Dpp6 (dipeptidyl peptidase like 6) - Rat Genome Database

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Gene: Dpp6 (dipeptidyl peptidase like 6) Rattus norvegicus
Analyze
Symbol: Dpp6
Name: dipeptidyl peptidase like 6
RGD ID: 68402
Description: Predicted to have potassium channel regulator activity. Involved in positive regulation of potassium ion transport and positive regulation of protein localization to plasma membrane. Localizes to cell surface; neuronal cell body; and voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant non-syndromic intellectual disability 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6); INTERACTS WITH bis(2-ethylhexyl) phthalate; bisphenol A; bromobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dipeptidyl aminopeptidase-like protein 6; dipeptidyl aminopeptidase-related protein; dipeptidyl peptidase IV-like protein; dipeptidyl peptidase VI; dipeptidylpeptidase 6; dipeptidylpeptidase VI; DPP VI; DPPX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.247,589,386 - 8,508,666 (-)NCBI
Rnor_6.0 Ensembl44,021,008 - 4,473,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.044,021,021 - 4,943,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.044,060,496 - 4,970,129 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.442,853,479 - 3,565,666 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.142,853,478 - 3,565,666 (-)NCBI
Celera42,039,300 - 2,691,360 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:8103397   PMID:18364354   PMID:19713751   PMID:20573902   PMID:21700703   PMID:21943606   PMID:22311982   PMID:22675523   PMID:23376485   PMID:23912628   PMID:24225951  


Genomics

Comparative Map Data
Dpp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.247,589,386 - 8,508,666 (-)NCBI
Rnor_6.0 Ensembl44,021,008 - 4,473,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.044,021,021 - 4,943,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.044,060,496 - 4,970,129 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.442,853,479 - 3,565,666 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.142,853,478 - 3,565,666 (-)NCBI
Celera42,039,300 - 2,691,360 (+)NCBICelera
Cytogenetic Map4q11NCBI
DPP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7153,887,097 - 154,894,285 (+)EnsemblGRCh38hg38GRCh38
GRCh387153,748,133 - 154,894,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377153,445,218 - 154,685,995 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367153,380,710 - 153,894,933 (+)NCBINCBI36hg18NCBI36
Build 367154,060,464 - 154,316,928 (+)NCBINCBI36hg18NCBI36
Build 347153,867,178 - 154,122,809NCBI
Celera7148,524,570 - 149,103,154 (+)NCBI
Celera7148,318,756 - 148,319,129 (-)NCBI
Cytogenetic Map7q36.2NCBI
HuRef7147,386,496 - 147,386,897 (+)NCBIHuRef
HuRef7147,843,601 - 148,104,076 (+)NCBIHuRef
HuRef7148,164,313 - 148,419,023 (+)NCBIHuRef
CHM1_17153,592,654 - 154,692,523 (+)NCBICHM1_1
CRA_TCAGchr7v27152,913,032 - 153,914,021 (+)NCBI
Dpp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39527,022,355 - 27,932,498 (+)NCBIGRCm39mm39
GRCm39 Ensembl527,022,201 - 27,932,503 (+)Ensembl
GRCm38526,817,357 - 27,727,500 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl526,817,203 - 27,727,505 (+)EnsemblGRCm38mm10GRCm38
MGSCv37527,143,897 - 28,054,040 (+)NCBIGRCm37mm9NCBIm37
MGSCv36527,148,144 - 28,057,245 (+)NCBImm8
Celera524,366,865 - 25,273,913 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map512.92NCBI
Dpp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554917,326,138 - 8,168,270 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554917,325,720 - 8,167,949 (+)NCBIChiLan1.0ChiLan1.0
DPP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17157,635,454 - 158,220,345 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7157,635,828 - 158,220,345 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07145,356,340 - 146,492,773 (+)NCBIMhudiblu_PPA_v0panPan3
DPP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11617,357,461 - 18,043,547 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1617,357,522 - 18,041,822 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1617,836,985 - 18,676,560 (+)NCBI
ROS_Cfam_1.01618,946,820 - 19,772,122 (+)NCBI
UMICH_Zoey_3.11617,458,435 - 18,143,487 (+)NCBI
UNSW_CanFamBas_1.01617,898,790 - 18,723,713 (+)NCBI
UU_Cfam_GSD_1.01617,951,354 - 18,776,429 (+)NCBI
Dpp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051183,479,982 - 4,328,689 (-)NCBI
SpeTri2.0NW_0049365278,574,455 - 9,423,445 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl183,148,481 - 3,905,410 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1183,148,479 - 3,905,845 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2183,287,948 - 3,570,413 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DPP6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121121,882,842 - 123,035,787 (+)NCBI
ChlSab1.1 Ensembl21122,441,548 - 123,035,792 (+)Ensembl
Dpp6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248002,725,353 - 3,585,987 (-)NCBI

Position Markers
D4Rat4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,935,610 - 7,935,781 (+)MAPPER
Rnor_6.044,364,715 - 4,364,885NCBIRnor6.0
Rnor_5.044,400,414 - 4,400,584UniSTSRnor5.0
RGSC_v3.443,237,190 - 3,237,361RGDRGSC3.4
RGSC_v3.443,237,191 - 3,237,361UniSTSRGSC3.4
RGSC_v3.143,237,190 - 3,237,361RGD
Celera42,359,289 - 2,359,459UniSTS
RH 2.0 Map40.0RGD
SHRSP x BN Map40.04RGD
FHH x ACI Map41.1801RGD
Cytogenetic Map4q11UniSTS
D4Rat139  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,761,995 - 7,762,132 (+)MAPPER
Rnor_6.044,193,723 - 4,193,859NCBIRnor6.0
Rnor_5.044,230,992 - 4,231,128UniSTSRnor5.0
RGSC_v3.443,037,683 - 3,037,822RGDRGSC3.4
RGSC_v3.443,037,684 - 3,037,822UniSTSRGSC3.4
RGSC_v3.143,037,683 - 3,037,822RGD
Celera42,523,609 - 2,523,747UniSTS
RH 2.0 Map40.0RGD
SHRSP x BN Map40.0RGD
FHH x ACI Map41.3201RGD
Cytogenetic Map4q11UniSTS
D4Arb13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,872,913 - 7,873,066 (+)MAPPER
Rnor_6.044,303,215 - 4,303,367NCBIRnor6.0
Rnor_5.044,338,454 - 4,338,606UniSTSRnor5.0
RGSC_v3.443,171,646 - 3,171,798UniSTSRGSC3.4
RGSC_v3.443,171,645 - 3,171,798RGDRGSC3.4
RGSC_v3.143,171,645 - 3,171,798RGD
RH 2.0 Map40.0RGD
SHRSP x BN Map40.08RGD
FHH x ACI Map41.3201RGD
Cytogenetic Map4q11UniSTS
D4Rat249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,676,771 - 7,677,007 (+)MAPPER
Rnor_6.044,108,269 - 4,108,504NCBIRnor6.0
Rnor_5.044,146,198 - 4,146,433UniSTSRnor5.0
RGSC_v3.442,938,589 - 2,938,825RGDRGSC3.4
RGSC_v3.442,938,590 - 2,938,825UniSTSRGSC3.4
RGSC_v3.142,938,247 - 2,938,852RGD
Celera42,607,516 - 2,607,741UniSTS
SHRSP x BN Map40.08RGD
SHRSP x BN Map40.08UniSTS
Cytogenetic Map4q11UniSTS
D4Got1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,949,085 - 7,949,208 (+)MAPPER
Rnor_6.044,377,736 - 4,377,858NCBIRnor6.0
Rnor_5.044,413,435 - 4,413,557UniSTSRnor5.0
RGSC_v3.443,250,662 - 3,250,785RGDRGSC3.4
RGSC_v3.443,250,663 - 3,250,785UniSTSRGSC3.4
RGSC_v3.143,250,662 - 3,250,785RGD
Celera42,345,864 - 2,345,986UniSTS
RH 2.0 Map40.0RGD
Cytogenetic Map4q11UniSTS
D4Got2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,810,244 - 7,810,377 (+)MAPPER
Rnor_6.044,241,885 - 4,242,017NCBIRnor6.0
Rnor_5.044,278,372 - 4,278,504UniSTSRnor5.0
RGSC_v3.443,086,917 - 3,087,050RGDRGSC3.4
RGSC_v3.443,086,918 - 3,087,050UniSTSRGSC3.4
RGSC_v3.143,086,917 - 3,087,050RGD
Celera42,480,994 - 2,481,116UniSTS
Cytogenetic Map4q11UniSTS
D4Got5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.248,253,041 - 8,253,170 (+)MAPPER
Rnor_6.044,682,158 - 4,682,284NCBIRnor6.0
Rnor_5.044,715,990 - 4,716,116UniSTSRnor5.0
RGSC_v3.443,557,260 - 3,557,387RGDRGSC3.4
RGSC_v3.443,557,261 - 3,557,387UniSTSRGSC3.4
RGSC_v3.143,557,260 - 3,557,387RGD
Celera42,047,591 - 2,047,717UniSTS
Cytogenetic Map4q11UniSTS
D4Got200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.248,203,532 - 8,203,701 (+)MAPPER
Rnor_6.044,632,646 - 4,632,814NCBIRnor6.0
Rnor_5.044,666,478 - 4,666,646UniSTSRnor5.0
RGSC_v3.443,507,913 - 3,508,081UniSTSRGSC3.4
Celera42,097,062 - 2,097,230UniSTS
Cytogenetic Map4q11UniSTS
D5Jcs89  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.248,259,413 - 8,259,550 (+)MAPPER
Rnor_6.044,688,524 - 4,688,660NCBIRnor6.0
Rnor_5.044,722,356 - 4,722,492UniSTSRnor5.0
RGSC_v3.443,563,627 - 3,563,763UniSTSRGSC3.4
Cytogenetic Map4q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4125545519Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4125545519Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4125545519Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4126654881Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4126803291Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4128352196Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4128352196Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4128352196Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4128352196Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4129778604Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4129778604Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4131554484Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)4142118977Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4304323179575658Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401755791834Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401764915903Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4304411426753655Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304780755324857Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:64
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000045773
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68 7
Low 3 20 23 11 4 11 3 3 6 34 33 11 3
Below cutoff 17 20 16 15 16 5 8 1 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045773   ⟹   ENSRNOP00000043113
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl44,021,008 - 4,473,307 (-)Ensembl
RefSeq Acc Id: NM_022850   ⟹   NP_074041
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.247,591,009 - 8,261,452 (-)NCBI
Rnor_6.044,022,644 - 4,690,562 (-)NCBI
Rnor_5.044,060,496 - 4,970,129 (-)NCBI
RGSC_v3.442,853,479 - 3,565,666 (-)RGD
Celera42,039,300 - 2,691,360 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235880   ⟹   XP_006235942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.247,589,386 - 8,043,973 (-)NCBI
Rnor_6.044,021,021 - 4,475,326 (-)NCBI
Rnor_5.044,060,496 - 4,970,129 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592501   ⟹   XP_017447990
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.247,589,386 - 8,508,666 (-)NCBI
Rnor_6.044,021,021 - 4,943,675 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592502   ⟹   XP_017447991
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.044,021,021 - 4,577,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592503   ⟹   XP_017447992
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.247,589,386 - 8,405,388 (-)NCBI
Rnor_6.044,021,021 - 4,837,007 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592504   ⟹   XP_017447993
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.247,589,386 - 8,100,391 (-)NCBI
Rnor_6.044,021,021 - 4,529,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107202   ⟹   XP_038963130
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.247,589,386 - 8,262,005 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_074041   ⟸   NM_022850
- Sequence:
RefSeq Acc Id: XP_006235942   ⟸   XM_006235880
- Peptide Label: isoform X3
- UniProtKB: F1LMR7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447990   ⟸   XM_017592501
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017447992   ⟸   XM_017592503
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017447991   ⟸   XM_017592502
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017447993   ⟸   XM_017592504
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000043113   ⟸   ENSRNOT00000045773
RefSeq Acc Id: XP_038963130   ⟸   XM_039107202
- Peptide Label: isoform X1
Protein Domains
DPPIV_N   Peptidase_S9

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 4259492 4259493 C T snv FHH/EurMcwi (MCW), Crl:SD (UDEL), FHH/EurMcwi (KNAW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 4222330 4222331 C T snv FHH/EurMcwi (RGD), FHH/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68402 AgrOrtholog
Ensembl Genes ENSRNOG00000030547 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000043113 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045773 UniProtKB/TrEMBL
Gene3D-CATH 2.140.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9B_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29272 UniProtKB/Swiss-Prot
NCBI Gene 29272 ENTREZGENE
Pfam DPPIV_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dpp6 PhenoGen
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC239089
UniProt DPP6_RAT UniProtKB/Swiss-Prot
  F1LMR7 ENTREZGENE, UniProtKB/TrEMBL
  P46101 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Dpp6  dipeptidyl peptidase like 6  Dpp6  dipeptidylpeptidase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Dpp6  dipeptidyl peptidase like 6  Dpp6  dipeptidyl peptidase like 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dpp6  dipeptidylpeptidase 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in brain 68240