnor_5.0448,488,676 - 48,488,908UniSTSRnor5.0
Rnor_5.0446,743,146 - 46,743,378UniSTSRnor5.0
RGSC_v3.4447,928,578 - 47,928,810UniSTSRGSC3.4
Celera445,364,025 - 45,364,257UniSTS
RH 3.4 Map4300.42UniSTS
Cytogenetic Map4q22UniSTS
RH138133  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2450,277,545 - 50,277,730 (+)MAPPERmRatBN7.2
Rnor_6.0448,816,604 - 48,816,788NCBIRnor6.0
Rnor_5.0448,609,015 - 48,609,199UniSTSRnor5.0
RGSC_v3.4448,047,724 - 48,047,908UniSTSRGSC3.4
Celera445,483,030 - 45,483,214UniSTS
RH 3.4 Map4285.6UniSTS
Cytogenetic Map4q22UniSTS
BF390067  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8450,986,006 - 50,986,197 (+)Marker Load Pipeline
mRatBN7.2450,020,194 - 50,020,385 (+)MAPPERmRatBN7.2
Rnor_6.0448,555,300 - 48,555,490NCBIRnor6.0
Rnor_5.0448,346,327 - 48,346,517UniSTSRnor5.0
RGSC_v3.4447,786,311 - 47,786,501UniSTSRGSC3.4
Celera445,227,735 - 45,227,925UniSTS
RH 3.4 Map4300.52UniSTS
Cytogenetic Map4q22UniSTS
UniSTS:498320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2450,274,908 - 50,276,068 (+)MAPPERmRatBN7.2
Rnor_6.0448,813,967 - 48,815,126NCBIRnor6.0
Rnor_5.0448,606,378 - 48,607,537UniSTSRnor5.0
RGSC_v3.4448,045,087 - 48,046,246UniSTSRGSC3.4
Celera445,480,393 - 45,481,552UniSTS
Cytogenetic Map4q22UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000112178   ⟹   ENSRNOP00000095226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl449,776,246 - 50,277,728 (+)Ensembl
RefSeq Acc Id: NM_031730   ⟹   NP_113918
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8450,742,485 - 51,243,540 (+)NCBI
mRatBN7.2449,776,702 - 50,277,746 (+)NCBI
Rnor_6.0448,309,283 - 48,816,804 (+)NCBI
Rnor_5.0448,099,455 - 48,609,215 (+)NCBI
RGSC_v3.4447,541,787 - 48,047,924 (+)RGD
Celera444,984,114 - 45,483,230 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108326   ⟹   XP_038964254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8450,741,595 - 50,843,366 (+)NCBI
mRatBN7.2449,775,812 - 49,877,551 (+)NCBI
Protein Sequences
Protein RefSeqs NP_113918 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964254 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40929 (Get FASTA)   NCBI Sequence Viewer  
  AAB19939 (Get FASTA)   NCBI Sequence Viewer  
  AAL93201 (Get FASTA)   NCBI Sequence Viewer  
  EDM15135 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095226
GenBank Protein Q63881 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113918   ⟸   NM_031730
- UniProtKB: Q99249 (UniProtKB/Swiss-Prot),   Q00090 (UniProtKB/Swiss-Prot),   Q63881 (UniProtKB/Swiss-Prot),   A0A8I6GL23 (UniProtKB/TrEMBL),   A6IE48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038964254   ⟸   XM_039108326
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000095226   ⟸   ENSRNOT00000112178
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63881-F1-model_v2 AlphaFold Q63881 1-630 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68393 AgrOrtholog
BioCyc Gene G2FUF-45524 BioCyc
Ensembl Genes ENSRNOG00000067416 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000112178 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv4 UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv4.2 UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv4_C UniProtKB/Swiss-Prot
  Shal-type_N UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  T1-type_BTB UniProtKB/Swiss-Prot
  VG_K_chnl UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:65180 UniProtKB/Swiss-Prot
NCBI Gene 65180 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 2 UniProtKB/Swiss-Prot
  PTHR11537 UniProtKB/Swiss-Prot
Pfam BTB_2 UniProtKB/Swiss-Prot
  DUF3399 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  Shal-type UniProtKB/Swiss-Prot
PhenoGen Kcnd2 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot
  KV42CHANNEL UniProtKB/Swiss-Prot
  KVCHANNEL UniProtKB/Swiss-Prot
  SHALCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000067416 RatGTEx
SMART BTB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A8I6GL23 ENTREZGENE, UniProtKB/TrEMBL
  A6IE48 ENTREZGENE, UniProtKB/TrEMBL
  KCND2_RAT UniProtKB/Swiss-Prot
  Q00090 ENTREZGENE
  Q63881 ENTREZGENE
  Q99249 ENTREZGENE
UniProt Secondary Q00090 UniProtKB/Swiss-Prot
  Q99249 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnd2  potassium voltage-gated channel subfamily D member 2  Kcnd2  potassium channel, voltage-gated Shal-related subfamily D, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnd2  potassium channel, voltage-gated Shal-related subfamily D, member 2  Kcnd2  potassium voltage-gated channel, Shal-related subfamily, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Kcnd2  potassium voltage-gated channel, Shal-related subfamily, member 2  Kcnd2  potassium voltage gated channel, Shal-related family, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnd2  potassium voltage gated channel, Shal-related family, member 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease reduced expression is seen in diabetes mellitus 68269
gene_disease reduced expression is seen in diabetes mellitus 628458
gene_disease reduced expression is seen in diabetes mellitus 628469
gene_disease reduced expression is seen in diabetes mellitus 628470
gene_disease reduced expression is seen in diabetes mellitus 628471
gene_domains contains 6 hydrophobic domains, the putative voltage sensing domain has only 5 basic residues 68269
gene_domains contains 6 hydrophobic domains, the putative voltage sensing domain has only 5 basic residues 628458
gene_domains contains 6 hydrophobic domains, the putative voltage sensing domain has only 5 basic residues 628469
gene_domains contains 6 hydrophobic domains, the putative voltage sensing domain has only 5 basic residues 628470
gene_domains contains 6 hydrophobic domains, the putative voltage sensing domain has only 5 basic residues 628471
gene_expression mRNA expressed in the brain and also in the cardiac atrium and ventricle 68269
gene_expression mRNA expressed in the brain and also in the cardiac atrium and ventricle 628458
gene_expression mRNA expressed in the brain and also in the cardiac atrium and ventricle 628469
gene_expression mRNA expressed in the brain and also in the cardiac atrium and ventricle 628470
gene_expression mRNA expressed in the brain and also in the cardiac atrium and ventricle 628471
gene_function forms voltage-gated outward current during repolarization in cardiac myocytes 68269
gene_mutations_overexpression overexpression preventes the AP duration prolongation as well as the increases in Ca2+ influx and Ca2+-transient amplitude induced by phenylephrine 633152
gene_other in stretozin-induced diabetic rats ventricular mRNA level decreased 68269
gene_other in stretozin-induced diabetic rats ventricular mRNA level decreased 628458
gene_other in stretozin-induced diabetic rats ventricular mRNA level decreased 628469
gene_other in stretozin-induced diabetic rats ventricular mRNA level decreased 628470
gene_other in stretozin-induced diabetic rats ventricular mRNA level decreased 628471
gene_physical_interaction forms heteromultimer channels with Kcnd4 which helps in increasing the rate of recovery from inactivation 68269
gene_physical_interaction forms heteromultimer channels with Kcnd4 which helps in increasing the rate of recovery from inactivation 628458
gene_physical_interaction forms heteromultimer channels with Kcnd4 which helps in increasing the rate of recovery from inactivation 628469
gene_physical_interaction forms heteromultimer channels with Kcnd4 which helps in increasing the rate of recovery from inactivation 628470
gene_physical_interaction forms heteromultimer channels with Kcnd4 which helps in increasing the rate of recovery from inactivation 628471
gene_process in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction 68269
gene_process in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction 628458
gene_process in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction 628469
gene_process in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction 628470
gene_process in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction 628471
gene_process contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle 68269
gene_process contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle 628458
gene_process contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle 628469
gene_process contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle 628470
gene_process contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle 628471
gene_protein 490 amino acids in size 68269