 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations |
Welcome {{ username}}
Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{gene.symbol}}: {{ gene.description }}
Save List to My RGD
| Create Name: | |
| Description: |
|
| Save what matters to you |
| {{ loginError }} |
| Sign in with your RGD account |
| Create New Account | Recover Password |
{{ watchLinkText }}
Select categories you would like to watch. Updates to this gene will be send to {{ username }}
Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
 |
Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
|
MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease AnnotationsGene-Chemical Interaction Annotations
|
|
|
Gene Ontology AnnotationsBiological Process
|
|
Cellular Component
|
|
|
Molecular Function
|
|
|
Molecular Pathway Annotations
|
|
References - curated| 1. | Alday A, etal., Channels (Austin). 2010 May-Jun;4(3):168-78. |
| 2. | Alonso G and Widmer H, Neuroscience. 1997 Apr;77(3):617-21. |
| 3. | Blair TA, etal., FEBS Lett 1991 Dec 16;295(1-3):211-3. |
| 4. | Chavira-Suarez E, etal., Biochem Biophys Res Commun. 2011 Jan 14;404(2):678-83. doi: 10.1016/j.bbrc.2010.12.041. Epub 2010 Dec 11. |
| 5. | Dabrowska J and Rainnie DG, Neuroscience. 2010 Dec 15;171(3):721-33. doi: 10.1016/j.neuroscience.2010.09.011. Epub 2010 Sep 16. |
| 6. | Deschenes I, etal., J Mol Cell Cardiol. 2008 Sep;45(3):336-46. Epub 2008 May 12. |
| 7. | Gardoni F, etal., J Biol Chem. 2007 Sep 28;282(39):28691-9. Epub 2007 Jul 16. |
| 8. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 9. | GOA data from the GO Consortium |
| 10. | Holmqvist MH, etal., Proc Natl Acad Sci U S A 2002 Jan 22;99(2):1035-40. |
| 11. | Jerng HH, etal., J Physiol. 2005 Nov 1;568(Pt 3):767-88. Epub 2005 Aug 25. |
| 12. | Kim J, etal., J Physiol. 2005 Nov 15;569(Pt 1):41-57. Epub 2005 Sep 1. |
| 13. | Kim J, etal., Neuron. 2007 Jun 21;54(6):933-47. |
| 14. | Kobayashi T, etal., J Mol Cell Cardiol. 2003 Sep;35(9):1073-82. |
| 15. | Liu YQ, etal., Front Cell Neurosci. 2014 Oct 14;8:329. doi: 10.3389/fncel.2014.00329. eCollection 2014. |
| 16. | MGD data from the GO Consortium |
| 17. | Nadal MS, etal., Neuron. 2003 Feb 6;37(3):449-61. |
| 18. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 19. | Nishiyama A, etal., Am J Physiol Heart Circ Physiol 2001 Oct;281(4):H1800-7. |
| 20. | Pipeline to import SMPDB annotations from SMPDB into RGD |
| 21. | RGD automated data pipeline |
| 22. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 23. | RGD automated import pipeline for gene-chemical interactions |
| 24. | Rhodes KJ, etal., J Neurosci. 2004 Sep 8;24(36):7903-15. |
| 25. | Roberds SL and Tamkun MM, Proc Natl Acad Sci U S A 1991 Mar 1;88(5):1798-802. |
| 26. | Rudakova E, etal., Pflugers Arch. 2015 Feb;467(2):299-309. doi: 10.1007/s00424-014-1521-3. Epub 2014 May 6. |
| 27. | Sanguinetti MC, etal., Mol Pharmacol. 1997 Mar;51(3):491-8. |
| 28. | Saygili E, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2898-905. Epub 2007 Feb 9. |
| 29. | Strassle BW, etal., J Comp Neurol. 2005 Apr 4;484(2):144-55. |
| 30. | Takeuchi S, etal., J Mol Cell Cardiol. 2000 Jul;32(7):1361-9. |
| 31. | Tseng GN Cardiovasc Res 1999 Jan;41(1):16-8. |
| 32. | Wickenden AD, etal., Am J Physiol 1999 May;276(5 Pt 2):H1599-607. |
| 33. | Yeola SW and Snyders DJ, Cardiovasc Res. 1997 Mar;33(3):540-7. |
| 34. | Zhou W, etal., Neuron. 2004 Feb 19;41(4):573-86. |
| 35. | Zobel C, etal., Circulation 2002 Oct 29;106(18):2385-91. |
References - uncurated| PubMed | 1840649 10676964 11040264 11606724 11847232 11923279 12592409 12626328 12754210 12829703 12835418 12843309 14551056 14613857 14980207 15454437 15485870 15671030 15946675 16176357 16271805 16553778 16636498 16648177 16820361 17026528 17122053 17475505 17725325 18045912 18088376 18363830 18371079 18463498 18513371 18515646 18603586 18815185 19213956 19261906 19267230 19453640 19713751 19857555 20573902 20920553 21034530 21252158 21273417 21451062 21472817 21511008 21895522 21943606 22098631 22245500 22511771 22700470 22815518 23066017 24037673 24404150 24486512 24811166 25043828 25756524 26179130 27259067 27322747 28566490 29996472 31935048 |
Genomics
Comparative Map Data| Kcnd2 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KCND2 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kcnd2 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kcnd2 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KCND2 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| LOC607881 (Canis lupus familiaris - dog) |
No map positions available. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kcnd2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KCND2 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KCND2 (Chlorocebus sabaeus - African green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kcnd2 (Heterocephalus glaber - naked mole-rat) |
No map positions available. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Position Markers| D4Rat15 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| D4Got29 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RH144078 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RH138133 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BF390067 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniSTS:498320 |
|
QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
||||||||
Expression
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_031730 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR07060003 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07072988 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01028963 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01028964 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01028965 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01028966 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01028967 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01028968 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01028969 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01028970 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01028971 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC117109 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF486814 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CB790894 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473959 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CO393575 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ214131 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| M59980 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| S64320 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | NM_031730 ⟹ NP_113918 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
|
||||||||||||||||||||
| Sequence: |
ACAGCGGCTGTGACCGCATTTCTGGAGCTACAACAACAGGTCGTCTTTTTGAGACGCCTTTGGChide sequence |
Protein Sequences| Protein RefSeqs | NP_113918 | (Get FASTA) | NCBI Sequence Viewer |
| GenBank Protein | AAA40929 | (Get FASTA) | NCBI Sequence Viewer |
| AAB19939 | (Get FASTA) | NCBI Sequence Viewer | |
| AAL93201 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM15135 | (Get FASTA) | NCBI Sequence Viewer | |
| Q63881 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_113918 ⟸ NM_031730 |
| - Peptide Label: | precursor |
| - UniProtKB: | Q63881 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDhide sequence |
Strain Variation
Strain Sequence Variants (Rnor 6.0)
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:68393 | AgrOrtholog |
| Gene3D-CATH | 1.20.120.350 | UniProtKB/Swiss-Prot |
| InterPro | BTB/POZ_dom | UniProtKB/Swiss-Prot |
| Ion_trans_dom | UniProtKB/Swiss-Prot | |
| K_chnl_volt-dep_Kv | UniProtKB/Swiss-Prot | |
| K_chnl_volt-dep_Kv4 | UniProtKB/Swiss-Prot | |
| K_chnl_volt-dep_Kv4.2 | UniProtKB/Swiss-Prot | |
| K_chnl_volt-dep_Kv4_C | UniProtKB/Swiss-Prot | |
| Shal-type_N | UniProtKB/Swiss-Prot | |
| SKP1/BTB/POZ_sf | UniProtKB/Swiss-Prot | |
| T1-type_BTB | UniProtKB/Swiss-Prot | |
| VG_K_chnl | UniProtKB/Swiss-Prot | |
| Volt_channel_dom_sf | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:65180 | UniProtKB/Swiss-Prot |
| NCBI Gene | 65180 | ENTREZGENE |
| PANTHER | PTHR11537 | UniProtKB/Swiss-Prot |
| Pfam | BTB_2 | UniProtKB/Swiss-Prot |
| DUF3399 | UniProtKB/Swiss-Prot | |
| Ion_trans | UniProtKB/Swiss-Prot | |
| Shal-type | UniProtKB/Swiss-Prot | |
| PhenoGen | Kcnd2 | PhenoGen |
| PRINTS | KV42CHANNEL | UniProtKB/Swiss-Prot |
| KVCHANNEL | UniProtKB/Swiss-Prot | |
| SHALCHANNEL | UniProtKB/Swiss-Prot | |
| SMART | BTB | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | SSF54695 | UniProtKB/Swiss-Prot |
| UniGene | Rn.87841 | ENTREZGENE |
| UniProt | KCND2_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
| UniProt Secondary | Q00090 | UniProtKB/Swiss-Prot |
| Q99249 | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2016-02-11 | Kcnd2 | potassium voltage-gated channel subfamily D member 2 | Kcnd2 | potassium channel, voltage-gated Shal-related subfamily D, member 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2015-01-26 | Kcnd2 | potassium channel, voltage-gated Shal-related subfamily D, member 2 | Kcnd2 | potassium voltage-gated channel, Shal-related subfamily, member 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2010-04-20 | Kcnd2 | potassium voltage-gated channel, Shal-related subfamily, member 2 | Kcnd2 | potassium voltage gated channel, Shal-related family, member 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2002-06-10 | Kcnd2 | potassium voltage gated channel, Shal-related family, member 2 | Name updated | 70584 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | reduced expression is seen in diabetes mellitus | 68269 |
| gene_disease | reduced expression is seen in diabetes mellitus | 628458 |
| gene_disease | reduced expression is seen in diabetes mellitus | 628469 |
| gene_disease | reduced expression is seen in diabetes mellitus | 628470 |
| gene_disease | reduced expression is seen in diabetes mellitus | 628471 |
| gene_domains | contains 6 hydrophobic domains, the putative voltage sensing domain has only 5 basic residues | 68269 |
| gene_domains | contains 6 hydrophobic domains, the putative voltage sensing domain has only 5 basic residues | 628458 |
| gene_domains | contains 6 hydrophobic domains, the putative voltage sensing domain has only 5 basic residues | 628469 |
| gene_domains | contains 6 hydrophobic domains, the putative voltage sensing domain has only 5 basic residues | 628470 |
| gene_domains | contains 6 hydrophobic domains, the putative voltage sensing domain has only 5 basic residues | 628471 |
| gene_expression | mRNA expressed in the brain and also in the cardiac atrium and ventricle | 68269 |
| gene_expression | mRNA expressed in the brain and also in the cardiac atrium and ventricle | 628458 |
| gene_expression | mRNA expressed in the brain and also in the cardiac atrium and ventricle | 628469 |
| gene_expression | mRNA expressed in the brain and also in the cardiac atrium and ventricle | 628470 |
| gene_expression | mRNA expressed in the brain and also in the cardiac atrium and ventricle | 628471 |
| gene_function | forms voltage-gated outward current during repolarization in cardiac myocytes | 68269 |
| gene_mutations_overexpression | overexpression preventes the AP duration prolongation as well as the increases in Ca2+ influx and Ca2+-transient amplitude induced by phenylephrine | 633152 |
| gene_other | in stretozin-induced diabetic rats ventricular mRNA level decreased | 68269 |
| gene_other | in stretozin-induced diabetic rats ventricular mRNA level decreased | 628458 |
| gene_other | in stretozin-induced diabetic rats ventricular mRNA level decreased | 628469 |
| gene_other | in stretozin-induced diabetic rats ventricular mRNA level decreased | 628470 |
| gene_other | in stretozin-induced diabetic rats ventricular mRNA level decreased | 628471 |
| gene_physical_interaction | forms heteromultimer channels with Kcnd4 which helps in increasing the rate of recovery from inactivation | 68269 |
| gene_physical_interaction | forms heteromultimer channels with Kcnd4 which helps in increasing the rate of recovery from inactivation | 628458 |
| gene_physical_interaction | forms heteromultimer channels with Kcnd4 which helps in increasing the rate of recovery from inactivation | 628469 |
| gene_physical_interaction | forms heteromultimer channels with Kcnd4 which helps in increasing the rate of recovery from inactivation | 628470 |
| gene_physical_interaction | forms heteromultimer channels with Kcnd4 which helps in increasing the rate of recovery from inactivation | 628471 |
| gene_process | in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction | 68269 |
| gene_process | in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction | 628458 |
| gene_process | in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction | 628469 |
| gene_process | in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction | 628470 |
| gene_process | in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction | 628471 |
| gene_process | contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle | 68269 |
| gene_process | contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle | 628458 |
| gene_process | contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle | 628469 |
| gene_process | contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle | 628470 |
| gene_process | contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle | 628471 |
| gene_protein | 490 amino acids in size | 68269 |
 |
| More on Kcnd2 | |
|
Alliance Gene |
|
NCBI Gene |
|
Ensembl Gene |
|
|
JBrowse: rn5 rn6 |
|
NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 68393 |
| Created: | 2001-07-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-02-04 |
| Status: | ACTIVE |
